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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | Synthesis of Large-Area, Few-Layer Graphene on Iron Foil by Chemical Vapor Deposition显示文摘我们表明一个简单、可控制的方法综合大区域,由优化化学蒸汽免职(CVD ) 的铁底层上的很少层 graphene 用甲烷和氢的混合物的方法。基于 Fe-C 阶段图的分析,为 Fe 表面上的 graphene 的成功的合成的一个合适的过程被设计。适当温度和冷却过程被发现在高度水晶的很少层 graphene 的合成很重要。基于 Graphene 的地效果晶体管(联邦货物税) 设备用产生很少层 graphene 被制作,并且与 3001150 cm2/ 的提取活动性显示出好质量(V 敢椠 ?? 敤瑢吗? | Yunzhou Xue Bin Wu Yunlong Guo Liping Huang Lang Jiang Jianyi Chen Dechao Geng Yunqi Liu Wenping Hu Gui Yu | 2011 | Nano Research2011，4，12： | 7 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 5 | Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis显示文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment. | Huiping Li Cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing Wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 6 | Characterization of the new scintillator Cs2LiYCl6:Ce3+显示文摘The first domestic inorganic scintillator, Cs_2LiYCl_6:Ce^(3+)(CLYC), was grown at Beijing Glass Research Institute using the vertical Bridgman method. In this work, we evaluated the performance of this new CLYC crystal in terms of its gamma-ray energy resolution and pulse shape discrimination(PSD) capability between neutrons and gamma rays. The decay times associated with different scintillation mechanisms were obtained by fitting decay functions to the neutron and gamma-ray waveform structures. We found an energy resolution of * 4.5% for 662-ke V gamma rays and efficient neutron/gamma PSD with a figure of merit of * 2.6. Under gamma-ray excitation, there is an ultrafast scintillation mechanism in CLYC with a decay time of approximately 2 ns, whereas there is no evidence of ultrafast decay under thermal neutron excitation. This work contributes to the promotion of domestic development of CLYC. | Kui-Nian Li Xian-Peng Zhang Qiang Gui Peng Jin Geng Tian | 2018 | Nuclear Science and Techniques2018，29，1： | 4 |
| 7 | Imazamox microbial degradation by common clinical bacteria: Acinetobacter baumannii IB5 isolated from black soil in China shows high potency显示文摘Herbicidal residues of imazamox are hazardous to some sensitive rotational aftercrops.The aim of the study was to isolate and identify a microbial strain capable of degrading imazamox.The strain IB5,capable of efficiently degrading imazamox,was isolated from an imazamox-contaminated soybean field in Heilongjiang Province,China.It was found to degrade 98.61%of 400 mg L^(-1) imazamox within 48 h by high-performance liquid chromatograph.Through morphological,physiological and biochemical characterization,and the 16 S rDNA sequencing,the strain was identified as Acinetobacter baumannii.An optimal degradation condition was obtained and verified:400 mg L^(-1) imazamox,0.1%(volume ratio) initial inoculum,37℃and pH 7.0.Four main products were captured in the liquid chromatograms and mass spectra,and a pathway for imazamox degradation by IB5 was proposed.This work provides a new suitable candidate for imazamox biodegradation and theoretical evidence for imazamox residue bioremediation.A.baumannii is a common clinical bacteria,but its imazamox-degrading feature has not been reported previously. | LIU Chun-guang YANG Xin LAI Yang LU Hong-gang ZENG Wei-min GENG Gui YANG Feng-shan | 2016 | Journal of Integrative Agriculture2016，15，8： | 4 |
| 8 | Microwave-assisted Green and Efficient Synthesis of N^6-(2-Hydroxyethyl)adenosine and its Analogues显示文摘An efficient protocol for the synthesis of N6-(2-Hydroxyethyl)adenosine and its analogues through nucleophilic substitution was developed. All the reactions were completed in 10 min under microwave irradiation. Using water as solvent makes our method eco-friendly and easy to handle with. | Gui Rong QU Ming Wei GENG Su Hui HAN Zhi Guang ZHANG Feng XUE | 2006 | Chinese Chemical Letters2006，17，9： | 3 |
| 9 | Quantitative Analysis of Relationship Between Pore Structure and Compressive Strength of Foamed Concrete显示文摘The effect of dry density,water-cement ratio,the addition of fly ash,and sand content on the porosity and pore distribution of foamed concrete is investigated.Digital microscopy and Image J software are employed to examine the landscape of pores with different sizes.Based on the Balshin empirical formula,a mathematical model is established to quantitatively predict the relationship between the pore structures and the compressive strength of foamed concrete.The results well demonstrate that there is a significant correlation between the modified formula and empirical parameters. | Geng Fei Yin Wanyun Xie Jianguang Liu Shoucheng Li Haoran Gui Jingneng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 2 |
| 10 | Ultrahigh Density Modulation of Aligned Single-Walled Carbon Nanotube Arrays显示文摘在圣切割石英上控制排列的围单人赛的碳 nanotube 数组(SWNT ) 的密度是在这些材料的各种各样的应用的关键步。然而为调节 SWNT 密度使用的生长机制化学蒸汽免职(CVD ) 方法仍然不好理解,阻止获得需要的结果的有效方法的发展。这里,我们报导完成的一条一般周期的途径超离频圣切割石英 substrateswith 密度上的 SWNT 数组的密度调整用改变 CH4 气体离开时间的一样的催化剂 densitiesby 与常规方法相比到多达 60 次增加了。这条途径对大量起始的催化剂密度,底层,催化剂类型和生长条件适用。我们为与不同的免费的碳集中联系的 SWNT 的催化剂尺寸依赖者成核建议一般机制,它解释所有观察。而且,模型的有效性被在周期的 CVD 途径包含关键参数的变化的系统的实验支持。 | Bin Wu Dechao Geng Yunlong Guo Liping Huang Jianyi Chen Yunzhou Xue Gui Yu Yunqi Liu Hisashi Kajiura Yongming Li | 2011 | Nano Research2011，4，10： | 1 |
| 11 | Construction and characterization of a BAC library for Carassius auratus gibelio, a gynogenetic polyploid fish 显示文摘 | Geng F S Zhou L Gui J F | 2005 | Animal Genetics2005，36，： | 1 |
| 12 | Insulin-like growth factor-2 enhances regulatory T cell functions and suppresses food allergy in an experimental model显示文摘 | Gui Yang Xiao-Rui Geng Jiang-Ping Song Yingying Wu Hao Yan Zhengke Zhan Litao Yang Weiyi He Zhi-Qiang Liu Shuqi Qiu Zhigang Liu Ping-Chang Yang | 2014 | The Journal of Allergy and Clinical Immunology2014，，： | 1 |
| 13 | Interleukin- 13 interferes with activation-induced t-ce apoptosis by repressing p53 expression显示文摘 | Li Yang Ling-Zhi Xu Zhi-Qiang Liu Gui Yang Xiao-Rui Geng Li-Hua Mo Zhi-Gang Liu Peng-Yuan Zheng Ping-Chang Yang | 2016 | Cellular & Molecular Immunology2016，13，5： | 1 |
| 14 | Application of finite element analysis in implant dentistry:A review of the literature显示文摘 | Geng J P Keson B C Tan Gui Rong Liu | 2001 | J Prosthet Dent2001，85，： | 1 |
| 15 | Near‐Equilibrium Chemical Vapor Deposition of High‐Quality Single‐Crystal Graphene Directly on Various Dielectric Substrates显示文摘 | Jianyi Chen Yunlong Guo Lili Jiang Zhiping Xu Liping Huang Yunzhou Xue Dechao Geng Bin Wu Wenping Hu Gui Yu Yunqi Liu | 2014 | Adv. Mater2014，，9： | 1 |
| 16 | Thermoelectric properties of S-substituted BiCuSeO at O sites:First-principles study显示文摘The conversion efficiency of a thermoelectric(TE)device is dependent on the dimensionless figure of merit defined as ZT=S^2σT/k,where T is absolute temperature. | Gui Yang QingXiu Yu HuiJuan Geng YuanXu Wang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 0 |
| 17 | The eff ect of Rhizophagus irregularis on salt stress tolerance of Elaeagnus angustifolia roots显示文摘We assessed the eff ects of arbuscular mycorrhizal fungi(AMF)Rhizophagus irregularis inoculation on salt stress tolerance in roots of the drought-tolerant plant Elaeagnus angustifolia.We studied a plant growth index,spore density and hyphal length density of AMF,the Na+contents and ultrastructure of root cells,as well as rhizosphere soil enzyme activities of mycorrhizal and non-mycorrhizal E.angustifolia seedlings under diff erent salt stress.Under salt stress,growth of E.angustifolia with mycorrhizal inoculation was higher than that of non-inoculated treatments.The spore density and hyphal length density decreased signifi cantly under salt stress in rhizosphere soil of mycorrhizal E.angustifolia seedlings(p<0.05).The root cells of E.angustifolia seedlings inoculated with R.irregularis at 300 mmol L−1 salt had more organelles,greater integrity,and lower root Na+contents than those of non-inoculated seedlings.In addition,the results showed notably higher activities of catalase,phosphatase,urease and saccharase in rhizosphere soil of the mycorrhizal seedlings in response to salinity compared to those of the non-mycorrhizal seedlings.Therefore,AMF inoculation could enhance salt stress tolerance in roots of E.angustifolia. | Wenyuan He Xiaoxu Fan Zixin Zhou Huanhuan Zhang Xiang Gao Fuqiang Song Gui Geng | 2020 | Journal of Forestry Research2020，31，6： | 0 |
| 18 | TRIM72‑mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells显示文摘Dear Editor,Autophagy is an evolutionarily conserved catabolic process that involves the sequestration and transport of organelles,macromolecules,or invading microorganisms to lysosomes for degradation[1].Sequestosome 1(p62/SQSTM1)was the first protein shown to bind target-associated ubiquitin(Ub)and LC3 conjugated to the phagophore membrane,thus,acting as an important autophagy receptor for ubiquitinated targets[2]. | Cheng‑Cheng Wang Hong Peng Zi Wang Jiao Yang Rong‑Gui Hu Chuan‑Yin Li Wu‑Jun Geng | 2023 | Military Medical Research2023，10，4： | 0 |
| 19 | Performance of the PRISM I,PIM2,PELOD-2 and PRISM IV scoring systems in western China:a multicenter prospective study显示文摘Background The aim of this study was to evaluate the performance of the four scoring tools in predicting mortality in pediatric intensive care units(PICUs)in western China.Methods This was a multicenter,prospective,cohort study conducted in six PICUs in western China.The performances of the scoring systems were evaluated based on both discrimination and calibration.Discrimination was assessed by calculating the area under the receiver operating characteristic curve(AUC)for each model.Calibration was measured across defined groups based on mortality risk using the Hosmer-Lemeshow goodness-of-fit test.Results A total of 2034 patients were included in this study,of whom 127(6.2%)died.For the entire cohort,AUCs for Pediatric Risk of Mortality Score(PRISM)I,Pediatric Index of Mortality 2(PIM2),Pediatric Logistic Organ Dysfunction Score-2(PELOD-2)and PRISM IV were 0.88[95%confidence interval(CI)0.85–0.92],0.84(95%CI 0.80–0.88),0.80(95%CI 0.75–0.85),and 0.91(95%CI 0.88–0.94),respectively.The Hosmer-Lemeshow goodness-of-fit Chi-square value was 12.71(P=0.12)for PRISM I,4.70(P=0.79)for PIM2,205.98(P<0.001)for PELOD-2,and 7.50(P=0.48)for PRISM IV[degree of freedom(df)=8].The standardized mortality ratios obtained with the PRISM I,PIM2,PELOD-2,and PRISM IV models were 0.87(95%CI,0.75–1.01),0.97(95%CI,0.85–1.12),1.74(95%CI,1.58–1.92),and 1.05(95%CI,0.92–1.21),respectively.Conclusions PRISM IV performed best and can be used as a prediction tool in PICUs in Western China.However,PRISM IV needs to be further validated in NICUs. | Xue-Peng Zhang Yun-Xia Feng Yang Li Guo-Yan Lu Xin-Yue Zhou Can-Zheng Wei Xi-Ying Gui Kai-Ying Yang Tong Qiu Jiang-Yuan Zhou Hua Yao Geng Zhang Wen-Qi Zhang Yu-Hang Hu Hong Wu Si-Yuan Chen Yi Ji | 2022 | World Journal of Pediatrics2022，18，12： | 0 |
| 20 | Multidimensional Analysis of Risk Factors Associated with Breast Cancer in Beijing,China:A Case-Control Study显示文摘Breast cancer is the most common cancer among women worldwide[1].In 2018,2.09 million new breast cancer cases were identified globally,accounting for 11.6% of all cancers in that year[2].The breast cancer incidence in Asian women has also increased rapidly over the past 30 years. | LI Ai Hua YE Yan CHEN Jun SUN Zhi Feng YUN Shui Ying TIAN Xing Kuan HU Zai Fang Sarah Robbins SCOTT YU Gui Xin HU Li WANG Zi Huan SUN Li Geng SHEN Zhuang | 2020 | Biomedical and Environmental Sciences2020，33，10： | 0 |
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