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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Role of extracellular matrix components in facial nerve regeneration: an experimental study 显示文摘 | Donzelli R Maiuri F Piscopo GA | 2006 | Neurol Res2006，28，8： | 1 |
| 3 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS) 显示文摘 | Gbadegesin R Hinkes B G Hoskins B E Vlangos C N Heerin ga S F Liu J | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 4 | Triaminotriazine DNA helicase inhibitors with antibacterial activity显示文摘 | MCKAY GA REDDY R ARHIN F | 2006 | Bioorg Med Chem Lett2006，16，5： | 1 |
| 5 | Aggressive meningeal tumors:review of a series显示文摘 | Younis GA Sawaya R DeMontd F | 1995 | J Neurosurg1995，82，： | 1 |
| 6 | Role of extracelluar matrix components in facial nerve regeneration:an experimental study显示文摘 | Donzelli R Maiuri F Piscopo GA | 2006 | Neurol Res2006，28，8： | 1 |
| 7 | Aggressive meningea tumors:review of a series显示文摘 | Younis GA Sawaya R DeMonte F | 1995 | J Neurosurg1995，82，： | 1 |
| 8 | Charge-voltage relationship of the first impulse corona in long air gap显示文摘 | Ortéga P Heilbronner F Rühling F | 2005 | Journal of Physics D:Applied Physics2005，，38： | 1 |
| 9 | Aggressive meningeal tumours:review of a series 显示文摘 | YOUNS GA SAWAYA R DEMOUTE F | 1995 | J Neurosurg1995，82，1： | 1 |
| 10 | Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes显示文摘 | Purrello F Vigneri R Clawson GA | 1982 | Science1982，216，4549： | 1 |
| 11 | Comparison of predicted and experimental erosion estimates in slurry duets 显示文摘 | Wood R J K Jones T F Ga~shalingam J | 2004 | Wear2004，256，： | 1 |
| 12 | The Hamilton depression rating scale in normals and depressives显示文摘 | Fava GA Kellner R Munari F | 1982 | Acta Psychiatrica Scandinavica1982，66，1： | 1 |
| 13 | Role of extracellular matrix components in facial nerve regeneration : an experimental study 显示文摘 | Donzelli R Maiuri F Piscopo GA | 2006 | Neurol Res2006，28，8： | 1 |
| 14 | Changes in white matter in long-term survivors of severe non-missile traumatic brain injury:a computational analysis of magnetic resonance images显示文摘 | Tomaiuolo F Worsley KL Lerch L Di Paola M Carlesimo GA Bonanni R | 2005 | J Neurotrauma2005，22，1： | 1 |
| 15 | Aggressive meningeal tumors: review of a series 显示文摘 | Younis GA Sawaya R DeMonte F | 1995 | J Neurosurg1995，82，： | 1 |
| 16 | Aggressive meningeal tumors: review of a series显示文摘 | Younis GA Sawaya R DeMonte F | 1995 | J Neurosurgery1995，82，： | 1 |
| 17 | Comparative diagnostic accuracy of T1-201 and Tc-99m sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women显示文摘 | Taillefer R DePuey EG Udelson JE Beller GA Latour Y Reeves F | 1997 | J Am Coll Cardiol1997，29，1： | 1 |
| 18 | Progesterone selectively increases amygdala reactivity in women显示文摘 | Van Wingen GA Van Broekhoven F Verkes R J | 2008 | Mol Psychiatry2008，13，3： | 1 |
| 19 | Role of extracellular matrix components in facial nerve regeneration:an experimental study显示文摘 | Donzelli R Maiuri F Piscopo GA | 2006 | Neurol Res2006，28，8： | 1 |
| 20 | Losses, Hostility, and depres- sion 显示文摘 | Fava GA Kellner R Munari F | 1982 | J Nerv Ment Dis1982，170，8： | 1 |
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