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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 3 | In search of models of pharmacoresistant epilepsy显示文摘 | Wahab A Albus K Gabriel S | 2010 | Epilepsia2010，51，： | 1 |
| 4 | The treatment of unstable thoracic spine fractures with transpedicular screw instrumentation: a 3- year consecutive series显示文摘 | Yue JJ Sossan A Selgrath C Deutsch Lawrence S Wilkens K Testaiuti M Gabriel JP | | 0，，： | 1 |
| 5 | Mapping small elevation changes over large areas: Dif- ferential radar interferometry显示文摘 | GABRIEL A K GOLDSTEIN R M ZEBKER H A | 1989 | Journal of Geophysi- cal Research1989，94，7： | 1 |
| 6 | The Klebsiella pneumoniae O antigen contributes to bactere- mia and lethality during murine pneumonia显示文摘 | Shankar- sinha Sunita Valencia Gabriel A Janes Brian K | 2004 | Infection and Im- munity2004，72，3： | 1 |
| 7 | Crossed Orbit Inter ferometry: Theory and Experimental Results from SIR B 显示文摘 | GABRIEl A K GOLDSTEIN R M | 1988 | International Journal of Remote Sensing1988，9，5： | 1 |
| 8 | Phenotypic shift of human amniotic epithelial cells in culture is associated with reduced osteogenic differentiation in vitro显示文摘 | G Stadler S Hennerbichler A Lindenmair A Peterbauer K Hofer M van Griensven C Gabriel H Redl S Wolbank | 2008 | Cytotherapy2008，，7： | 1 |
| 9 | Distributed MEMS:New challenges for computation显示文摘 | BERLIN A GABRIEL K J | 1997 | IEEE Computational Science and Engineering Journal1997，4，1： | 1 |
| 10 | Crossed orbit interferometry, theory and experimental results from SIR-B 显示文摘 | GABRIEL A K GOLDSTEIN R M | 1988 | International Journal of Remote Sensing1988，9，5： | 1 |
| 11 | Assessment of long-term nipple projection:a comparison of three techniques显示文摘 | SHESTAK K C GABRIEL A LANDECKER A | 2002 | Plast Reconstr Surg2002，110，78： | 1 |
| 12 | Electronic detection of specific protein binding using nanotube FET devices显示文摘 | Star A Gabriel J-C P Bradley K | | 0，，04： | 1 |
| 13 | Crossed Orbit Interferometry: Theory and Experimental Results from SIR-B显示文摘 | GABRIEL A K GOLDSTEIN R M | 1988 | International Journal of Remote Sensing1988，9，5： | 1 |
| 14 | Interaction of aromatic compounds with carbon nanotubes: correlation to the Hammett parameter of the substituent and measured carbon nanotube FET response显示文摘 | STAR A GABRIEL J C P BRADLEY K | 2003 | Nano Lett2003，3，4： | 1 |
| 15 | Mapping Small E1 evation Changes over Large Areas: Differential Radar Interferometry显示文摘 | Gabriel A K Goldstein R M Zebker H A | 1989 | Journal of Geophysical Research1989，，： | 1 |
| 16 | Crossed orbit interferometry:Theory and experimental results from SIR-B 显示文摘 | Gabriel A K R M Goldstein | 1988 | Int J Remote Sensing1988，9，8： | 1 |
| 17 | Explorato- ry ananlysis of seeding effects on rainfall: Illinois 1989 显示文摘 | Changnon S A Gabriel K R W estcott N E | 1995 | Appl Meteor1995，34，： | 1 |
| 18 | A mouse model of basal-like breast carcinoma with metaplastic elements 显示文摘 | McCarthy A Savage K Gabriel A | 2007 | J Pathol2007，211，4： | 1 |
| 19 | Efficacy of photody- namic therapy in vulvar lichen sclerosus treatment based on im- munohistochemical analysis of CD34,CD44,myelinbasic protein, and Ki67 antibodies显示文摘 | Olejek A Steplewska K Gabriel A | 2010 | Int J Gynecol Cancer2010，20，9： | 1 |
| 20 | Mus- cle activation patterns in subjects with and without low back pain 显示文摘 | NEWCOMER K L JACOBSON T D GABRIEL D A | 2002 | Archives of Physical Medicine and Rehabilitation2002，83，6： | 1 |
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