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| 1 | Abyssal Circulation in the Philippine Sea显示文摘The abyssal circulation in the Philippine Sea(PS)is investigated,with outputs from the Simple Ocean Data Assimilation version 2.2.4(SODA224).The deep-water currents in SODA224 are carefully evaluated,with sparse in situ observations in the North Pacific Ocean.In the upper deep layer(20003000 m)of the PS,a strong westward current,which originates from the Northeast Pacific Basin and enters the PS through the Yap-Mariana Junction,exists along 1114 N.This strong westward current bifurcates into two western boundary currents off the Philippines.The northward-flowing current flows out of the PS around 2021 N,whereas the southward-flowing current transports deep water from the northern hemisphere to the southern hemisphere.In the lower deep layer(30004500 m),the inflow water first flows northward to the east of the Western Mariana Basin and then turns westward at approximately 18 N.The inflow water mainly enters the Philippine Basin(PB),with a small part turning southward to constitute a weak cyclonic circulation.The water entering the PB mainly merges into a strong southward western boundary current in the south-ern PB.In the bottom layer(below 4500 m),both the northeast and northwest PB show single cyclonic gyres,whereas the south PB shows a single anticyclonic gyre.Moreover,comparisons with the observations indicate the possible existence of a cyclonic sense of circulation over the Philippine Trench.The current study provides the implications for future observations,which are needed to fur-ther investigate the temporospatial variations of the abyssal circulation in the PS on multiple scales. | ZHAI Fangguo GU Yanzhen | 2020 | Journal of Ocean University of China2020，19，2： | 5 |
| 2 | Climatology and seasonal variability of satellite-derived chlorophyll a around the Shandong Peninsula显示文摘The chlorophyll a(Chl a)is an important indicator of marine ecosystems.The spatiotemporal variation of the Chl a greatly aff ects the mariculture and marine ranching in coastal waters of the Shandong Peninsula.In the current study,the climatology and seasonal variability of surface Chl-a concentration around the Shandong Peninsula are investigated based on 16 years(December 2002-November 2018)of satellite observations.The results indicate that the annual mean Chl-a concentration is greater in the Bohai Sea than in the Yellow Sea and decreases from coastal waters to off shore waters.The highest Chl-a concentrations are found in Laizhou Bay(4.2-8.0 mg/m^(3)),Haizhou Bay(4.2-5.9 mg/m^(3))and the northeast coast of the Shandong Peninsula(4.4-5.0 mg/m^(3)),resulting from the combined eff ects of the intense riverine input and long residence time caused by the concave shape of the coastline.The seasonal Chl-a concentration shows a significant spatial variation.The Chl-a concentrations in these three subregions generally exhibit an annual maximum in August/September,due to the combined eff ects of sea surface temperature,river discharge and sea surface wind.In the southeast coast region,however,the Chl-a concentration is lowest throughout the year and reaches a maximum in February with a minimum in July,forced by the seasonal evolution of the Yellow Sea Cold Water and monsoon winds.The interannual Chl-a concentration trends vary among regions and seasons.There are significant increasing trends over a large area around Haizhou Bay from winter to summer,which are mainly caused by the rising sea surface temperature and eutrophication.In other coastal areas,the Chl-a concentration shows decreasing trends,which are clearest in summer and induced by the weakening land rainfall.This study highlights the differences in the Chl-a dynamics among regions around the Shandong Peninsula and is helpful for further studies of coupled physical-ecological-human interactions at multiple scales. | Xiukai SONG Yanzhen GU Fangguo ZHAI Peiliang LI Pengxia LIU Zizhou LIU Wenfan WU Yaozu CHEN Xiangyang JIANG Jianlong HE | 2021 | Journal of Oceanology and Limnology2021，39，4： | 3 |
| 3 | Internal wave parameters retrieval from space-borne SAR image显示文摘基于散布成像的成像机制和微波为海洋的表面特征建模的海洋的内部波浪 SAR,我们开发了一个新方法从 SAR 形象提取内部波浪参数。第一,起始的风地从 NCEP 分析数据,海水密度和海洋的内部波浪被导出 pycnocline 深度从利未夫数据被估计,内部波浪导致的表面水流根据 KDV 方程被计算。NRCS 侧面然后被解决行动平衡方程并且使用海表面雷达反散射模型模仿。风和内部波浪 pycnocline 深度被一步一步地使用两分方法让模仿的数据接近 SAR 图象调整。然后,当在模仿的信号和 SAR 图象之间合适的最好出现时,风速度, pycnocline 深度,阶段速度,组速度和内部波浪的振幅能从 SAR 形象被检索。方法在 Dongsha 岛附近在一幅景色 SAR 图象上被测试,在华南海,结果证明模仿的海洋的内部波浪 NRCS 侧面象90%一样高在有关联系数的 SAR 图象上在对那的好同意,并且从 SAR 形象检索的海洋的内部波浪的振幅与 SODA 数据是可比较的。而且,阶段速度在华南海从另外的 16 幅景色 SAR 图象检索了在对描述在内部波浪阶段速度和水深度之间的关系的实验公式的好同意,根平均数平方和相对错误是不到 0.11 ms -1并且7%,分别地,显示 SAR 图象为在这份报纸开发的内部波浪参数检索和方法是有用的会聚、适用。 | Kaiguo FAN Bin FU Yanzhen GU Xingxiu YU Tingting LIU Aiqin SHI Ke XU Xilin GAN | 2015 | Frontiers of Earth Science2015，9，4： | 2 |
| 4 | Seasonal variability in dissolved oxygen in the Bohai Sea,China显示文摘Deoxygenation has frequently appeared in coastal ecosystems over the past century due to the joint infl uence of increasing anthropogenically induced nutrient inputs and global warming.The semi-enclosed Bohai Sea is a typical system that is prone to deoxygenation,with regular hypoxia events consistently recorded in recent decades.Based on in-situ observation data collected in large-scale voyage surveys in the Bohai Sea during 2008-2017,the seasonal variability in dissolved oxygen(DO)and its controlling mechanisms were studied.The results indicated that in spring and autumn,the DO distributions exhibited similar spatial patterns in the surface and bottom layers,while in summer,its spatial distribution was characterized by large-scale oxygen-poor zones distributed off the Qinhuangdao Coast and the central southern Bohai Sea in the bottom layer.The controlling mechanisms of the DO distribution varied from season to season.Spring and autumn DO distributions were dominated by the seawater temperature.Under the combined eff ects of stratifi cation and decomposition,the summer bottom DO exhibited dual-core distribution.On the one hand,stratifi cation could greatly impede vertical mixing,resulting in reduced bottom DO replenishment.On the other hand,the increased bottom organic matter intensifi ed the decomposition processes,inducing massive DO consumption and elevated dissolved inorganic nitrogen concentrations.In addition,the stronger stratifi cation might be the reason for the more severe deoxygenation in the southern oxygen-poor zones in summer.Our study provides guidance for an in-depth understanding of the DO seasonality in the Bohai Sea and the mechanisms that modulate it and for the improvement of hypoxia forecasts in ocean models. | Yaozu CHEN Fangguo ZHAI Yanzhen GU Jing CAO Cong LIU Xingchuan LIU Zizhou LIU Peiliang LI | 2022 | Journal of Oceanology and Limnology2022，40，1： | 2 |
| 5 | Dimethyl phthalate ester degradation by two planktonic and immobilized bacterial consortia显示文摘 | WANG Yingying FAN Yanzhen GU Jidong | 2004 | International Biodeterioration & Biodegradation2004，53，2： | 1 |
| 6 | Cold Water in the Lee of the Batanes Islands in the Luzon Strait显示文摘Using satellite remote sensing data and hydrological observation data,this study investigated the cold water in the lee of the Batanes Islands in the Luzon Strait.The formation of cold water in climate is mainly due to the geostrophic heat advection on the east and west sides of the Batanes Islands:the Kuroshio separates into two branches on the east and west sides of the Batanes Islands.These two branches cause two warm tongues by transferring heat from low latitudes to mid-latitudes,and then the two warm tongues lead to the formation of the relatively cold water in the lee of the Batanes Islands.Further study shows that the cold water range has obvious seasonal and inter-annual variations.Except for August,the seasonal variation of the cold water range is caused by the interaction of geostrophic heat advection and net surface heat flux,whereas the low temperature in August in the lee of the Batanes Islands is caused by the island wake effect.The inter-annual of the cold water range is related to the difference in the meridional velocity between the east and west sides of the Batanes Islands,and the correlation coefficient can reach−0.68 at the 95%confidence level. | SUN Ruili ZHAI Fangguo ZHANG Guosheng GU Yanzhen CHI Nianping | 2020 | Journal of Ocean University of China2020，19，6： | 1 |
| 7 | Managing chronic wounds during novel coronavirus pneumonia outbreak显示文摘To the Editor In December of 2019,a widespread outbreak of novel coro-navirus pneumonia(NCP)occurred in Wuhan,China.On January 12,2020,the virus causing NCP was named as“2019-nCoV”by the World Health Organization[1,2].The World Health Organization renamed NCP as“COVID-19”.COVID-19 is a highly contagious respiratory virus that poses a serious threat to human health worldwide.At present,COVID-19 has been classified as a Class B infectious disease in China,and management of Class A infectious diseases has been adopted.As of March 10,2020,80932 cases were diagnosed and confirmed as COVID-19 in China,with 60002 cured cases and 3140 death.Meanwhile,34656 cases were diagnosed and confirmed as COVID-19 abroad. | Rui Wang Yanzhen Peng Yufeng Jiang Jianwen Gu | 2020 | Burns & Trauma2020，8，1： | 1 |
| 8 | Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms显示文摘 | Gu Jidong Fan Yanzhen Shi Hanchang | 2002 | Marine Pollution Bulletin2002，，45： | 1 |
| 9 | Aerobic degradation of phthalic acid by FY-1 from sewage sludge at high concentration显示文摘 | Wang YingYing Fan Yanzhen Gu JiDong | 2003 | World Journal of Microbiology & Biotechnology2003，19，： | 1 |
| 10 | Relationship between structures of substituted indole compounds and their degradation by marine anaerobic microorganisms显示文摘 | Gu Jidong Fan Yanzhen Shi Hanchang | 2002 | Marine Pollution Bulletin2002，，45： | 1 |
| 11 | Aerobic degradation of phthalic acid by Comamonas acidovaoran Fy - 1 and dimethyl phthalate esters by two reconstituted consortia from sewage sludge at high concentrations 显示文摘 | Wang Yingying Fan Yanzhen Gu Jidong | 2003 | World Journal of Microbiology and Biotechnology2003，19，8： | 1 |
| 12 | Observation of the supercritical Pearl River plume front under the downwelling-favorable winds显示文摘For the Pearl River plume, the supercritical, distinct plume front appears in downwelling-favorable winds, which is easily observed due to the distinct boundary between the plume water and the ambient water. In this paper, in situ and satellite observations of a plume front are utilized to explore the Pearl River plume front properties under the downwelling-favorable winds. Field observations clearly show frontal structure, especially the two-layer structure in the plume water and the downward-motion of water in the frontal region. The Advanced Synthetic Aperture Radar(ASAR) images are also analyzed to unveil the plume front: there is a white stripe on the west side out of the river mouth under downwelling-favorable winds, which is identified as a supercritical plume front, and the width of the plume front is about 250 m. The normalized velocity gradient shows the intense velocity convergence in the front region. Also, analyses of ASAR images imply that the river discharge plays an important role in controlling the location and shape of the front. | BAI Peng GU YanZhen LUO Lin ZHANG WanLei FAN KaiGuo | 2015 | Science China Earth Sciences2015，58，11： | 0 |
| 13 | Tidal energy budget in the Zhujiang(Pearl River) Estuary显示文摘Tidal energy budget in the Zhujiang(Pearl River) Estuary(ZE) is evaluated by employing high-resolution baroclinic regional ocean modeling system(ROMS). The results obtained via applying the least square method on the model elevations are compared against the tidal harmonic constants at 18 tide stations along the ZE and its adjacent coast. The mean absolute errors between the simulation and the observation of M_2, S_2, K_1 and O_1 are 4.6, 2.8, 3.2 and 2.8 cm in amplitudes and 9.8°, 15.0°, 4.6° and 4.6° in phase-lags, respectively. The comparisons between the simulated and observed sea level heights at 11 tide gauge stations also suggest good model performance. The total tidal energy flux incoming the ZE is estimated to be 343.49 MW in the dry season and larger than 336.18 MW in the wet season, which should due to higher mean sea level height and heavier density in the dry season. M_2, K_1, S_2, O_1 and N_2, the top five barotropic tidal energy flux contributors for the ZE,import 242.23(236.79), 52.97(52.08), 24.49(23.96), 16.22(15.91) and 7.10(6.97) MW energy flux into the ZE in dry(wet) season, successively and respectively. The enhanced turbulent mixing induced by eddies around isolated islands and sharp headlands dominated by bottom friction, interaction between tidal currents and sill topography or constricted narrow waterways together account for the five energy dissipation hotspots, which add up to about 38% of the total energy dissipation inside the ZE. | BAI Peng GU Yanzhen LI Peiliang WU Kejian | 2016 | Acta Oceanologica Sinica2016，35，5： | 0 |
| 14 | Seasonal variation of the shape and location of the Luzon cold eddy显示文摘Using observational data from multiple satellites,we studied seasonal variations of the shape and location of the Luzon cold eddy(LCE)northwest of Luzon Island.The shape and location of the LCE have obvious seasonal variations.The LCE occurs,develops,and disappears from December to April of the next year.During this period,the shape of the LCE changed from a flat ellipse to a circular ellipse,and the change in shape can be reflected by the increase of the ellipticity of the LCE from 0.16 to 0.82.The latitude of center location of the LCE changes from 17.4°N to 19°N,and the change in latitude can reach 1.6°.Further study showed that seasonal variation of the northeast monsoon intensity leads to the change in the shape and location of the LCE.The seasonal variation of the LCE shape can significantly alter the spatial distribution of the thermal front and chlorophyll a northwest of the Luzon Island by geostrophic advection. | Ruili Sun Peiliang Li Yanzhen Gu Chaojie Zhou Cong Liu Lin Zhang | 2023 | Acta Oceanologica Sinica2023，42，5： | 0 |
| 15 | Decadal variations of the North Pacific Tropical Water at 137°E显示文摘The decadal variations of the North Pacifi c Tropical Water (NPTW) at 137°E in the western North Pacific Ocean are investigated based on the repeated hydrographic observations along with two global gridded ocean products. The results indicate that the maximum salinity of NPTW experiences signifi cant quasi-decadal variations, having maxima around 1979, 1987, 1995, 2004, and 2012, while minima around 1974, 1983, 1991, 1999, and 2008 during the period of interest. The NPTW area also shows similar quasidecadal variation, expanding/shrinking as its maximum salinity increases/decreases at the 137°E section. These variations are induced mainly by changes in the mixed layer salinity in the source region and largescale circulation in the northwestern tropical Pacific Ocean, both of which are related to the Pacific Decadal Oscillation. The underlying processes at work are further confi rmed through conducting the subsurface salinity budget analysis. Besides, short-term processes are also at work through nonlinear interactions, especially after 2000. | LIN Wenqiang ZHAI Fangguo GU Yanzhen LI Peiliang | 2019 | Journal of Oceanology and Limnology2019，37，5： | 0 |
| 16 | Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia显示文摘Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers,best exemplified by loss-offunction mutations in genes encoding components of the TGF-βsignaling pathway in colorectal and pancreatic cancers.Alternatively,gain-of-function oncogene mutations can also disrupt antiproliferative TGF-βsignaling.However,the molecular mechanisms underlying oncogene-induced modulation of TGF-βsignaling have not been extensively investigated.Here,we show that the oncogenic BCR-ABL1 of chronic myelogenous leukemia(CML)and the cellular ABL1 tyrosine kinases phosphorylate and inactivate Smad4 to block antiproliferative TGF-βsignaling.Mechanistically,phosphorylation of Smad4 at Tyr195,Tyr301,and Tyr322 in the linker region interferes with its binding to the transcription co-activator p300/CBP,thereby blocking the ability of Smad4 to activate the expression of cyclin-dependent kinase(CDK)inhibitors and induce cell cycle arrest.In contrast,the inhibition of BCR-ABL1 kinase with Imatinib prevented Smad4 tyrosine phosphorylation and re-sensitized CML cells to TGF-β-induced antiproliferative and pro-apoptotic responses.Furthermore,expression of phosphorylation-site-mutated Y195F/Y301F/Y322F mutant of Smad4 in Smad4-null CML cells enhanced antiproliferative responses to TGF-β,whereas the phosphorylation-mimicking Y195E/Y301E/Y322E mutant interfered with TGF-βsignaling and enhanced the in vivo growth of CML cells.These findings demonstrate the direct role of BCR-ABL1 tyrosine kinase in suppressing TGF-βsignaling in CML and explain how Imatinib-targeted therapy restored beneficial TGF-βanti-growth responses. | Lijing Wang Shuchen Gu Fenfang Chen Yi Yu Jin Cao Xinran Li Chun Gao Yanzhen Chen Shuchong Yuan Xia Liu Jun Qin Bin Zhao Pinglong Xu Tingbo Liang Hongyan Tong Xia Lin Xin-Hua Feng | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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