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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Withholding of drip irriga- tion between transplanting and flowering increases the yield of field- grown tomato under plastic mulch 显示文摘 | Ngouajio M Wang Guangyao Goldy R | 2007 | Agricultural Water Manage- ment2007，87，3： | 1 |
| 3 | HPV communication: A review of existing research and recommendations for patient education显示文摘 | Anhang R Goodman A Goldie SJ | 2004 | CA Cancer J Clin2004，54，5： | 1 |
| 4 | HPV communication:Review of existing research and recommendations for patient education显示文摘 | Anhang R Goodman A Goldie S J | | 0，，： | 1 |
| 5 | Capso- somes: Subcompartmentalizing polyelectrolyte capsules using li- posomes 显示文摘 | STADLER B CHANDRAWATI R GOLDIE K | 2009 | Langmuir2009，25，67： | 1 |
| 6 | HPV Communication:review of existing research and recommendations for patient education显示文摘 | Anhang R Goodman A Goldie SJ | 2004 | CA Cancer J Clin2004，54，5： | 1 |
| 7 | Ankle injuries in basketball: injury rate and risk factors 显示文摘 | McKay G D Goldie P A Payne W R | 2001 | British Jour- nal of Sports Medicine2001，35，2： | 1 |
| 8 | HPV communication: review of existing research and recommendations for patient education显示文摘 | Anhang R Goodman A Goldie SJ | 2004 | CA Cancer J Clin2004，54，5： | 1 |
| 9 | Withholding of drip irrigation between transplanting and flowering increases the yield of field-grown tomato under plastic mulch显示文摘 | NGOUAJIO M WANG G GOLDY R | 2007 | Agricultural water management2007，87，3： | 1 |
| 10 | Capso- somes : subcompartmentalizing polyelectrolyte capsules using liposomes 显示文摘 | STADLER B CHANDRAWATI R GOLDIE K | 2009 | Langmuir2009，25，12： | 1 |
| 11 | Endothelin-l-induced potentiation of human airway smooth muscle proliferation : an ETA receptor mediated phenomenon 显示文摘 | Panettieri R A Goldie R G Rigby P J | 1996 | Br J Pharmacol1996，118，： | 1 |
| 12 | Influence of regional differences in ETA and ETB receptor subtype proportions on endothelin-1-induced contractions in porcine isolated trachea and bronchus显示文摘 | Goldie RG Aprile ACD Cvetkouski R | 1996 | Br J Pharmacol1996，117，： | 1 |
| 13 | A Rho kinase inhibitor,Y-27632 inhibits pulmonary eosinophilia,bronchoconstriction and airways hyperresponsiveness in allergic mice显示文摘 | Henry P J Mann T S Goldie R G | 2005 | Pulm Pharmacol Ther2005，18，1： | 1 |
| 14 | Withholding of drip irrigation between transplanting and flowering increases the yield of field grown tomato under plastic mulch显示文摘 | Ngouajio M Wang G Goldy R | 2007 | Agricultural Water Man agement2007，87，3： | 1 |
| 15 | The response of primary rat and human osteoblasts and an immortalized rat osteoblast cell line to orthopaedic materials: comparative sensitivity of several toxicity indices显示文摘 | R MACNAIR E. H RODGERS C MACDONALD A WYKMAN I GOLDIE M.H GRANT | 1997 | Journal of Materials Science: Materials in Medicine1997，，2： | 1 |
| 16 | Diversification and the rate of molecular evolution: no evidence of a link in mammals 显示文摘 | Goldie X Lanfear R Bromham L | 2011 | BMC Evol Biol2011，11，1： | 1 |
| 17 | HPV Commanication: review of existing yesearch and recommendations for patient education 显示文摘 | Anhang R Good A Goldie SJ | 2004 | Cancer J Clin2004，54，5： | 1 |
| 18 | In vitro biocompatibility testing of polymers for orthopaedic implants using cultured fibroblasts and osteoblasts显示文摘 | Morrison C Macnair R MacDonald C Wykman A Goldie I Grant M H | 1995 | Biomaterials1995，16，13： | 1 |
| 19 | Embryo culture as a means of intro- gressory seedlessness from Vitis vinifera to Vitis rotundlfolia 显示文摘 | GOLDY R G EMERSHAD R L | 1988 | HortScience1988，23，5： | 1 |
| 20 | HPV comm un ication:review of existing research and recomm endations for patient education显示文摘 | Anhang R Goodm an A Goldie SJ | 2004 | Cancer JC lin2004，54，5： | 1 |
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