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| 1 | Plasma membrane changes during programmed cell deaths显示文摘破裂并且未经触动的血浆膜古典主义地被看作特点坏死并且 apoptotic 房间死亡分别地。因此,当坏死触发发炎时, apoptosis 通常被认为一个非煽动性的过程。necroptosis 和 pyroptosis 上的最近的研究,规划坏死的二种类型,表明那血浆膜破裂在 necroptosis 期间由 MLKL 隧道被调停,但是取决于非选择的 gasdermin D (GSDMD ) 毛孔在 pyroptosis 期间。重要地,由 MLKL 隧道执行的垂死的房间的形态学能与由 GSDMD 毛孔执行了那被区分开来。有趣地,它最近被发现 apoptotic 房间的那第二等的坏死,发生在 apoptosis 以后的房间细胞溶解的一种以前相信的非调整的形式,能被象 pyroptosis 的一样的血浆膜毛孔形成规划并且执行。另外, pyroptosis 与 pyroptotic 身体被联系,它有一些类似到 apoptotic 身体。因此,不同房间死亡节目导致血浆膜的特殊改组过程。给释放细胞内部的内容的性质在导致房间的 immunogenicity,不是仅仅膜破裂或正直而且血浆膜故障的性质将决定的 dying/dead 起一个关键作用的事实得到有免疫力的回答的一个房间以及它的能力的命运。在这评论,我们将在 apoptosis, necroptosis 和 pyroptosis 的地里讨论最近的进展,与位于在在房间的垂死的房间和他们的含意上观察的血浆膜变化下面的机制上的一个重音得到死亡的 immunogenicity。 | Yingying Zhang Xin Chen Cyril Gueydan Jiahuai Han | 2018 | Cell Research2018，28，1： | 57 |
| 2 | Raman Spectroscopy and Imaging of Graphene显示文摘Graphene has many unique properties that make it an ideal material for fundamental studies as well as for potential applications.Here we review recent results on the Raman spectroscopy and imaging of graphene.We show that Raman spectroscopy and imaging can be used as a quick and unambiguous method to determine the number of graphene layers.The strong Raman signal of single layer graphene compared to graphite is explained by an interference enhancement model.We have also studied the effect of substrates,the top layer deposition,the annealing process,as well as folding(stacking order)on the physical and electronic properties of graphene.Finally,Raman spectroscopy of epitaxial graphene grown on a SiC substrate is presented and strong compressive strain on epitaxial graphene is observed.The results presented here are highly relevant to the application of graphene in nano-electronic devices and help in developing a better understanding of the physical and electronic properties of graphene. | Zhenhua Ni Yingying Wang Ting Yu Zexiang Shen | 2008 | Nano Research2008，1，4： | 51 |
| 3 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 4 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 5 | Parameterizing soil organic carbon's impacts on soil porosity and thermal parameters for Eastern Tibet grasslands显示文摘This study investigates the stratification of soil thermal properties induced by soil organic carbon (SOC) and its impacts on the parameterization of the thermal properties. Soil parameters were measured for alpine grassland stations and North China flux stations, with a total of 34 stations and 77 soil profiles. Measured data indicate that the topsoils of alpine grasslands contain high SOC contents than underlying soil layers, which leads to higher soil porosity values and lower thermal conductivity and bulk density values in the topsoils. However, this stratification is not evident at the lowland stations due to low SOC contents. Evaluations against measured data show that three thermal conductivity schemes used in land surface models severely overestimate the values for soils with high SOC content (i.e. topsoils of alpine grassland), but they are better for soils with low SOC content. A new parameterization is then developed to take the impacts of SOC into account. The new one can well estimate the soil thermal conductivity values in both low and high SOC content cases, and therefore, it is a potential candidate of thermal conductivity scheme to be used in land surface models. | CHEN YingYing YANG Kun TANG WenJun QIN Jun ZHAO Long | 2012 | Science China Earth Sciences2012，55，6： | 31 |
| 6 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 7 | Role of Resistin in Inflammation and Inflammation-Related Diseases显示文摘Resistin 是最新识别的 adipocyte 属于一个充满半胱氨酸的蛋白质家庭的分泌荷尔蒙。它在啮齿类动物在白脂肪质的纸巾被表示并且也在人在几另外的纸巾被发现了。胰岛素,葡萄糖,许多 cytokines 和反糖尿病的 thiazolidinediones 是 resistin 基因表示的管理者。Resistin 第一被建议涉及胰岛素抵抗并且打 2 糖尿病。最近,与象动脉粥样硬化和关节炎一样的发炎和发炎相关的疾病相关被发现。 | Shanshan Pang Yingying Le | 2006 | Cellular & Molecular Immunology2006，3，1： | 25 |
| 8 | Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat显示文摘407,663 的一个总数表示了小麦,大麦,玉米,米饭,和蜀黍的顺序标签(EST ) ,从 GenBank/dbEST 获得了,被用来寻找简单顺序重复(SSR ) 。10,253 EST-SSRs 的一个总数,说明了 2.52% 所有 EST,被识别。用教材首相 5.0, 1367 EST-SSR 教材对被设计,哪个 715 与高质量被综合。 715 教材对在五庄稼在一样的 PCR 条件,和有效教材对下面在小麦,米饭,玉米,棉花,和大豆上被测试是 500 (69.93%), 383 (53.57%), 452 (63.22%), 357 (49.93%),并且 388 (56.27%)分别地。这显示了在扩及远距离的种类之间的 EST-SSR 标记的高可转移性。另外,有 240 loci 的 139 EST-SSR 教材对在由使用小麦的中国春天 nulli-tetrasomic 线的所有 21 个小麦染色体上是局部性的。 | Linzhi Li Junjun Wang Ying Guo Fangshan Jiang Yunfeng Xu Yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 25 |
| 9 | Subchondral bone microenvironment in osteoarthritis and pain显示文摘Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain,causing disability and economic burden.The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends.Basic and clinical research on osteoarthritis has been carried out for decades,but many questions remain unanswered.The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear.Accumulating evidence shows that subchondral bone lesions,including bone marrow edema and angiogenesis,develop earlier than cartilage degeneration.Clinical interventions targeting subchondral bone have shown therapeutic potential,while others targeting cartilage have yielded disappointing results.Abnormal subchondral bone remodeling,angiogenesis and sensory nerve innervation contribute directly or indirectly to cartilage destruction and pain.This review is about bone-cartilage crosstalk,the subchondral microenvironment and the critical role of both in osteoarthritis progression.It also provides an update on the pathogenesis of and interventions for osteoarthritis and future research targeting subchondral bone. | Yan Hu Xiao Chen Sicheng Wang Yingying Jing Jiacan Su | 2021 | Bone Research2021，9，3： | 24 |
| 10 | Livelihood diversification and cropland use pattern in agro-pastoral mountainous region of eastern Tibetan Plateau显示文摘这研究在 Keerma 村庄里检验了生计多样化和农田使用模式,在 Jinchuan 定位了县,东方西藏的高原。通过成层的随机的采样调查,提供参加机会的农村估价。 | ZHANG Liping ZHANG Yili YAN dianzhong WU Yingying | 2008 | Journal of Geographical Sciences2008，18，4： | 23 |
| 11 | Livelihood diversification of farmers and nomads of eastern transect in Tibetan Plateau显示文摘在西藏的高原的农民和流浪者的生计被草地和草药的资源退化严重地影响。怎么帮助他们完成生计多样化是一个关键持续发展问题。这份报纸在西藏的高原在东方横断的 3 个区域检验生计财产,生计多样化水平和农民和流浪者的生计策略。结果证明生计多样化是流行策略。从高山塞满区域到山高原区域和高原区域,生计多样化水平被减少,并且扩大生计的生计活动和比例也减少。有举起的增加的生计财产和生计多样化水平减少,主要出现在人的财产和自然财产。生计多样化水平是高度有生计财产的关联词,主要出现在自然财产,人的财产和社会财产。仍然基于存在生计财产,农民和流浪者的生计改进策略主要正在提起家畜和挖的植物,并且更少的农民和流浪者认为离开农场是雇用或做的生意。在高原区域的流浪者应该在高山峡区域和山高原区域从人的扩大生计的经验学习大部分。因此,政府的帮助应该集中于减轻生计多样化的限制因素并且帮助他们改进他们的能力建立扩大类型生计。 | YAN Jianzhong WU Yingying ZHANG Yili ZHOU Shaobin | 2010 | Journal of Geographical Sciences2010，20，5： | 22 |
| 12 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 13 | An-2 Encodes a Cytokinin Synthesis Enzyme that Regulates Awn Length and Grain Production in Rice显示文摘大量词法、生理的特点在驯服下面在栽培米饭 Oryza sativa 和野米饭 Oryza rufipogon 之间变化了。这里,我们报导 An-2 基因克隆,编码象蛋白质 6 一样的孤独的盖伊(OsLOGL6 ) ,它在 O 催化细胞激动素合成的最后的步。rufipogon。在 theawnless indica Guangluai 4 的基因背景怀有 An-2 的野等位基因的 near-isogenic 线证明 An-2 由由每植物每圆锥花序和 tillers 减少谷物提高房间分割,而是减少谷物生产支持芒延伸。我们表明在 An-2 地点的一个基因变化在减少芒长度并且在驯养的米饭增加 tiller 和谷物数字上有大影响。基因 expressionpatterns 的分析建议 An-1 调整芒的形成初发,并且 An-2 支持芒延伸。在栽培米饭的 theAn-2 地点的核苷酸差异被发现显著地与野米饭的相比被减少,建议 An-2 地点受到人工的选择。我们因此在 An-2 的基因变化的选择由于减少的芒长度并且增加的 proposethat 在栽培米饭的谷物产量。 | Benguo Gu Taoying Zhou Jianghong Luo Hui Liu Yongchun Wang Yingying Shangguan Jingjie Zhu Yan Li Tao Sang Zixuan Wang Bin Han | 2015 | Molecular Plant2015，8，11： | 22 |
| 14 | Scene text detection and recognition: recent advances and future trends显示文摘 | Yingying ZHU Cong YAO Xiang BAI | 2016 | Frontiers of Computer Science2016，10，1： | 20 |
| 15 | Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives显示文摘Ginseng is among the oldest traditional Chinese medicinal herbs and is widely used in China and Southeast Asia. Over the past 50 years, considerable research has focused on the chemical constituents, pharmacological action, and clinical applications of ginseng. In this review, we examine the current state of research on ginseng, including the main active ingredient ginsenoside, its pharmacological effects on the cardiovascular system, and mechanisms of action. We focus on what is known of the effects of ginseng against atherosclerosis, arrhythmia, myocardial ischemia, and its inhibition of ventricular remodeling, providing a basis for expanding the clinical applications of ginseng. | Yingying Sun Yue Liu Keji Chen | 2016 | Science China(Life Sciences)2016，59，3： | 20 |
| 16 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 17 | Computed tomography-based radiomics for prediction of neoadjuvant chemotherapy outcomes in locally advanced gastric cancer: A pilot study显示文摘Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography(CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017. All patients underwent upper abdominal CT during the unenhanced, late arterial phase(AP) and portal venous phase(PP) before the administration of neoadjuvant chemotherapy. In total, 19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model. Thirty-two combinations of feature selection and classification methods were examined. Receiver operating characteristic(ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response(non-GR) based on tumor regression grade(TRG).Results: The mean area under the curve(AUC) ranged from 0.194 to 0.621 in the AP, and from 0.455 to 0.722 in the PP, according to different combinations of feature selection and the classification methods. There was only one cross-combination machine-learning method indicating a relatively higher AUC(>0.600) in the AP, while 12 cross-combination machine-learning methods presented relatively higher AUCs(all >0.600) in the PP. The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significantly prognostic performance in the PP(AUC, 0.722±0.108; accuracy, 0.793; sensitivity, 0.636; specificity,0.889; Z=2.039; P=0.041).Conclusions: It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT. | Zhenhui Li Dafu Zhang Youguo Dai Jian Dong Lin Wu Yajun Li Zixuan Cheng Yingying Ding Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，4： | 18 |
| 18 | The Current Situation on Major Depressive Disorder in China:Research on Mechanisms and Clinical Practice显示文摘Depression is the most disabling disorder worldwide that accounts for the highest proportion of global burden attributable to mental disorders. Major depressive disorder(MDD) is characterized by deep sadness, reduced energy,vegetative nervous system dysregulation, cognitive dysfunction, and even a high suicidal tendency. Although other treatment choices are available, antidepressant medication is the front-line treatment option for MDD. Regarding clinical efficacy, only ~50% of patients respond to frontline antidepressants, and <33% obtain remission. Currently, objective indexes to guide clinical decisions are still lacking. Furthermore, knowledge about the neurobiological mechanisms underlying discrepant antidepressant outcomes is still also fragmentary. In the present review, we discuss the current research progress and clinical opinions on MDD in China. | Zhenghua Hou Wenhao Jiang Yingying Yin Zhijun Zhang Yonggui Yuan | 2016 | Neuroscience Bulletin2016，32，4： | 16 |
| 19 | Diagnosis of brain death: confirmatory tests after clinical test显示文摘 | Su Yingying Yang Qinglin Liu Gang Zhang Yan Ye Hong Gao Daiquan Zhang Yunzhou Chen Weibi | 2014 | Chinese Medical Journal2014，，7： | 16 |
| 20 | Nutritional composition and antioxidant activity of twenty mung bean cultivars in China显示文摘Interest in mung bean(Vigna radiata L.) as a functional food is growing; however, studies on the nutritional composition of major mung bean cultivars planted in China are limited.Twenty Chinese mung bean cultivars were collected and their nutritional compositions including starch, fat, protein, and phytochemicals were analyzed. The cultivars were found to have a high amount of resistant starch, accounting for 16.1%–22.3% of total starch, and balanced amino acid constitutions. Palmitic acid and linoleic acid were the two dominant fatty acids, accounting for respectively 32.4% and 36.1% of all of the assayed fatty acids. Four bound phenolic acids(syringic, caffeic, p-coumaric, and ferulic acids) and two free phenolic acids(caffeic and ferulic acids) were identified by HPLC. The antioxidant activity of 70%ethanol extracts from the 20 mung bean cultivars was evaluated. Their DPPH and ABTS+free-radical-scavenging capacity ranged from 28.13 ± 2.24 to 35.68 ± 0.71 μmol g-1and from3.82 ± 0.25 to 13.44 ± 1.76 μmol g-1, respectively. Significant positive correlations of ABTS+free-radical-scavenging capacity with total phenolic acids and total flavonoid contents were observed. These results suggest that Chinese mung bean cultivars are rich in balanced nutrients and that their phytochemicals should be considered as potential sources of natural antioxidants. | Zhenxing Shi Yang Yao Yingying Zhu Guixing Ren | 2016 | The Crop Journal2016，4，5： | 16 |
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