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| 1 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 2 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 3 | Natural polypeptides treat pollution complex: Moistureresistant multi-functional protein nanofabrics for sustainable air filtration显示文摘有象优秀过滤效率, eco 友好,和环境稳定性那样的特征的绿多功能的空气过滤器的开发极其被要求探讨弄脏的空气的增加的担心。自然蛋白质例如酱油蛋白质和明胶,作为由于富有的功能的组的多功能的空气过滤材料是吸引人的候选人;然而,这些简历材料对潮湿脆弱,它在实践限制他们的宽广申请。在这个工作,从丰富的玉米导出的玉米朊的恐水病的蛋白质第一次被修改经由 electrospinning 生产高效的 nanofilters。玉米朊 nanofabrics 在无毒的溶剂和 co-electrospinning 代理人的帮助下被制作, poly (乙烯氧化物) 。结果表明基于玉米朊的 nanofabrics 为从 0.1 ~ 10 m 的不同尺寸的微粒事的同时的移动显示出高效率(>99.5%) 并且某些气体的有毒的化学药品(>70%) 。另外,到纤维素纸巾的优秀潮湿抵抗和好粘附用作空气过滤器底层的玉米朊 nanofabrics 表演。这研究基于象玉米朊那样的蛋白质为开发多功能的绿空气过滤器正在答应材料的恐水病的天赋表明那 nanofabrics。 | Huafeng Tian Xuewei Fu Min Zheng Yu Wang Yichao Li Aimin Xiang Wei-Hong Zhong | 2018 | Nano Research2018，11，8： | 5 |
| 4 | Severity of early allograft dysfunction following donation after circulatory death liver transplantation:a multicentre study显示文摘Background:Early allograft dysfunction(EAD)is associated with decreased graft and patient survival rates.This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death(DCD)liver transplantation(LT).Furthermore,the influence of operative time on EAD incidence was also evaluated.Methods:In this retrospective,multicentre cohort study,nomograms were established based on a single-centre training cohort(n=321)and validated in a 3-center validation cohort(n=501).Results:The incidence rate of EAD was 46.4%(149/321)in the training cohort and 40.5%(203/501)in the validation cohort.Of the 149 EAD patients in the training cohort,77 patients with either elevated alanine aminotransferase(ALT)or aspartate aminotransferase(AST)were classified as having EAD type A,and the rest of the EAD patients were classified as having EAD type B.Recipients with EAD type B had lower graft and patient survival rates than recipients with EAD type A(P=0.043 and 0.044,respectively).We further developed a nomogram to predict EAD(graft weight,cold ischemia time,donor age,model for end-stage liver disease(MELD)score)and another nomogram to predict EAD type B(graft weight,cold ischemia time,MELD score).The nomograms for the prediction of EAD and EAD type B had good discrimination[concordance index(C-index)=0.712(0.666-0.758),0.707(0.641-0.773)]and calibration[Hosmer-Lemeshow(HL)P=0.384,P=0.425]in the validation cohort.An increased operative time(>6 h)was associated with increased EAD and EAD type B incidence in the high-risk group(P=0.005,P=0.020,respectively).Conclusions:EAD type B was associated with decreased graft and patient survival rates.The novel nomograms effectively predicted the incidence of EAD and EAD type B in DCD LT patients. | Kun Wang Di Lu Yuhui Liu Wangyao Li Li Zhuang Zhenyu Ma Qinfen Xie Binhua Pan Yichao Wu Junli Chen Lidan Lin Xiaowen Feng Qiang Wei Xuyong Wei Haiyang Xie Zhengxin Wang Shusen Zheng Xiao Xu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 4 |
| 5 | MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness显示文摘Asthma is one of the most common heterogeneous airway diseases.Worldwide,the prevale nee of doctor-diagnosed asthma in adults was reported to be 4.3%in 2OO3.^(1)In China,the overall prevalence of asthma duri nq 2012 a nd 2015 was 4.2%,represe nting 45.7 million Chinese adults.^(2)Although comprehensive approaches have been used in clinical practice,a considerable number of people are still hospitalized for acute exacerbation of asthma every year.In China,15.5%of asthmatics reported at least one emergency room visit and 7.2%reported at least one hospital admission due to exacerbation of respiratory symptoms.^(2)A need exists to clarify the mechanism of asthma's pathogenesis and to identify more appropriate and precise therapies for asthma. | Yahui Liu Juan Du Xinnan Liu Lingbiao Wang Yichao Han Chunrong Huang Rui Liang Fang Zheng Guochao Shi Bin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 6 | Time-Domain Analysis of Underground Station-Layered Soil Interaction Based on High-Order Doubly Asymptotic Transmitting Boundary显示文摘Based on the modified scale boundary finite element method and continued fraction solution,a high-order doubly asymptotic transmitting boundary(DATB)is derived and extended to the simulation of vector wave propagation in complex layered soils.The high-order DATB converges rapidly to the exact solution throughout the entire frequency range and its formulation is local in the time domain,possessing high accuracy and good efficiency.Combining with finite element method,a coupled model is constructed for time-domain analysis of underground station-layered soil interaction.The coupled model is divided into the near and far field by the truncated boundary,of which the near field is modelled by FEM while the far field is modelled by the high-order DATB.The coupled model is implemented in an open source finite element software,OpenSees,in which the DATB is employed as a super element.Numerical examples demonstrate that results of the coupled model are stable,accurate and efficient compared with those of the extended mesh model and the viscous-spring boundary model.Besides,it has also shown the fitness for long-time seismic response analysis of underground station-layered soil interaction.Therefore,it is believed that the coupled model could provide a new approach for seismic analysis of underground station-layered soil interaction and could be further developed for engineering. | Tingjin Liu Siyuan Zheng Xinwei Tang Yichao Gao | 2019 | Computer Modeling in Engineering & Sciences2019，，9： | 2 |
| 7 | Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide显示文摘Dear Editor,Follicular lymphoma(FL)represents the most common subtype of indolent non-Hodgkin's lymphoma(NHL)with distinct pathological,cytogenetic,and molecular features,accounting for 9.7%of NHLs in China[1].FL maintains a differentiation stage similar to germinal center(GC)B cells and is divided into grades 1,2,3A,and 3B[2].Up to 90%of FLs harbor the t(14;18)(q32;q21)/BCL2 apoptosis regula-tor(BCL2)-immunoglobulin heavy locus(IGH)transloca-tion and epigenetic modifier mutations,particularly lysine methyltransferase 2D(KMT2D)and CREB-binding pro-tein(CREBBP)[2]. | Nan Wang Wei Qin Zhong Zheng Ming Zhao Jie Xiong Hai Fang Rui Sun Yichao Wang Chen Li Lei DongXiaojian Sun Li Wang Pengpeng Xu Shu Cheng Haimin Xu Fan Zhang Weili Zhao | 2022 | Cancer Communications2022，42，2： | 2 |
| 8 | Dynamic degradation patterns of porous polycaprolactone/β-tricalcium phosphate composites orchestrate macrophage responses and immunoregulatory bone regeneration显示文摘Biodegradable polycaprolactone/β-tricalcium phosphate(PT)composites are desirable candidates for bone tissue engineering applications.A higherβ-tricalcium phosphate(TCP)ceramic content improves the mechanical,hydrophilic and osteogenic properties of PT scaffolds in vitro.Using a dynamic degradation reactor,we estab-lished a steady in vitro degradation model to investigate the changes in the physio-chemical and biological properties of PT scaffolds during degradation.PT46 and PT37 scaffolds underwent degradation more rapidly than PT scaffolds with lower TCP contents.In vivo studies revealed the rapid degradation of PT(PT46 and PT37)scaffolds disturbed macrophage responses and lead to bone healing failure.Macrophage co-culture assays and a subcutaneous implantation model indicated that the scaffold degradation process dynamically affected macro-phage responses,especially polarization.RNA-Seq analysis indicated phagocytosis of the degradation products of PT37 scaffolds induces oxidative stress and inflammatory M1 polarization in macrophages.Overall,this study reveals that the dynamic patterns of biodegradation of degradable bone scaffolds highly orchestrate immune responses and thus determine the success of bone regeneration.Therefore,through evaluation of the biological effects of biomaterials during the entire process of degradation on immune responses and bone regeneration are necessary in order to develop more promising biomaterials for bone regeneration. | Hao Wu Xinghui Wei Yichao Liu Hui Dong Zhen Tang Ning Wang Shusen Bao Zhigang Wu Lei Shi Xiongfei Zheng Xiaokang Li Zheng Guo | 2023 | Bioactive Materials2023，，3： | 1 |
| 9 | Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells显示文摘 | Puwang Li Yichao Wang Fanbo Zeng Lijue Chen Zheng Peng Ling Xue Kong | 2011 | Carbohydrate Research2011，，6： | 1 |
| 10 | Synthesis of diverse well-defined functional polymers based on hydrozirconation and subsequent anti-markovnikov halogenation of 1,2-polybutadiene 显示文摘 | Zheng Jun Liu Feng Lin Yichao | 2012 | Macromolecules2012，45，3： | 1 |
| 11 | Abnormal event detection by a weakly supervised temporal attention network显示文摘Abnormal event detection aims to automatically identify unusual events that do not comply with expectation.Recently,many methods have been proposed to obtain the temporal locations of abnormal events under various determined thresholds.However,the specific categories of abnormal events are mostly neglect,which are important to help in monitoring agents to make decisions.In this study,a Temporal Attention Network(TANet)is proposed to capture both the specific categories and temporal locations of abnormal events in a weakly supervised manner.The TANet learns the anomaly score and specific category for each video segment with only video-level abnormal event labels.An event recognition module is exploited to predict the event scores for each video segment while a temporal attention module is proposed to learn a temporal attention value.Finally,to learn anomaly scores and specific categories,three constraints are considered:event category constraint,event separation constraint and temporal smoothness constraint.Experiments on the University of Central Florida Crime dataset demonstrate the effectiveness of the proposed method. | Xiangtao Zheng Yichao Zhang Yunpeng Zheng Fulin Luo Xiaoqiang Lu | 2022 | CAAI Transactions on Intelligence Technology2022，7，3： | 1 |
| 12 | Derivation of the multi-model generalized labeled multi-Bernoulli filter:a solution to multi-target hybrid systems显示文摘In this study,we extend traditional(single-target)hybrid systems to multi-target hybrid systems with a focus on the multi-maneuvering-target tracking system.This system consists of a continuous state,a discrete and switchable state,and a discrete,time-constant,and unique state.By defining a new generalized labeled multi-Bernoulli density,we prove that it is closed under the Chapman-Kolmogorov prediction and Bayes update for multi-target hybrid systems.In other words,we provide the exact derivation of a solution to this system,i.e.,the multi-model generalized labeled multi-Bemoulli filter,which has been developed without strict proof. | Weihua WU Yichao CAI Hongbin JIN Mao ZHENG Xun FENG Zewen GUAN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，1： | 1 |
| 13 | Deep learning-based radiomics allows for a more accurate assessment of sarcopenia as a prognostic factor in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies and is a major cause of cancer-related mortalities worldwide(Forner et al.,2018;He et al.,2023).Sarcopenia is a syndrome characterized by an accelerated loss of skeletal muscle(SM)mass that may be age-related or the result of malnutrition in cancer patients(Cruz-Jentoft and Sayer,2019).Preoperative sarcopenia in HCC patients treated with hepatectomy or liver transplantation is an independent risk factor for poor survival(Voron et al.,2015;van Vugt et al.,2016). | Zhikun LIU Yichao WU Abid Ali KHAN Lun LU Jianguo WANG Jun CHEN Ningyang JIA Shusen ZHENG Xiao XU | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，1： | 0 |
| 14 | Sensitizing effect of Nd^(3+) on Tb^(3+) activated ZrP_(2)O_(7) long persistent phosphor materials显示文摘The long persistent phosphors of Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)with Nd^(3+)as sensitized ions and Tb^(3+)as emission centers were synthesized using high temperature solid state reaction.The crystal structure and defects,excitation and emission spectra,decay curves and thermoluminescence(TL) curves of the phosphors were investigated.The synthesized Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is essentially in line with the standard card PDF#49-1079.The emission band with main peak at 548 nm exhibits the characteristic transitions of ^(5)D_(3)-^(7)F_(j)(j=5,4) and ^(5)D_(3)-^(7)F_(j)(j=6,5,4,3) of Tb^(3+).The analysis of excitation and emission spectra shows that there exists the overlap between the emission peaks of Nd^(3+)at 466 and 485 nm and the excitation of Tb^(3+)at 443 and 485 nm,and the energy transfer from Nd^(3+)to Tb^(3+)plays an important role in the improvement of luminescence properties.The decay curves shows that Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)has longer afterglow time than ZrP_(2)O_(7) and Zr_(0.982)P_(2)O_(7):0.018 Tb^(3+).Additionally,the TL curves indicate that the trap depth at 0.72 eV in Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is to the benefit of the afterglow time.The possible luminescence mechanism of ZrP_(2)O_(7):Tb^(3+),Nd^(3+)is proposed on the basis of the XPS spectra,EPR spectra,excitation and emission spectra,decay curves,TL curves and the analysis of defect equations. | Meihua Wu Wen Chen Siyuan Liu Yichao Sun Lingfeng Huang Guoliang Chen Zishan Zheng | 2021 | Journal of Rare Earths2021，39，7： | 0 |
| 15 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 16 | Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4(BRD4) inhibitors显示文摘Targeting bromodomain-containing protein 4(BRD4) has been proved to be an effective strategy for cancer therapy.To date,numerous BRD4 inhibitors and degraders have been identified,some of which have advanced into clinical trials.In this work,a focused library of new [1,2,4]triazolo [1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4.WS-722 inactivated BRD4(BD1/BD2),BRD2(BD1/BD2) and BRD3(BD1/BD2) broadly with the IC_(50) values less than 5 μmol/L.Besides,WS-722 inhibited growth of THP-1 cells with an IC_(50) value of 3.86 μmol/L.Like(+)-JQ1,WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability.Docking studies showed that WS-722 occupied the central acetyl-lysine(Kac) binding cavity and formed a hydrogen bond with Asn140.In THP-1 cells,WS-722 showed target engagement to BRD4.Cellular effects of WS-722 on THP-1 cells were also examined,showing that WS-722 could block c-MYC expression,induce G0/G1 phase arrest and p21 up-regulation,and promote differentiation of THP-1 cells.BRD4 inhibition by WS-722 resulted in cell apoptosis and upregulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines.The [1,2,4]triazolo[1,5-a]pyrimidine is a new template for the development of new BRD4 inhibitors. | Shuai Wang Dandan Shen Lijie Zhao Xiaohan Yuan Jialing Cheng Bin Yu Yichao Zheng Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 0 |
| 17 | Thymic-specific regulation of TCR signaling by Tespa1显示文摘Double-positive(DP)thymocytes undergo positive selection to become mature single-positive CD4+and CD8+T cells in response to T cell receptor(TCR)signaling.Unlike mature T cells,DP cells must respond to low-affinity self-peptide-MHC ligands before full upregulation of their surface TCR expression can occur.Thus,DP thymocytes must be more sensitive to ligands than mature T cells.A number of molecules have been found that are able to enhance the strength of the TCR signal to facilitate positive selection.However,almost all of these molecules are also active in mature T cells.Themis(thymocyte expressed molecule involved in selection)and Tespa1(thymocyte expressed positive selection associated 1)are two recently discovered molecules essential for optimal TCR signaling and thymocyte development.A deficiency in both molecules leads to defects in positive selection.Here,we compared the relative contributions of Themis and Tespa1 to positive selection in thymocytes.We show that Tespa1 deficiency led to more limited and specific gene expression profile changes in cells undergoing positive selection.In mixed bone marrow transfer experiments,Tespa1^(−/−)cells showed more severe defects in thymocyte development than Themis^(−/−)cells.However,Tespa1^(−/−)cells showed a substantial degree of homeostatic expansion and became predominant in the peripheral lymphoid organs,suggesting that Tespa1 is a thymic-specific TCR signaling regulator.This hypothesis is further supported by our observations in Tespa1 conditional knockout mice,as Tespa1 deletion in peripheral T cells did not affect TCR signaling or cell proliferation.The different regulatory effects of Tespa1 and Themis are in accordance with their nonredundant roles in thymocyte selection,during which Tespa1 and Themis double knockouts showed additive defects. | Jun Lyu Pengfei Wang Ting Xu Yichao Shen Zejin Cui Mingzhu Zheng Guo Fu Linrong Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 0 |
| 18 | Experimental observations of the characteristics of hot electron and nonlinear processesproduced in special material显示文摘Making use of disk targets composed of several peculiar materials (foamAn, foam C8H8) and hohlraum with a special structure, experiments have been doneat 'Xing Guang - II' laser facility, which study the characteristics of hot electronsand the related nonlinear processes such as Stimulated airman Scattering (SRS), TwoPlasma Decay (TPD), Stimulated Brillouin Scattering (SBS), etc. | QI Lanying JIANG Xiaohua ZHENG Jian WANG Yichao LI Sanwei LI Chaoguang ZHANG Wenhai ZHENG Zhijian(Laboratory fo T Lacer Fusion, Institute of Nuclear Physics and Chemistry, CAEP,Chengdu 610003) | 1999 | Nuclear Science and Techniques1999，10，2： | 0 |
| 19 | Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis显示文摘Polyetheretherketone(PEEK)has been an alternative material for titanium in bone defect repair,but its clinical application is limited by its poor osseointegration.In this study,a porous structural design and activated surface modification were used to enhance the osseointegration capacity of PEEK materials.Porous PEEK scaffolds were manufactured via fused deposition modeling and a polydopamine(PDA)coating chelated with magnesium ions(Mg^(2+))was utilized on the surface.After surface modification,the hydrophilicity of PEEK scaffolds was significantly enhanced,and bioactive Mg^(2+)could be released.In vitro results showed that the activated surface could promote cell proliferation and adhesion and contribute to osteoblast differentiation and mineralization;the released Mg^(2+)promoted angiogenesis and might contribute to the formation of osteogenic H-type vessels.Furthermore,porous PEEK scaffolds were implanted in rabbit femoral condyles for in vivo evaluation of osseointegration.The results showed that the customized three-dimensional porous structure facilitated vascular ingrowth and bone ingrowth within the PEEK scaffolds.The PDA coating enhanced the interfacial osseointegration of porous PEEK scaffolds and the released Mg^(2+)accelerated early bone ingrowth by promoting early angiogenesis during the coating degradation process.This study provides an efficient solution for enhancing the osseointegration of PEEK materials,which has high potential for translational clinical applications. | Xinghui Wei Wenhao Zhou Zhen Tang Hao Wu Yichao Liu Hui Dong Ning Wang Hai Huang Shusen Bao Lei Shi Xiaokang Li Yufeng Zheng Zheng Guo | 2023 | Bioactive Materials2023，，2： | 0 |
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