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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Dielectronic satellite spectra for highly charged helium -like ions: Ⅵ-iron spectra with improved inner-shell and helium- like excitation rates 显示文摘 | Bely-dubau F Faucher P Dubau J Gabriel A H | 1982 | Mon Not R Astron Soc1982，198，： | 1 |
| 3 | The structure of haplotype blocks in the human genome 显示文摘 | GABRIEL S B SEHAFFNER S F NGUYEN H | 2002 | Science2002，296，5576： | 1 |
| 4 | Docetaxel for treatment of solid tumours: a systematic review of clinical data 显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncot2005，6，7： | 1 |
| 5 | A functional cloning strategy, based on a binary PVX-expression vector, to isolate HR-inducing cDNAs of plant pathogens 显示文摘 | Takken F L W Luderer R Gabriels S H E J | 2000 | The Plant Journal2000，24，2： | 1 |
| 6 | Standard precipitation index to track drought and assess impact of rainfall on watertables in irrigation areas显示文摘 | Khan S Gabriel H F Rana T | 2008 | Irrigation and Drainage System2008，22，2： | 1 |
| 7 | Docetaxel for treatment of solid tumours:a systematic review of clinical data显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncol2005，6，4： | 1 |
| 8 | Standard precipitation index to track drought and assess impact of rainfall on watertables in irrigation areas显示文摘 | Khan S Gabriel H F Rana T | 2008 | Irrigation and Drainage Systems2008，22，2： | 1 |
| 9 | MCNP5 delayed neutron fraction ealeulation in training reactor VR-1 显示文摘 | Svetozar M Jan H Gabriel F | 2008 | Journal of Electrical Engineering2008，59，4： | 1 |
| 10 | Short-course antiretroviral therapy in primary HIV infection 显示文摘 | SPARTAC Trial Investigators Fidler S Porter K Ewings F Frater J Ramjee G Cooper D Rees H Fisher M Schechter M Kaleebu P Tambussi G Kinloch S Miro JM Kelleher A McClure M Kaye S Gabriel M Phillips R Weber J Babiker A | 2013 | N Engl J Med2013，368，3： | 1 |
| 11 | The structure of haplotype blocks in the human genome显示文摘 | Gabriel S B Schaffner S F Nguyen H | 2002 | Science2002，296，5576： | 1 |
| 12 | One way to a superconducting RF gun:first measurement with the gun cavity显示文摘 | Barhels E Buttig H Gabriel F | 2000 | Nuclear Instruments & Methods2000，，445： | 1 |
| 13 | Nerve Grouth Factor Deliverg by Gene Transfer Induces Differential Outgrowth of Sensorg,Motor and Noaradrenergic Neuritis after Adult Rats Spinl Cord Injury显示文摘 | TUSZYNSKI M H GABRIEL K GAGE F H | 1996 | Exp Neurol1996，137，1： | 1 |
| 14 | A functional cloning strategy,based on a binary PVX-expression vector,to isolate HR-inducing cDNAs of plant pathogens显示文摘 | Takken F L W Luderer R Gabriel S H E J | 2000 | Plant J2000，24，： | 1 |
| 15 | c DNA-AFLP combined with functional analysis reveals novel genes in-volved in the hypersensitive response显示文摘 | GABRIELS S H TAKKEN F L VOSSEN J H | 2006 | Molecular plant microbe interaction2006，19，6： | 1 |
| 16 | The structure of haplotype blocks in the human genome显示文摘 | Gabriel S B Schaffner S F Nguyen H | 2002 | Science2002，296，5576： | 1 |
| 17 | Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor and noradrenergic neuritis after adult spinal cord injury 显示文摘 | Tuszynski M H Gabriel K Gage F H | 1996 | Exp Neurol1996，137，1： | 1 |
| 18 | Empirical-computational methods in the study of creeping waves显示文摘 | Gabriel F H | 1990 | IEEE Transactions on Antennas and Propagation1990，38，1： | 1 |
| 19 | The structure of haplotype blocks in the human genome显示文摘 | Gabriel S B Schaffner S F Nguyen H Moore J M Roy J Blumenstiel B | 2002 | Science2002，296，： | 1 |
| 20 | Docetaxel for treatment of solid tumours:a systematic review of clinical data显示文摘 | Alberto M Frank F Gabriel H | | 0，，07： | 1 |
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