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| 1 | DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China显示文摘Objective: To evaluate the feasibility of DNA image cytometry(DNA-ICM) as a primary screening method for esophageal squamous cell cancer(ESCC).Methods: A total of 5,382 local residents aged 40–69 years from three high-risk areas in China(Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol's iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity(SE), specificity(SP), negative predictive values(NPV) and positive predictive values(PPV) as well as their 95% confidence intervals(95% CI) for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic(ROC) curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer.Results: DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions(χ~2=18.016, P<0.001). The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia(LGIN), high grade intraepithelial neoplasia(HGIN), and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test(cutoff point 5,803) combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance(ASCUS)] were separately 72.1%(95% CI: 70.3%-73.9%), 43.3%(95% CI: 41.3%-45.3%), 22.8%(95% CI: 21.1%-24.5%) and 87.0%(95% CI: 85.7%-88.3%) for LGIN, 85.7%(95% CI: 84.3%-87.1%), 41.3%(95% CI: 39.3%-43.3%), 4.6%(95% CI: 3.8%-5.4%) and 98.9%(95% CI: 98.5%-99.3%) for HGIN, and 96.0%(95% CI: 95.2%-96.8%), 40.8%(95% CI: 38.8%-42.8%), 1.7%(95% CI: 1.2%-2.2%) and 99.9%(95% CI: 99.8%-100.0%) for ESCC.Conclusions: It is possible to use DNA-ICM test as a primary screening method before endoscopic screening for esophageal cancer. | Meng Wang Changqing Hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei | 2016 | Chinese Journal of Cancer Research2016，28，4： | 15 |
| 2 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical Cancer—China,2003–2017显示文摘Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in China.Methods:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in China.We performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical cancer.Results:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−2017.For females<50 years,a decreasing trend in ASIR and a stable trend in ASMR were observed in urban areas after 2009.But the ASIR and ASMR kept increasing in rural areas during the whole period.For females>50 years,the ASIR and ASMR increased both in urban and rural areas.Age-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole period.The cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural areas.Conclusions:The increases in cervical cancer incidence and mortality rates can be mostly explained by period effects.We observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas. | Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2022 | China CDC weekly2022，4，48： | 4 |
| 3 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Female Breast Cancer—China,2003-2017显示文摘Introduction:This study reported the trends in female breast cancer incidence and mortality rates in China,and analyzed the corresponding age-periodcohort effects.Methods:Data from 22 population-based cancer registries in China between 2003 and 2017 were analyzed.Age-standardized incidence rates(ASIR)and mortality rates(ASMR)were calculated using Segi’s world standard population.Joinpoint regression was employed to evaluate trends,and age-period-cohort effects were examined using the intrinsic estimator method.Results:The ASIR for female breast cancer exhibited a more rapid increase in rural areas compared to urban areas across all age groups.The most substantial increase was observed in the 20-34 age group in rural areas[annual percent change(APC)=9.0%,95%confidence interval(CI):7.0%-11.0%,P<0.001].The ASMR for females under 50 years old remained stable from 2003 to 2017 in both urban and rural areas.However,the ASMR for females over 50 in rural areas and those over 65 in urban areas demonstrated a significant increase,with the most pronounced increase observed among females over 65 in rural areas(APC=4.9%,95%CI:2.8%-7.0%,P<0.001).Age-period-cohort analysis revealed increasing period effects and decreasing cohort effects for female breast cancer incidence and mortality rates in both urban and rural settings.Notably,the cohort effect for incidence displayed a slight upward trend for females born between 1983 and 1992 in rural areas.Conclusions:Our study revealed a rapid increase in breast cancer incidence among younger generations and an accelerated mortality rate in older populations residing in rural areas.To effectively address the growing burden of female breast cancer in China,it is essential to develop and implement targeted intervention strategies. | Kexin Sun Lin Lei Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2023 | China CDC weekly2023，5，15： | 1 |
| 4 | Flux Adjustable Permanent Magnet Machines:A Technology Status Review显示文摘Flux adjustable permanent magnet machines(FAPMMs)are a novel type of permanent magnet(PM)machines which are able to flexibly adjust the field excitation flux linkage and offer the distinctive advantages of high power density and high efficiency.They have attracted ever-increasing interests and are promising candidate machines for electric vehicle,machine-tool and aircraft applications.In this paper,the state-of-the-art of various FAPMMs are comprehensively reviewed according to three means of flux-adjustment,i.e.electrically adjusted by either auxiliary field windings or armature winding change,mechanically adjusted magnetic reluctances of flux paths,and memory machines by magnetizing/demagnetizing PMs.The corresponding flux-adjustable principles and electromagnetic characteristics are systematically elaborated and quantitatively compared.Their merits and demerits are highlighted,together with their recent developments. | Hui Yang Z.Q.Zhu Heyun Lin Wenqiang Chu | 2016 | Chinese Journal of Electrical Engineering2016，2，2： | 1 |
| 5 | Using the CENTURY model to assess the impact of land reclamation and management practices in oasis agriculture on the dynamics of soil organic carbon in the arid region of North-western China显示文摘 | Wenqiang Xu Xi Chen Geping Luo Qing Lin | 2010 | Ecological Complexity2010，，1： | 1 |
| 6 | 4350<ce:hsp sp='0.25'/>W quasi-continuous-wave operation of a diode face-pumped ceramic Nd: YAG slab laser显示文摘 | Junchi Chen Jiang Li Jialin Xu Wenbin Liu Yong Bo Xiqi Feng Yiting Xu Dongliang Jiang Zhongzheng Chen Yubai Pan Yading Guo Biao Yan Chang Guo Lei Yuan Hongtao Yuan Yanyong Lin Yunsheng Xiao Qinjun Peng Wenqiang Lei Dafu Cui Zuyan Xu | 2014 | Optics and Laser Technology2014，，： | 1 |
| 7 | High room-temperature magnetization in Co-doped TiO_(2) nanoparticles promoted by vacuum annealing for different durations显示文摘To clarify the contribution of oxygen vacancies to room-temperature ferromagnetism(RTFM)in cobalt doped TiO_(2)(Co-TiO_(2)),and in order to obtain the high level of magnetization suitable for spintronic devices,in this work,Co-TiO_(2) nano-particles are prepared via the sol-gel route,followed by vacuum annealing for different durations,and the influence of vacu-um annealing duration on the structure and room-temperature magnetism of the compounds is examined.The results reveal that with an increase in annealing duration,the concentration of oxygen vacancies rises steadily,while the saturation magnetiza-tion(Ms)shows an initial gradual increase,followed by a sharp decline,and even disappearance.The maximum Ms is as high as 1.19 emu/g,which is promising with respect to the development of spintronic devices.Further analysis reveals that oxygen va-cancies,modulated by annealing duration,play a critical role in tuning room-temperature magnetism.An appropriate concentra-tion of oxygen vacancies is beneficial in terms of promoting RTFM in Co-TiO_(2).However,excessive oxygen vacancies will result in a negative impact on RTFM,due to antiferromagnetic superexchange interactions originating from nearest-neighbor Co^(2+)ions. | Wenqiang Huang Rui Lin Weijie Chen Yuzhu Wang Hong Zhang | 2021 | Journal of Semiconductors2021，42，7： | 0 |
| 8 | 小鼠早期胚胎发育的蛋白质组表达图景显示文摘文章简介胚胎着床前的发育是一个复杂而又精密调控的过程,该过程由合子基因组活化后的母源蛋白质和新合成的蛋白质介导。尽管基因组和转录组的研究使我们对这一过程的遗传学调控程序有了丰富的理解,但是蛋白质表达的动态图景尚有待揭示。利用定量质谱的方法,课题组从8000个小鼠胚胎的6个时期的胚胎中(合子,2-,4-,8-细胞,桑葚胚和囊胚)定量了5000个蛋白质的表达谱。 | 高亚威 刘晓雨 唐彬 李翀 Zhaohui Kou Lin Li Wenqiang Liu You Wu Xiaochen Kou Jingyi Li Yanhong Zhao Jiqing Yin Hong Wang She Chen 廖鲁剑 高绍荣 | 2018 | 科学新闻2018，0，4： | 0 |
| 9 | Application of Sensory Evaluation in the Concealer Product Research显示文摘 | Ping Ma Gang Huo Wenqiang Lin | 2016 | China Detergent & Cosmetics2016，1，1： | 0 |
| 10 | Distribution of shallow water delta sand bodies and the genesis of thick layer sand bodies of the Triassic Yanchang Formation, Longdong Area, Ordos Basin显示文摘Based on the cores from 47 wells and logging data of 130 wells,the main types of sand bodies in the shallow water delta of the Chang 8_(2) sub-member in the Triassic Yanchang Formation,Longdong Area,Ordos Basin were comprehensively analyzed,the distribution characteristics of sand bodies more than 20 m thick were identified,and the genetic types of the thick sand bodies were sorted out.In this region,thick-bed sand bodies can be divided into two types according to the shape and position:type 1 is the sand body in wide strip and is distributed between the average high water mark and the average low water mark;type 2 is distributed on both sides of the average low water mark and is in irregular lump shape.Based on the principle of the volume distribution of sediments and the change rule of accommodation space,the genetic models of two types of thick-bed sand bodies in the Chang 8_(2) sub-member are superimposed distributary channel sand bodies in high accommodation space and superimposed composite sand bodies in low accommodation space. | LIU Hanlin QIU Zhen XU Liming WANG Fengqin TONG Qiang LIN Jiahao YIN Shuai WANG Wenqiang | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 11 | Construction of physical crosslink-based chitosan/liquid crystal composite hydrogel and evaluation on their cytocompatibility显示文摘In order to provide a novel biomimetic composite substrate for tissue engineering and explore the interaction between cells and this type of material,we developed chitosan/liquid crystal(CS/LC)composite hydrogel with embedded LC phases by composing of cholesterol hydroxypropyl cellulose ester liquid crystalline material and CS.The micromorphology of CS/LC composite hydrogels exhibited‘islands-sea’phase separation structures similar to the‘fluid mosaic model’of biomembrane.In vitro cell compatibility study suggested that 3T3 is fibroblasts exhibited better initial cell adhesions and higher proliferation rates on the composite hydrogel than on the polystyrene control plate and the pure LC membrane.This novel CS/LC composite hydrogel provides more favorable interface for cell growth and proliferation and may serve as potentially active substrate for engineering interfaces to live cells. | Lin Du Xiaohui Yang Wenqiang Li Xuhui Luo Hao Wu Jiaqing Zhang Mei Tu | 2017 | Regenerative Biomaterials2017，4，1： | 0 |
| 12 | Band Structure Calculations of Dispersive Photonic Crystals in 3D using Holomorphic Operator Functions显示文摘We propose a finite element method to compute the band structures of dispersive photonic crystals in 3D.The nonlinear Maxwell’s eigenvalue problem is formulated as the eigenvalue problem of a holomorphic operator function.The N´ed´elec edge elements are employed to discretize the operators,where the divergence free condition for the electric field is realized by a mixed form using a Lagrange multiplier.The convergence of the eigenvalues is proved using the abstract approximation theory for holomorphic operator functions with the regular approximation of the edge elements.The spectral indicator method is then applied to compute the discrete eigenvalues.Numerical examples are presented demonstrating the effectiveness of the proposed method. | Wenqiang Xiao Bo Gong Junshan Lin Jiguang Sun | 2023 | Communications in Computational Physics2023，33，2： | 0 |
| 13 | Dual-band reflective polarization converter based on metasurface显示文摘In this paper,a dual-band and reflective polarization converter based on metasurface is proposed.Its unit cell is composed of two layers of metal plates separated by a dielectric substrate.The simulation results show that the proposed converter is able to convert x-or y-polarized incident waves into cross-polarized waves perfectly in frequency bands of 6.75–10.59 GHz and 17.78–19.61 GHz,and the polarization conversion ratio(PCR)is nearly 100%,which can also convert linearly polarized waves into circularly polarized waves at four frequencies.It can be widely used in applications of radar satellites,antenna design and telecommunication with the function of realizing polarization conversion in two bands and achieving high PCR simultaneously. | LIN Xiaofang ZHANG Xu CHANG Ming LI Wenqiang YU Siyang ZHANG Maolong | 2023 | Optoelectronics Letters2023，19，12： | 0 |
| 14 | Response of soil respiration to short-term changes in precipitation and nitrogen addition in a desert steppe显示文摘Changes in precipitation and nitrogen(N)addition may significantly affect the processes of soil carbon(C)cycle in terrestrial ecosystems,such as soil respiration.However,relatively few studies have investigated the effects of changes in precipitation and N addition on soil respiration in the upper soil layer in desert steppes.In this study,we conducted a control experiment that involved a field simulation from July 2020 to December 2021 in a desert steppe in Yanchi County,China.Specifically,we measured soil parameters including soil temperature,soil moisture,total nitrogen(TN),soil organic carbon(SOC),soil microbial biomass carbon(SMBC),soil microbial biomass nitrogen(SMBN),and contents of soil microorganisms including bacteria,fungi,actinomyces,and protozoa,and determined the components of soil respiration including soil respiration with litter(RS+L),soil respiration without litter(RS),and litter respiration(RL)under short-term changes in precipitation(control,increased precipitation by 30%,and decreased precipitation by 30%)and N addition(0.0 and 10.0 g/(m^(2)·a))treatments.Our results indicated that short-term changes in precipitation and N addition had substantial positive effects on the contents of TN,SOC,and SMBC,as well as the contents of soil actinomyces and protozoa.In addition,N addition significantly enhanced the rates of RS+L and RS by 4.8%and 8.0%(P<0.05),respectively.The increase in precipitation markedly increased the rates of RS+L and RS by 2.3%(P<0.05)and 5.7%(P<0.001),respectively.The decrease in precipitation significantly increased the rates of RS+L and RS by 12.9%(P<0.05)and 23.4%(P<0.001),respectively.In contrast,short-term changes in precipitation and N addition had no significant effects on RL rate(P>0.05).The mean RL/RS+L value observed under all treatments was 27.63%,which suggested that RL is an important component of soil respiration in the desert steppe ecosystems.The results also showed that short-term changes in precipitation and N addition had significant interactive effects on the rates of RS+L,RS,and RL(P<0.001).In addition,soil temperature was the most important abiotic factor that affected the rates of RS+L,RS,and RL.Results of the correlation analysis demonstrated that the rates of RS+L,RS,and RL were closely related to soil temperature,soil moisture,TN,SOC,and the contents of soil microorganisms,and the structural equation model revealed that SOC and SMBC are the key factors influencing the rates of RS+L,RS,and RL.This study provides further insights into the characteristics of soil C emissions in desert steppe ecosystems in the context of climate change,which can be used as a reference for future related studies. | MA Jinpeng PANG Danbo HE Wenqiang ZHANG Yaqi WU Mengyao LI Xuebin CHEN Lin | 2023 | Journal of Arid Land2023，15，9： | 0 |
| 15 | Ion beam figuring of continuous phase plates based on the frequency filtering process显示文摘 | Mingjin XU Yifan DAI Xuhui XIE Lin ZHOU Shengyi LI Wenqiang PENG | 2017 | Frontiers of Mechanical Engineering2017，12，1： | 0 |
| 16 | Genome transfer for the prevention of female infertility caused by maternal gene mutation显示文摘Poor oocyte quality is associated with early embryo developmental arrest and infertility.Maternal gene plays crucial roles in the regulation of oocyte maturation,and its mutation is a common cause of female infertility.However,how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive.Here,we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutationecaused female infertility.We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation(ZGA)during the maternal-zygotic transition.We next perform genome transfer at the oocyte(spindle transfer or polar body transfer)and zygote(early pronuclear transfer or late pronuclear transfer)stages to validate the feasibility of preventing Zar1 mutationecaused infertility.We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring.Moreover,those pups grow to adulthood and show normal fertility.Therefore,our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation. | Dandan Bai Jin Sun Yanping Jia Jiqing Yin Yalin Zhang Yanhe Li Rui Gao Xiling Du Kunming Li Jiaming Lin Zhifen Tu Yu Wang Jiaping Pan Shanshan Liang Yi Guo Jingling Ruan Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Fengchao Wang Xiaoming Teng Wenqiang Liu Shaorong Gao | 2020 | Journal of Genetics and Genomics2020，47，6： | 0 |
| 17 | Boosting wheat functional genomics via an indexed EMS mutant library of KN9204显示文摘A better understanding of wheat functional genomics can improve targeted breeding for better agronomic traits and environmental adaptation.However,the lack of gene-indexed mutants and the low transformation efficiency of wheat limit in-depth gene functional studies and genetic manipulation for breeding.In this study,we created a library for KN9204,a popular wheat variety in northern China,with a reference genome,transcriptome,and epigenome of different tissues,using ethyl methyl sulfonate(EMS)mutagenesis.This library contains a vast developmental diversity of critical tissues and transition stages.Exome capture sequencing of 2090 mutant lines using KN9204 genome-designed probes revealed that 98.79%of coding genes had mutations,and each line had an average of 1383 EMS-type SNPs.We identified new allelic variations for crucial agronomic trait-related genes such as Rht-D1,Q,TaTB1,and WFZP.We tested 100 lines with severemutations in 80 NAC transcription factors(TFs)under drought and salinity stress and identified 13 lines with altered sensitivity.Further analysis of three lines using transcriptome and chromatin accessibility data revealed hundreds of direct NAC targets with altered transcription patterns under salt or drought stress,including SNAC1,DREB2B,CML16,and ZFP182,factors known to respond to abiotic stress.Thus,we have generated and indexed a KN9204 EMS mutant library that can facilitate functional genomics research and offer resources for genetic manipulation of wheat. | Dongzhi Wang Yongpeng Li Haojie Wang Yongxin Xu Yiman Yang Yuxin Zhou Zhongxu Chen Yuqing Zhou Lixuan Gui Yi Guo Chunjiang Zhou Wenqiang Tang Shuzhi Zheng Lei Wang Xiulin Guo Yingjun Zhang Fa Cui Xuelei Lin Yuling Jiao Yuehui He Junming Li Fei He Xigang Liu Jun Xiao | 2023 | Plant Communications2023，4，4： | 0 |
| 18 | 2-22 Fine Structure in theαDecay of 223U显示文摘Isotope 223U synthesized and identified[1;2].αenergy of 8 780(40)keV and a half-life of 55(10)μs.Theαenergy was calculated by subtracting knownαenergy of 219Th from measured decay sum energy of 223U and its daughter 219Th.Based on the advanced digital pulse processing technique,a new measurement forα-particle energy and half-life of 223U was performed at the gas-filled recoil separator,Spectrometer for Heavy Atoms and Nuclear Structure(SHANS).The isotope 223U was produced in the fusion-evaporation reaction 187Re(40Ar,p3n)223U. | Sun Mingdao Liu Zhong Huang Tianheng Zhang Wenqiang Wang Jianguo Liu Xiaoyu Ding Bing Gan Zaiguo Ma Long Yang Huabing Zhang Zhiyuan Yu Lin Jiang Jian Wang Kailong Wang Yongsheng Liu Minliang Li Zhihuan Li Jing Wang Xiang Lu Hongyang Lin Chenjian Sun Lijie Ma Nanru Yuan Cenxi Zuo Wei Xu Hushan Zhou Xiaohong Xiao Guoqing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 19 | Decadal variations of the North Pacific Tropical Water at 137°E显示文摘The decadal variations of the North Pacifi c Tropical Water (NPTW) at 137°E in the western North Pacific Ocean are investigated based on the repeated hydrographic observations along with two global gridded ocean products. The results indicate that the maximum salinity of NPTW experiences signifi cant quasi-decadal variations, having maxima around 1979, 1987, 1995, 2004, and 2012, while minima around 1974, 1983, 1991, 1999, and 2008 during the period of interest. The NPTW area also shows similar quasidecadal variation, expanding/shrinking as its maximum salinity increases/decreases at the 137°E section. These variations are induced mainly by changes in the mixed layer salinity in the source region and largescale circulation in the northwestern tropical Pacific Ocean, both of which are related to the Pacific Decadal Oscillation. The underlying processes at work are further confi rmed through conducting the subsurface salinity budget analysis. Besides, short-term processes are also at work through nonlinear interactions, especially after 2000. | LIN Wenqiang ZHAI Fangguo GU Yanzhen LI Peiliang | 2019 | Journal of Oceanology and Limnology2019，37，5： | 0 |
| 20 | The Convergence of Euler-Maruyama Method of Nonlinear Variable-Order Fractional Stochastic Differential Equations显示文摘In this paper,we first prove the existence and uniqueness theorem of the solution of nonlinear variable-order fractional stochastic differential equations(VFSDEs).We futher constructe the Euler-Maruyama method to solve the equations and prove the convergence in mean and the strong convergence of the method.In particular,when the fractional order is no longer varying,the conclusions obtained are consistent with the relevant conclusions in the existing literature.Finally,the numerical experiments at the end of the article verify the correctness of the theoretical results obtained. | Shanshan Xu Lin Wang Wenqiang Wang | 2023 | Advances in Applied Mathematics and Mechanics2023，15，4： | 0 |
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