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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Optical generation,detection and non-destructive testing applications of terahertz waves显示文摘Optoelectronic terahertz generation and detection play a key role in the applications of non-destructive testing,which involves different areas such as physics,biological,material science,imaging,explosions detection,astronomy applications,semiconductor technology and superconductiong electronics. In this article,we present a reviewof the principle and performance of typical terahertz sources,detectors and non-destructive testing applications. On this basis,the newdevelopment and trends of terahertz radiation detectors are also discussed. | ZHANG Weili LIANG Dachuan TIAN Zhen HAN Jiaguang GU Jianqiang HE Mingxia OUYANG Chunmei | 2016 | Instrumentation2016，3，1： | 8 |
| 3 | Terahertz surface plasmonic waves: a review显示文摘Terahertz science and technology promise many cutting-edge applications.Terahertz surface plasmonic waves that propagate at metal–dielectric interfaces deliver a potentially effective way to realize integrated terahertz devices and systems.Previous concerns regarding terahertz surface plasmonic waves have been based on their highly delocalized feature.However,recent advances in plasmonics indicate that the confinement of terahertz surface plasmonic waves,as well as their propagating behaviors,can be engineered by designing the surface environments,shapes,structures,materials,etc.,enabling a unique and fascinating regime of plasmonic waves.Together with the essential spectral property of terahertz radiation,as well as the increasingly developed materials,microfabrication,and time-domain spectroscopy technologies,devices and systems based on terahertz surface plasmonic waves may pave the way toward highly integrated platforms for multifunctional operation,implementation,and processing of terahertz waves in both fundamental science and practical applications.We present a review on terahertz surface plasmonic waves on various types of supports in a sequence of properties,excitation and detection,and applications.The current research trend and outlook of possible research directions for terahertz surface plasmonic waves are also outlined. | Xueqian Zhang Quan Xu Lingbo Xia Yanfeng Li Jianqiang Gu Zhen Tian Chunmei Ouyang Jiaguang Han Weili Zhang | 2020 | Advanced Photonics2020，2，1： | 7 |
| 4 | Plasmon-induced transparency in terahertz metamaterials显示文摘The quantum phenomena of electromagnetically induced transparency(EIT)or plasmonic analogue of electromagnetically induced transparency(PIT)can be mimicked in the classical resonators,leading to a unique way to explore the coherent coupling mechanism in metamaterial systems.Various metamaterial structures have been proposed to excite and manipulate the PIT efect with flexibility and performance with geometry-controllable,polarization-independent,broadband-transparency and active-modulated characteristics.These in turn promise the fascinating functionalities and applications of the PIT efects,such as slow-light components,nonlinear devices and high-sensitivity sensors.Here,we present a review on the progress in developing the PIT efect in terahertz metamaterials over the past few years. | JING HuiHui ZHU ZhiHua ZHANG XueQian GU JianQiang TIAN Zhen OUYANG ChunMei HAN JiaGuang ZHANG WeiLi | 2013 | Science China(Information Sciences)2013，56，12： | 5 |
| 5 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 6 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 7 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 8 | Structural features and antioxidant activity of tannin from persimmon pulp显示文摘 | Gu Haifeng Li Chunmei Xu Yujuan | 2008 | Food Research International2008，41，2： | 1 |
| 9 | Structural features and antioxidant activity of tannin from persimmon pulp显示文摘 | GU Haifeng LI Chunmei XU Yujuan | 2008 | Food Research International2008，41，2： | 1 |
| 10 | Structural features and antioxidant activity of tannin from persimmon pulp显示文摘 | GU Haifeng LI Chunmei XU Yujuan | 2008 | Food Research International2008，41，2： | 1 |
| 11 | Meta-optics inspired surface plasmon devices显示文摘Surface plasmons(SPs)are electromagnetic surface waves that propagate at the interface between a conductor and a dielectric.Due to their unique ability to concentrate light on two-dimensional platforms and produce very high local-field intensity,SPs have rapidly fueled a variety of fundamental advances and practical applications.In parallel,the development of metamaterials and metasurfaces has rapidly revolutionized the design concepts of traditional optical devices,fostering the exciting field of meta-optics.This review focuses on recent progress of meta-optics inspired SP devices,which are implemented by the careful design of subwavelength structures and the arrangement of their spatial distributions.Devices of general interest,including coupling devices,on-chip tailoring devices,and decoupling devices,as well as nascent SP applications empowered by sophisticated usage of meta-optics,are introduced and discussed. | Quan Xu Yuanhao Lang Xiaohan Jiang Xinyao Yuan Yuehong Xu Jianqiang Gu Zhen Tian Chunmei Ouyang Xueqian Zhang Jiaguang Han Weili Zhang | 2023 | Photonics Insights2023，2，1： | 1 |
| 12 | Structural features and antioxidant activity of tannin from persimmon pulp显示文摘 | GU Haifeng LI Chunmei XU Yujuan | 2008 | Food Research International2008，41，2： | 1 |
| 13 | Active-Thermal-Tunable Terahertz Absorber with Temperature-Sensitive Material Thin Film显示文摘It is shown that active-tunable terahertz absorbers can be realized in a sandwich-structured system comprising an ultrathin dielectric film(polyimide) on a temperature-sensitive substrate(InSb) with a metal film on the back by utilizing the intrinsic carrier density(N) variation in InSb. When increasing the temperature from 250 to 320 K, N in InSb varied from ~5.50×1015 to ~2.98×1016 cm–3. Fixing the thickness of dielectric film with the value of 1.37 μm, the absorption peak shifted from 1.41 to 3.29 THz while keeping absorption higher than 99%. This active tunability can respond to even a slight temperature perturbation, and shows polarization insensitivity as well as high tolerance of incidence-angle(absorption peak can still exceed 90% even the incidence angle reaches 60°). Besides, the refractive index of polyimide(PI) has thermal stability at the terahertz range and the merit of good workability. These characteristics guarantee the stability of activetunable performance. The peculiarities and innovations of this proposal promise a wide range of high efficiency terahertz devices, such as thermal sensors, spatial light modulators(SLMs) and so on. | Zhao Zhang Zhen Tian Chao Chang Xueguang Wang Xueqian Zhang Chunmei Ouyang Jianqiang Gu Jiaguang Han Weili Zhang | 2018 | Nanotechnology and Precision Engineering2018，1，2： | 1 |
| 14 | Ettect ot soybean variety on anti-nutritional factors content and growth performance and nutrients metabolism in rat显示文摘 | GU Chunmei PAN Hongbin SUN Zewel | 2010 | International Journal of Molecular Sciences2010，11，： | 1 |
| 15 | Structural features and antioxidant activity of tannin from persimmon pulp显示文摘 | Gu Haifeng Li Chunmei Xu Yujuan | 2008 | FoodResearch International2008，41，2： | 1 |
| 16 | Controllable resistive switching of STO:Ag/SiO2-based memristor synapse for neuromorphic computing显示文摘Resistive random-access memory(RRAM)is a promising technology to develop nonvolatile memory and artificial synaptic devices for brain-inspired neuromorphic computing.Here,we have developed a STO:Ag/SiO_(2) bilayer based memristor that has exhibited a filamentary resistive switching with stable endurance and long-term data retention ability.The memristor also exhibits a tunable resistance modulation under positive and negative pulse trains,which could fully mimic the potentiation and depression behavior like a bio-synapse.Several synaptic plasticity functions,including long-term potentiation(LTP)and long-term depression(LTD),paired-pulsed facilitation(PPF),spike-rate-dependent-plasticity(SRDP),and post-tetanic potentiation(PTP),are faithfully implemented with the fabricated memristor.Moreover,to demonstrate the feasibility of our memristor synapse for neuromorphic applications,spike-timedependent plasticity(STDP)is also investigated.Based on conductive atomic force microscopy observations and electrical transport model analyses,it can be concluded that it is the controlled formation and rupture of Ag filaments that are responsible for the resistive switching while exhibiting a switching ratio of~10;along with a good endurance and stability suitable for nonvolatile memory applications.Before fully electroforming,the gradual conductance modulation of Ag/STO:Ag/SiO_(2)/p^(++)-Si memristor can be realized,and the working mechanism could be explained by the succeeding growth and contraction of Ag filaments promoted by a redox reaction.This newly fabricated memristor may enable the development of nonvolatile memory and realize controllable resistance/weight modulation when applied as an artificial synapse for neuromorphic computing. | Nasir Ilyas Jingyong Wang Chunmei Li Hao Fu Dongyang Li Xiangdong Jiang Deen Gu Yadong Jiang Wei Li | 2022 | Journal of Materials Science & Technology2022，，2： | 1 |
| 17 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 18 | Correction: Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfsw9bx5fbnkxck6f5q.ffgz.tsg.suse.edu.cn/10.1038/s41423-021-00758-w In the version of this article initially published,one unintended error was made during manuscript editing.The title of the article was not in accordance with that of the original manuscript,and the correct statement is“Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease”.The results and conclusions are not affected. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 19 | Function Analyses of Geographic Information System on Rural Distribution Network显示文摘With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution network, in order to develop rural distribution network. | FANG Junlong FAN Yongcun ZHANG Chunmei GU Shumin | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，2： | 0 |
| 20 | GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease显示文摘Peripheral bacterial infections without impaired blood brain barrier integrity have been attributed to the pathogenesis of Parkinson's disease(PD).Peripheral infection promotes innate immune training in microglia and exacerbates neuroinflammation.However,how changes in the peripheral environment mediate microglial training and exacerbation of infection-related PD is unknown.In this study,we demonstrate that GSDMD activation was enhanced in the spleen but not in the CNS of mice primed with low-dose LPS.GSDMD in peripheral myeloid cells promoted microglial immune training,thus exacerbating neuroinflammation and neurodegeneration during PD in an IL-1R-dependent manner.Furthermore,pharmacological inhibition of GSDMD alleviated the symptoms of PD in experimental PD models.Collectively,these findings demonstrate that GSDMD-induced pyroptosis in myeloid cells initiates neuroinflammation by regulating microglial training during infection-related PD.Based on these findings,GSDMD may serve as a therapeutic target for patients with PD. | Bingwei Wang Yan Ma Sheng Li Hang Yao Mingna Gu Ying Liu You Xue Jianhua Ding Chunmei Ma Shuo Yang Gang Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
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