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| 1 | Novel susceptibility genes in inflammatory bowel disease显示文摘The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. | Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell Jack Satsangi | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 2 | Utility of faecal calprotectin analysis in adult inflammatory bowel disease显示文摘The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic relapsing, remitting disorders. Diagnosis, along with assessment of disease activity and prognosis present challenges to managing clinicians. Faecal biomarkers, such as faecal calprotectin, are a non-invasive method which can be used to aid these decisions. Calprotectin is a calcium and zinc binding protein found in the cytosol of human neutrophils and macrophages. It is released extracellularly in times of cell stress or damage and can be detected within faeces and thus can be used as a sensitive marker of intestinal inflammation. Faecal calprotectin has been shown to be useful in the diagnosis of IBD, correlates with mucosal disease activity and can help to predict response to treatment or relapse. With growing evidence supporting its use, over the last decade this faecal biomarker has significantly changed the way IBD is managed. | Lyn A Smith Daniel R Gaya | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 3 | Catastrophic gastrointestinal complication of systemic immunosuppression显示文摘We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone.The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis.Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus(HSV)and cytomegalovirus(CMV)respectively.Viral infection of the upper gastrointestinal tract is a recognised complication of immunosuppression and HSV is one of the most common pathogens.CMV on the other hand most commonly causes a colitis or less commonly oesophagitis.CMV enteritis is rare as is the synchronous infection with two viral agents in an immunocompromised patient having being described in a few case series only.Viral infection of the gastrointestinal tract in immunocompromised patients should be treated with systemic anti-viral medication and consideration to withdrawal of the immunosuppressive therapy if possible and appropriate.The authors highlight the need for a high suspicion of viral infection in immunosuppressed patients presenting with upper gastrointestinal bleeding. | Lyn Alexandra Smith Mitali Gangopadhyay Daniel R Gaya | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Combined effect of high pressure treatments and the lactoperoxidase system on the inactivation of Listeria monocytogenes in cold-smoked salmon显示文摘 | Raquel Montiel Daniel Bravo María de Alba Pilar Gaya Margarita Medina | 2012 | Innovative Food Science and Emerging Technologies2012，，： | 1 |
| 5 | A prospective evaluation of the predictive value of faecal calprotectin in quiescent Crohn’s disease显示文摘 | Graham D. Naismith Lyn A. Smith Sarah J.E. Barry Joanna I. Munro Susan Laird Karen Rankin Allan J. Morris Jack W. Winter Daniel R. Gaya | 2014 | Journal of Crohn’s and Colitis2014，，： | 1 |
| 6 | Enhanced Recovery After Surgery Protocols for Open Hepatectomy—Physiology, Immunomodulation, and Implementation显示文摘 | Andrew J. Page Aslam Ejaz Gaya Spolverato Tiffany Zavadsky Michael C. Grant Daniel J. Galante Elizabeth C. Wick Matthew Weiss Martin A. Makary Christopher L. Wu Timothy M. Pawlik | 2015 | Journal of Gastrointestinal Surgery2015，，2： | 1 |
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