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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | Laparoscopic pancreaticoduodenectomy: experience of 22 cases显示文摘 | Francesco Corcione Felice Pirozzi Diego Cuccurullo Domenico Piccolboni Valerio Caracino Francesco Galante Daniele Cusano Antonio Sciuto | 2013 | Surgical Endoscopy2013，，6： | 5 |
| 3 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 4 | Sensing Sulfur Conditions: Simple to Complex Protein Regulatory Mechanisms in Plant Thiol Metabolism显示文摘硫是必要的因为植物生长和开发,和为维持硫和 thiol 新陈代谢的分子的系统紧被控制。从一个生物化学的观点,植物 thiol 新陈代谢的规定加亮自然的能力设计在条件的一个范围下面对多重输入和细胞的要求作出回应的小径。在这评论,我们集中于形成生物化学的硫由把包含硫的混合物的细胞内部的集中翻译成关键新陈代谢的步骤的控制在植物察觉到的分子的基础的规章的机制。这些机制从简单(底层可获得性,反应的热力学的性质,反馈抑制,和细胞器本地化) 到精致(multienzyme 建筑群和基于 thiol 的氧化还原作用开关的形成) 。最终,这些规章的系统的动态相互影响为在植物察觉到并且维持硫吸收和 thiol 新陈代谢是批评的。 | Hankuil Yi Ashley Galant Geoffrey E. Ravilious Mary L. Preuss Joseph M. Jez | 2010 | Molecular Plant2010，3，2： | 4 |
| 5 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 6 | Anomalous behaviour detection using one-class support vector machine and remote sensing images: a case study of algal bloom occurrence in inland waters显示文摘Algal blooms are a frequent subject in scientific discussions and are the focus of many recent studies,mainly due to their adverse effect on society.Given the lack of ground truth data and the need to develop tools for their detection and monitoring,this research proposes a novel method to automate detection.Concepts derived from multi-temporal image series processing,spectral indices and classification with Oneclass Support Vector Machine(OC-SVM)are used in this proposal.Imagery from multi-spectral sensors on Landsat-8 and MODIS were acquired through the Google Earth Engine API(GEE API).In order to evaluate our method,two bloom detection case studies(Lake Erie(USA)and Lake Taihu(China))were performed.Comparisons were made with methods based on spectral index thresholds.Also,to demonstrate the performance of the OC-SVM classifier compared to other machine learning methods,the proposal was adapted to be used with a Random Forest(RF)classifier,having its results added to the analysis.In situ measurements show that the proposed method delivers highly accurate results compared to spectral index thresholding approaches.However,a drawback of the proposal refers to its higher computational cost.The application of the new method to a real-world bloom case is demonstrated. | Pedro Henrique Moraes Ananias Rogério Galante Negri | 2021 | International Journal of Digital Earth2021，14，7： | 2 |
| 7 | Focal Expression and Final Activity of Matrix Metalloproteinases May Explain Irregular Dysfunctional Endometrial Bleeding显示文摘 | Christine Galant Martine Berlière Dominique Dubois Jean-Christophe Verougstraete Alain Charles Pascale Lemoine Isabelle Kokorine Yves Eeckhout Pierre J. Courtoy Etienne Marbaix | 2004 | The American Journal of Pathology2004，，1： | 2 |
| 8 | The treatment of stable and unstable proximal femoral fractures with a new trochanteric nail: results of a multicentre study with the Veronail显示文摘 | Franco Lavini L. Renzi-Brivio R. Aulisa F. Cherubino P. L. Seglio N. Galante W. Leonardi M. Manca | 2008 | Strategies in Trauma and Limb Reconstruction2008，，1： | 2 |
| 9 | The impact of the COVID-19 pandemic on the mental health of young people:A comparison between China and the United Kingdom显示文摘Purpose:As COVID-19 spreads globally and affects people's health,there are concerns that the pandemic and control policies may have psychological effects on young people(age from 17 to 35 years).This psychological impact might vary in different countries,and thus we compared the prevalence of self-reported psychological distress,loneliness and posttraumatic stress symptoms(PTSS)among young people in the United Kingdom(UK)and China at the beginning of the COVID-19 pandemic.Methods:Data of this study came from two sources.One source was the first wave of COVID-19 study in Understanding Society,a special wave of the UK household longitudinal study,which provided the high-quality,national-wide representative panel data.The sample comprised 1054 young people.The other source was an online survey on the mental health of 1003 young people from Shanghai,a highly developed area in China.The questionnaire included questions on the prevalence of common mental disorders(cut-off score≥4),loneliness and potential PTSS(cut-off≥33).Univariable analyses were conducted to test the differences in the self-reported prevalence of psychological distress and loneliness between the two groups.Multivariable logistic regression analyses were run to explore the predictors of psychological distress and loneliness among all the young people from England and Shanghai.Results:Among the samples with self-reported psychological distress,the UK sample accounted for 34.4%(n=1054)and the Chinese sample accounted for 14.1%(n=1003).The difference between the two groups was statistically significant(p<0.001).Additionally,57.1%of people in the UK and 46.7%in China reported that they sometimes or often felt lonely,of which the difference is statistically significant(p<0.001).Regression analysis of the entire samples showed that nationality,gender,psychotherapy and loneliness were significant predictors of 12-item General Health Questionnaire scores,while the variables of age and living alone were not.Significant predictors of self-reported loneliness were the nationality,gender,age,living alone and psychotherapy.In China,123(12.3%)young people,49 men(11.3%)and 74 women(13.0%),met the criteria of PTSS symptoms(cut-off scores≥33).These scores were only collected in China.Conclusion:This evidence suggests that mental health and loneliness reported by young people were lower in China than that in the UK during the studied period.More research is needed to understand these differences.If the differential negative psychological impacts are confirmed,country-specific measures of prevention and intervention should be adopted to improve the mental health of young people under the ongoing impact of the pandemic. | Ming-Bo Liu Geraldine Dufour Zhuo-Er Sun Julieta Galante Chen-Qi Xing Jing-Ye Zhan Li-Li Wu | 2021 | Chinese Journal of Traumatology2021，24，4： | 2 |
| 10 | Scouring of flax rove with the aid of enzymes显示文摘 | Ossola M Galante Y M | 2004 | Enzyme and Microbial Technology2004，，34： | 1 |
| 11 | Medical diagnostic X-ray and thyroid cancer显示文摘 | Inskip PD Ekbon A Galant MR | 1995 | J Natl Cance Inst1995，87，： | 1 |
| 12 | Normal Variants and Frequent Marrow Alterations that Simulate Bone Marrow Lesions at MR Imaging显示文摘 | Bruno C. Vande Berg Frédéric E. Lecouvet Christine Galant Baudouin E. Maldague Jacques Malghem | 2005 | Radiologic Clinics of North America2005，，： | 1 |
| 13 | Air surgical residents prepared for mass casualty inci- dents J Surg Res显示文摘 | Galante J M | 2004 | 121 (2) :273-7612004，121，2： | 1 |
| 14 | Alternative splicing and genetic diversity: silencers are more frequently modified by SNVs associated with alternative exon/intron borders显示文摘 | de Souza JES Ramalho RF Galante PAF | 2011 | Nucleic Acids Research2011，39，： | 1 |
| 15 | The biologic effects of implant materials显示文摘 | Galante JO Lemons J Spector I | 1991 | J Orthop Res1991，9，5： | 1 |
| 16 | Spondylolisthesis and tight hamstrings显示文摘 | Barash HL Galante JO Lambert CN | 1970 | J Bone Joint Surg1970，52，： | 1 |
| 17 | A non-isothermal, non-equimolar transient kinetic model for gas-solid reactions显示文摘 | PATISSON F GALANT FRANCOIS M ABLITZER D | 1998 | Chem Eng Sci1998，53，4： | 1 |
| 18 | An analysis of blood management in patients having a total hip or knee arthroplasty显示文摘 | Bierbaum BE Callaghan JJ Galante JO | 1999 | J Bone Joint Surg Am1999，81，1： | 1 |
| 19 | Compositional and structural characterization of pectic material from Frozen Concentrated Orange Juice 显示文摘 | Galant A L Luzio GA Widmer W W | 2014 | Food Hydrocolloids2014，35，： | 1 |
| 20 | An analysis of blood management in patients having a total hip or knee arthroplasty显示文摘 | Bierdaum BE Callaghan JJ Galante JO | 1999 | J Bone Joint Surg Am1999，210，： | 1 |
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