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| 1 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 2 | Temporal and spatial variability response of groundwater level to land use/land cover change in oases of arid areas显示文摘这份报纸由使用地理信息系统(GIS ) 在 Sangong 河分水岭在干旱绿洲在地下水水平的时间、空间的可变性上在陆地使用 / 盖住变化(LUCC ) 的影响上进行案例研究,遥感(RS ) 和 geostatistical 方法。在在 1978, 1987 和 1998 的分水岭的地下水水平的时间、空间的可变性是由使用 semivariogram 模型和 Kriging 插值的 regressed。在 1978 从天线图象导出的 LUCC 分类地图,在 1987 的 Landsat TM 图象和在 1998 的 Landsat ETM 图象被用来迭加并且与地下水深度的不同等值线图在这些区域分析 LUCC 类型的变换关系。结果证明地下水的变化再装不在整个绿洲是那么重要的,但是时间、空间的 LUCC 在从 1978 ~ 1998 的 20 年的时期期间在正常流动时期或在高流动时期是重要的,并且在他们之间有靠近的关联。通常有地下水水平(33.4%) 的中等空间关联,并且空间自相关距离是 17.78 km。地下水水平严厉地被改变的区域也是陆地资源逐渐地被利用的区域,它主要包括农田,树林,和大楼的利用,工业并且采矿陆地。学习表明 LUCC 强烈在干旱绿洲影响地下水水平的时间、空间的可变性。学习结果具有为讲道理地利用浅地下水资源并且维持干旱绿洲的稳定性的直接、实际的意义。 | YAN Jinfeng CHEN Xi LUO Geping GUO Quanjun | 2006 | Chinese Science Bulletin2006，51，A01： | 12 |
| 3 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 4 | Flow hydraulic characteristic effect on sediment and solute transport on slope erosion 显示文摘 | Guo Tailong Wang Quanjun Li Dingqiang | 2013 | Catena2013，，107： | 1 |
| 5 | Improved empirical DC I-V model for 4H-SiC MESFETs显示文摘A novel empirical large signal direct current(DC) I-V model is presented consider-ing the high saturation voltage,high pinch-off voltage,and wide operational range of drain voltage for 4H-SiC MESFETs.A comparison of the presented model with Statz,Materka,Curtice-Cubic,and recently reported 4H-SiC MESFET large signal I-V models is made through the Levenberg-Marquardt method for fitting in nonlin-ear regression.The results show that the new model has the advantages of high accuracy,easily making initial value and robustness over other models.The more accurate results are obtained by the improved channel modulation and saturation voltage coefficient when the device is operated in the sub-threshold and near pinch-off region.In addition the new model can be implemented to CAD tools di-rectly,using for design of 4H-SiC MESFET based RF&MW circuit,particularly MMIC(microwave monolithic integrate circuit). | CAO QuanJun ZHANG YiMen ZHANG YuMing LV HongLiang WANG YueHu TANG XiaoYan GUO Hui | 2008 | Science in China(Series F)2008，51，8： | 1 |
| 6 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 7 | Generation of knockout rabbits using transcription activator-like effector nucleases显示文摘Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platformscontributing to redefine the boundaries of modern biological research. They are composed of a non-specificcleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications byinducing efficient DNA double-strand breaks at desired loci. Among other remarkable uses, these nucleases havebeen employed to produce gene knockouts in mid-size and large animals, such as rabbits and pigs, respectively.This approach is cost effective, relatively quick, and can produce invaluable models for human disease studies,biotechnology or agricultural purposes. Here we describe a protocol for the efficient generation of knockout rabbitsusing transcription activator-like effector nucleases, and a perspective of the field. | Yu Wang Nana Fan Jun Song Juan Zhong Xiaogang Guo Weihua Tian Quanjun Zhang Fenggong Cui Li Li Philip N Newsome Jon Frampton Miguel A Esteban Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 0 |
| 8 | Ensemble learning system to identify nutritional risk and malnutrition in cancer patients without weight loss information显示文摘Dear Editor,Malnutrition is a prevalent disease in oncology practice(Arends et al.,2017).With its cancer-specific prevalence ranging from 21%–72%,malnutrition is responsible for 10%–20% cancer deaths(Yin et al.,2021b).However,malnutrition is often underestimated,misclassified,or left untreated in cancer care(Hébuterne et al.,2014). | Liangyu Yin Jie Liu Ming Liu Jin Zheng Aiguo Xu Quanjun Lyu Yongdong Feng Zengqing Guo Hu Ma Jipeng Li Zhikang Chen Hui Wang Zengning Li Chunling Zhou Xi Gao Min Weng Qinghua Yao Wei Li Tao Li Hanping Shi Hongxia Xu | 2023 | Science China(Life Sciences)2023，66，5： | 0 |
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