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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Methane reforming kinetics within a Ni-YSZ SOFC anode support显示文摘 | Ethan S H Gaurav K G Zhu H Y | 2005 | Appl Catal A2005，95，1： | 1 |
| 3 | Do Context and Personality Matter: Trust and Privacy Concerns in Disclosing Private Information Online显示文摘 | GAURAV B FATEMEH M Z DAVID G | 2015 | Information & Management2015，，8： | 1 |
| 4 | Malignant peripheral nerve sheath tumors显示文摘 | Gaurav G Antonios M Allen M | 2008 | Neurosurg Clln N Am2008，19，1： | 1 |
| 5 | Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents 显示文摘 | GAURAV G SUVARNA GK | 2006 | Eur J Med Chem2006，41，2： | 1 |
| 6 | Chemotherapeutic interventions against tuberculosis显示文摘 | Neeraj S Gaurav G Babita A | 2012 | Pharmaceuticals2012，5，7： | 1 |
| 7 | Tuning and sensitivity enhancement of surface plasmon resonance sensor显示文摘 | Gaurav G Jun K | 2007 | Sensors and Actuators B2007，122，2： | 1 |
| 8 | An image retrieval system with automatic query modification 显示文摘 | GAURAV A ASHWIN T V SUGATA G | 2002 | IEEE Trans on Multimedia2002，4，2： | 1 |
| 9 | Tuning and sensitivity enhancement of surface plasmon resonance sensor 显示文摘 | Gaurav G Jun K | 2007 | Sensors and Actuators B2007，122，2： | 1 |
| 10 | Fast dissolving drug delivery and its technologies显示文摘 | GAURAV K SAMITA G | 2012 | Pharm Inn J2012，1，2： | 1 |
| 11 | Genome wide DNA methyla- tion profiling for epigenetic alteration in coronary artery disease patients显示文摘 | Priyanka S Gaurav G Arun K | 2014 | Gene2014，541，1： | 1 |
| 12 | Using neural networks and GIS to forecast land use changes: a Land Transformation Model显示文摘 | Bryan C Pijanowski Daniel G Brown Bradley A Shellito Gaurav A Manik | 2002 | Computers Environment and Urban Systems2002，，6： | 1 |
| 13 | Adaptive beamforming measurements using fourelement portable and mobile arrays显示文摘 | Joshi Gaurav G Dietrich Carl B Stutzman Warren L | 2005 | IEEE Transations on Antennas and Propagarion2005，53，12： | 1 |
| 14 | Sensitivi- ty assessment of wave heights to surface forcing in Cook Inlet, Alaska显示文摘 | Gaurav Singhal Vijay G Panchang James A Nelsonc | 2013 | Continental Shelf Research2013，63，： | 1 |
| 15 | Quantitative relationship of stress Tc-99m sestamibi lung uptake with resting Tl-201 lung uptake and with indices of left ventricular dysfunction and coronary artery disease显示文摘 | Gaurav M Patel Thomas H Hauser J.Anthony Parker Duane S Pinto Gregory P Sanders Franz C Aepfelbacher Polyxeni Koutkia Peter G Danias | 2004 | Journal of Nuclear Cardiology2004，，4： | 1 |
| 16 | Methane reforming kinetics within a Ni-YSZ SOFC anode support显示文摘 | ETHAN S H GAURAV K G ZHU H DEAN A M KEE R J MAIER L DEUTSCHMANN O | 2005 | Appl Catal A2005，295，1： | 1 |
| 17 | Using neural networks and GIS to forecast land use changes: a Land Transformation Model显示文摘 | Bryan C Pijanowski Daniel G Brown Bradley A Shellito Gaurav A Manik | 2002 | Computers, Environment and Urban Systems2002，，6： | 1 |
| 18 | Suspected cerebral arterial gas embolism during a laparoscopic Nissen fundoplication显示文摘We present the first case report known to us of a suspected cerebral arterial gas embolism(CAGE) leading to transient left-sided hemiparesis after a laparoscopic Nissen fundoplication. During the operation there was no evidence of hemodynamic compromise and the endtidal carbon dioxide level and oxygen saturation had been within normal limits. Radiological studies and transesophageal echocardiography showed no abnormalities. We conclude that CAGE can occur during uncomplicated laparoscopic surgery even in the absence of demonstrable intracardiac shunts. | Gaurav V Kulkarni P Marco Fisichella Barbara G Jericho | 2013 | World Journal of Anesthesiology2013，2，3： | 0 |
| 19 | Rosai-Dorfman病特异性表达OCT2:显示独特的单核-巨噬细胞表型显示文摘Rosai-Dorfman病是一类累及淋巴结且具有显著异质性和临床特征的自限性组织细胞疾病,确诊该病前需排除其他组织肿瘤,尤其需与Erdheim-Chester病和朗格汉斯细胞组织细胞增生症鉴别。作者收集33例Rosai-Dorfman病,对其组织学和免疫表型特征进分析。患者年龄21~79岁,中位年龄54岁,女性占多数(73%,n=24)。根据WHO(2016)组织细胞肿瘤修订新分类,24例皮肤外病变被归为“R”组. | 王婷(摘译) 余英豪(审校) Ravindran A Gaurav G Go R S | 2022 | 临床与实验病理学杂志2022，38，8： | 0 |
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