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| 1 | SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells显示文摘Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and initiation of atherosclerosis. We have previously shown that endothelium-specific over-expression of class III deacetylase SIRT1 decreases atherosclerosis. We therefore addressed the hypothesis that SIRT1 suppresses ICAM-1 expression in the endothelial cells. Here, we found that expression of SIRT1 and ICAM-1 was significantly induced by PMA and ionomycin (PMA/Io) in human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated over-expression of SIRT1 significantly inhibited PMA/Io-induced ICAM-1 expression in HUVECs. Knockdown of SIRT1 by RNA interference (RNAi) resulted in increased expression of ICAM-1 in HUVECs. Luciferase report assay showed that over-expression of SIRT1 suppressed ICAM-1 promoter activity both in basic and in PMA/Io-induced conditions. We further found that SIRT1 was involved in transcription complex binding on the ICAM-1 promoter by chromatin immunoprecipitation (ChIP) assays. Furthermore, SIRT1 RNAi increased NF-κB p65 binding ability to the ICAM-1 promoter by ChIP assays. Overall, these data suggests that SIRT1 inhibits ICAM-1 expression in endothelial cells, which may contribute to its anti-atherosclerosis effect. | JIA YuYan GAO Peng CHEN HouZao WAN YanZhen ZHANG Ran ZHANG ZhuQin YANG RuiFeng WANG Xu XU Jing LIU DePei | 2013 | Science China(Life Sciences)2013，56，1： | 9 |
| 2 | Influence of acupuncture with exercise training on learning and memory functions, as well as microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region, in a rat model of cerebral infarction显示文摘The present study was designed to determine microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region in a rat model of middle cerebral artery occlusion. The rats were treated with acupuncture at Baihui (GV 20), Qubin (GB 7), and Qianding (GV 21) points, in addition to exercise training. Results were compared with rats undergoing exercise training only. The Y-maze method and immunohistochemistry revealed decreased error frequency of passing through Y-maze, as well as significantly increased microtubule-associated protein-2 and synaptophysin expression, in the acupuncture with exercise training group compared with the model and exercise training groups after 5 weeks. Microtubule-associated protein-2 and synaptophysin expressions negatively correlated with error frequency of passing through the Y-maze. These results suggested that acupuncture combined with exercise training improved learning and memory functions in a rat model of cerebral infarction. The mechanisms of action were hypothesized to be associated with dendritic or synaptic plasticity in the ipsilateral hippocampal CA3 region. | Wei Jiang Liubing Li Min Yang Yanzhen Bi Kehui Hu Peng Zhang Yixin Shen Qian Yu | 2011 | Neural Regeneration Research2011，6，27： | 4 |
| 3 | Anomaly secure detection methods by analyzing dynamic characteristics of the network traffic in cloud communications显示文摘 | Wei Xiong Hanping Hu Naixue Xiong Laurence T. Yang Wen-Chih Peng Xiaofei Wang Yanzhen Qu | 2013 | Information Sciences2013，，： | 1 |
| 4 | Managing chronic wounds during novel coronavirus pneumonia outbreak显示文摘To the Editor In December of 2019,a widespread outbreak of novel coro-navirus pneumonia(NCP)occurred in Wuhan,China.On January 12,2020,the virus causing NCP was named as“2019-nCoV”by the World Health Organization[1,2].The World Health Organization renamed NCP as“COVID-19”.COVID-19 is a highly contagious respiratory virus that poses a serious threat to human health worldwide.At present,COVID-19 has been classified as a Class B infectious disease in China,and management of Class A infectious diseases has been adopted.As of March 10,2020,80932 cases were diagnosed and confirmed as COVID-19 in China,with 60002 cured cases and 3140 death.Meanwhile,34656 cases were diagnosed and confirmed as COVID-19 abroad. | Rui Wang Yanzhen Peng Yufeng Jiang Jianwen Gu | 2020 | Burns & Trauma2020，8，1： | 1 |
| 5 | Observation of the supercritical Pearl River plume front under the downwelling-favorable winds显示文摘For the Pearl River plume, the supercritical, distinct plume front appears in downwelling-favorable winds, which is easily observed due to the distinct boundary between the plume water and the ambient water. In this paper, in situ and satellite observations of a plume front are utilized to explore the Pearl River plume front properties under the downwelling-favorable winds. Field observations clearly show frontal structure, especially the two-layer structure in the plume water and the downward-motion of water in the frontal region. The Advanced Synthetic Aperture Radar(ASAR) images are also analyzed to unveil the plume front: there is a white stripe on the west side out of the river mouth under downwelling-favorable winds, which is identified as a supercritical plume front, and the width of the plume front is about 250 m. The normalized velocity gradient shows the intense velocity convergence in the front region. Also, analyses of ASAR images imply that the river discharge plays an important role in controlling the location and shape of the front. | BAI Peng GU YanZhen LUO Lin ZHANG WanLei FAN KaiGuo | 2015 | Science China Earth Sciences2015，58，11： | 0 |
| 6 | Tidal energy budget in the Zhujiang(Pearl River) Estuary显示文摘Tidal energy budget in the Zhujiang(Pearl River) Estuary(ZE) is evaluated by employing high-resolution baroclinic regional ocean modeling system(ROMS). The results obtained via applying the least square method on the model elevations are compared against the tidal harmonic constants at 18 tide stations along the ZE and its adjacent coast. The mean absolute errors between the simulation and the observation of M_2, S_2, K_1 and O_1 are 4.6, 2.8, 3.2 and 2.8 cm in amplitudes and 9.8°, 15.0°, 4.6° and 4.6° in phase-lags, respectively. The comparisons between the simulated and observed sea level heights at 11 tide gauge stations also suggest good model performance. The total tidal energy flux incoming the ZE is estimated to be 343.49 MW in the dry season and larger than 336.18 MW in the wet season, which should due to higher mean sea level height and heavier density in the dry season. M_2, K_1, S_2, O_1 and N_2, the top five barotropic tidal energy flux contributors for the ZE,import 242.23(236.79), 52.97(52.08), 24.49(23.96), 16.22(15.91) and 7.10(6.97) MW energy flux into the ZE in dry(wet) season, successively and respectively. The enhanced turbulent mixing induced by eddies around isolated islands and sharp headlands dominated by bottom friction, interaction between tidal currents and sill topography or constricted narrow waterways together account for the five energy dissipation hotspots, which add up to about 38% of the total energy dissipation inside the ZE. | BAI Peng GU Yanzhen LI Peiliang WU Kejian | 2016 | Acta Oceanologica Sinica2016，35，5： | 0 |
| 7 | A MOF/poly(thioctic acid)composite for enhanced gold extraction from water matrices显示文摘With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great interest.Construction of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains challenging.Here,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing adsorbents.Solid-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the composite.The material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites. | Ruiqing Li Sen Yan Tianwei Xue Rongxing Qiu Yin Li Wenli Hao Guangkuo Xu Yanliang Wang Yanzhen Hong Yuzhong Su Hongtao Wang Shuliang Yang Li Peng Jun Li | 2024 | Nano Research2024，17，1： | 0 |
| 8 | 'Heterozygous Treatment'Method to Improve the Biased Status of the Damp-Heat Constitution and Symptom Integral:Randomized Controlled Trial显示文摘Objective:To observe the clinical effect of'heterozygous treatment'intervening the damp-heat constitution.Method:One hundred and six cases with damp-heat constitution were randomly divided into the observation group and control group,fifty-three cases for each group.Lianpu drink was given to the two groups,and the observation group was treated with scraping,acupuncture,cupping,constitution care and popularization of constitution science for'heterozygous treatment'based on the control group.70 days later,'constitution classification and determination table of traditional Chinese medicine'was used to determine,and statistics was applied to analyze the change of the symptoms of the two groups before and after the intervention.Results:in the observation group,compared to before the intervention,symptoms like dirty and oily complexion,yellow greasy tongue,bitter taste,dullness and scanty dark urine were significantly improved(P<0.05),and improvement of the above symptoms was greater than the control group(P<0.05).Conclusion:There is no significant difference between the two groups(P>0.05).Conclusion:the'heterozygous treatment'method can significantly improve the clinical symptoms of people with damp-heat constitution,with a better role in regulating. | Xianbing Hou Haizhang Wang Yanzhen Huo Peng Su Hui Zhao | 2018 | Journal of Advances in Medicine Science2018，1，1： | 0 |
| 9 | Mesoporous poly(ionic liquid)s with dual active sites for highly efficient CO_(2)conversion显示文摘Atmospheric CO_(2)concentrations are soaring due to the continued use of fossil fuels in energy production,an anthropogenic activity that is playing a leading role in global warming.Thus,research aimed at the capture and conversion of CO_(2)into value-added products,such as cyclic carbonates,is booming.While CO_(2)is an abundant,cheap,non-toxic,and readily accessible Cl feedstock,its thermodynamic stability necessitates the development of highly efficient catalysts that are able to promote chemical reactions under mild conditions.In this work,a novel mesoporous poly(ionic liquid)with dual active sites was synthesized through a facile method that involves co-polymerization,post-synthetic metalation,and supercritical CO_(2)drying.Due to a high density of nucleophilic and electrophilic sites,the as-prepared poly(ionic liquid),denoted as P2D-4BrBQA-Zn,offers excellent performance in a CO_(2)cycloaddition reaction using epichlorohydrin as the substrate(98.9%conversion and 96.9%selectivity).Moreover the reaction is carried out under mild,solvent-free,and additive-free conditions.Notably,P2D-4BrBQA-Zn also efficiently promotes the conversion of various other epoxide substrates into cyclic carbonates.Overall,the catalyst is found to have excellent substrate compatibility,stability,and recyclability. | Yawen Fu Yanan Xu Zepeng Zeng Abdul-Rauf Ibrahim Jin Yang Shuliang Yang Yaqiang Xie Yanzhen Hong Yuzhong Su Hongtao Wang Yanliang Wang Li Peng Jun Li Wendy L.Queen | 2023 | Green Energy & Environment2023，8，2： | 0 |
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