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| 1 | Retrospective epidemiological study of thyroid nodules by ultrasound in asymptomatic subjects显示文摘 | Sharen Gaowa Zhang Bo Zhao Ruina Sun Jie Gai Xiaorong Lou Huiping | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 2 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 3 | Identification, Genetic Analysis and Mapping of Resistance to Phytophthora sojae of Pm28 in Soybean显示文摘Phytophthora sojae Kanfman and Gerdemann (P. sojae) is one of the most prevalent pathogens and causes Phytophthora root rot, which limits soybean production worldwide. Development of resistant cultivars is a cost-effective approach to controlling this disease. In this study, 127 soybean germplasm were evaluated for their responses to Phytophthora sojae strain Pm28 using the hypocotyl inoculation technique, and 49 were found resistant to the strain. The hypocotyl of P1, P2, F1, and F2:3 of two crosses of Ludou 4 (resistant)×Youchu 4 (susceptible) and Cangdou 5 (resistant)×Williams (susceptible) were inoculated with Pm28, and were used to analyze the inheritance of resistance. The population derived from the cross of Ludou 4×Youchu 4 was used to map the resistance gene (designated as Rps9) to a linkage group. 932 pairs of SSR primers were used to detect polymorphism, and seven SSR markers were mapped near the resistance gene. The results showed that the resistance to Pm28 in Ludou 4 and Cangdou 5 was controlled by a single dominant gene Rps9, which was located on the molecular linkage group N between the SSR markers Satt631 (7.5 cM) and Sat_186 (4.3 cM). | WU Xiao-ling ZHANG Bao-qiang SUN Shi ZHAO Jin-ming YANG Feng GUO Na GAI Jun-yi XING Han | 2011 | Agricultural Sciences in China2011，10，10： | 13 |
| 4 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 5 | Verification and fine-mapping of QTLs conferring days to flowering in soybean using residual heterozygous lines显示文摘The results of QTL mapping based on a primary mapping population should be further verified and refined for its real utilization in marker-assisted selection or map-based cloning.The primary mapping population contains 114 BC1F1 plants of the backcross between Essex (maturity group V,MG V) as the donor parent and ZDD2315 (MG II) as the recurrent parent.In this study,a genetic linkage map with 250 SSR markers spanning a total length of 2963.5 cM on 25 linkage groups (LG) was constructed using software MAPMAKER3.0.Six kinds of genetic statistical models of 4 softwares,i.e.WinQTL Cartographer Version 2.5,IciMapping Version 2.0,MapQTL Version 5.0 and QTLnetwork Version 2.0,were used to map QTLs conferring days to flowering of the BC1F3 lines.Nine QTLs were mapped on 6 different linkage groups (LG).Of those,6 QTLs were detected by at least two different genetic statistical models,while the other three were detected by only one procedure.Among the three QTLs,Flwdt7 was mapped between Sat_213 and Satt643 on LG C2 with only 11.0% contribution rate.For confirmation of Flwdt7,5 RHL populations were developed through selfing eight BC1F5 plants heterozygous at seven markers around the locus.The RHL populations with the same segregating loci were bulked and used to construct a secondary linkage map of the specific segment using software JoinMap 3.0.The genetic distances among the markers on the specific segment became shorter than those of the whole genome map.On the secondary map,Flwdt7 was mapped between Satt277 and Satt489,next to its primary interval Sat_213-Satt643,with distance 1.40 cM to Satt277 and 0.45 cM to Satt489,confidence interval narrowed to 2.7 cM,and contribution rate increased to 36.8%.The results were confirmed with significance analysis among marker genotypes on individual loci and comparison analysis of target marker intervals among near isogenic lines (plants).Thus the strategy by using residual heterozygous lines for QTL fine-mapping on target segments based on primary whole genome scanning with multiple mapping models was demonstrated to be effective. | SU ChengFu LU WeiGuo ZHAO TuanJie GAI JunYi | 2010 | Chinese Science Bulletin2010，55，6： | 6 |
| 6 | Advances in core–shell engineering of carbon-based composites for electromagnetic wave absorption显示文摘Electromagnetic(EM)absorption is paving the way to overcome the challenges related to conventional shielding strategy against EM pollution through sustainable energy dissipation.As characteristic functional media that can interact with electric or magnetic field branch,EM wave absorption materials(EWAMs)have received extensive attention and realized considerable development in the past two decades,where carbon-based composites are always considered as promising candidates for high-performance EMAWs due to their synergetic loss mechanism as well as diversified composition and microstructure design.Recent progress indicates that there is more and more interest in the fabrication of carbon-based composites with unique core–shell configuration.On one hand,core–shell configuration usually ensures good chemical homogeneity of final products and provides some positive protections for the components with susceptibility to corrosion,on the other hand,it creates enough heterogeneous interfaces between different EM components,which may bring enhanced polarization effect and intensify the consumption of EM energy.In this review,we firstly introduce EM wave absorption theory,and then highlight the advances of core–shell engineering in carbonbased composites in terms of built-in carbon cores and built-out carbon shells.Moreover,we also show some special core–shell carbon-based composites,including carbon/carbon composites,assembled composites,and decorated composites.After analyzing EM absorption performance of some representative composites,we further propose some challenges and perspectives on the development of core–shell carbon-based composites. | Lixue Gai Honghong Zhao Fengyuan Wang Pan Wang Yonglei Liu Xijiang Han Yunchen Du | 2022 | Nano Research2022，15，10： | 5 |
| 7 | Genetic diversity,geographic differentiation and evolutionary relationship among ecotypes of Glycine max and G. soja in China显示文摘The knowledge of origin and evolution of cultivated soybeans is one of the basic issues in both biology and agronomy of the crop. In order to investigate the nuclear and cytoplasmic genetic diversity, geographic differentiation and genetic relationship among geographic ecotypes of cultivated (Glycine max) and wild (G. soja) soybeans, the allelic profiles at 60 nuclear simple-sequence repeat (nuSSR) loci and 11 chloroplastic SSR (cpSSR) loci evenly distributed on whole genome of 393 landraces and 196 wild accessions from nation-wide growing areas in China were analyzed. (i) The genetic diversity of the wild soybean was obviously larger than that of the cultivated soybean, with their nuSSR and cpSSR alleles as 1067 vs. 980 and 57 vs 44, respectively. Of the 980 nuclear alleles detected in the cultivated soybean, 377 new ones (38.5%) emerged, while of the 44 chloroplastic alleles in the cultivated soybean, seven new ones (15.9%) emerged after domestication. (ii) Among the cultivated geographic ecotypes, those from southern China, including South-Central China, Southwest China and South China possessed relatively great genetic diversity than those from northern China, while among the wild geographic ecotypes, the Middle and Lower Changjiang Valleys wild ecotype showed the highest genetic diversity. (iii) The analysis of molecular variance, association analysis between geographic grouping and molecular marker clustering and analysis of specific-present alleles of ecotypes demonstrated that the geographic differentiation of both cultivated and wild soybeans associated with their genetic differentiation, or in other words, had their relevant genetic bases. (iv) The cluster analysis of all accessions clearly showed that the wild accessions from Middle and Lower Changjiang Valleys and South-Central & Southwest China had relatively small genetic distances with all cultivated accessions. The UPGMA dendrogram among geographic ecotypes further showed that the genetic distances between all cultivated ecotypes and the Middle and Lower Changjiang Valleys wild ecotype were smaller than those with other wild ones, including their local wild counterparts. Therefore, it is inferred that the wild ancestors in southern China, especially those from Middle and Lower Changjiang Valleys might be the common ancestor of all the cultivated soybeans. | WEN ZiXiang, ZHAO TuanJie, DING YanLai & GAI JunYi Soybean Research Institute of Nanjing Agricultural University National Center for Soybean Improvement National Key Laboratory for Crop Genetics and Germplasm Enhancement, Nanjing 210095, China | 2009 | Chinese Science Bulletin2009，54，23： | 5 |
| 8 | Exploration of presence/absence variation and corresponding polymorphic markers in soybean genome显示文摘This study was designed to reveal the genome‐wide distribution of presence/absence variation(PAV) and to establish a database of polymorphic PAV markers in soybean. The 33 soybean whole‐genome sequences were compared to each other with that of Williams 82 as a reference genome. A total of 33,127 PAVs were detected and 28,912 PAV markers with their primer sequences were designed as the database NJAUSoyPAV_1.0. The PAVs scattered on whole genome while only 518(1.8%) overlapped with simple sequence repeats(SSRs) in BARCSOYSSR_1.0database. In a random sample of 800 PAVs, 713(89.13%) showed polymorphism among the 12 differential genotypes. Using 126 PAVs and 108 SSRs to test a Chinese soybean germplasm collection composed of 828 Glycine soja Sieb. et Zucc. and Glycine max(L.) Merr. accessions, the per locus allele number and its variation appeared less in PAVs than in SSRs. The distinctness among alleles/bands of PCR(polymerase chain reaction) products showed better in PAVs than in SSRs, potential in accurate marker‐assisted allele selection. The association mapping results showed SSR t PAV was more powerful than any single marker systems.The NJAUSoyPAV_1.0 database has enriched the source of PCR markers, and may fit the materials with a range of per locus allele numbers, if jointly used with SSR markers. | Yufeng Wang Jiangjie Lu Shouyi Chen Liping Shu Reid G.Palmer Guangnan Xing Yan Li Shouping Yang Deyue Yu Tuanjie Zhao Junyi Gai | 2014 | Journal of Integrative Plant Biology2014，56，10： | 5 |
| 9 | Molecular mechanisms underlying the cholesterollowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with Iovastatin显示文摘 | Zuo-quan XIE Gai LIANG Lu ZHANG Qi WANG Yi QU Yang GAO Li-bo LIN Sai YE Ji ZHANG Hui WANG Guo-ping ZHAO Qing-hua ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，9： | 5 |
| 10 | Mapping Quantitative Trait Loci Associated with Aluminum Toxin Tolerance in NJRIKY Recombinant Inbred Line Population of Soybean (Glycine max)显示文摘To investigate the genetic mechanism of Al-tolerance in soybean, a recombinant inbred line population (RIL) with 184 F2:7:11 lines derived from the cross of Kefeng No.1 × Nannong 1138-2 (Al-tolerant × Al-sensitive) were tested in pot experiment with sand culture medium in net room in Nanjing. Four traits, i.e. plant height, number of leaves, shoot dry weight and root dry weight at seedling stage, were evaluated and used to calculate the average membership index (FAi) as the indicator of Al-tolerance. The composite interval mapping (CIM) under WinQTL Cartographer v. 2.5 detected five QTLs (i.e. qFAi-1, qFAi- 2, qFAi-3, qFAi-4 and qFAi-5), explaining 5.20%-9.07% of the total phenotypic variation individually. While with the multiple interval mapping (MIM) of the same software, five QTLs (qFAi-1, qFAi-5, qFAi-6, qFAi-7, and qFAi-8) explaining 5.7%-24.60% of the total phenotypic variation individually were mapped. Here qFAi-1 and qFAi-5 were detected by both CIM and MIM with the locations in a same ?anking marker region, GMKF046-GMKF080 on B1 and satt278-sat_95 on L, respectively. While qFAi-2 under CIM and qFAi-6 under MIM both on D1b2 were located in neighboring regions with their confidence intervals overlapped and might be the same locus. Segregation analysis under major gene plus polygene inheritance model showed that Al-tolerance was controlled by two major genes (h2mg = 33.05%) plus polygenes (h2pg = 52.73%). Both QTL mapping and segregation analysis confirmed two QTLs responsible for Al-tolerance with relatively low heritability, and there might be a third QTL, confounded with the polygenes in segregation analysis. | Bo Qi Paul Korir Tuanjie Zhao Deyue Yu Shouyi Chen Junyi Gai | 2008 | Journal of Integrative Plant Biology2008，50，9： | 4 |
| 11 | Intravascular Ultrasound Classification of Plaque in Angiographic True Bifurcation Lesions of the Left Main Coronary Artery显示文摘 | Li Li Debabrata Dash Lu-Yue Gai Yun-Shan Cao Qiang Zhao Ya-Rong Wang Yao-Jun Zhang Jun-Xia Zhang | 2016 | Chinese Medical Journal2016，，13： | 4 |
| 12 | Detecting the QTL-allele system controlling seed-flooding tolerance in a nested association mapping population of soybean显示文摘Soil flooding stress,including seed-flooding,is a key issue in soybean production in highrainfall and poorly drained areas.A nested association mapping(NAM)population comprising 230 lines of two recombinant inbred line(RIL)populations with a common parent was established and tested for seed-flooding tolerance using relative seedling length as indicator in two environments.The population was genotyped using RAD-seq(restriction site-associated DNA sequencing)to generate 6137 SNPLDB(SNP linkage disequilibrium block)markers.Using RTM-GWAS(restricted two-stage multi-locus multiallele genome-wide association study),26 main-effect QTL with 63 alleles and 12 QEI(QTL×environment)QTL with 27 alleles in a total of 33 QTL with 78 alleles(12 dual-effect alleles)were identified,explaining respectively 50.95%and 14.79%of phenotypic variation.The QTL-alleles were organized into main-effect and QEI matrices to show the genetic architecture of seed-flooding tolerance of the three parents and the NAM population.From the main-effect matrix,the best genotype was predicted to have genotypic value 1.924,compared to the parental value range 0.652–1.069,and 33 candidate genes involved in six biological processes were identified and confirmed byχ2 test.The results may provide a way to match the breeding by design strategy. | Muhammad Jaffer Ali Guangnan Xing Jianbo He Tuanjie Zhao Junyi Gai | 2020 | The Crop Journal2020，8，5： | 3 |
| 13 | A New Species of Jiangxialepis(Galeaspida)from the Lower Telychian(Silurian)of Jiangxi and its Biostratigraphic Significance显示文摘A new species of Shuyuidae(Eugaleaspiformes,Galeaspida),Jiangxialepis jiujiangensis sp.nov.,is described from the lower Telychian(Llandovery,Silurian)Qingshui Formation in Jiujiang,Jiangxi Province,China.The new species differs from the type species J.retrospina from Wuhan,Hubei Province in its sharp and posteriorly positioned median dorsal spine and narrow spine-shaped inner cornual processes.The Silurian strata in Xiushui–Wuning area has provided a standard framework for the correlation of Silurian shallow marine red beds in South China.Thus,the finding of J.jiujiangensis from the Silurian Lower Red Beds(LRBs)in Jiangxi Province bears very important biostratigraphic significance.It can directly compare to Jiangxialepis retrospina from the Fentou Formation in Wuhan,Hubei Province in the genus level.This indicates that the age of the fish-bearing strata in Wuhan is most likely to be the early Telychian rather than middle Telychian as previously assumed. | SHAN Xianren ZHAO Wenjin GAI Zhikun | 2023 | Acta Geologica Sinica(English Edition)2023，97，2： | 3 |
| 14 | Electrochemical micromachining of microgroove arrays on phosphor bronze surface for improving the tribological performance显示文摘A high friction coefficient and a low wear rate of contacted surfaces are essential elements to friction pairs between the stator and the rotor in ultrasonic motors. It has been shown that surface textures have a significant effect on improving the tribological performance of friction pairs.In this paper, microgroove arrays are introduced to the stator surface for improving the tribological performance of friction pairs between the stator and the rotor in ultrasonic motors. Microgrooves were fabricated on a phosphor bronze surface by through-mask electrochemical micromachining(TMEMM). Parameters, namely, the electrolyte inlet pressure, applied voltage, pulse duty cycle,and frequency, were varied to investigate their influences on the dimensions and morphology of the microgrooves. Results showed that the width and depth of the microgrooves were strongly affected by the applied voltage and frequency, while the morphology of the microgrooves was dependent on the electrolyte inlet pressure and the pulse duty cycle. Compared with a smooth surface, the friction coefficient increased from 0.245 to 0.334 and less abrasion was obtained when a surface was textured with microgrooves of which the width and depth were 185.6 and 57.6 lm,respectively. Microgroove arrays might play an important role in enhancing the performance of ultrasonic motors. | Xuan ZHOU Ningsong QU Zhibao HOU Gai ZHAO | 2018 | Chinese Journal of Aeronautics2018，31，7： | 3 |
| 15 | Neovascularization in the carotid atherosclerotic plaque is not associated with inflammatory cell aggregation显示文摘 | GAI Jing-jing LIU Hong-bin LI Juan XIE Lei-xing ZHAO Xi-hai CHENG Liu-quan CHEN Hui-jun WANG Yong YIN Da-yi LIU Jia-jin ZHANG Xiong-wei | 2013 | Chinese Medical Journal2013，，16： | 3 |
| 16 | The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice显示文摘Extracellular vesicles(EVs)from mesenchymal stromal cells(MSCs)have previously been shown to protect against brain injury caused by hypoxia-ischemia(HI).The neuroprotective effects have been found to relate to the anti-inflammatory effects of EVs.However,the underlying mechanisms have not previously been determined.In this study,we induced oxygen-glucose deprivation in BV-2 cells(a microglia cell line),which mimics HI in vitro,and found that treatment with MSCs-EVs increased the cell viability.The treatment was also found to reduce the expression of pro-inflammatory cytokines,induce the polarization of microglia towards the M2 phenotype,and suppress the phosphorylation of selective signal transducer and activator of transcription 3(STAT3)in the microglia.These results were also obtained in vivo using neonatal mice with induced HI.We investigated the potential role of miR-21a-5p in mediating these effects,as it is the most highly expressed miRNA in MSCs-EVs and interacts with the STAT3 pathway.We found that treatment with MSCs-EVs increased the levels of miR-21a-5p in BV-2 cells,which had been lowered following oxygen-glucose deprivation.When the level of miR-21a-5p in the MSCs-EVs was reduced,the effects on microglial polarization and STAT3 phosphorylation were reduced,for both the in vitro and in vivo HI models.These results indicate that MSCs-EVs attenuate HI brain injury in neonatal mice by shuttling miR-21a-5p,which induces microglial M2 polarization by targeting STAT3. | Dan-Qing Xin Yi-Jing Zhao Ting-Ting Li Hong-Fei Ke Cheng-Cheng Gai Xiao-Fan Guo Wen-Qiang Chen De-Xiang Liu Zhen Wang | 2022 | Neural Regeneration Research2022，17，10： | 2 |
| 17 | Effect of superfine grinding on properties of ginger powder显示文摘 | Xiaoyan Zhao Zaibin Yang Guosheng Gai Yufeng Yang | 2008 | Journal of Food Engineering2008，，2： | 2 |
| 18 | Comparison of main bioactive compounds in tea infusions with different seasonal Forsythia suspensa leaves by liquid chromatography–tandem mass spectrometry and evaluation of antioxidant activity显示文摘 | Jiao Jiao Qing-Yan Gai Meng Luo Wei Wang Cheng-Bo Gu Chun-Jian Zhao Yuan-Gang Zu Fu-Yao Wei Yu-Jie Fu | 2012 | Food Research International2012，，： | 2 |
| 19 | Warm dense matter research at HIAF显示文摘The research activities on warm dense matter driven by intense heavy ion beams at the new project High Intensity heavy-ion AcceleratorFacility (HIAF) are presented. The ion beam parameters and the simulated accessible state of matter at HIAF are introduced, respectively. Theprogresses of the developed diagnostics for warm dense matter research including high energy electron radiography, multiple-channel pyrometer,in-situ energy loss and charge state of ion detector are briefly introduced. | Rui Cheng Yu Lei Xianming Zhou Yuyu Wang Yanhong Chen Yongtao Zhao Jieru Ren Lina Sheng Jiancheng Yang Zimin Zhang Yingchao Du Wei Gai Xinwen Ma Guoqing Xiao | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 20 | Fusarielin E,a new antifungal antibiotic from Fusarium sp.显示文摘新抗真菌的抗菌素, fusarielin E,从导出水兵的真菌镰刀霉 sp 被孤立。它的结构根据各种各样的 NMR 分光镜的分析和 HR-FAB-MS 被建立。Fusarielin E 对 Pyricularia oryzae 显示了重要生物效能。 | Yue Gai Ling Ling Zhao Chang Qi Hu Hui Ping Zhang | 2007 | Chinese Chemical Letters2007，18，8： | 2 |
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