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| 1 | Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn 显示文摘 | SIQUEIRA J M JR PETERS R R GAZOLA A C | 2007 | Life Sci2007，80，： | 1 |
| 2 | Potential insulin secreta-gogue effects of isovitexin and swertisin isolated from Wilbrandiaebracteata roots in non - diabetic rats 显示文摘 | Folador P Cazarolli L H Gazola A C | 2010 | Fitoterapia2010，81，8： | 1 |
| 3 | Evaluation of the antitumoral effect of dihydrocucurbitacin-B in both in vitro and in vivo models 显示文摘 | SIQUEIRA J M GAZOLA A C FARIAS M R | 2009 | Cancer Chemother Pharmacol2009，64，： | 1 |
| 4 | Anti - in- flammatory effects of a triterpenoid isolated from Wilbran- dia ebracteata Cogn 显示文摘 | Siqueira J M Peters R R Gazola A C | 2007 | Life Sciences2007，80，15： | 1 |
| 5 | Lippia alba, Melissa officinalis and Cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats 显示文摘 | Ruth Gazola Denise Machado Campos Ruggiero | 2004 | Pharmacological Research2004，50，5： | 1 |
| 6 | Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats显示文摘 | Folador P Cazarolli L H Gazola A C | 2010 | Fitoterapia2010，81，： | 1 |
| 7 | Lippia alba, Melissa officinalis and Cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats 显示文摘 | Gazola R Machado D Ruggiero C | 2004 | Pharmacological Research2004，50，5： | 1 |
| 8 | CYP1A1,CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms显示文摘AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer(SCRC) risk. METHODS Six hundred forty-one individuals(227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1 *2A, CYP1A1 *2C CYP2E1 *5B and CYP2E1 *6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The EPHX1 Tyr113 His, EPHX1 His139 Arg and CYP1A1 *2C polymorphisms were detected by real-time PCR. Chisquared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version 2.05.RESULTS Age over 6 2 years was a risk factor for SCRC development(OR = 7.54, 95%CI: 4.94-11.50, P < 0.01). Male individuals were less susceptible to SCRC(OR = 0.55, 95%CI: 0.35-0.85, P < 0.01). The CYP2E1*5B polymorphism was associated with SCRC in the codominant(heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, P < 0.01), dominant(OR = 2.82, 95%CI: 1.74-4.55, P < 0.01), overdominant(OR = 2.58, 95%CI: 1.59-4.19, P < 0.01), and log-additive models(OR = 2.84, 95%CI: 1.78-4.52, P < 0.01). The CYP2E1*6 polymorphism was associated with an increased SCRC risk in codominant(heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, P < 0.01; homozygous polymorphic : OR = 7. 3 2, 9 5 % C I : 1.85-28.96, P < 0.01), dominant(OR = 2.97, 95%CI: 1.97-4.50, P < 0.01), recessive(OR = 5.26, 95%CI: 1.35-20.50, P = 0.016), overdominant(OR = 2.64, 95%CI: 1.74-4.01, P < 0.01), and log-additive models(OR = 2.78, 95%CI: 1.91-4.06, P < 0.01). The haplotype formed by the minor alleles of the CYP2E1*5B(C) and CYP2E1*6(A) polymorphisms was associated with SCRC(P = 0.002). However, the CYP1A1 *2A, CYP1A1 *2C, EPHX1 Tyr113 His and EPHX1 His139 Arg polymorphisms were not associated with SCRC.CONCLUSION In conclusion, the results demonstrated that CYP2E1*5B and CYP2E1*6 minor alleles play a role in the development of SCRC. | Glaucia Maria M Fernandes Anelise Russo Marcela Alcantara Proenca Nathalia Fernanda Gazola Gabriela Helena Rodrigues Patrícia Matos Biselli-Chicote Ana Elizabete Silva Joao Gomes Netinho érika Cristina Pavarino Eny Maria Goloni-Bertollo | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 9 | Potential insulin secret agogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats显示文摘 | Folador P Cazarolli LH Gazola AC | 2010 | Fitoterapia2010，81，8： | 1 |
| 10 | Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteataCogn显示文摘 | Siqueira JM Jr Peters RR Gazola AC | 2007 | Life Sci2007，80，15： | 1 |
| 11 | Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats显示文摘 | FOLADOR P CAZAROLLI L H GAZOLA A C | | 0，，8： | 1 |
| 12 | Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models显示文摘 | Maurilio da Silva Morrone Adriano Martimbianco de Assis Ricardo Fagundes da Rocha Juciano Gasparotto Andressa Córneo Gazola Geison Modesti Costa Silvana Maria Zucolotto Leonardo H. Castellanos Freddy A. Ramos Eloir Paulo Schenkel Flávio Henrique Reginatto | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 13 | Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn显示文摘 | Siqueira J M Jr Peters R R Gazola A C | 2007 | Life Sci2007，80，15： | 1 |
| 14 | Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn显示文摘 | Siqueira JM Jr Peters RR Gazola AC | 2007 | Life Sci2007，80，15： | 1 |
| 15 | 比较饮食摄取l-卡尼汀和dl-卡尼汀对氨中毒和肝代谢的作用(英文)显示文摘AIM: To compare the effects of chronic supplementationwith l-carnitine (LCT) and dl-carnitine (DLC) on am-monia toxicity and hepatic metabolism. METHODS:Three groups of male adult rats were studied: 1) supple-mented with LCT (1.2 mmol·kg-1·d-1 ), 2) supple-mented with DLC (1.2 mmol·kg-1·d-1 ), and 3) con-trol froup (COG) not supplemented. RESULTS: Thetreatment with LCT decreased the toxicity to ammonia.However, the supplementation with DLC did not showany significant effect. In contrast, the effects of thesupplementation with LCT and DLC on hepaticmetabolism were quite similar, ie, both groups showed:(a) intensified ammonia uptake and decreased urea pro- | Vilma A F G GAZOLA Gisele LOPES Rose M M DIAS Rui CURI Roberto B BAZOTTE | 2001 | Acta Pharmacologica Sinica2001，22，4： | 0 |
| 16 | 食物中添加ι-卡尼汀对大鼠肝代谢ι-丙氨酸的作用(英文) | Vilma A F G GAZOLA, Gisele LOPES, Daniel M LIMEIRA, Ricardo GALLETTO, Sebastiao GAZOLA, Rui CURI, Roberto B BAZOTTE (State University of Maringa, SUM, Department of Pharmacy and Pharmacology, Maringa, PR, 87020-900 University of Sao Paulo, Sao Paulo, SP, 05508-900, Brazil) | 2002 | Acta Pharmacologica Sinica2002，23，4： | 0 |
| 17 | Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats显示文摘AIM: To compare the acute effects of l-carnitine (LCT) and dl-carnitine (DLC) on hepatic catabolism of l-alanine and l-glutamine in rats. METHODS: Livers from 24 h fasted and fed rats were perfused in situ. The substrates l-alanine (5 mmol/L) and l-glutamine (5 mmol/L) were employed. The gluconeogenic and ureogenic activity was measured as the difference between the rates of glucose and urea released during and before the infusion of l-glutamine or l-alanine. RESULTS: LCT (60 μmol/L) but not DLC (60 μmol/L and 120 μmol/L) increased the production of glucose and urea from l-glutamine. However, neither LCT (60 μmol/L and 120 μmol/L) nor DLC (60μmol/L and 240 μmol/L) showed any significant effect on hepatic glucose and urea production from l-alanine. CONCLUSION: The results showed a different acute effect of LCT and DLC on the activation of hepatic gluconeogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT. | Gisele LOPES Vilma A F G GAZOLA Sharize B GALENDE Wilson ALVES-DO-PRADO Rui CURI Roberto B BAZOTTE | 2004 | Acta Pharmacologica Sinica2004，25，10： | 0 |
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