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| 1 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 2 | Comparison of two in vitro angiogenesis assays for evaluating the effects of netrin-1 on tube formation显示文摘Netrin-1 是也调整脉管的开发的神经指导暗示。然而,争论结果在 vivo 并且在 vitro 在脉管的开发有关 netrin-1 的角色被获得了。在现在的学习,二在 vitro angiogenesis 试金与相比评估藏匿由的 netrin-1 的效果 retrovirally 试管形成上的 transduced 黑瘤房间(Mel2a-netrin1 ) 。结果证明在调节媒介(厘米) 在 matrigel 试金从控制, Mel2a-netrin1 和 Mel2a 房间导致的试管形成没有明显的差别。在哪个 endothelial 房间然而与人的成纤维细胞是 co 有教养的,在 vitro 试金的另外一个的结果证明那 Mel2a-netrin1 厘米禁止了试管形成,据说通过堵住人的脐的静脉 endothelial 房间(HUVEC ) 的延伸和结合。这些结果证实 matrigel 试金不能表明 netrin-1 的 anti-angiogenic 角色。 | Hui Guo Yin Jia Min Shang Yuan Zhang Fu'an Xie Heng Wang Mingjing Yuan Li Yuan Jura Ye | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 3 | Aging and aging-related diseases:from molecular mechanisms to interventions and treatments显示文摘Aging is a gradual and irreversible pathophysiological process.It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases,including neurodegenerative diseases,cardiovascular diseases,metabolic diseases,musculoskeletal diseases,and immune system diseases.Although the development of modern medicine has promoted human health and greatly extended life expectancy,with the aging of society,a variety of chronic diseases have gradually become the most important causes of disability and death in elderly individuals.Current research on aging focuses on elucidating how various endogenous and exogenous stresses(such as genomic instability,telomere dysfunction,epigenetic alterations,loss of proteostasis,compromise of autophagy,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,altered intercellular communication,deregulated nutrient sensing)participate in the regulation of aging.Furthermore,thorough research on the pathogenesis of aging to identify interventions that promote health and longevity(such as caloric restriction,microbiota transplantation,and nutritional intervention)and clinical treatment methods for aging-related diseases(depletion of senescent cells,stem cell therapy,antioxidative and anti-inflammatory treatments,and hormone replacement therapy)could decrease the incidence and development of aging-related diseases and in turn promote healthy aging and longevity. | Jun Guo Xiuqing Huang Lin Dou Mingjing Yan Tao Shen Weiqing Tang Jian Li | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 4 | Multi-scale coupling analysis of urbanization and ecosystem services supply-demand budget in the Beijing-Tianjin-Hebei region, China显示文摘Rapid economic development and human activities have severely affected ecosystem function.Analysis of the spatial distribution of areas of rapid urbanization is the basis for optimizing urban-ecological spatial design.This paper evaluated the spatial distribution of urbanization in the Beijing-Tianjin-Hebei(BTH)region,and then quantified the ecosystem services(ES)budget in the region based on an ES supply and demand matrix.The results showed that(1)urbanization patterns in the BTH region were relatively stable from 2000 to 2015,with clear patterns of low levels of urbanization in the northwest and high levels in the southeast;(2)areas with positive ES budget values were found throughout the region,except in built-up areas,with high ES supply areas concentrated in the northwest,and high ES demand areas in the southeast;(3)at both the county and prefecture-city levels,urbanization had negative,positive,and negative correlations with ES supply,demand,and budget,respectively;(4)the coupling coordination degree(CCD)increased,with high CCD values in the southeast.Based on these results,policy recommendations include strengthening rational land-use planning and ecosystem management,promoting the coordinated development of the economy and ecological function,and coordinating the provision of production-life-ecological functions. | ZHANG Fan XU Ning WANG Chao GUO Mingjing Pankaj KUMAR | 2023 | Journal of Geographical Sciences2023，33，2： | 0 |
| 5 | Enhancing thermoelectric performance of n-type AgBi_(3)S_(5)through synergistically optimizing the effective mass and carrier mobility显示文摘AgBi_(3)S_(5) is a new n-type thermoelectric material that is environmentally friendly and composed of elements of earth-abundant,non-toxic and high performance-cost ratio.This compound features an intrinsically low thermal conductivity derived from its complex monoclinic structure.However,the terrible electrical transport properties greatly limited the improvement of thermoelectric performance.Most previous studies considered that carrier concentration is the main reason for low electrical conductivity and focused on improving carrier concentration by aliovalent ion doping.In this work,we found that the critical parameter that restricts the electric transport performance of AgBi_(3)S_(5)was the extremely low carrier mobility instead of the carrier concentration.According to the Pisarenko relationships and density functional theory calculations,Nb doping can sharpen the conduction band of AgBi_(3)S_(5),which contributes to reducing the effective mass and improving the carrier mobility.With a further increase of the Nb doping content,the conduction band convergence can enlarge the effective mass and preserve the carrier mobility.Combined with the decrease in lattice thermal conductivity due to the intensive phone scattering,a maximum ZT value of~0.50 at 773 K was achieved in Ag_(0.97)Nb_(0.03)Bi_(3)S_(5),which was~109.6%higher than that of pure AgBi3S5.This work will stimulate the new exploration of high-performance thermoelectric materials in ternary metal sulfides. | Xin Qian Xiaoxue Zhang Haoran Guo Bangfu Ding Mingjing Chen Jiang-Long Wang Li-Dong Zhao Shu-Fang Wang | 2023 | Journal of Materiomics2023，9，5： | 0 |
| 6 | Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine显示文摘Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine ZF2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary Fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary Fig.1b,c). | Mengyu Guo Mingjing Cao Jiufeng Sun Ziwei Chen Xin Wang Lianpan Dai George F.Gao Yuliang Zhao Yaling Wang Chunying Chen | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
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