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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 3 | Experience with one and a half ventricular repair显示文摘 | Kreutzer C Mayorquim RC Kreutzer GA | 1999 | J Thorac Cardiovasc Surg1999，117，4： | 2 |
| 4 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 5 | Activation of long-term synaptic plasticity efuses suppression of epileptiform activity in rat hippocampal slices显示文摘 | Benedict C Albensi GA Erln S | 2004 | Brain Res2004，1998，1： | 1 |
| 6 | Congenital choledochal cyst:video-guided laparoscopic treatment显示文摘 | Cerofolini A Rebonato M Bergamaschi G Ferrari C Chiappetta A | 1995 | Surg Laparosc Endosc1995，5，： | 1 |
| 7 | Obesity in pregnancy 显示文摘 | Davies GA Maxwell C McLeod L | 2010 | J Obstet Gynaecol Can2010，32，2： | 1 |
| 8 | Treatment of femoral neck fractures in elderly patients over 60 years of age which is the ideal modality of primary joint replacement显示文摘 | Ossendorf C Scheyerer MJ Wanner GA | 2010 | Patient Saf Surg2010，4，1： | 1 |
| 9 | Frontal lobe epielpsy:diagnosis and surgical treatment 显示文摘 | Wetin NM Cohen GA Maher C | 2002 | Neurosurg Rev2002，25，3： | 1 |
| 10 | Radiotherapy for in situ extramammary Paget disease of the vulva显示文摘 | Moreno-Arias GA Conill C Sola-Casas MA | 2003 | J Dermatolog Treat2003，14，： | 1 |
| 11 | The coxibs,selective inhibitors of cyclooxygenase-2显示文摘 | FITZGERALD GA PATRONO C | 2001 | N Engl J Med2001，345，6： | 1 |
| 12 | Platelet-active drugs : the rela- tionships among dose, effectiveness, and side effects:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy 显示文摘 | Patrono C Coller B FitzGerald GA | 2004 | Chest2004，12，6： | 1 |
| 13 | Probiotics, enteric and diarrheal diseases, and global health显示文摘 | Preidis GA Hill C Guerrant RL | 2011 | Gastroenterology2011，140，1： | 1 |
| 14 | Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci:position statement from the Joint SHEA and APIC Task Force显示文摘 | Weber SG Huang SS Oriola S W.Huskins C Noskin GA Harriman K | | American Journal of Infection Control0，，： | 1 |
| 15 | Evaluation of bifidobacterial community composition in the human gut by means of a targeted amplicon sequencing (ITS) protocol 显示文摘 | Milani C Lugli GA Turroni F | 2014 | FEMS Microbial Ecol2014，90，2： | 1 |
| 16 | Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers显示文摘 | Calin GA~ Sevignani C~ Dumitru CD | 2004 | Proc Nail Acad Sci U S A2004，101，9： | 1 |
| 17 | Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers显示文摘 | Calin GA Sevignani C Dumitru CD | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 18 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS) 显示文摘 | Gbadegesin R Hinkes B G Hoskins B E Vlangos C N Heerin ga S F Liu J | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 19 | Opioid receptor subtype control of galinin-induced feeding显示文摘 | York DA Bray GA | 1996 | Peptides1996，17，2： | 1 |
| 20 | Genetic variability in envelope-associated protein genes of closely related group A strains of respiratory syncytial virus显示文摘 | Zheng H Storch GA Zang C | 1999 | Virus Res1999，59，： | 1 |
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