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| 1 | Utilisation of transparent synthetic soil surrogates in geotechnical physical models: A review显示文摘Efforts to obtain non-intrusive measurement of deformations and spatial flow within soil mass prior to the advent of transparent soils have perceptible limitations. The transparent soil is a two-phase medium composed of both the synthetic aggregate and fluid components of identical refractive indices aiming at attaining transparency of the resulting soil. The transparency facilitates real life visualisation of soil continuum in physical models. When applied in conjunction with advanced photogrammetry and image processing techniques, transparent soils enable the quantification of the spatial deformation, displacement and multi-phase flow in physical model tests. Transparent synthetic soils have been successfully employed in geotechnical model tests as soil surrogates based on the testing results of their geotechnical properties which replicate those of natural soils. This paper presents a review on transparent synthetic soils and their numerous applications in geotechnical physical models. The properties of the aggregate materials are outlined and the features of the various transparent clays and sands available in the literature are described. The merits of transparent soil are highlighted and the need to amplify its application in geotechnical physical model researches is emphasised. This paper will serve as a concise compendium on the subject of transparent soils for future researchers in this field. | Abideen Adekunle Ganiyu Ahmad Safuan A.Rashid Mohd Hanim Osman | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，4： | 12 |
| 2 | In vitro inhibition activity of polyphenol-rich extracts from Syzygium aromaticum(L.)Merr.& Perry(Clove)buds against carbohydrate hydrolyzing enzymes linked to type 2 diabetes and Fe^(2+)-induced lipid peroxidation in rat pancreas显示文摘Objective:To investigate and compare the inhibitor)'properties)of free and bound phenolic extracts of clove bud against carbohydrate hydrolyzing enzymes(alpha-amylase&alphaglucosidase)and Fe^(2+)-induced lipid peroxidation in rat pancreas in vitro.Methods:The free phenolics were extracted with 80%.(v/v)acetone,while bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate.Then,the interaction of the extracts with alpha-amylase and alpha-glucosidase was subsequently assessed.Thereafter,the total phenolic contents and antioxidant activities of the extracts were determined.Results:The result revealed that both extracts inhibited alpha-amylase and alpha-glucosidase in a dose-dependent manner.However,the alpha-glucosidase inhibitory activity of the extracts were significantly(P<0.05)higher than their alpha-amylase inhibitory activity.The free phenolics(31.67 mg/g)and flavonoid(17.28 mg/g)contents were significantly(P<0.05)higher than bound phenolic(23.52 mg/g)and flavonoid(13.70 mg/g)contents.Both extracts also exhibited high antioxidant activities as typified by their high reducing power,LI diphenyl-2-picrylhydrazyl(DPPH)and 2,2-azinobis-3-ethylbenzo-thiazoline-6-sulfonate(ABTS)radical scavenging abilities,as well as inhibition of Fe^(2+)-induced lipid peroxidation in rat pancreas in vitro.Conclusions:This study provides a biochemical rationale by which clove elicits therapeutic effect on type 2 diabetes. | Stephen Adeniyi Adefegha Ganiyu Oboh | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 11 |
| 3 | Differential degradation of crude oil (Bonny Light) by four Pseudomonas strains显示文摘Four hydrocarbon degraders isolated from enriched oil-and asphalt-contaminated soils in Lagos,Nigeria,were tested for their petroleum degradation potentials.All the isolates were identified as species of Pseudomonas.Pseudomonas putida P11 demonstrated a strong ability to degrade kerosene,gasoline,diesel,engine oil and crude oil while P.aeruginosa BB3 exhibited fair degradative ability on crude oil,gasoline,engine oil,anthracene and pyrene but weak on kerosene,diesel and dibenzothiophene.Pseudomonas putida WL2 and P.aeruginosa MVL1 grew on crude oil and all its cuts tested with the latter possessing similar polycyclic aromatic potentials as P11.All the strains grew logarithmically with 1-2 orders of magnitude and with generation time ranging significantly between 3.07 and 8.55 d at 0.05 level of confidence.Strains WL2 and MVL1 utilized the oil substrate best with more than 70% in 6 d experimental period,whereas the same feat was achieved by P11 in 12 d period.BB3 on the other hand degraded only 46% within 6 d.Interestingly,data obtained from gas chromatographic analysis of oil recovered from the culture fluids of MVL1 confirmed near-disappearance of major peaks(including aliphatics and aromatics) in the hydrocarbon mixture. | Oluwafemi S.Obayori Sunday A.Adebusoye Adams O.Adewale Ganiyu O.Oyetibo Odunola O.Oluyemi Rashid A.Amokun Matthew O.Ilori | 2009 | Journal of Environmental Sciences2009，21，2： | 10 |
| 4 | Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes显示文摘Objective:To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica(M.indica) and Mucuna urens(M.urens) seeds extracts against some key enzymes(-amylase,-glucosidasc and aldose reductase) implicated in the pathology and complications of type 2 diabetes in vitro.Methods:Reverse phase chromatographic quantification of the major flavonoids and phenolic acids in the seeds extracts was carried out using high performance liquid chromatography coupled with diode array detection.The inhibitory activities of the seeds extracts against-amylase and-glucosidase were estimated using soluble starch and p-nitrophenylglucopyranosidc as their respective substrates.Inhibition of aldose reductase activity by the extracts was assayed using partially purified lens homogenate of normal male rat as source of enzyme;inhibition of Fe^(2+)-induced lipid peroxidation by extracts was tested in rat pancreas homogenate.Results:The chromatography result revealed that extracts of both seeds had appreciable levels of some major flavonoids and phenolic acids of pharmacological importance,including gallic acid,chlorogenic acid,caffeic acid,ellagic acid,catechin,rutin,quercitrin.quercetin and kaempferol.Extracts of both seeds effectively inhibited-amylase,-glucosidase and aldose reductase activities in a dose-dependent manner,having inhibitory preference for these enzymes in the order of aldose reductase>-glucosidase>-amylase.With lower half-maximal inhibitory concentrations(IC50)against-amylase,-glucosidase,and aldose reductase,M.indica had stronger inhibitory potency against these enzymes than M.urens.Extracts of both seeds also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,with M.indica being more potent than M.urens.Conclusions:The results obtained provide support for a possible use of M.indica and M.urens seeds in managing hyperglycemia and preventing the complications associated with it in type 2diabetes. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Afolabi Akintunde Akindahunsi Aline Augusti Boligon Margareth Linde Athayde | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，11： | 4 |
| 5 | Attenuation of oxidative stress and hepatic damage by some fermented tropical legume condiment diets in streptozotocin-induced diabetes in rats显示文摘Objective:To investigate the modulatory effect of fermented legume condiments diet on oxidative stress in streptozotocin(STZ) induced diabetic rats.Methods:Adult male Wistar rats were randomly divided into six groups with six animals in each group.Diabetes was induced by intraperitoneal injection of STZ(35 mg/kg b.w.).After being confirmed diabetic,the rats were fed with fermented Bambara groundnut.Locust bean and Soybean diets for 14 days.The plasma was obtained after 14-day treatment and analyzed for hepatic damage marker enzymes(AST,ALT and ALP) and in vivo antioxidant indices.Results:The diabetic untreated rats showed elevated (P<0.05) levels of AST,ALT.ALP and malondialdehyde with reduced activities of glutathiones -transferase,catalase as well as plasma reduced glutathione,vitamin C and total protein content.However,treatment of diabetic rats with lermenled legume condiments diets for 14 days significantly(P<0.05) reversed the above parameters towards normalcy,suggesting their modulation of oxidative stress,which mav be due to their high phenolic content and antioxidant capacity.Conclusions:The attenuation of oxidative stress and protection of hepatic tissue damage by the legume condiment diets in STZ induced diabetic rats compare favourably with that of metformin,a well known oral hypoglycemic drug. | Adedayo O Ademiluyi Ganiyu Oboh | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 3 |
| 6 | Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro显示文摘The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in vitro.Phenolics(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric methods.The extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to health.The extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent manner.The half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(P<0.05),and were in the order of liver>kidney>lungs.The extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>kidney.T.tetraptera fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola Aline Augusti Boligon Margareth Linde Athayde | 2016 | Food Science and Human Wellness2016，5，1： | 3 |
| 7 | Antioxidant properties of aqueous extracts of unripe Musa Paradisiaca on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro显示文摘Objective:To evaluate and compare antioxidant activities of the aqueous extracts of unripe plantain(Musa paradisiaca),assess their inhibitory action on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro and to cliaracterize the main phenolic constituents of the plantain products using gas chromatography analysis.Methods:Aqueous extracts of plantain products(raw,elastic pastry,roasted and boiled)(lour ol 0.1 g/mL(each)were used to determine their total phenol,total flavonoid,1,1 diphenyl-2 picrylhydrazyl(DPPH)and hydroxyl(OH)radical scavenging ability.The inhibitory effect of the extracts on sodium nitropmsside induced lipid peroxidation was also determined.Results:The results revealed that all the aqueous extracts showed antioxidant activity.The boiled Hour had highest DPPH and OH radical scavenging ability while raw Hour had the highest Fe^(2+)chelating ability,sodium nilroprusside inhibitor)effect and vitamin C content.The antioxidant results showed that elastic pastry had the highest total phenol and total flavonoid content.Characterization of the unripe plantain products for polyphenol contents using gas chromatography showed varied quantity of apigenin,myricetin.luteolin,capsaicin,isorhaemnetin.caffeic acid,kampferol,quercetin,p-hydroxybenzoic acid,shogaol,glycitein and gingerol per product on the spectra.Conclusions:Considering the antioxidant activities and ability to inhibit lipid peroxidation of unripe plantain,this could justify their traditional use in the management/prevention of diseases related to stress. | Sidiqat Adamson Shodehinde Ganiyu Oboh | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 2 |
| 8 | Methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours inhibit some key enzymes linked to the pathology and complications of type 2 diabetes in vitro显示文摘The inhibitory effect of methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours on some key enzymes[α-amylase,α-glucosidase and aldose reductase(AR)]linked to the pathology and complications of type 2 diabetes(T2D);and their antioxidant properties were evaluated.The antioxidant properties evaluated were DPPH•and ABTS•^+scavenging abilities,reducing power,and antioxidant phytochemicals(total phenolics,tannins,total flavonoids and total saponins).Extracts of both flours inhibitedα-amylase,α-glucosidase and AR in a dose-dependent manner.The half-maximal inhibitory concentrations(IC50)of B.eurycoma onα-amylase,α-glucosidase,AR and lipid peroxidation were lower than those of D.microcarpum,indicating that it had stronger inhibitory potency than D.microcarpum.B.eurycoma also had significantly(P<0.05)higher DPPH•and ABTS•^+scavenging abilities,and reducing power than D.microcarpum.The antioxidant phytochemicals(total phenolics,tannins,total flavonoids and total saponins)were also significantly(P<0.05)higher in B.eurycoma than D.microcarpum.The inhibitory effect of B.eurycoma and D.microcarpum extracts onα-amylase,α-glucosidase and AR activities may be attributed to the combined action of their polyphenols and total saponins,and this may be a possible mechanism of action providing support for their use in managing hyperglycemia and the complications of T2D. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Afolabi Akintunde Akindahunsi | 2015 | Food Science and Human Wellness2015，4，4： | 1 |
| 9 | Modulatory effects of dietary inclusion of garlic(Allium sativum) on gentamycin-induced hepatotoxicity and oxidative stress in rats显示文摘Objective:To investigate die ameliorative effect of dietary inclusion of garlic(Allium sativum)on gentamycin-induced hepatotoxicity in rats.Methods:Adult male rats were randomly divided into four groups with sis animals in each group.Groups 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2%and 4%garlic respeetively for 27 d prior to gentamycin administration.Hepatotoxicity was induced by the intraperitoneal administration at gentamycin(100 mg/kg body weight)for 3 d.The liver and plasma were studied for hepatotoxicity and antioxidant indices.Results:Gentamycin induces hepatic damage as revealed by significant(P<0.05)elevation of liver damage marker enzymes(aspartate transaminase and alanine aminotransferase)and reduction in plasma albumin level.Gentamycin also eaused a significant(P<0.05)alteration in plasma and liver enzymatic(catalase,glutathione and super oxygen dehydrogenises)and non-enzymatic(glutathione and vitamin C)antioxidant indices with concomitant increase in the malondialdehyde content;however,there was a significant(P<0.05)restoration of the antioxidant status coupled with significant(P<0.05)decrease in the tissues malondialdehyde content,following consumption of diets containing garlic.Conclusions:These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity,improve antioxidant status and modulate oxidative stress;a function attributed to their phenolic constituents. | Adedayo O Ademiluyi Ganiyu oboh Tosin R Owoloye Oluwaseun J Agbebi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 1 |
| 10 | Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto ( Bixa orellana ) seeds显示文摘 | Ganiyu Oboh Toyin L. Akomolafe Stephen A. Adefegha Abayomi O. Adetuyi | 2010 | Experimental and Toxicologic Pathology2010，，3： | 1 |
| 11 | Larval habitats of mosquito fauna in Osogbo metropolis,Southwestern Nigeria显示文摘Objective:To determine the larval habitats of mosquito fauna and possible impact of land use/land cover changes on the epidemiology of mosquito-bome diseases in Osogbo metropolis,Southwestern,Nigeria.Methods:All accessible larval habitats were surveyed between May and September,2011in Osogbo metropolis while Land Use/Land cover of the city was analyzed using 2 Lansat Multispectral Scanner satellite imagery of SPOT 1986 and T.ANDSAT TM 2009.Results:A total of six species namely,Aedes aegypti,Aedes albopictus,Aedes vittatus,Anopheles gambiae complex,Culex quinquefascialus and Erelmapodite chrysogaster were encountered during the study.The occurrence and contribution of disused tyres was significantly higher(P<0.05)than the other habitats encountered,while there were no significant differences in the contribution of gutters/run-offs.septic tanks/drums,ground pools/open drains and discarded containers lo the breeding of mosquitoes(P>0.05).The accessible land use/land covered of the study area between 1986 and 2009 showed that the wet land coverage and settlement area increased from 0.19 lo 9.09 hectare and 1.00 to 2.01 hectare respectively while the forest area decreased from 60.18 to 50.14 hectare.Conclusion:The contribution of the habitats coupled with the increasing rale of flooded environment which could provide ample breeding sites for mosquitoes call for sustained environmental sanitation and management in Osogbo metropolis. | Monsuru Adebayo Adeleke Wasiu Olalekan Adebimpe Abdulwasiu Oladele Hassan Sunday Olukayode Oladejo IsmailOlaoye Ganiyu Olatunji Olatunde Taiwo Adewole | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 1 |
| 12 | Antioxidant properties of methanolic extracts of mistletoes(viscum album)from cocoa and cashew trees in Nigeria显示文摘 | OLUWASEUN A A GANIYU O | 2008 | African Journal of Biotechnology2008，7，17： | 1 |
| 13 | Coupling of membrane filtration and advanced oxidation processes for removal of pharmaceutical residues: A critical re- view 显示文摘 | Ganiyu S O Van Hullebusch E D Cretin M Esposito G Otu- ran M A | 2015 | Separation and Purification Technology2015，1563，： | 1 |
| 14 | Effects of Acupuncture, Core-stability Exercises, and Treadmill Walking Exercises in Treating a Patient with Postsurgical Lumbar Disc Herniation: A Clinical Case Report显示文摘 | Sokunbi Oluwaleke Ganiyu Kachalla Fatimah Gujba | 2014 | Journal of Acupuncture and Meridian Studies2014，，： | 1 |
| 15 | Plasma Nitric Oxide and Acute Phase Proteins after Moderate and Prolonged xercises显示文摘 | Kazeem A Olubayo A Ganiyu A | 2012 | Iran J Basic Med Sci2012，15，1： | 1 |
| 16 | Antioxidant properties of methanolic extracts of mistletoes(Viscum album)from cocoa and cashew trees in Nigeria显示文摘 | Oluwaseun A A Ganiyu O | 2008 | African Journal of Biotechnology2008，7，17： | 1 |
| 17 | Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto ( Bixa orellana ) seeds显示文摘 | Ganiyu Oboh Toyin L. Akomolafe Stephen A. Adefegha Abayomi O. Adetuyi | 2010 | Experimental and Toxicologic Pathology2010，，3： | 1 |
| 18 | Mechanisms of medicinal plants in the treatment of diabetic wound显示文摘Wound repair is noticeably prolonged in a diabetic state due to a faulty inflammatory process and an underlying neuropathy.Several medicinal plants and their products have been of prime importance for the management of wounds over the years.Various mechanisms whereby medicinal plants elicit their action in wound repair are revealed and some plants are proven to be experimentally effective in enhancing wound closure and achieving healing.The mechanisms identified include hyperglycemic control,alleviation of physiological inflammation,controlled oxidative stress,infection control,and influence on gene expression.Information in this review was sourced from research and review articles in electronic databases such as Web of Science,Scopus,PubMed,and Google Scholar. | Oluwakemi V.Adeleke Stephen A.Adefegha Ganiyu Oboh | 2023 | Asian Pacific Journal of Tropical Biomedicine2023，13，6： | 0 |
| 19 | Phenolics from grapefruit peels inhibit HMG-CoA reductase and angiotensin-I converting enzyme and show antioxidative properties in endothelial EA.Hy 926 cells显示文摘This study sought to investigate the possible mechanisms for the use of phenolic extracts from grapefruit peels in the management/prevention of cardiovascular complications.The effects of the phenolic extracts on key enzymes relevant to cardiovascular diseases[3-hydroxy-methyl-3-glutaryl coenzyme A reductase(HMG-CoA reductase)and angiotensin-I converting enzyme(ACE)],cellular antioxidant activity in human endothelial cells(EA.Hy 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS)]scavenging abilities were investigated.The phenolic contents of the extracts were investigated using HPLC–DAD.There was no significant(P>0.05)difference in the HMG-CoA reductase inhibitory ability of the two extracts,while the bound phenolic extracts had a stronger ACE inhibitory ability than the soluble free phenolics.The extracts also showed intracellular antioxidant activity in human endothelial(EA.Hy 926)cells.Furthermore,the bound phenolics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free phenolics.The HPLC analysis revealed the presence of flavonoids(quercetin and kaempferol),phenolics acids(resveratrol,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antioxidative properties and inhibition of enzymes relevant to the management of cardiovascular complications showed that grapefruit peels could be used as nutraceuticals for the management of such conditions. | Ayokunle O.Ademosun Ganiyu Oboh Sabina Passamonti Federica Tramer Lovro Ziberna Aline Augusti Boligon Margareth Linde Athayde | 2015 | Food Science and Human Wellness2015，4，2： | 0 |
| 20 | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination显示文摘Background:Children with sickle cell disease(SCD)are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread.This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine.Method:The levels of humoral(innate and adaptive)immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD.Serum innate humoral immune factors[Complement factors(C1q and C4),transferrin,ferritin,and C-reactive protein(CRP)]and adaptive humoral immune factors[IgG,IgA,IgM,and IgE]were determined using ELISA.Nutritionally essential trace elements such as iron(Fe),copper(Cu),and zinc(Zn)were measured also using an atomic absorption spectrophotometer.Results:The serum levels of certain innate humoral immune factors(ferritin,CRP,and C4),only one adaptive humoral immune factors(IgE),and essential trace elements(Fe,Zn,and Cu)were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels.Conclusion:Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors.This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD. | Ganiyu Olatunbosun Arinola Elizabeth Disu Adedokun Babatunde Christopher Olopade Olufunmilayo Olopade | 2022 | Blood Science2022，4，3： | 0 |
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