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| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 3 | Objective evaluation correlated with human judgment-an approach to the optimization of vehicle handling control system显示文摘 | GUO K H ZONG C F KONG F S | 2002 | International Journal of Vehicle Design2002，29，1： | 2 |
| 4 | On the linear hydrodynamic forces and the maneuverability of an unmanned untethered submersible with streamlined body (2nd Report)显示文摘 | CHIU F C and GUO J and HUANG C C and WANG J P | 1997 | Journal of Society of Naval Architects of Japan1997，182，： | 2 |
| 5 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 6 | Stress corrosion cracking of pipeline steel in soil environments of eastern china显示文摘 | Li G F Huang C B Guo H | 2007 | Key Engineering Materials2007，，： | 1 |
| 7 | Vinyl Acetate Formation in the Reaction of Acetylene with Acetic Acid Catalyzed by Zinc Acetate Supported on Porous Carbon Spheres显示文摘 | Yan F W Guo C Y Yan F | 2010 | Russian Journal of Physical ChemistryA2010，84，5： | 1 |
| 8 | Expression and localization of human lysozyme in the endosoerm of transgenic rice 显示文摘 | YANG D C GUO F L Liu B | 2003 | Planta2003，216，： | 1 |
| 9 | Controlled synthesis ofmesoporous Si02/Ni3Si205(0H)4 core-shell microsphereswith tunable chamber structures via a self -templatemethod显示文摘 | Guo Z Y Du F L Li G C | 2008 | Chem Commu2008，，： | 1 |
| 10 | Removal of elemental mercury from coal combustion flue gas by chloride-impregnated activa- ted carbon显示文摘 | Zeng H C Jin F Guo J | 2004 | Fuel2004，83，1： | 1 |
| 11 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 12 | Nuciferine prevents Hepatic Steatosis and injury induced by a high-fat diet in Hamsters显示文摘 | Guo F C Yang X Li X X | 2013 | Plos One2013，8，63： | 1 |
| 13 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 14 | Water-soluble carbon and the carbon dioxide pulse are regulated by the extent of soil drying and rewetting显示文摘 | Guo X Drury C F Yang X | 2014 | Soil Science Society of America Journal2014，78，4： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Long-lasting and transmission-blocking activity of antibodies to Plasmodiurn falciparurn elicited in mice by protein conjugates of Pfs25 显示文摘 | Kubler Kielb J Majadly F Wu Y Narum D L Guo C Miller L H Shiloach J Robbins J B and Schneerson R | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，1： | 1 |
| 17 | Transurethral plasmakinetie vaporization of prostate for treatment of the aged BPH patients显示文摘 | Guo C Li F Wang B | 2004 | J Clin Urol2004，19，2： | 1 |
| 18 | Enhancement of plasticity of Fe-based bulk metallic glass by Ni substitution for Fe显示文摘 | Guo S F Li N Zhang C | 2010 | J Alloys Compd2010，504，1： | 1 |
| 19 | Lyotropic liquid crystal systems in drug delivery显示文摘 | Guo C Wang J Cao F | 2010 | Drug Discov Today2010，15，2324： | 1 |
| 20 | Synthesis and characterization of carbon-coated LiNil/3Col/3Mnl/3Oz cathode material prepared by polyvinyl alcohol pyrolysis route 显示文摘 | GUO R SHIP F CHENG X Q DU C Y | 2009 | Journal of Alloys and Compounds2009，473，： | 1 |
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