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| 1 | Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis显示文摘The recent outbreak of COVID-19 has been rapidly spreading on a global scale.To date,there is no specific vaccine against the causative virus,SARS-CoV-2,nor is there an effective medicine for treating COVID-19,thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19.By extracting and analyzing all available published clinical data,we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19.Specifically,preexisting chronic conditions such as hypertension,cardiovascular disease,chronic kidney disease,and diabetes are strongly associated with an increased risk of developing severe COVID-19;surprisingly,however,we found no correlation between chronic liver disease and increased disease severity.In addition,we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality.Given the high risk of comorbidity and the high mortality rate associated with tissue damage,organ function should be monitored closely in patients diagnosed with COVID-19,and this approach should be included when establishing new guidelines for managing these high-risk patients.Moreover,additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe,potentially fatal complications,and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease.Taken together,these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19. | Xinhui Wang Xuexian Fang Zhaoxian Cai Xiaotian Wu Xiaotong Gao Junxia Min Fudi Wang | 2020 | Research2020，，1： | 13 |
| 2 | Numerical simulation of mould filling process for pressure plate and valve handle in LFC显示文摘In lost foam casting (LFC), the distribution of polymer beads during the bead filling process is not uniform, and the collision between polymer beads determines the distribution of two-phase flow of gas and solid. The interaction between the gas and solid phases reveals as coupling effect of the force that gas exerts on particles or vice versa, or that among particles. The gas-solid flow in filling process is nonlinearity, which makes the coupling effect an essential point to carry out a simulation properly. Therefore, information of each particle's motion is important for acquiring the law of filling process. In bead filling process, compressed air is pressed into mold cavity, and discharged from gas vent, creating a pressure difference between outer and inner space near the gas vent. This pressure difference directly changes the spatial distribution and motion trace of gas and solid phases. In this paper, Discrete Element Method (DEM) and Computational Fluid Dynamics (CFD) are employed to simulate the fluid dynamic character based on Newton's Third Law of Motion. The simulation results of some casting products such as pressure plate and valve handle are compared with the result obtained from practical experiment in order to test the feasibility of DEM. The comparison shows that this DEM method can be a very promising tool in the mould filling simulation of beads' movement. | Jiang Junxia Li Qinliang Wu Zhichao Chen Liliang | 2010 | China Foundry2010，7，4： | 9 |
| 3 | Characteristics and dynamics analysis of Populus euphratica populations in the middle reaches of Tarim River显示文摘Populus euphratica Oliv. is widely distributed along the Tarim River. Maintaining stability of P. euphratica population is important to local development. This study explored the static life table, survivorship curves and four function curves (survival rate, cumulative mortality rate, mortality density, and hazard rate), and development index of P. euphratica population in the middle reaches of Tarim River. The results indicated that the age structure of P. euphratica population belonged to positive pyramidal type, which meant young age-class individuals occupied most populations. The number ofⅠ-Ⅱage classes accounted for 66.2% of whole population, and this indicated that there were abundant subsequent seedlings resources to support the growth of P. euphratica population in the middle reaches of Tarim River. The survivorship curve of P. euphratica belonged to the Deevey Ⅲ (concave-type) and the development index was 47.72%. Four function curves revealed that the individuals of P. euphratica sharply decreased at the initial stage and then leveled off at the late stage of survival curve. Time sequence prediction models predicted that the number of midlife individuals would increase in future 10, 20, 30 years, and P. euphratica population grew steadily as a result of rich saplings. | Wu, JunXia Zhang, XiMing Deng, ChaoZhou Liu, GuoJun Li, Hong | 2010 | Journal of Arid Land2010，2，4： | 9 |
| 4 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 5 | Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms显示文摘Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.Here,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.We validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin expression.Interestingly,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s effects.In addition,AUR induces IL-6 via the NF-κB pathway.In C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin saturation.Whereas chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in females.Further analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)mice.Notably,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)activity.We demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron metabolism.In conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders. | Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 6 | An HDR Imaging Method With DTDI Technology for Push-Broom Cameras显示文摘通常,高动态范围(HDR ) 成像基于拿二或有不同暴露的一样的景色的更多的图画。由于在照相机和景色之间的一个高速度的相对运动,然而,要用于推扫帚遥感照相机,为这种技术是难的。为在推扫帚遥感应用的 HDR 成像的缘故,现在的纸建议没有冗余的图象传感器或光部件,能产生 HDR 图象的一个创新方法。明确地,这份报纸与数字领域 time-delay-integration (DTDI ) 采用一个区域数组互补金属氧化物半导体(互补金属氧化物半导体) 为成像的技术而不是多于一个排图象传感器采用,从而与不同暴露拍摄超过一张照片。然后由与一个简单算法熔化二幅原来的图象的一幅新 HDR 图象能被完成。由进行实验,图象的动态范围(医生) 由 26.02 dB 增加。建议方法被证明有效并且在在照相机和场面之间有一个相对运动的另外的成像应用有潜力。 | Wu SUN Chengshan HAN Xucheng XUE Hengyi LV Junxia SHI Changhong HU Xiangzhi LI Yao FU Xiaonan JIANG Liang HUANG Hongyin HAN | 2018 | Photonic Sensors2018，8，1： | 4 |
| 7 | Microstructure and Mechanical Properties of Galvanized Steel/AA6061 Joints by Laser Fusion Brazing Welding显示文摘Laser fusion brazing welding was proposed.Galvanized steel/AA6061 lapped joint was obtained by laser fusion brazing welding technique using the laser-induced aluminium molten pool spreading and wetting the solid steel surface.Wide joint interface was formed using the rectangular laser beam coupled with the synchronous powder feeding.The result showed that the tiny structure with the composition of a-Al and Al–Si eutectic was formed in the weld close to the Al side.And close to the steel side,a layer of compact Fe–Al–Si intermetallics,including the Al-rich FeAl3,Fe2Al5 phases and Al–Fe–Si s1 phase,was generated with the thickness of about 10–20 lm.Transverse tensile shows the brittlefractured characteristic along to the seam/steel interface with the maximum yield strength of 152.5 MPa due to the existence of hardening phases s1 and Al–Fe intermetallics. | Junxia L Wuxiong Yang Shikai Wu Xudong Zhao Rongshi Xiao | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 3 |
| 8 | Trends in Stroke Mortality Rate--China,2004-2019显示文摘Introduction:Stroke has been the leading cause of death in China for decades.This study described the trends in stroke mortality in China from 2004 to 2019.Methods:Data was obtained from the National Disease Surveillance Point(DSP)system.A descriptive analysis was conducted.The adjusted mortality rate(AMR)and age-standardized mortality rate(ASMR)of stroke were calculated.Results:From 2004 to 2019,the ASMR substantially decreased,with a reduction of 39.8%,but the AMR stayed relatively stable.The mortality rate of stroke in rural areas was consistently higher than in urban areas.A geographical gradient in mortality of stroke was also apparent,with an increased rate in the western part of China and a decreased rate in the eastern part of China.In central China,the rate remained relatively stable.Conclusions:Although the ASMR of stroke continued to decline in China,the stagnant crude mortality rates suggested that China had not achieved sufficient decline to offset the demographic forces of population growth and ageing.More vigorous and effective prevention and treatment strategies are urgently needed to mitigate the disease burden of stroke in China,especially in areas with high stroke burden and limited resources. | Junxia Cheng Wei Wang Jianwei Xu Ling Yin Yunning Liu Jing Wu | 2022 | China CDC weekly2022，4，24： | 3 |
| 9 | Prediction of sorghum miRNAs and their targets with computational methods显示文摘microRNAs 是 21-nt 的一个班在 post-transcriptional 起关键作用的长、非编码、最新识别的 RNA 基因规定。他们的目标涉及各种各样的生物过程,包括开发,新陈代谢,和压力反应。尽管很多 miRNAs 在许多种类被报导了,在蜀黍的 miRNAs 的报告是有限的。基于 genomic 调查顺序(GSS ) 和 microRNA (miRNA ) 使用相同搜索第二等的结构, 17 新 miRNAs 的一个总数在这个工作被识别。他们被发现在 11 个 miRNA 家庭之中不均匀的分布式。一些 miRNA 基因在多重地点并且在超过一 genomic 上下文被发现。大多数 miRNAs 在一样的王国以内被保存,但是我们在蜀黍发现 sbi-miR127 和 sbi-miR466 与 H 显示出保存。现代人并且 M。musculus 分别地。经由联机软件 miRU 的那些 17 新 miRNAs 的分析证明他们可能调整 64 目标基因,其大多数涉及 RNA 处理,新陈代谢,房间周期,蛋白质降级,压力反应和交通。11 个 miRNA 家庭中的至少 7 个指向在新陈代谢和压力反应是必要的蛋白质,包括 NADPH 细胞色素 P450 reductase, nucleoside diphosphate kinase 和 superoxide dismutase,建议 miRNAs 起在生物过程的一个必要作用。 | DU JiangFeng WU YongJun FANG XiaoFeng CAO JunXia ZHAO Liang TAO ShiHeng | 2010 | Chinese Science Bulletin2010，55，13： | 2 |
| 10 | Transfer function based equivalent modeling method for wind farm显示文摘To effectively study the dynamics of power systems with large-scale wind farms(WFs), an equivalent model needs to be developed. It is well known that back-toback converters and their controllers are important for the dynamic responses of the wind turbine(WT) under disturbances. However, the detailed structure and parameters of the back-to-back converters and their controllers are usually unknown to power grid operators. Hence, it is difficult to build an accurate equivalent model for the WF using the component model-based equivalent modeling method. In this paper, a transfer function based equivalent modeling method for the WF is proposed. During modeling, the detailed structure and parameters of the WF are not required. The objective of the method is reproducing the output dynamics of the WF under the variation of the wind speed and power grid faults. A decoupled parameter-estimation strategy is also developed to estimate the parameters of the equivalent model. A WF that consists of 16 WTs is used to test the proposed equivalent model. Additionally,the proposed equivalent modeling method is applied to build the equivalent model for a real WF in Northwest China. The effectiveness of the proposed method is validated by the real measurement data. | Feng WU Junxia QIAN Ping JU Xiaoping ZHANG Yuqing JIN Dan XU Michael STERLING | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 2 |
| 11 | A locally adaptive fil- ter of interferometrie phase images 显示文摘 | WU Nan FENG Dazheng LI Junxia | 2006 | IEEE GRS Letters2006，3，1： | 1 |
| 12 | Ultrasound enhanced electrochemical oxidation of phenol and phthalic acid on boron-doped diamond electrode显示文摘 | Guohua Zhao Junxia Gao Shihao Shen Meichuan Liu Dongming Li Meifen Wu Yanzhu Lei | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 13 | Concept and model of 'supporting capacity of water resources' in urban areas显示文摘 | Zuo Qiting Ma Junxia Wu Zening | 2005 | Sustainable Water Management Solutions for Large Cities IAHS Publication2005，293，： | 1 |
| 14 | A locally a-daptive filter of interferometric phase images 显示文摘 | WU Nan FENG Dazheng LI Junxia | 2006 | IEEE Geoscience and Remote Sensing Letters2006，3，1： | 1 |
| 15 | Numerical simulation and analysis of mould filling process in lost foam casting显示文摘In lost foam casting(LFC)the foam pattern is the key criterion,and the filling process is crucialto ensure the high quality of the foam pattern.Filling which lacks uniformity and denseness will cause variousdefects and affect the surface quality of the casting.The influential factors of the filling process are realized in thisresearch.Optimization of the filling process,enhancement of efficiency,decrease of waste,etc.,are obtained bythe numerical simulation of the filling process using a computer.The equations governing the dense gas-solid two-phase flow are established,and the physical significanceof each equation is discussed.The Euler/Lagrange numerical model is used to simulate the fluid dynamiccharacteristics of the dense two-phase flow during the mould filling process in lost foam casting.The experimentsand numerical results showed that this method can be a very promising tool in the mould filling simulation of beads’movement. | Jiang Junxia Wu Zhichao Chen Liliang Hao Jing | 2008 | China Foundry2008，5，3： | 1 |
| 16 | Monitoring the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)during high-temperature solid state synthesis via in situ SEM显示文摘The particle morphology determined by the sintering process is the director factor affecting the electrochemical performance of Ni-rich NMC cathode materials.To prepare the ideal NMC particles,it is of great significance to understand the morphological changes during sintering process.In this work,the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)synthesis at temperature ranging from 300–1080℃were observed by in situ SEM.The uniform mixture of spherical Ni_(0.8)Mn_(0.1)Co_(0.1)(OH)_(2)precursor and lithium sources(LiOH)was employed by high temperature solid-state process inside the SEM,which enables us to observe morphology changes in real time.The results show that synthetic reaction of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)usually includes three processes:the raw materials’dehydration,oxidation,and combination,accompanied by a significant reduction in particle size,which is important reference to control the synthesis temperature.As heating temperature rise,the morphology of mixture also changed from flake to brick-shaped.However,Ni nanoparticle formation is apparent at higher temperature~1000℃,suggesting a structural transformation from a layered to a rock-salt-like structure.Combining the in-situ observed changes in size and morphology,and with the premise of ensuring the morphology change from flakes to bricks,reducing the sintering temperature as much as possible to prevent excessive reduction in particle size and layered to a rock-salt structure transformation is recommended for prepare ideal NMC particles. | Liang Tang Xiaopeng Cheng Rui Wu Tianci Cao Junxia Lu Yuefei Zhang Ze Zhang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 17 | Concept and Model of Supporting Capacity of Water Resources in Urban Areas显示文摘 | Zuo Qiting Ma Junxia Wu Zening | 2005 | Sustainable Water Management Solutions for Large Cities IAHS Publication2005，293，： | 1 |
| 18 | A Locally Adaptive Filter of Interferometric Phase Images显示文摘 | Wu Nan Feng Dazheng Li Junxia | 2006 | IEEE Geoscience and Remote Sensing Letters2006，3，1： | 1 |
| 19 | A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection显示文摘Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for HIAF-BRing.Method Based on the optical characteristics,unwanted particles are safely deflected to a specific internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power supplies.Results Taking alignment and multipolefield errors into account,discarded beam can be dumped within 5 ms with an efficiency of more than 99.8%at any operation stage.Conclusion The proposed beam dump solution satisfies the machine protection requirements for BRing and can provide a new idea for similar facilities. | Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang Sheng Lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 20 | Monitoring and Modeling the Effects of Groundwater Flow on Arsenic Transport in Datong Basin显示文摘Although arsenic-contaminated groundwater in the Datong Basin has been studied for more than 10 years, little has been known about the complex patterns of solute transport in the aquifer systems. Field monitoring and transient 3D unsaturated groundwater flow modeling studies were carried out on the riparian zone of the Sanggan River at the Datong Basin, northern China, to better understand the effects of groundwater flow on As mobilization and transport. The results indicate that irrigation is the primary factor in determining the groundwater flow paths. Irrigation can not only increase groundwater level and reduce horizontal groundwater velocity and thereby accelerate vertical and horizontal groundwater exchange among sand, silt and clay formations, but also change the HSconcentration, redox conditions of the shallow groundwater. Results of net groundwater flux estimation suggest that vertical infiltration is likely the primary control of As transport in the vadose zone, while horizontal water exchange is dominant in controlling As migration within the sand aquifers. Recharge water, including irrigation return water and flushed saltwater, travels downward from the ground surface to the aquifer and then nearly horizontally across the sand aquifer. The maximum value of As enriched in the riparian zone is roughly estimated to be 1 706.2 mg·d-1 for a horizontal water exchange of 8.98 m3·d-1 close to the river and an As concentration of 190 μg·L-1. | Qian Yu Yanxin Wang Rui Ma Chunli Su Ya Wu Junxia Li | 2014 | Journal of Earth Science2014，25，2： | 1 |
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