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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Paradoxical sleep deprivation increases plasma endothelin levels 显示文摘 | Palma B D Gabriel A Bignotto M | 2002 | Braz J Med Biol Res2002，35，1： | 1 |
| 3 | Apoptosis in uterine epithelium and decidua in response to implantation:evidence for two different pathways显示文摘 | Joswig A Gabriel HD Kibschull M | 2003 | Reprod Biol Endocrinol2003，1，： | 1 |
| 4 | Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control 显示文摘 | Gabriel D A M Deshusses | 2003 | Proceedings of the National Academy of Science of the United States of America2003，100，11： | 1 |
| 5 | The treatment of unstable thoracic spine fractures with transpedicular screw instrumentation: a 3- year consecutive series显示文摘 | Yue JJ Sossan A Selgrath C Deutsch Lawrence S Wilkens K Testaiuti M Gabriel JP | | 0，，： | 1 |
| 6 | G-DBSCAN:A GPU accelerated algorithm for density-based clustering显示文摘 | Guilherme A Gabriel R Daniel M | 2013 | Procedia Computer Science2013，18，： | 1 |
| 7 | Prediction of firmness and soluble solids content of blueberries using hyperspectral reflectance imaging显示文摘 | GABRIEL A L LU R F AGUILERA J M | 2013 | Journal of Food Engineering2013，115，： | 1 |
| 8 | Mapping small elevation changes over large areas: Dif- ferential radar interferometry显示文摘 | GABRIEL A K GOLDSTEIN R M ZEBKER H A | 1989 | Journal of Geophysi- cal Research1989，94，7： | 1 |
| 9 | Precipitation of Al3Sc in binary Al-Sc alloys显示文摘 | GABRIEL M N ALAN J A | 2001 | Materials Science and Engineering A2001，318，12： | 1 |
| 10 | Quality of orange juice drink subjected to a predictive model-based pasteurization process 显示文摘 | GABRIEL A A AZANZA M P V | 2009 | Journal of Food Quality2009，32，4： | 1 |
| 11 | Atomistic simulation of amorphousgermaniumand its solid phase epitaxial recrystallization显示文摘 | Posselt M Gabriel A | 2009 | Physical Review B2009，80，04： | 1 |
| 12 | Crossed Orbit Inter ferometry: Theory and Experimental Results from SIR B 显示文摘 | GABRIEl A K GOLDSTEIN R M | 1988 | International Journal of Remote Sensing1988，9，5： | 1 |
| 13 | Phenotypic shift of human amniotic epithelial cells in culture is associated with reduced osteogenic differentiation in vitro显示文摘 | G Stadler S Hennerbichler A Lindenmair A Peterbauer K Hofer M van Griensven C Gabriel H Redl S Wolbank | 2008 | Cytotherapy2008，，7： | 1 |
| 14 | Paradoxical sleep deprivation increases plasma endothelin levels显示文摘 | Palma BD Gabriel A Jr Bignotto M | 2002 | Braz J Med Biol Res2002，35，1： | 1 |
| 15 | Expression of focal adhesion kinase in patients with endometrial cancer: a clinieopathologic study 显示文摘 | Gabriel B Hasenburg A Waizenegger M | 2009 | Int J Gynecol Cancer2009，19，7： | 1 |
| 16 | Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong显示文摘 | Christl A Donnelly Azra C Ghani Gabriel M Leung | 2003 | Lancet2003，361，： | 1 |
| 17 | Chemopre- ventive potential of 13-Sitosterol in experimental colon cancer model-an in vitro and in vivo study 显示文摘 | Albert A B Savarimuthu I Gabriel M P | 2010 | BMC Complement Al- tern Med2010，10，： | 1 |
| 18 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 19 | Crossed orbit interferometry, theory and experimental results from SIR-B 显示文摘 | GABRIEL A K GOLDSTEIN R M | 1988 | International Journal of Remote Sensing1988，9，5： | 1 |
| 20 | Synthetic mimic of antimicrobial peptide with nonmembrane- disrupting antibacterial properties显示文摘 | Gabriel G J Madkour A E Dabkowski J M | 2008 | Biomacromolecules2008，9，11： | 1 |
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