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| 1 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery显示文摘A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles(MSNs) and formed low molecular weight gel(LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel. | Wenxia Gao Yalong Hu Long Xu Miaochang Liu Huayue Wu Bin He | 2018 | Chinese Chemical Letters2018，29，12： | 4 |
| 3 | A photocleavable low molecular weight hydrogel for light-triggered drug delivery显示文摘A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative.~1H NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and π-π stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm,77.5 mW/cm^2). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition. | Qihong Liu Hao Wang Guotao Li Miaochang Liu Jinchang Ding Xiaobo Huang Wenxia Gao Huayue Wu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 4 | Response of grain size of Quaternary gravels to climate and tectonics in the northern Tibetan Plateau显示文摘The widely distributed thick gravel deposits along the rim of the Tibetan Plateau have been long thought to be the product of rapid tectonic uplift of the plateau. However, this has been challenged by recent works that suggest these thick gravels may be the result of climate change. In this paper we carried out a detailed field measurement of gravel grain sizes from the Jiuquan and Gobi Gravel Beds in the top of the Laojunmiao section in the Jiuxi Basin in the northern margin of Qilian Mts. (northern Tibetan Plateau). The results suggest that the grain sizes of the Jiuquan and Gobi Gravel Beds over the last 0.8 Ma are characterized by nine coarse-fine cycles having strong 100-ka and 41-ka periodicities that correlate well with the loess-paleosol monsoon record and isotopic global climatic record from deep sea sediments as well as by a long trend of coarsening in gravel grain size. The coarse gravel layers were formed during the warm-humid interglaciations while the fine layers correspond to the cold-dry glaciations. Because the paleoclimate in NW China began to get dramatically drier after the mid-Pleistocene, we think the persistent coarsening of gravel grain size was most probably caused by the rapid uplift of the northern Tibetan Plateau, and that the orbital scale cyclic variations in gravel grain size were driven by orbital forcing factors that were superimposed on the tectonically-forced long-term coarsening trend in gravel size. These findings also shed new light on the interaction results of climate and tectonics in relation to the uplift of the Tibetan Plateau. | FU KaiDao FANG XiaoMin GAO JunPing HAN WenXia LI LiLi | 2007 | Science China Earth Sciences2007，50，1： | 3 |
| 5 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 6 | Expression levels and genetic polymorphisms of interleukin-2 and interleukin-10as biomarkers of Graves’ disease显示文摘 | Cuige Liang Wenhua Du Qingyu Dong Xiaomeng Liu Wenxia Li Yueli Wang Guanqi Gao | 2015 | Experimental and Therapeutic Medicine2015，，： | 1 |
| 7 | Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase显示文摘Radix Bupleuri(RB)is commonly used to treat depression,but it can also lead to hepatotoxicity after longterm use.In many anti-depression prescriptions,RB is often used in combination with Radix Paeoniae Alba(RPA)as an herb pair.However,whether RPA can alleviate RB-induced hepatotoxicity remain unclear.In this work,the results confirmed that RB had a dose-dependent antidepressant effect,but the optimal antidepressant dose caused hepatotoxicity.Notably,RPA effectively reversed RB-induced hepatotoxicity.Afterward,the mechanism of RB-induced hepatotoxicity was confirmed.The results showed that saikosaponin A and saikosaponin D could inhibit GSH synthase(GSS)activity in the liver,and further cause liver injury through oxidative stress and nuclear factor kappa B(NF-kB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)pathway.Furthermore,the mechanisms by which RPA attenuates RBinduced hepatotoxicity were investigated.The results demonstrated that RPA increased the abundance of intestinal bacteria with glycosidase activity,thereby promoting the conversion of saikosaponins to saikogenins in vivo.Different from saikosaponin A and saikosaponin D,which are directly combined with GSS as an inhibitor,their deglycosylation conversion products saikogenin F and saikogenin G exhibited no GSS binding activity.Based on this,RPA can alleviate the inhibitory effect of saikosaponins on GSS activity to reshape the liver redox balance and further reverse the RB-induced liver inflammatory response by the NFkB/NLRP3 pathway.In conclusion,the present study suggests that promoting the conversion of saikosaponins by modulating gut microbiota to attenuate the inhibition of GSS is the potential mechanism by which RPA prevents RB-induced hepatotoxicity. | Congcong Chen Wenxia Gong Junshen Tian Xiaoxia Gao Xuemei Qin Guanhua Du Yuzhi Zhou | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 1 |
| 8 | In vivo inducing collagen regeneration of biodegradable polymer microspheres显示文摘Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials.The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers.Herein,eight biodegradable polymers with different molecular weights,chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications.Polymer microspheres with 20-100 lmwere prepared.The in vitro degradation study showed that poly(L-lactic-co-glycolic acid)75/25 microspheres degraded the fastest,whereas poly(L-lactic acid)(PLLA)microspheres with intrinsic viscosity of 6.89([g]¼6.89)with the highest molecular weight showed the slowest degradation rate.After these microspheres were fabricated dermal fillers according to the formula of SculptraVR,they were injected subcutaneously into the back skin of rabbits.In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres.The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time.PLLA([g]¼3.80)microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect.These properties of size,morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. | Yixin Zhang Hanwen Liang Qian Luo Jianlin Chen Nan Zhao Wenxia Gao Yuji Pu Bin He Jing Xie | 2021 | Regenerative Biomaterials2021，8，5： | 1 |
| 9 | Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation显示文摘 | Wenxia Gao Xiaoqing Lin Xiepeng Lin | 2011 | Carbohydr Poly2011，84，4： | 1 |
| 10 | Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures显示文摘 | Chen Gao Liya Zhou Wenxia Zhu Hongyun Wang Ruijuan Wang Yunfei He Zhiyun Li | 2015 | Neuroscience Letters2015，，： | 1 |
| 11 | Degradation of 4-aminophenol by hydrogen peroxide oxidation using enzyme from Serratia marcescens as catalyst显示文摘This paper reports on the degradation of 4-aminophenol using hydrogen peroxide as oxidizer and the enzyme from Serratia marcescens AB 90027 as catalyst.The effecting factors during degradation and the degrading mechanism were studied.Also,the location of the enzyme in the cell,which could catalyze the degradation of 4-aminophenol,was analyzed.The results showed that to degrade 50 mL of 4-aminophenol whose concentration was 500 mg/L,the optimal conditions were:volume of H_(2)O_(2)=3 mL,temperature=40-60°C and pH=9-10.In the degra-dation process,4-aminophenol was first converted to benzo-quinone and NH3,then organic acids including maleic acid,fumaleic acid,and oxalic acid were formed,and then finally CO_(2) and H2O were generated as final products.The enzyme that could catalyze the degradation of 4-aminophenol was mainly extracellular enzyme. | SUN Min YAO Risheng YOU Yahua DENG Shengsong GAO Wenxia | 2007 | Frontiers of Environmental Science & Engineering2007，1，1： | 1 |
| 12 | In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy显示文摘The copper(Ⅱ)diethyldithiocarbamate(Cu(DDC)2)complex exhibited excellent inhibition to cancer cells.The usual administration is intravenous injection for disulfram and oral for copper.A new strategy was reported to improve the administration efficiency of the Cu(DDC)2 drug.Poly(lactide-co-glycolide)(PLGA)nanoparticles were used to trap disulfram and copper gluconate separately,the two types of drug loaded nanoparticles were injected in mesothelioma-bearing nude mice via intraperitoneal injection.The in vivo formation of Cu(DDC)2 complex was induced by disulfiram and Cu^2+ released from PLGA nanoparticles.This stra tegy avoided many obstacles in the use of Cu(DDC)2 complex as chemothe rapeutic and exhibited excellent anticancer activity to mesothelioma. | Yixin Zhang Shunjie Ding Junhua Li Xinyu Peng Jing Li Jing Chang Wenxia Gao Bin He | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 13 | A Mg^(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing显示文摘Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired.Herein,we reported a composite antibacterial hydrogel PDA-PAM/Mg^(2+)that shows excellent self-healing and tissue adhesive property,and photothermal antibacterial functions for accelerating wound healing.The gel was composed of polyacrylamide(PAM),polydopamine(PDA),and magnesium(Mg^(2+))and prepared via a two-step procedure:an alkali-induced dopamine pre-polymerization and followed radical polymerization process.The composite gel shows excellent tissue adhesiveness and Mg^(2+)-synergized photothermal antibacterial activity,inducing a survival rate of 5.29% for S.aureus and 7.06%for E.coli after near infrared light irradiation.The composite hydrogel further demonstrated efficient bacteria inhibition,enhanced wound healing and collagen deposition in a full-thickness skin defect rat model.Together,the PDA-PAM/Mg^(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion,wound healing,and antibacterial functions. | Zhaoyuan Guo Zhuangzhuang Zhang Nan Zhang Wenxia Gao Jing Li Yuji Pu Bin He Jing Xie | 2022 | Bioactive Materials2022，7，9： | 0 |
| 14 | Control of MSC Differentiation by Tuning the Alkyl Chain Length of Phe- nylboroinc Acid Based Low-molecular-weight Gelators显示文摘 | Jing He Yalong Hu Fang Wu Bin He Wenxia Gao | 2018 | Journal of Bionic Engineering2018，15，4： | 0 |
| 15 | Enhanced low-field magnetocaloric effect in Nb and Al co-substituted EuTiO_(3)compounds显示文摘The magnetic ground state switching between antiferromagnetic(AFM)and ferromagnetic(FM)states in EuTiO_(3)provides the feasibility of regulating its magnetic properties and magnetocaloric effect.First-principles calculations demonstrate that the magnetic ground states for EuTi_(0.875)Nb_(0.0625)Al_(0.0625)O_(3),EuTi_(0.8125)Nb_(0.125)Al_(0.)0_(625)O_(3),and EuTi_(0.75)Nb_(0.125)Al_(0.125)O_(3)are FM coupling.Experimental results also exhibit the FM coupling domination in these compounds,accompanied by a significantly enhanced low magnetic field magnetocaloric effect.The maximum magnetic entropy change of all the samples surpasses15 J kg^(-1)K^(-1)with a field change of 1 T.which is 1.4 times as large as that of bulk EuTiO_(3).Especially,the maximum refrigerating capacity for EuTi_(0.8125)Nb_(0.125)Al_(0.0625)O_(3)compound is evaluated to be 88.1 J kg^(-1),more than three times of that of EuTiO_(3).The remarkable magnetocaloric performances prove Nb and Al co-substituted EuTiO_(3)compounds to be competitive candidates for magnetic refrigeration in the liquid helium temperature regime. | Huicai Xie Wenxia Su Haiming Lu Zhaojun Mo Dunhui Wang Hao Sun Lu tian Xinqiang Gao Zhenxing Li Jun Shen | 2022 | Journal of Materials Science & Technology2022，，23： | 0 |
| 16 | Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine显示文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development. | Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 17 | Salt/current-triggered stabilization of β-cyclodextrins encapsulated host-guest low-molecular-weight gels显示文摘Host-guest supramolecular gels were developed via the self-assembly of inclusion complexes(ICs) ofβ-cyclodextrins/phenylboronic acid gelator(PBA).Salts and current were involved in the self-assembly to stabilize the host-guest gels.The stability of the gels was greatly improved after salts were added.The stable time of gels was extended from 2.5 h to 120 h with the addition of NH_4 NO_3 at the concentration of 2.5×10^(-2) g/mL.The morphology of the gel was affected by the concentrations of NH_4NO_3.SEM images revealed that the gels were three-dimensional nanofibrous networks,the sizes of fibers decreased with decreasing NH_4NO_3 concentrations,which affected the stability of gels,further proved by the rheological properties of gels.More stable gels were obtained with current stimulation,the stable time of the gel was increased from 2.5 h to 55 h with current by adding NaBF_4.The current also exhibited significant influence on the aggregation as the voltage varied(0-500 mV) with a constant concentration of salts.The result showed the self-assembly process of host-guest gel could be well controlled via the addition of salts and current to desired morphology and stability. | Huan Xu Chaoyu Zhou Chuanjiang Jian Sunhai Yang Miaochang Liu Xiaobo Huang Wenxia Gao Huayue Wu | 2020 | Chinese Chemical Letters2020，31，2： | 0 |
| 18 | Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism显示文摘Chaigui granules(CG)are a compound composed of six herbal medicines with significant antidepressant effects.However,the antidepressant mechanism of CG remains unclear.In the present study,we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergic signaling.First,the regulatory effect of CG on purine metabolites in the prefrontal cortex(PFC)of chronic unpredictable mild stress(CUMS)rats was analyzed by ultra high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)targeted quantitative analysis.Meanwhile,purinergic receptors(P2X7 receptor(P2X7R),A1 receptor(A1R)and A2A receptor(A2AR))and signaling pathways(nod-like receptor protein 3(NLRP3)inflammasome pathway and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)pathway)associated with purine metabolism were analyzed by western blotting and enzyme-linked immunosorbent assay(ELISA).Besides,antidepressant mechanism of CG by modulating purine metabolites to activate purinergic receptors and related signaling pathways was dissected by exogenous supplementation of purine metabolites and antagonism of purinergic receptors in vitro.An in vivo study showed that the decrease in xanthine and the increase in four purine nucleosides were closely related to the antidepressant effects of CG.Additionally,purinergic receptors(P2X7R,A1R and A2AR)and related signaling pathways(NLRP3 inflammasome pathway and cAMP-PKA pathway)were also significantly regulated by CG.The results of exogenous supplementation of purine metabolites and antagonism of purinergic receptors showed that excessive accumulation of xanthine led to activation of the P2X7R-NLRP3 inflammasome pathway,and the reduction of adenosine and inosine inhibited the A1R-cAMP-PKA pathway,which was significantly ameliorated by CG.Overall,CG could promote neuroprotection and ultimately play an antidepressant role by inhibiting the xanthine-P2X7R-NLRP3 inflammasome pathway and activating the adenosine/inosine-A1R-cAMP-PKA pathway. | Jiajun Chen Tian Li Dehua Huang Wenxia Gong Junsheng Tian Xiaoxia Gao Xuemei Qin Guanhua Du Yuzhi Zhou | 2023 | Journal of Pharmaceutical Analysis2023，13，12： | 0 |
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