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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 3 | Clinical outcome after management of unprotected left main in-stent restenosis after bare metal or drug-eluting stents显示文摘也的背景培植赤裸的金属 stent (BMS ) 或 drug-eluting stent (DES ) 与没有防卫的左主要狭窄(UPLMS ) 为病人在每天实践被使用了。仍然有数据 regading 的缺乏 UPLMS in-stent 狭窄(ISR ) 的随后的结果。在 stenting 被包括以后,现在的学习与 UPLMS ISR 在 BMS 或 DES.Methods 病人的培植以后在 determing 瞄准了 UPLMS ISR 病人的临床的结果。主要端点是累积主要不利心脏的事件(向) ,包括心脏的死亡,心肌的梗塞(Ml ) ,和目标容器 revascularization (TVR ).Results UPLMS ISR 率 14.8%(n=73, 15.7% 在 BMS 以后, 14.5% 为 DES ) 在以后平均(3.89 | CHEN Shao-liang XU Bo Gary Mintz YE Fei ZHANG Jun-jie KAN Jing SUN Xue-wen ZHANG Ai-ping CHEN Jin-guo QIAN Jun Kwan Tak W | 2010 | Chinese Medical Journal2010，，7： | 3 |
| 4 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 5 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 6 | 水合作用与身体活动:科学概念及实际应用显示文摘 | Gary W Mack Ph.D. Michael F.Bergeron | 2001 | 体育科学2001，21，3： | 2 |
| 7 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002，，1： | 2 |
| 8 | Visual Function Assessment Questionnaires显示文摘 | Robert W Massof Gary S Rubin | 2001 | Survey of Ophthalmology2001，，6： | 2 |
| 9 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 10 | Temperature-insensitive near-infrared spectro scopic measurement of glucose in aqueous solutions显示文摘 | Hazen Kevin H Arnold Mark A Small Gary W | 1994 | Applied Spectroscopy1994，48，4： | 1 |
| 11 | Marked improvement of PAC and BAG cloning is achieved using electroelution of pulsed-field gelseperated partial digested of genomic DNA显示文摘 | Scott J S Yuko O Gary W L | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 12 | Deformable Model Retrieval Based on Topological and Geometric Signatures 显示文摘 | Gary K L Tam Rynson W H Lau | 2007 | IEEE Transactions on Visualization and Computer Graphics (S1077-2626)2007，13，3： | 1 |
| 13 | Physical Properties of Polymer/clay Nanocomposites显示文摘 | Clois E Powell Gary W Beall | 2006 | Current Opinion in Solid State and Materials Science2006，0，： | 1 |
| 14 | Harmonic diffractive lenses 显示文摘 | DONALD W S GARY E S | 1995 | Appl Opt1995，34，： | 1 |
| 15 | Besifloxacin,a novel fluoroquinolone,has broad-spectrum in vitro activity against aerobic and anaerobic bacteria显示文摘 | Haas W Chris M P Gary E Z | 2009 | Antimicrob Agents Chemother2009，53，8： | 1 |
| 16 | PET of Brain Amyloid and Tau in Mild Cognitive Impairment显示文摘 | Gary W Small M | 2006 | N Engl J Med2006，355，： | 1 |
| 17 | Solid-state reactive sintering of transparent polycrystalline Nd YAG ceramics 显示文摘 | Lee Sang-ho Sujarinee Kochawattana w Messing Gary L | 2006 | Journal of American Ceramic Society2006，89，6： | 1 |
| 18 | Polyphenol content and health benefits of raisins显示文摘 | GARY W ARIANNA C | 2010 | Nutrition Research2010，30，8： | 1 |
| 19 | Comparison of dis- ease severity and incidence at different growth stages of naturally infected canola plants under field conditions by pycnidiospores of Phoma lingam as a main source of inoc- ulum显示文摘 | Kaveh G Fernando D W G Gary C | 2011 | Canadian Journal of Plant Pathology2011，33，3： | 1 |
| 20 | An analytical approach for characterizing harmonic and interharmonic currents generated by VSI-Fed adjustable speed drives 显示文摘 | Gary W Chang Shin-Kuan Chen | 2005 | IEEE Transactions on Power Delivery2005，20，5： | 1 |
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