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| 1 | Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses显示文摘Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication,mouse microglia and astrocytes were isolated,infected with human H1N1 and avian H5N1 influenza viruses,and examined for their immune responses. We observed homogeneously distributed viral receptors,sialic acid (SA)-α2,3-Galactose (Gal) and SA-α2,6-Gal,on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection (p.i.). Expression of IL-1β,IL-6 and TNF-α mRNA examined at 6 h and 24 h p.i. was up-regulated,and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β,IL-6 and TNF-α at 6 h and 24 h p.i. were also induced,with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis,cytopathy,and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. | Gefei Wang Juan Zhang Weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei Lin Xiaoyang Jiao Kangsheng Li | 2008 | Cellular & Molecular Immunology2008，5，2： | 28 |
| 2 | Seasonal variation of eddy kinetic energy in the South China Sea显示文摘Mesoscale eddy activity and its modulation mechanism in the South China Sea (SCS) are investigated with newly reprocessed satellite altimetry observations and hydrographic data. The eddy kinetic energy (EKE) level of basin-wide averages show a distinct seasonal cycle with the maximum in August-December and the minimum in February-May. Furthermore, the seasonal pattern of EKE in the basin is dominated by region offshore of central Vietnam (OCV), southwest of Taiwan Island (SWT), and southwest of Luzon (SWL), which are also the breeding grounds of mesoscale eddies in the SCS. Instability theory analysis suggests that the seasonal cycle of EKE is modulated by the baroclinic instability of the mean flow. High eddy growth rate (EGR) is found in the active eddy regions. Vertical velocity shear in the upper 50-500 m is crucial for the growth of baroclinic instability, leading to seasonal EKE evolution in the SCS. | WANG Hui WANG Dakui LIU Guimei WU Huiding LI Ming | 2012 | Acta Oceanologica Sinica2012，31，1： | 11 |
| 3 | Fault Systems and Their Mechanisms of the Formation and Distribution of the Tarim Basin,NW China显示文摘This article aims to analyze the main controlling factors of development,distribution and evolution of the fault systems in the Tarim Basin.Based on the seismic profile interpretation,comprehensive analysis of the drilling and geologic data,six fault systems maybe recognized in the Tarim Basin,they are the foreland fault system of the South Tianshan Mountain,the northern Tarim uplift fault system,North Tarim depression fault system,central fault system,Southwest Tarim fault system,and Southeast Tarim fault system.It is indicated that the main differences exist at the development,evolution and distribution of the fault systems in the Tarim Basin.The sub-fault systems can be recognized according to the differences of the fault development and distribution in the interior of the fault system.It is characterized that the multi-level differential development and distribution of the fault systems exist in the Tarim Basin.The fault belt developed in the Paleozoic strata mainly distribute at the paleo-uplift and paleo-slope in the interior of the Tarim Basin,and the fault belt occurred in the Meso–Cenozoic beds mainly develop at the peripheral foreland depressions.Zonal and segment differential development and distribution of the fault systems also exist in the Tarim Basin.The formation and distribution of the Tarim fault systems is of complex controlling mechanisms.Poly-phase structural movement and tectonic transition controls the multi-phase differential development and distribution of the fault systems in the Tarim Basin.Multi-level differential development and distribution is controlled by multi-level detachment belt and regional unconformities.Zonal and segment differential development and distribution of the Tarim fault systems maybe controlled by pre-existed basement structural texture.The major direction of the fault systems in the Tarim Basin is controlled by the later stage basin-mountain coupling. | Liangjie Tang Taizhu Huang Haijun Qiu Guimei Wan Meng Li Yong Yang Daqing Xie Gang Chen | 2014 | Journal of Earth Science2014，25，1： | 6 |
| 4 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 5 | Role of Ekman Transport Versus Ekman Pumping in Driving Summer Upwelling in the South China Sea显示文摘Relative roles of Ekman transport and Ekman pumping in driving summer upwelling in the South China Sea(SCS) are examined using QuikSCAT scatterometer wind data.The major upwelling regions in the SCS are the coastal regions east and southeast of Vietnam(UESEV),east and southeast of Hainan Island(UESEH),and southeast of Guangdong province(USEG).It is shown that the Ekman transport due to alongshore winds and Ekman pumping due to offshore wind stress curl play different roles in the three upwelling systems.In UESEV,Ekman pumping and Ekman transport are equally important in generating upwelling.The Ekman transport increases linearly from 0.49 Sv in May to 1.23 Sv in August,while the Ekman pumping increases from 0.36 to 1.22 Sv during the same period.In UESEH,the mean estimates of Ekman transport and Ekman pumping are 0.14 and 0.07 Sv,respectively,indicating that 33% of the total wind-driven upwelling is due to Ekman pumping.In USEG,the mean Ekman transport is 0.041 Sv with the peak occurring in July,while Ekman pumping is much smaller(0.003 on average),indicating that the upwelling in this area is primarily driven by Ekman transport.In the summers of 2003 and 2007 following El Ni o-Southern Oscillation(ENSO) events,both Ekman transport and Ekman pumping decrease in UESEV due to the abnormally weak southwest monsoon.During the same events,however,Ekman transport is slightly enhanced and Ekman pumping is weakened in UESEH and USEG. | WANG Dakui WANG Hui LI Ming LIU Guimei WU Xiangyu | 2013 | Journal of Ocean University of China2013，12，3： | 3 |
| 6 | Spatio-temporal variability of chlorophyll a and its responses to sea surface temperature, winds and height anomaly in the western South China Sea显示文摘To understand the response of marine ecosystem to environmental factors, the oceanographic (physical and biochemical) data are analyzed to examine the spatio-temporal distributions of chlorophyll a (Chl a) associated with surface temperature, winds and height anomaly for long periods (1997-2008) in the western South China Sea (SCS). The results indicate that seasonal and spatial distributions of Chl a are primarily influenced by monsoon winds and hydrography. A preliminary Empirical Orthogonal Function (EOF) analysis of remotely sensed data is used to assess basic characteristics of the response process of Chl a to physical changes, which reveals interannual variability of anomalous low Chl a values corresponding to strong El Ni o (1997-1998), high values corresponding to strong La Ni a (1999-2000), low Chl a corresponding to moderate El Ni o (2001-2003), upward Chl a after warm event in 2005 off the east coast of Vietnam. The variability of Chl a in nearshore and the Mekong River Estuary (MER) waters also suggests its response to these warm or cold processes. Considering the evidence for covariabilities between Chl a and sea surface temperature, winds, height anomaly (upwelling or downwelling), cold waters input and strong winds mixing may play important roles in the spatial and temporal variability of high Chl a. Such research activities could be very important to gain a mechanistic understanding of ecosystem responses to the climate change in the SCS. | GAO Shan WANG Hui LIU Guimei LI Hai | 2013 | Acta Oceanologica Sinica2013，32，1： | 3 |
| 7 | Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference,and delays morphine extinction in rats显示文摘Objective It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP) than either compound alone. Methods A morphine-paired CPP experiment was used to study the effects of low doses of MK-801, ceftriaxone and a combination of both on reward-related memory (acquisition, extinction, and reinstatement of morphine preference) in rats. Results A low dose of neither MK-801 (0.05 mg/kg, i.p.) nor ceftriaxone (25 mg/kg, i.p.) alone effectively impaired CPP behaviors. However, when applied in combination, they reduced the acquisition of morphine-induced CPP and completely prevented morphine reinstatement. Their combination also notably impaired the extinction of morphine-induced CPP. Conclusion The combined action of a low dose of an NMDAR antagonist (MK-801) and GLT-1 activation by ceftriaxone effectively changed different phases of CPP behavior. | Yaodong Fan Haichen Niu Joshua D. Rizak Ling Li Guimei Wang Liqi Xu He Ren Hao Lei Hualin Yu | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 8 | Metathesis of 1-butene and 2-butene to propene over Re_2O_7 supported on macro-mesoporous γ-alumina prepared via a dual template method显示文摘Macro-mesoporous γ-alumina support(MMA) was prepared by a sol-gel route in aqueous medium using pseudo-boehmite as aluminum source and polystyrene microspheres and Pluronic P123 as hard and soft dual templates,respectively.MMA had a BET specific surface area of about 259 m2 g-1,total pore volume of about 1.61 cm3 g-1,macropore diameter of about 102 nm,and mesopore diameter of about 14 nm.Re2O7/MMA and conventional Re2O7/Al2O3 were prepared by a incipient-wetness impregnation method,and their catalytic performances in the metathesis of 1-butene and 2-butene were tested in a fixed-bed tubular reactor.The result showed that Re2O7/MMA possessed higher activity and far longer working life-span than conventional Re2O7/Al2O3. | Lei Sang Sheng-Li Chen Guimei Yuan Min Zheng Ju You Aicheng Chen Rui Li Lanjing Chen | 2012 | Journal of Natural Gas Chemistry2012，21，2： | 2 |
| 9 | Azeotropic distillation-assisted preparation of nanoscale gamma-alumina powder from waste oil shale ash显示文摘 | Baichao An Guijuan Ji Wenying Wang Shucai Gan Jijing Xu Guimei Gao Guanghuan Li | 2009 | Chemical Engineering Journal2009，，1： | 1 |
| 10 | Construction of expressing plasmids of recombinant FN polypeptides with bifunctional-domain and the characterization of the products expressed inE. coli显示文摘 | Feng Zuohua Zhang Guimei Li Dong Zhang Hui | 1996 | Journal of Tongji Medical University1996，，2： | 1 |
| 11 | Soil respiration in a mixed urban forest in China in relation to soil temperature and water content显示文摘 | Wenjing Chen Xin Jia Tianshan Zha Bin Wu Yuqing Zhang Chunyi Li Xiaoping Wang Guimei He Haiqun Yu Guopeng Chen | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 12 | The composite asphalt pavement structure serrice life analysis which setting the graded gravel between the asphalt surface layer and the semi-rigid base layer显示文摘 | SHI GUIMEI LI DONGGUO | 2012 | Advanced Materials Research2012，，： | 1 |
| 13 | Preparation of mesoporous alumina with large pore size and their supported rhenium oxide catalysts in metathesis of 1-butene and 2-butene to propene显示文摘Mesoporous γ-aluminas with large pore size(up to 19 nm,denoted as MA19) are prepared from dispersed pseudo-boehmite using pluronic P123 as template.It is found that these mesoporous alumina supported rhenium oxide catalysts were more active and have far longer working life-span in gas-phase metathesis of 1-butene and 2-butene to propene than rhenium oxide on conventional alumina with small pore size(5 nm).At 60°C and atmospheric pressure with WHSV = 1 h-1,the similar stable conversions of butene(ca.55%) for all the 13 wt% Re 2 O 7 /alumina catalysts were obtained near the chemical equilibrium,and the stable working life-spans of Re 2 O 7 /MA19 were far longer than that of Re 2 O 7 /Al 2 O 3,being about 70 h and 20 h,respectively. | Lei Sang Sheng-Li Chen Guimei Yuan Zheng Zhou Rui Li Aicheng Chen Min Zheng Ju You | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 1 |
| 14 | The composite asphalt pave- ment structure serrice life analysis which setting the graded gravel between the asphalt surface layer and the semi--rigid base layer 显示文摘 | Shi Guimei Li Dongguo | 2012 | Advanced Materials Re- search2012，，44： | 1 |
| 15 | Study on relationbetween banana tissue culture technology and off-type rate显示文摘 | ZOU Yu LIN Guimei WEI Huafang LI Chaosheng LI Xiaoquan MOU Haifei WU Daidong ZHANG Jinzhong | 2008 | Guangxi Horticulture2008，19，6： | 1 |
| 16 | Long noncoding RNAs as potential biomarkers in gastric cancer: Opportunities and challenges显示文摘 | Ziguo Yang Xiaobo Guo Guimei Li Yulong Shi Leping Li | 2015 | Cancer Letters2015，，： | 1 |
| 17 | A hindcast of the Bohai Bay oil spill during June to August 2011显示文摘An operational three-dimensional oil spill model is developed by the National Marine Environmental Forecasting Center(NMEFC), State Oceanic Administration, China, and the model has been running for 9 a. On June 4 and 17,2011, oil is spilled into the sea water from two separate oil platforms in the Bohai Bay, i.e., Platforms B and C of Penglai 19-3 oilfield. The spill causes pollution of thousands of square kilometres of sea area. The NMEFC's oil spill model is employed to study the Penglai 19-3 oil-spill pollution during June to August 2011. The wind final analysis data of the NMEFC, which is based on a weather research and forecasting(WRF) model, are analyzed and corrected by comparing with the observation data. A corrected current filed is obtained by forcing the princeton ocean model(POM) with the corrected wind field. With the above marine environmental field forcing the oil spill model, the oil mass balance and oil distribution can be produced. The simulation is validated against the observation, and it is concluded that the oil spill model of the NMEFC is able to commendably simulate the oil spill distribution. Thus the NMEFC's oil spill model can provide a tool in an environmental impact assessment after the event. | YANG Yiqiu LI Yan LIU Guimei PAN Qingqing WANG Zhaoyi | 2017 | Acta Oceanologica Sinica2017，36，11： | 1 |
| 18 | Model Free Adaptive Predictive Control of Desulfurization Slurry pH Based on CPS Framework显示文摘In order to improve the slurry pH control accuracy of the absorption tower in the wet flue gas desulfurization process,a model free adaptive predictive control algorithm for the desulfurization slurry pH which is based on a cyber physical systems framework is proposed.First,aiming to address system characteristics of non-linearity and pure hysteresis in slurry pH change process,a model free adaptive predictive control algorithm based on compact form dynamic linearization is proposed by combining model free adaptive control algorithm with model predictive control algorithm.Then,by integrating information resources with the physical resources in the absorption tower slurry pH control process,an absorption tower slurry pH optimization control system based on cyber physical systems is constructed.It is turned out that the model free adaptive predictive control algorithm under the framework of the cyber physical systems can effectively realize the high-precision tracking control of the slurry pH of the absorption tower,and it has strong robustness. | Jian Liu Xiaoli Li Kang Wang Fuqiang Wang Guimei Cui | 2020 | Journal of Beijing Institute of Technology2020，29，4： | 0 |
| 19 | Identification of the primary motor area by three-dimensional reconstruction of the corticospinal tract using diffusion tensor imaging显示文摘Functional MRI (fMRI) is widely used as a non-invasive method for the evaluation of pre-operation motor function.However,patients with cortical function impairment,such as those with hemiparesis,can rarely achieve hand clenching,a typical fMRI task for central sulcus identification,and the method is also of limited use in uncooperative children.Thus,it is important to develop a new method for identifying primary motor areas (PMA) in such individuals.This study used corticospinal tractography to identify the PMA in 20 patients with deep-seated brain tumor.Two regions of interest were set within the brainstem for corticospinal tract (CST) fiber tracking:one at the level of the pons and the other at the level of the cerebral peduncle.The CST fiber tracking results and fMRI activation signals were merged with three-dimensional anatomic MRI findings.The consistency of identifying the PMA by CST and fMRI was analyzed.fMRI activation signals were distributed mainly in the contralateral central sulcus around the omega-shaped hand knob.The CST consistently propagated from the pons and cerebral peduncle to the suspected PMA location.There was a good correlation between CST fiber tracking results and fMRI activation signals in terms of their abilities to identify the PMA.The differences between fMRI and CST fiber tracking findings may result from our functional task,which consisted only of hand movements.Our results indicate that diffusion tensor imaging is a useful brain mapping technique for identifying the PMA in paralyzed patients and uncooperative children. | Guojun Deng Luo Li Guimei Chen Erming Zeng Xiangzuo Xiao Meihua Li Tao Hong Donghai Li | 2011 | Neural Regeneration Research2011，6，14： | 0 |
| 20 | 甲羟戊酸通路是疫苗佐剂研发的可药化靶点显示文摘文章简介佐剂是疫苗的一部分,能帮助疫苗更快速、持久地产生免疫应答。在现代疫苗的研发中,佐剂有着不可或缺的作用。但是到目前为止,FDA批准上市的佐剂只有铝佐剂,MF-59,AS03以及AS04等几种。 | 夏贇 谢永华 于正森 Hongying Xiao Guimei Jiang Xiaoying Zhou Yunyun Yang Xin Li Meng Zhao Liping Li Mingke Zheng Shuai Han Zhaoyun Zong Xianbin Meng Haiteng Deng Huahu Ye Yunzhi Fa Haitao Wu Eric Oldfield Xiaoyu Hu 刘万里 石彦 张永辉 | 2019 | 科学新闻2019，0，2： | 0 |
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