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| 1 | Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function显示文摘Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs(mi RNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings. | Jian Zhang Sha Li Lu Li Meng Li Chongye Guo Jun Yao Shuangli Mi | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 162 |
| 2 | Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China显示文摘AIM:To investigate the prevalence of minimal hepatic encephalopathy(MHE)and to assess corresponding health-related quality of life(HRQoL)in hospitalized cirrhotic patients in China.METHODS:This multi-center cross-sectional study included 16 teaching hospitals,which were members of 'Hepatobiliary Cooperation Group,Society of Gastroenterology,Chinese Medical Association',from different areas of China carried out between June and October in 2011.All the eligible hospitalized cirrhotic patients(n = 538)were required to complete triplicate number connection tests combined with one digit symbol test for diagnosing MHE.Patients' clinical examination data were complemented by a modified questionnaire assessing HRQoL.Written informed consent was obtained from each patient.RESULTS:Male was predominant(68.6%)in 519 patients who met the criteria of the study,with a mean age of 49.17 ± 11.02 years.The most common cause of liver cirrhosis was chronic hepatitis B(55.9%).The prevalence of MHE was 39.9% and varied by ChildPugh-Classification score(CPC-A:24.8%,CPC-B:39.4% and CPC-C:56.1%,P < 0.01).MHE(P < 0.01)and higher CPC scores(P < 0.01)were associated with a high HRQoL scores(reflecting poorer quality of life).The prevalence of MHE was proportionate to CPC(P = 0.01)and high quality of life scores(P = 0.01).CONCLUSION:Hospitalized cirrhotic patients have a high prevalence of MHE that is proportionate to the degree of liver function and HRQoL impairment. | Ji-Yao Wang Ning-Ping Zhang Bao-Rong Chi Yu-Qing Mi Li-Na Meng Ying-Di Liu Jiang-Bin Wang Hai-Xing Jiang Jin-Hui Yang Yun Xu Xiao Li Jian-Ming Xu Guo Zhang Xin-Min Zhou Yu-Zheng Zhuge De-An Tian Jin Ye Yu-Lan Liu | 2013 | World Journal of Gastroenterology2013，19，30： | 64 |
| 3 | Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt显示文摘The Mianle tectonic zone (Mianle zone), an ancient suture zone in addition to the Shangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianle tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in the Qinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring the mountain-building orogenesis of the central orogenic system and the entire process of the major Chinese continental amalgamation during the Indosinian. | ZHANG Guowei1, DONG Yunpeng1, LAI Shaocong1, GUO Anlin1, MENG Qingren2, LIU Shaofeng3, CHENG Shunyou1, YAO Anping1, ZHANG Zongqing4, PEI Xianzhi5 & LI Sanzhong6 1. Department of Geology, Northwest University, Xian 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Earth Science and Resource Faculty, China University of Geosciences, Beijing 100083, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 5. Changan University, Xian 710054, China 6. Qingdao University of Oceanography, Qingdao 266003, China | 2004 | Science China Earth Sciences2004，47，4： | 57 |
| 4 | Entropy generation extremum and entransy dissipation extremum for heat exchanger optimization显示文摘The applicability of the extremum principles of entropy generation and entransy dissipation is studied for heat exchanger optimization. The extremum principle of entransy dissipation gives better optimiza-tion results when heat exchanger is only for the purpose of heating and cooling, while the extremum principle of entropy generation is better for the heat exchanger optimization when it works in the Brayton cycle. The two optimization principles are approximately equivalent when the temperature drops of the streams in a heat exchanger are small. | LIU XiongBin MENG JiAn GUO ZengYuan | 2009 | Chinese Science Bulletin2009，54，6： | 49 |
| 5 | Small sphincterotomy combined with endoscopic papillary large balloon dilation vs sphincterotomy alone for removal of common bile duct stones显示文摘AIM:To evaluate the efficacy and safety of endoscopic papillary large diameter balloon dilation(EPLBD)following limited endoscopic sphincterotomy(EST)and EST alone for removal of large common bile duct(CBD)stones.METHODS:We retrospectively compared EST+EPLBD(group A,n=64)with EST alone(group B,n=89)for the treatment of large or multiple bile duct stones.The success rate of stone clearance,procedure-related complications and incidents,frequency of mechanical lithotripsy use,and recurrent stones were recorded.RESULTS:There was no statistically significant difference between the two groups regarding periampullary diverticula(35.9%vs 34.8%,P>0.05),pre-cut sphincterotomy(6.3%vs 6.7%,P>0.05),size(12.1±2.0mm vs 12.9±2.6 mm,P>0.05)and number(2.2±1.9vs 2.4±2.1,P>0.05)of stones or the diameters of CBD(15.1±3.3 mm vs 15.4±3.6 mm,P>0.05).The rates of overall stone removal and stone removal in the first session were not significantly different between the two groups[62/64(96.9%)vs 84/89(94.4%),P>0.05;and 58/64(90.6%)vs 79/89(88.8%),P>0.05,respectively].The rates of post-endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasemia were not significantly different between the two groups[3/64(4.7%)vs 4/89(4.5%),P>0.05;7/64(10.9%)vs 9/89(10.1%),P>0.05,respectively].There were no cases of perforation,acute cholangitis,or cholecystitis in the two groups.The rate of bleeding and the recurrence of CBD stones were significantly lower in group A than in group B[1/64(1.6%)vs 5/89(5.6%),P<0.05;1/64(1.6%)vs 6/89(6.7%),P<0.05,respectively].CONCLUSION:EST+EPLBD is an effective and safe endoscopic approach for removing large or multiple CBD stones. | Shi-Bin Guo Hua Meng Zhi-Jun Duan Chun-Yan Li | 2014 | World Journal of Gastroenterology2014，20，47： | 43 |
| 6 | Selection and development of representative simple sequence repeat primers and multiplex SSR sets for high throughput automated genotyping in maize显示文摘In the current study, 1900 maize simple sequence repeat (SSR) primers published in MaizeGDB were screened utilizing reference literature, 15 representative Chinese maize inbred lines and 15 Chinese maize hybrids from national regional testing. In total, 500 highly polymorphic primers were identified and used to construct a genetic map. 100 evenly distributed primers, 10 primers per chromosome, were further selected as a set of universal SSR core primers, recommended as preferred primers for general studies. These core primers were then redesigned and used to construct a high throughput multiplex PCR system based on a five-color fluorescence capillary detection system. We report here that two sets of ten-plex PCR combinations have been constructed, each consisting of 10 primers, with one primer per chromosome. | WANG FengGe ZHAO JiuRan DAI JingRui YI HongMei KUANG Meng SUN YanMei YU XinYan GUO JingLun WANG Lu | 2007 | Chinese Science Bulletin2007，52，2： | 35 |
| 7 | Semi-Fredholm Spectrum and Weyl's Theorem for Operator Matrices显示文摘当鈭? B (H)和 B 鈭? B (K)被给时,我们由 M C 表示在这份报纸对形式的 Hilbert 空间 H 鈯? K 起作用的一个操作员,首先,我们为是上面的 semi-Fredholm (更低的半 鈥揊r edholm ,或 Fredholm )的 M C 给必要、足够的条件为一些 C 鈭? B 的操作员( K , H )。另外,让(A)={ 位鈭吗?? :A?位 I 不是一个上面的 semi-Fredholm 操作员 } 鈭 ? B 的上面的半鈥揊r edholm 光谱是(H) 并且让(A)={ 位鈭吗?? :A?位 I 不是一个更低的半鈥揊r edholm 操作员 } 是 A 的更低的半鈥揊r edholm 光谱。我们证明经过从被移开某些开的子集完成从前者,也就是说。 | Xiao Hong CAO Mao Zheng GUO Bin MENG | 2006 | Acta Mathematica Sinica,English Series2006，22，1： | 34 |
| 8 | A method for gravity anomaly separation based on preferential continuation and its application显示文摘基于 Pawlowski (1995 ) 建议的优先的继续方法,我们在各种各样的来源互相是 uncorrelated 与,继续高度足够大的情况中与优先的向上的继续操作员为严肃异例分离建议一个方法和过程。我们也为估计最佳介绍一个方法向上继续的高度,与不同继续高度基于分析一个综合严肃异例的优先的向上的继续操作员的特征变化。方法在铁存款上在未加工的 Bouguer 严肃数据上被测试。结果证明方法高效地并且清楚地把数据分开成地区性的异例和剩余异例。 | Meng Xiaohong Guo Lianghui Chen Zhaox Li Shuling Shi Lei | 2009 | Applied Geophysics2009，6，3： | 31 |
| 9 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 10 | Wet Cupping Therapy Improves Local Blood Perfusion and Analgesic Effects in Patients with Nerve-Root Type Cervical Spondylosis显示文摘Objective: To observe wet cupping therapy(WCT) on local blood perfusion and analgesic effects in patients with nerve-root type cervical spondylosis(NT-CS). Methods: Fifty-seven NT-CS patients were randomly divided into WCT group and Jiaji acupoint-acupuncture(JA) group according a random number table. WCT group(30 cases) was treated with WCT for 10 min, and JA group(27 cases) was treated with acupuncture for 10 min. The treatment efficacies were evaluated with a Visual Analogue Scale(VAS). Blood perfusion at Dazhui(GV 14) and Jianjing(GB 21) acupoints(affected side) was observed with a laser speckle flowmetry, and its variations before and after treatment in both groups were compared as well. Results: In both groups, the VAS scores significantly decreased after the intervention(P<0.01), while the blood perfusion at the two acupoints significantly increased after intervention(P<0.05); however, the increasement magnitude caused by WCT was obvious compared with JA(P<0.05). Conclusion: WCT could improve analgesic effects in patients with NT-CS, which might be related to increasing local blood perfusion of acupunct points. | MENG Xiang-wen WANG Ying PIAO Sheng-ai LV Wen-tao ZHU Cheng-hui MU Ming-yuan LI Dan-dan LIU Hua-peng GUO Yi | 2018 | Chinese Journal of Integrative Medicine2018，24，11： | 33 |
| 11 | Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1显示文摘Background: Resveratrol, a plant phenol, affords protection against inflammation and oxidative stress. The objective of this study was to investigate the effects of dietary resveratrol supplementation during pregnancy and lactation on the antioxidant status of sows and piglets and on antioxidant gene expression and pathway in placenta.Methods: Forty sows were allotted to 2 dietary treatments 20 d after breeding. Sows were fed a control diet and a control diet with 300 mg/kg resveratrol. Oxidative stress biomarkers and antioxidant enzymes were measured in the placenta, milk, and plasma of sows and piglets. Antioxidant gene expression and protein expression of Kelch-like ECH-associated protein 1-Nuclear factor E2-related factor 2(Keap1-Nrf2), nuclear factor kappa B-p65(NFκB-p65) and sirtuin1(Sirt1) were quantified in the placenta.Results: Dietary resveratrol increased the litter and piglets weaning weights. Antioxidant status in the milk, placenta and plasma of sows and piglets was partially improved by dietary resveratrol. In placenta, Nrf2 protein expression was increased and Keap1 protein expression was decreased by dietary resveratrol. The m RNA expression of antioxidant genes including catalase(CAT), glutathione peroxidase 1(GPX1), GPX4, superoxide dismutase 1(SOD1)and heme oxygenase 1(HO1), and phase 2 detoxification genes, including glutamate-cysteine ligase modifier(GCLM), microsomal glutathione S-transferase 1(MGST1) and UDP glucuronosyltransferase family 1 member A1(UGT1 A1), was increased by dietary resveratrol. Dietary resveratrol also increased Sirt1 and phosphorylated NFκB-p65 protein expression in the placenta. We failed to observe any influences of dietary resveratrol on pro-inflammatory cytokine levels, including those of interleukin 1β(IL-1β), IL-6, IL-8 and tumor necrosis factor α(TNF-α). However, we observed that the m RNA expression of IL-8 in placenta was reduced by maternal resveratrol. In addition, dietary resveratrol showed interactive effects with day of lactation on activities of SOD and CAT and levels of malonaldehyde(MDA) and hydrogen peroxide(H2 O2) in milk.Conclusions: Dietary resveratrol supplementation during pregnancy and lactation improves the antioxidant status of sows and piglets, which is beneficial to the reproductive performance of sows. Dietary resveratrol regulates placental antioxidant gene expression by the Keap1-Nrf2 pathway and Sirt1 in placenta. | Qingwei Meng Tao Guo Gaoqiang Li Shishuai Sun Shiqi He Baojing Cheng Baoming Shi Anshan Shan | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 33 |
| 12 | Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus显示文摘背景松香油绑定蛋白质 4 ( RBP4 ), adipocyte 分泌了 cytokine ,最近被发现相反地与葡萄糖 transporter 的表示被相关( GLUT4 ) 4 在胰岛素抵抗(红外)声明学习试图评估 cinnamaldehyde (锡)的反糖尿病的功效并且介绍与红外和类型 2 糖尿病 mellitus ( T2DM ) .The 有一种亲密关系, berberine (赌注),和 metformin (相遇)象他们 RBP4-GLUT4 system.Methods 老鼠上的影响一样, T2DM | ZHANG Wei XU Yan-cheng GUO Fang-jian MENG Ye LI Ming-li | 2008 | Chinese Medical Journal2008，，21： | 30 |
| 13 | Distribution and genesis of the anomalously high porosity zones in the middle-shallow horizons of the northern Songliao Basin显示文摘High-quality reservoirs occur in the middle-shallow horizons of the northern Songliao Basin. The distribution and genesis of their anomalously high porosity zones were studied using measured porosities, examination of ordinary thin sections and blue epoxy resin-impregnated thin sections and by SEM. The results show that there are three anomalously high porosity zones at the depth of 450-900 m, 1,300-1,900 m, 2,050-2,350 m respectively, named zone i, zone ii and zone iii from top to bottom. Horizontally, zone i and zone ii are distributed all over the basin except in the Southeastern Uplift, while zone iii is only distributed in the Central Depression. Zone i was formed by meteoric water leaching as well as organic acid dissolution. Zones ii and iii were dominantly formed by organic acid dissolution. Additionally, clay mineral transformation generating H+ and hydrocarbon emplacement retarding the cementation of sandstones are also important for the formation of zones ii and iii. | Meng Yuanlin Liang Hongwei Meng Fanjin Wu Heyong Wang Cheng Xiu Hongwen Zhang Anda Li Yaguang Guo Rixin | 2010 | Petroleum Science2010，7，3： | 29 |
| 14 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 15 | Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ显示文摘蓼 multiflorum Thunb (下午) 的根在中国被使用了治疗许多疾病,例如便秘,头发和 hyperlipemia 的早 graying。最近的证据证明那位首相在人引起特质的导致药的肝损害(IDILI ) 。在这研究,我们基于 LPS 的非肝毒素的剂量在 IDILI 的一个老鼠模型调查了导致下午的肝损害的分子的基础。SD 老鼠口头上地被管理下午的 3 潜在地肝毒素的混合物:cis 芪配糖物(cis-SG, 50 mg/kg ) , trans-SG (50 mg/kg ) 或 emodin (5 mg/kg ) ,由 LPS 的注射列在后面(2.8 mg/kg, iv ) 。浆液和肝组织学被评估在 LPS 以后的 7 h 注射。在测试的 3 混合物之中, cis-SG,然而并非 emodin 或 trans-SG,当与 LPS 结合了时,在老鼠导致了严重的肝损害。在血浆的著名计算机生产厂商和在血浆和肝纸巾的煽动性的 cytokines 的层次显著地被提高。肝纸巾显示出增加的损害, hepatocyte apoptosis,和巨噬细胞渗入,并且减少房间增长。Microarray 分析揭示了在 peroxisome 之间的否定关联激活 proliferator 的受体 --(PPAR-) 并且 LPS/cis-SG-induced 肝损害。Immunohistochemical 染色和 RT-PCR 结果进一步证实 cis-SG 显著地在 LPS/cis-SG-treated 老鼠的肝纸巾禁止了 PPAR- 小径的激活。有 PPAR- 收缩筋 pioglitazone 的预告的处理(500 g/kg, ig ) 颠倒的 LPS/cis-SG-induced 肝损害,它与禁止原子因素 kappa B (NF-B ) 被联系小径。这些数据证明 cis 芪配糖物导致免疫学的通过在 IDILI 的一个老鼠模型压制 PPAR- 的特质的 hepatotoxicity。 | Ya-kun MENG Chun-yu LI Rui-yu LI Lan-zhi HE He-rong CUI Ping YIN Cong-en ZHANG Peng-yan LI Xiu-xiu SANG Ya WANG Ming NIU Ya-ming ZHANG Yu-ming GUO Rong SUN Jia-bo WANG Zhao-fang BAI Xiao-he XIAO | 2017 | Acta Pharmacologica Sinica2017，38，10： | 30 |
| 16 | The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells显示文摘AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP on the proliferation of NIH 3T3 cells was measured by incorporation of 3H-TdR. Receptor-binding assay of 125I-AFP was performed to detect the properties of AFP receptor in NIH 3T3 cells. The influences of AFP on the [cAMP]i and the activities of protein kinase A (PKA) were determined. Western blot was used to detect the change of K-ras P21 protein expression. RESULTS The proliferation of NIH 3T3 cells treated with 0-80 mg/L of AFP was significantly enhanced. The Scatchard analysis indicated that there were two classes of binding sites with KD of 2.722×10-9M (Bmax=12810 sites per cell) and 8.931× 10-SM (Bmax=l19700 sites per cell) respectively. In the presence of AFP (20 mg/L), the content of cAMP and activities of PKA were significantly elevated . The level of K-ras P21 protein was upregulated by AFP at the concentration of 20 mg/L. The monoclonal antibody against AFP could reverse the effects of AFP on the cAMP content, PKA activity and the expression of K-ras p21 gene. CONCLUSION The effect of AFP on the cell proliferation was achieved by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras p21 gene. | MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG HE, Guo GUANG DU, GANG LI1 Department of Biochemistry and Molecular Biology, 2 Department of Biophysics, Health Science Center, Peking University, Beijing 100083, China | 2002 | Cell Research2002，12，2： | 27 |
| 17 | Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines显示文摘瞄准:识别在 DNA hyper-methylation 之间的关系并且嘘在 hyperme-thylated 的一修正, silenced 肿瘤压制或在人的胃的癌症房间线并且到的基因倡导者阐明 DNA 甲基化的改变是否能影响嘘一修正。方法:我们使用了染色质免疫降水(薄片) 估计地位的试金嘘在 p16 和 mutL 相当或相同的事物的倡导者区域的一乙酰化作用和甲基化 1 (MLH1 ) 在 2 根胃的癌症房间线, SGC-7901 和 MGC-803 的基因。我们使用了 methylation 特定的 PCR (MSP ) 评估 5-Aza-2'-deoxycytidine (5-Aza-dC ) 的效果, trichostatin A (TSA ) 或他们 DNA 甲基化上的联合治疗地位。我们使用了 RT-PCR 决定是否改变嘘在 5-Aza-dC 和 TSA 治疗以后的一修正地位在基因表示被反映。结果:为在二根房间线的 p16 和 MLH1 基因,与 DNA hypermethylation 联系的 silenced 部位被描绘由嘘一 H3-K9 hypoacetylation 和 hypermethylation 并且嘘一 H3-K4 hypomethylation。有 TSA 的治疗导致了中等增加了嘘在没有效果在上的 silenced 部位的一 H3-K9 乙酰化作用嘘基因表示上的一 H3-K9 甲基化和最小的效果。相反,有 5-Aza-dC 的治疗很快减少了嘘在 silenced 部位的一 H3-K9 甲基化并且导致了二基因的复活。有 5-Aza-dC 和 TSA 的联合治疗是在在显示出 DNA hypermethylation 的部位重新激活基因表示的协同的。同样,嘘一 H3-K4 甲基化没在 TSA 处理以后被影响,并且在 5-Aza-dC 处理以后在 silenced 部位中等增加了。结论:在倡导者 CpG 岛的 DNA 的 Hypermethylation 与肿瘤的 transcriptional silencing 有关压制或基因。在倡导者的不同区域的组蛋白 H3-K9 甲基化在胃的癌症房间与每基因的 DNA 甲基化地位学习了相互关联。然而,嘘一 H3-K9 乙酰化作用和 H3-K4 甲基化相反地在胃的癌症房间与每基因的 DNA 甲基化地位相关。DNA 甲基化的改变影响嘘一修正。 | Chun-Feng Meng Xin-Jiang Zhu Guo Peng Dong-Qiu Dai | 2007 | World Journal of Gastroenterology2007，13，46： | 27 |
| 18 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 19 | TANDEM and GMAW Twin Wire Welding of Q690 Steel Used in Hydraulic Support显示文摘Compared with using semi-automatic gas shielded arc welding, using automatic TANDEM twin wire welding and twin wire gas metal arc welding (GMAW) to weld Q690 steel, a low-alloy high-strength structural steel used in the hydraulic support in the fully-mechanized mining face, the welding speed, deposition rate, production environment and welding quality can be obviously improved. Compared with GMAW twin wire welding, a refined microstructure in the weld and heat-affected zone (HAZ), narrow HAZ and improved joint strength were achieved with TANDEM on Q690. Also, due to the push-pull pulsed way in TANDEM welding, the droplet transfer, distribution on heat flow and interaction between two arcs were completely different from those in GMAW twin wire system. The heat input of TANDEM is only about 76.6% of GMAW, and correspondingly, the welding speed and welding seam can be obviously improved. The complete oscillation caused by TANDEM pulsed current occurred in the welding pool, which refined the grains in the microstructure. The results show that TANDEM twin wire welding is very suitable in the welding of Q690 used in the hydraulic support. | FANG Chen-fu MENG Xiao-hui HU Qing-xian WANG Feng-jiang REN He WANG Hai-song GUO Yu MAO Ming | 2012 | Journal of Iron and Steel Research(International)2012，19，5： | 22 |
| 20 | Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes显示文摘心脏的纤维变性被认为糖尿病的心肌症(DCM ) 的起始的变化。我们证明了 curcumin 在 DCM 减轻骨胶原免职,但是机制仍然保持未知。在这研究,我们寻求了在 vivo 并且在 vitro 在心脏的纤维变性上调查 curcumin 的效果并且阐明内在的机制。试验性的糖尿病被与高精力饮食相结合的低剂量的 streptozotocin (STZ ) 的注射在老鼠导致。老鼠口头上地与 curcumin 被对待(300 | Shuang GUO Xiang-wen MENG Xiao-song YANG Xiu-fen LIU Chang-han OU-YANG Chao LIU | 2018 | Acta Pharmacologica Sinica2018，39，2： | 23 |
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