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| 1 | Genome Editing and Double-Fluorescence Proteins Enable Robust Maternal Haploid Induction and Identification in Maize显示文摘 | Le Dong Lina Li Changlin Liu Chenxu Liu Shuaifeng Geng Xinhai Li Changling Huang Long Mao Shaojiang Chen Chuanxiao Xie | 2018 | Molecular Plant2018，11，9： | 22 |
| 2 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 3 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 4 | Research of multi-path routing based on network coding in space information networks显示文摘A multi-path routing algorithm based on network coding is proposed for combating long propagation delay and high bit error rate of space information networks. On the basis of traditional multi-path routing, the algorithm uses a random linear network coding strategy to code data packets. Code number is determined by the next hop link status and the number of current received packets sent by the upstream node together. The algorithm improves retransmission and cache mechanisms through using redundancy caused by network coding. Meanwhile, the algorithm also adopts the flow distribution strategy based on time delay to balance network load. Simulation results show that the proposed routing algorithm can effectively improve packet delivery rate,reduce packet delay, and enhance network performance. | Yu Geng Zhong Congjiu Lan Xiaoyu Zhang Chi Wei Lina Liu Yansong | 2014 | Chinese Journal of Aeronautics2014，27，3： | 3 |
| 5 | Semi-crosslinked polyacrylamides as high-resolution and dynamic self-coating sieving matrices for protein capillary electrophoresis显示文摘This paper describes non-gel capillary sieving electrophoresis employing semi-crosslinked polyacrylamide as a high performance and low viscous replaceable separation matrix for separation of non-denatured protein separation. Arising from the fine sieving and dynamic coating ability of this polymer, a mixture of basic proteins lysozyme, cytochrome C, ribonuclease A, and trypsin was resolved with excellent reproducibility. Mixing different semi-crosslinked polyacrylamides together further improves the separation. The separtion mechanism was analyzed. With network structure developed to an intermediate state between crosslinked gel and linear polymer solutions, these semi-crosslinked polyacrylamide polymers demonstrate a promise as a new class of size sieving separation medium, not only in capillary electrophoresis, but also in microfluidic chip separation schemes. | ZHOU Jin XU JianDong XIE Yao QU Feng DENG YuLin GENG LiNa | 2008 | Chinese Science Bulletin2008，53，19： | 2 |
| 6 | Characteriza- tion and gas sensitivity study of polyaniline/SnO2 hybrid material prepared by hydrothermal route 显示文摘 | Geng Lina Zhao Yingqiang Huang Xueliang | 2007 | Sensors and Actuators B: Chemical2007，120，2： | 1 |
| 7 | Clinical signifi- cance of IEX- 1 expression in ovarian carcinoma 显示文摘 | Liping Han Lina Geng Xiangrong Liu | 2011 | Ultra- structural Pathology2011，35，46： | 1 |
| 8 | Inventorying heavy metal pollution in redeveloped brownfield and its policy contribution: Case study from Tiexi District, Shenyang, China显示文摘 | Wanxia Ren Bing Xue Yong Geng Lina Sun Zhixiao Ma Yunsong Zhang Bruce Mitchell Liming Zhang | 2014 | Land Use Policy2014，，： | 1 |
| 9 | Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip显示文摘Monolayer of 3-(triethoxysilyl) propyl isocyanate was prepared on the slide by self-assembled tech-nique. X-ray photoelectron spectroscopy (XPS) was employed to analyze the elementary composition of the film. Contact angle of distilled water was measured to characterize the surface state. It was shown that 3-(triethoxysilyl) propyl isocyanate had been successfully assembled on the slide. The in-crease of contact angle to 80° demonstrated that the hydrophobicity of the surface of chip was in-creased significantly. Moreover, further self-assembly of bovine serum albumin (BSA) on 3-(trietho- xysilyl) propyl isocyanate was also carried out with the advantages such as simple and convenient preparation. Therefore, the potential of broader applications in the modification of micro-channel in the μ-TAS system, the immobilization of protein or peptide and the surface modification of materials are all expectative. | XIE Yao GENG LiNa QU Feng LUO AiQin DENG YuLint | 2009 | Chinese Science Bulletin2009，54，5： | 1 |
| 10 | Effects of SiC particle pretreatment and stirring parameters on the microstructure and mechanical properties of SiCp/Al–6.8Mg composites fabricated by semi-solid stirring technique显示文摘 | Hongwei Zhang Lin Geng Lina Guan Lujun Huang | 2010 | Materials Science & Engineering A2010，，1： | 1 |
| 11 | A β-cyclodextrin covalent organic framework used as a chiral stationary phase for chiral separation in gas chromatography显示文摘Chiral covalent organic frameworks(CCOFs) featuring chirality, stability, and good porosity have attracted a considerable amount of attention due to their important applications, such as asymmetric catalysis, chiral separation, and chiral recognition. In this study, a β-cyclodextrin(β-CD) covalent organic framework(β-CD-COF) diluted with polysiloxane OV-1701 was explored as a novel chiral stationary phase(CSP) for gas chromatography(GC) separation of racemates. The β-CD-COF coated capillary column had excellent selectivity, not only for the separation of linear alkanes, linear alcohols, fatty acid methyl esters mixture, the Grob mixture and positional isomers, but also for the resolution of chiral compounds, including chiral alcohols, aldehydes, ethers, and amino acid derivatives. In addition, the β-CD-COF-coated capillary column presented good repeatability and reproducibility. This work indicated the great potential of the CCOFs coated capillary column for the chromatographic separation of enantiomers. | Bo Tang Wei Wang Huipeng Hou Yiquan Liu Zongkun Liu Lina Geng Liquan Sun Aiqin Luo | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 12 | Characterization and gas sensitivity study of polyaniline/SnO2 hybrid material prepared by hydrothermal route 显示文摘 | Geng Lina Zhao Yingqiang Huang Xueliang | 2007 | Sensors and Actuators B: Chemical2007，120，2： | 1 |
| 13 | Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: A randomized, double blind, parallel-controlled study versus tibolone显示文摘 | Wenpei Bai Hans-Heinrich Henneicke-von Zepelin Shuyu Wang Shurong Zheng Jianli Liu Zhonglan Zhang Li Geng Lina Hu Jiao Chunfeng Eckehard Liske | 2007 | Maturitas2007，，： | 1 |
| 14 | Rapid,specific and sensitive detection of Vibrio vulnificus by loop-mediated isothermal amplification targeted to vvhA gene显示文摘Vibrio vulnificus is an estuarine bacterial pathogen for human.The rapid,specific and sensitive detection of V.vulnificus is urgently needed for early disease diagnosis and timely treatment of V.vulnificus infection.In the study,a loop-mediated isothermal amplification(LAMP) technique was developed for V.vulnificus detection with a set of primers,composed of two out primers and two inner primers targeted to vvh A gene.The optimal amplification temperature was 63°C and the reaction only took 35 min.The amplification products could not only be detected by agarose gel electrophoresis with ladder-like pattern bands,but also could be visualized using calcein with naked eye directly.Forty-five strains were tested for the specificity of LAMP assay,and all the V.vulnificus strains were identified correctly while other strains were negative results.The sensitive of the new LAMP assay was 100-fold more sensitive than the conventional PCR.Meanwhile,all the V.vulnificus strains were detected correctly in spiked,clinical and environmental samples by the new LAMP assay.Compared with other well-known techniques,the new LAMP assay targeted to vvh A gene was extremely rapid,simple,sensitive and specific for V.vulnificus identification. | ZHANG Lina WANG Mingyi CONG Dianxia DING Shuyan CONG Rinan YUE Jinyong GENG Jianli HU Chengjin | 2018 | Acta Oceanologica Sinica2018，37，4： | 1 |
| 15 | A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection显示文摘Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for HIAF-BRing.Method Based on the optical characteristics,unwanted particles are safely deflected to a specific internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power supplies.Results Taking alignment and multipolefield errors into account,discarded beam can be dumped within 5 ms with an efficiency of more than 99.8%at any operation stage.Conclusion The proposed beam dump solution satisfies the machine protection requirements for BRing and can provide a new idea for similar facilities. | Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang Sheng Lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 16 | H2S sensitivety study of polypyrrole/WO3 materials 显示文摘 | Geng Lina Huang X L | 2006 | Solid state Elecronics2006，50，5： | 1 |
| 17 | Evaluation of Spatial Variability of Soil Properties in a Long-Term Experimental Tobacco Station in Southwest China显示文摘 | Jiang Houlong Wang Hongfeng Li Najia Xu Anding Yang Chao Chen Yiyin Li Yong Geng Lina Liu Guo-Shun | 2014 | Journal of Agricultural Science and Technology(A)2014，4，9： | 1 |
| 18 | Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI显示文摘In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic effect.Specifically,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal design.In the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation terminals.In order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam line.However,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation uniformity.To mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at SESRI.In the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS waveforms.In this paper,the method and experimental results were introduced. | HOU Lingxiao YUAN Youjin SHEN Guodong RUAN Shuang LIU Jie ZHU Yunpeng WANG Geng GUO Hongliang LYU Mingbang GAO Daqing XU Zhiguo SHENG Lina YANG Jiancheng | 2024 | 原子能科学技术2024，58，4： | 0 |
| 19 | Hierarchically Porous Biomass Carbon Derived from Orange Peel for Atomically Dispersed Co-N-C Sites Toward Advanced Oxygen Reduction Reaction显示文摘Use of the transition-metal single atomsupported by carbon is an innovative technique that enhances the electrocatalytic behavior of the oxygen reduction reaction(ORR)for Zn-air batteries(ZABs).Yet,building such catalysts with stable and efficient electron/mass transport pathways,as well as high catalytic activity and stability remains a critical challenge.Here,we develop a hierarchically porous biomass carbon to anchor atomically dispersed Co atoms,simultaneously addressing the active sites’emergence and stability,and electron/mass transit.The optimum catalyst achieves fabulous electrocatalytic behavior with a half-wave potential of 0.82 V for ORR.More impressively,the ZAB with its well-tailored catalyst exhibits extraordinary combined performance,including a high zenith power density of 139.89mW·cm^(−2),outstanding specific capacity,and remarkable rate durability.This rational design strategy can be applied to create high-efficiency and inexpensive electrocatalysts for sustainable energy conversion and storage devices. | Hui Wang Xinghao Zhang Xiaohui Li Yutong Li Debin Kong Zhiyuan Zhen Lina Geng Linjie Zhi Zhongtao Li | 2023 | Renewables2023，1，3： | 0 |
| 20 | BMRMIA:A Platform for Radiologists to Systematically Learn Automated Medical Image Analysis by Three Dimensional Medical Decision Support System显示文摘Contribution:This paper designs a learning and training platform that can systematically help radiologists learn automated medical image analysis technology.The platform can help radiologists master deep learning theories and medical applications such as the three-dimensional medical decision support system,and strengthen the teaching practice of deep learning related courses in hospitals,so as to help doctors better understand deep learning knowledge and improve the efficiency of auxiliary diagnosis.Background:In recent years,deep learning has been widely used in academia,industry,andmedicine.An increasing number of companies are starting to recruit a large number of professionals in the field of deep learning.Increasing numbers of colleges and universities also offer courses related to deep learning to help radiologists learn automated medical image analysis techniques.For now,however,there is no practical training platform that can help radiologists learn automated medical image analysis systematically.ApplicationDesign:The platform proposes the basic learning,model combat,business application(BMR)concept,including the learning guidance system and the assessment training system,which constitutes a closed-loop learning guidance mode of“learning-assessment-training-learning”.Findings:The survey results show that most of radiologists met their learning expectations by using this platform.The platform can help radiologists master deep learning techniques quickly,comprehensively and firmly. | Yankun Cao Lina Xu Zhi Liu Xiaoyan Xiao Mingyu Wang Qin Li Hongji Xu Geng Yang | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 0 |
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