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| 1 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Development and evaluation of a CERES-type model for winter oilseed rape显示文摘 | Gabrielle B Denoroy P Gosse G Justes E Andersen M N | 1998 | Field Crops Research1998，57，： | 1 |
| 4 | Emotion, learning and organizational change: Towards an integration of psychoanalytic and other perspectives显示文摘 | Antonacopoulou E P Gabriel Y | 2001 | Journal of Or- ganizational Change Management2001，14，5： | 1 |
| 5 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 6 | Bioelectrochemical control of neural cell development on conducting polymers 显示文摘 | lorge E C lose L P Gabriel R H-L | 2010 | Biomaterials2010，31，35： | 1 |
| 7 | Trigeminal and facial schwannoma: a case load and review of the literature显示文摘 | Gennaro P Nastro Siniscalchi E Gabriele G | 2012 | Eur Rev Med Pharmacol Sci2012，16，4： | 1 |
| 8 | Checkppoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells 显示文摘 | Gergia I T Kaliopi N M Gabriel E P | 2005 | Cancer Res2005，65，11： | 1 |
| 9 | Nationwide analysis of short-term surgical outcomes of minimally invasive esophagectomy for malignancy 显示文摘 | Thirunavukarasu P Gabriel E Attwood K | 2016 | Int J Surg2016，25，： | 1 |
| 10 | Emergence of Zaire ebola virus disease in Guinea-Preliminary report 显示文摘 | Baize S Pannetier D Oestereich L Rieger T Koivogui L Magassouba N Soropogui B Sow MS Keita S De Clerck H Tiffany A Dominguez G Loua M Traore A Kolie M Malano ER Heleze E Bocquin A Mely S Raoul H Caro V Cadar D Gabriel M Pahlmann M Tappe D Schmidt- Chanasit J Impouma B Diallo AK Formenty P Van Herp M G/inther S | 2014 | N Engl J Med2014，371，15： | 1 |
| 11 | Helix 4 mutants of the Bacillus thuringiensis insecticidal toxin Cry1Aa display altered pore-forming abilities显示文摘 | VINCENT V GABRIELLE P CECIL E | 2004 | Applied Environment Microbiology2004，70，： | 1 |
| 12 | Surgical manage- ment of non - small cell lung cancer with synchronous brain metas- tases显示文摘 | BONNETI'E P PUYO P GABRIEL C | 2001 | Chest2001，119，5： | 1 |
| 13 | Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE 显示文摘 | SYMMONS D P GABRIEL S E | 2011 | Nature Reviews Rheumatology2011，7，7： | 1 |
| 14 | International prevalence, recognition, and treatment of cardiocascular risk factors in outpatients with atherothrom- bosis 显示文摘 | BHATT D L GABRIEL S P MAGNUS O E | 2006 | JAMA2006，295，2： | 1 |
| 15 | A low-voltage,low quiescent current,low drop-out regulator显示文摘 | Gabriel A Mora R Allen P E | 1998 | IEEE J Sol Sta Circ1998，33，1： | 1 |
| 16 | Outcomes of microfracture in professional basketball players 显示文摘 | Douglas L Cerynik Gabriel E Lewullis Brian C Joves Michael P Palmer James A Tom | 2009 | Knee Surgery Sports Traumatology Arthroscopy2009，17，9： | 1 |
| 17 | Emergence of Zaire Ebola virus disease in Guinea 显示文摘 | Baize S Pannetier D Oestereich L Rieger T Koivogui L Magassouba N Soropogui B Sow MS Keita S De Clerck H Tiffany A Dominguez G Loua M Traore A Kolie M Malano ER Heleze E Bocquin A Mely S Raoul H Caro V Cadar D Gabriel M Pahlmann M Tappe D Schmidt- Chanasit J Impouma B Diallo AK Formenty P Van Herp M Gtinther S | 2014 | N Engl J Med2014，371，15： | 1 |
| 18 | Effect of anthocyanin's extract from flour of roselle calyx (Hibiscus sabdariffa) on growth and pigmenta- tion of goldfish (Carassius auratus) 显示文摘 | Ver6nica P E Gabriel A G Pablo Emilio V E | 2012 | Thai J Vet Med2012，42，1： | 1 |
| 19 | Effect of acute heat on heat shock protein expression in the liver of broiler显示文摘 | Gabriel J E J A Ferro R M P Stee ANI | 1996 | Bri Poul Sci1996，37，： | 1 |
| 20 | Human gamma interferron production by cytotoxic T lymphocytes sensitized during hepatitis A virus infection显示文摘 | Gabriel P Koscielniak E | 1988 | J Virol1988，62，10： | 1 |
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