|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surgery for colorectal liver metastases: The evolution of determining prognosis显示文摘Despite improvements in the multi-modality treatment of colorectal liver metastasis (CRLM), survival after resection remains varied. Determining prognosis after surgical resection has historically been predicated on preoperative clinicopathological factors such as primary tumor stage, carcinoembryonic antigen levels, number of liver metastases, presence of extrahepatic disease, as well as other factors. While scoring systems have been developed by combining certain preoperative fac- tors, these have been inconsistent in accurately deter- mining prognosis. There has been increasing interest in the use of biologic and molecular markers to predict prognosis following CRLM. The role of markers such as KRAS, BRAF, p53, human telomerase reverse transcrip- tase, thymidylate synthase, Ki-67, and hypoxia inducible factor-1α and their correlation with accurately predict- ing survival after surgical resection have been sup- ported by several studies. Furthermore, other elements such as pathological response to chemotherapy and the presence of circulating tumor cells have shown promise in accurately determining prognosis after resection for colorectal liver metastasis.We herein review past, present, and possible future markers of prognosis among colorectal cancer patients with liver metastasis undergo-ing resection with curative intent. | Gaya Spolverato Aslam Ejaz Nilo Azad Timothy M Pawlik | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 7 |
| 2 | Novel susceptibility genes in inflammatory bowel disease显示文摘The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. | Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell Jack Satsangi | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 3 | Utility of faecal calprotectin analysis in adult inflammatory bowel disease显示文摘The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic relapsing, remitting disorders. Diagnosis, along with assessment of disease activity and prognosis present challenges to managing clinicians. Faecal biomarkers, such as faecal calprotectin, are a non-invasive method which can be used to aid these decisions. Calprotectin is a calcium and zinc binding protein found in the cytosol of human neutrophils and macrophages. It is released extracellularly in times of cell stress or damage and can be detected within faeces and thus can be used as a sensitive marker of intestinal inflammation. Faecal calprotectin has been shown to be useful in the diagnosis of IBD, correlates with mucosal disease activity and can help to predict response to treatment or relapse. With growing evidence supporting its use, over the last decade this faecal biomarker has significantly changed the way IBD is managed. | Lyn A Smith Daniel R Gaya | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 4 | Catastrophic gastrointestinal complication of systemic immunosuppression显示文摘We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone.The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis.Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus(HSV)and cytomegalovirus(CMV)respectively.Viral infection of the upper gastrointestinal tract is a recognised complication of immunosuppression and HSV is one of the most common pathogens.CMV on the other hand most commonly causes a colitis or less commonly oesophagitis.CMV enteritis is rare as is the synchronous infection with two viral agents in an immunocompromised patient having being described in a few case series only.Viral infection of the gastrointestinal tract in immunocompromised patients should be treated with systemic anti-viral medication and consideration to withdrawal of the immunosuppressive therapy if possible and appropriate.The authors highlight the need for a high suspicion of viral infection in immunosuppressed patients presenting with upper gastrointestinal bleeding. | Lyn Alexandra Smith Mitali Gangopadhyay Daniel R Gaya | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 5 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 6 | A multicenter United States—Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B显示文摘 | Robert P. Perrillo Teresa Wright Jorge Rakela Gary Levy Eugene Schiff Robert Gish Paul Martin Jules Dienstag Paul Adams Rolland Dickson Gaya Anschuetz Steve Bell Lynn Condreay Nathaniel Brown | 2001 | Hepatology2001，，2： | 2 |
| 7 | Identification of QTLs and candidate genes for physiological traits associated with drought tolerance in cotton显示文摘Background:Cotton is mainly grown for its natural fiber and edible oil.The fiber obtained from cotton is the indispensable raw material for the textile industries.The ever changing climatic condition,threatens cotton production due to a lack of sufficient water for its cultivation.Effects of drought stress are estimated to affect more than 50%of the cotton growing regions.To elucidate the drought tolerance phenomenon in cotton,a backcross population was developed from G.tomentosum,a drought tolerant donor parent and G.hirsutum which is highly susceptible to drought stress.Results:A genetic map of 10888 SNP markers was developed from 200 BC_2F_2 populations.The map spanned 4191.3 centi-Morgan(c M),with an average distance of 0.1047 c M,covering 51%and 49%of At and Dt sub genomes,respectively.Thirty stable Quantitative trait loci(QTLs)were detected,in which more than a half were detected in the At subgenome.Eighty-nine candidate genes were mined within the QTL regions for three traits:cell membrane stability(CMS),saturated leaf weight(SLW)and chlorophyll content.The genes had varied physiochemical properties.A majority of the genes were interrupted by introns,and only 15 genes were intronless,accounting for 17%of the mined genes.The genes were found to be involved molecular function(MF),cellular component(CC)and biological process(BP),which are the main gene ontological(GO)functions.A number of mi RNAs were detected,such as mi R164,which is associated with NAC and MYB genes,with a profound role in enhancing drought tolerance in plants.Through RT-q PCR analysis,5 genes were found to be the key genes involved in enhancing drought tolerance in cotton.Wild cotton harbors a number of favorable alleles,which can be exploited to aid in improving the narrow genetic base of the elite cotton cultivars.The detection of 30 stable QTLs and 89 candidate genes found to be contributed by the donor parent,G.tomentosum,showed the significant genes harbored by the wild progenitors which can be exploited in developing more robust cotton genotypes with diverse tolerance levels to various environmental stresses.Conclusion:This was the first study involving genome wide association mapping for drought tolerance traits in semi wild cotton genotypes.It offers an opportunity for future exploration of these genes in developing highly tolerant cotton cultivars to boost cotton production. | MAGWANGA Richard Odongo LU Pu KIRUNGU Joy Nyangasi CAI Xiaoyan ZHOU Zhongli AGONG Stephen Gaya WANG Kunbo LIU Fang | 2020 | Journal of Cotton Research2020，3，1： | 2 |
| 8 | Anti-angiogenesis therapies:their potential in cancer management 显示文摘 | Eichholz A Merchant S Gaya AM | 2010 | Onco Target Ther2010，24，3： | 1 |
| 9 | Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions:intermediates,influence of dosage and inorganic anions显示文摘 | Gaya U I Abdullah A H Zainal Z | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 10 | MicroRNA expression profiling in classic hodgkin lymphoma显示文摘 | Navarro A Gaya A Martinez A | | 0，，05： | 1 |
| 11 | Innovation and network structural dynamics : Study of the alliance network of a ma- jor sector of the biotechnology industry显示文摘 | Brigitte Gaya Bernard Dousset | 2005 | Research Poli- cy2005，34，5： | 1 |
| 12 | Heteroge- neous photocatalytic degradation of organic contaminants over titanium dioxide: A review of fundamentals, pro- gress and problems显示文摘 | Umar Ibrahim Gaya Abdul Halim Abdullah | 2008 | Journal of Photochemistry and Photobiology: C2008，，9： | 1 |
| 13 | Micelar Flocculation of Anionic Surfactants显示文摘 | Talens F I Paten P Gaya S | 1998 | Langmuir1998，14，： | 1 |
| 14 | Cardiac Complications After Radical Radiotherapy显示文摘 | Maria Martinou Andrew Gaya | 2013 | Seminars in Oncology2013，，： | 1 |
| 15 | Vesicoureteral reflux: can the urethra be adequately assessed by using contrast-enhanced voiding US of the bladder?显示文摘 | Berrocal T Gaya F Arjonilla A | 2005 | Radiology2005，234，1： | 1 |
| 16 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 17 | Heterogeneous photocatalytic degradation of organic contaminants over Titanium dioxide:A review of fundamentals,progress and problems显示文摘 | Gaya U I Abdullah A H | 2008 | Journal of Photochemistry and Photobiology C:Photochemistry Reviews2008，9，1： | 1 |
| 18 | Heterogeneous photocatalytic degradation of organic contaminants over titanium dioxide: a review of fundamentals, progress and problems 显示文摘 | Gaya U I Abdullah A H | 2008 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2008，9，1： | 1 |
| 19 | Review ofintrauterine adhesiolysis at the Aminu Kano Teaching Hospital, Kano, Nigeria显示文摘 | GAYA S A ADAMU I S YAKASAI I A | 2012 | Ann Aft Med2012，11，2： | 1 |
| 20 | Malignant disease in patients with long-term renal transplants显示文摘 | Gaya SBM Rees AJ Lechler RI | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员