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| 1 | Approximate Maximum Likelihood Algorithm for Moving Source Localization Using TDOA and FDOA Measurements显示文摘A closed-form approximate maximum likelihood(AML) algorithm for estimating the position and velocity of a moving source is proposed by utilizing the time difference of arrival(TDOA) and frequency difference of arrival(FDOA) measurements of a signal received at a number of receivers.The maximum likelihood(ML) technique is a powerful tool to solve this problem.But a direct approach that uses the ML estimator to solve the localization problem is exhaustive search in the solution space,and it is very computationally expensive,and prohibits real-time processing.On the basis of ML function,a closed-form approximate solution to the ML equations can be obtained,which can allow real-time implementation as well as global convergence.Simulation results show that the proposed estimator achieves better performance than the two-step weighted least squares(WLS) approach,which makes it possible to attain the Cramér-Rao lower bound(CRLB) at a sufficiently high noise level before the threshold effect occurs. | YU Huagang HUANG Gaoming GAO Jun WU Xinhui | 2012 | Chinese Journal of Aeronautics2012，25，4： | 28 |
| 2 | Particle flters for probability hypothesis density flter with the presence of unknown measurement noise covariance显示文摘In Bayesian multi-target fltering,knowledge of measurement noise variance is very important.Signifcant mismatches in noise parameters will result in biased estimates.In this paper,a new particle flter for a probability hypothesis density(PHD)flter handling unknown measurement noise variances is proposed.The approach is based on marginalizing the unknown parameters out of the posterior distribution by using variational Bayesian(VB)methods.Moreover,the sequential Monte Carlo method is used to approximate the posterior intensity considering non-linear and non-Gaussian conditions.Unlike other particle flters for this challenging class of PHD flters,the proposed method can adaptively learn the unknown and time-varying noise variances while fltering.Simulation results show that the proposed method improves estimation accuracy in terms of both the number of targets and their states. | Wu Xinhui Huang Gaoming Gao Jun | 2013 | Chinese Journal of Aeronautics2013，26，6： | 9 |
| 3 | Cadmium pollution enhanced ozone damage to winter wheat:biochemical and physiological evidences显示文摘Combined effects of ozone (O3) and cadmium (Cd) on growth and physiology of winter wheat (Triticum aestivum L.cv.JM22) were determined.Wheat plants were grown without or with Cd and exposed to charcoal-filtered air (< 10 ppb O3) or elevated O 3 (80 ± 5 ppb,7 hr/day) for 20 days.Results showed that O 3 considerably depressed light saturated net photosynthetic rate (-20%),stomatal conductance (-33%),chlorophyll content (-33%),and total biomass (-29%) without Cd.The corresponding decreases were further enhanced by 45%,56%,60% and 59%,respectively with Cd,indicating a synergistic effect of O3 and Cd on wheat.Ozone significantly increased the activity of superoxide dismutase (46%),catalase (48%) and peroxidase (56%).However,great increases in malondialdehyde (MDA) content (2.55 folds) and intercellular CO2 concentration (1.13 folds) were noted in O3 +Cd treatment compared to control.Our findings demonstrated that the increased anti-oxidative activities in wheat plants exposed to O3 +Cd might not be enough to overcome the adverse effects of the combination of both pollutants as evidenced by further increase in MDA content,which is an important indicator of lipid peroxidation.Precise prediction model on O3 damages to crop should be conducted to ensure agricultural production security by considering environmental constraints in an agricultural system in peri-urban regions. | Yong Li Caihong Li Yanhai Zheng Guanglei Wu Tana Wuyun Hong Xu Xinhua He Gaoming Jiang | 2011 | Journal of Environmental Sciences2011，23，2： | 7 |
| 4 | Two-dimensional LDH nanodisks modified with hyaluronidase enable enhanced tumor penetration and augmented chemotherapy显示文摘The condensed tumor extracellular matrix(ECM)consisting of cross-linked hyaluronic acid(HA)is one of the key factors that result in the aberrant tumor microenvironment and severely impair drug delivery and tumor penetration.Herein,we report a simple design of a hyaluronidase(HAase)-modified layered double hydroxide(LDH)nanoplatform loaded with anticancer drug doxorubicin(DOX)for enhanced tumor penetration and augmented chemotherapy.In our approach,LDH nanodisks were synthesized via a co-precipitation method,modified with HAase by electrostatic attraction,and finally physically loaded with DOX.The formulated DOX/LDH-HAase complexes show a high DOX loading percentage of 34.2%with good colloidal stability,retain 86.1%of the enzyme activity,and release DOX in a pH-responsive manner having a faster release rate under slightly acidic tumor microenvironment than that under a physiological condition.With the catalytic activity of HAase to digest the HA nearby the cancer cells,the developed DOX/LDH-HAase complexes enable more significant uptake by cancer cells and penetration in 3-dimensional tumor spheroids than enzyme-free DOX/LDH complexes,thus displaying much better antitumor efficacy in vitro than the latter.The more significant tumor penetration and inhibition of the DOX/LDH-HAase complexes than that of the DOX/LDH complexes was further demonstrated by in vivo tumor imaging and therapeutic activity assessments.Our study suggests a unique nanomedicine platform combined with both anticancer drug and enzyme for improved tumor penetration and chemotherapy,which is promising for effective chemotherapy of different types of stroma-rich tumors. | Gaoming Li Yu Fan Lizhou Lin Rong Wu Mingwu Shen Xiangyang Shi | 2021 | Science China Chemistry2021，64，5： | 2 |
| 5 | N_2O decomposition over K/Na-promoted Mg/Zn–Ce–cobalt mixed oxides catalysts显示文摘Three groups of cobalt mixed oxide catalysts(Mg/Zn–Co, Mg/Zn–Ce–C, K/Na–Mg/Zn–Ce–Co)were prepared by sol–gel or impregnation methods. The synergistic effects of transition metal, rare earth metal and alkali metal on cobalt mixed catalysts for nitrous oxide(N2O)decomposing to N2 and O2were investigated. The experimental results revealed that the catalytic activity for N2 O decomposition was promoted as Co2+was replaced partially by Zn2+/Mg2+, moreover, the characterization analysis by XRD and XPS showed that Zn2+/Mg2+replaced Co2+successfully into the spinel structure of Co3O4 and promoted significantly the catalytic activity. Especially, the addition of CeO2 and K2O/Na2O decreased the binding energy and resulted in an increase in the density of the electron cloud around Co and an improvement of the catalytic activity. Of the investigated cobalt mixed catalysts, the best catalytic activity was shown by 2% K–Zn0.5–Ce0.05–Co catalyst. | Jinli Zhang Hui Hu Jie Xu Gaoming Wu Zhaowei Zeng | 2014 | Journal of Environmental Sciences2014，26，7： | 2 |
| 6 | Adsorption of bilirubin by aminecontaining polyacrylamid resins 显示文摘 | Wu Gaoming Brown GR | 1991 | Reactive Polymers1991，14，1： | 1 |
| 7 | Restoration and management of the Inner Mongolia grassland requires a sustainable strategy 显示文摘 | Jiang Gaoming Han Xingguo Wu Jianguo | 2006 | AMBIO2006，35，4： | 1 |
| 8 | Phase separation of the nuclear pore complex facilitates selective nuclear transport to regulate plant defense against pathogen and pest invasion显示文摘The nuclear pore complex(NPC),the sole exchange channel between the nucleus and cytoplasm,is composed of several subcomplexes,among which the central barrier determines the permeability/selectivity of the NPC to dominate the nucleocytoplasmic trafficking essential for many important signaling events in yeast and mammals.How plant NPC central barrier controls selective transport is a crucial question remaining to be elucidated.In this study,we uncovered that phase separation of the central barrier is critical for the permeability and selectivity of plant NPC in the regulation of various biotic stresses.Phenotypic assays of nup62 mutants and complementary lines showed that NUP62 positively regulates plant defense against Botrytis cinerea,one of the world’s most disastrous plant pathogens.Furthermore,in vivo imaging and in vitro biochemical evidence revealed that plant NPC central barrier undergoes phase separation to regulate selective nucleocytoplasmic transport of immune regulators,as exemplified by MPK3,essential for plant resistance to B.cinerea.Moreover,genetic analysis demonstrated that NPC phase separation plays an important role in plant defense against fungal and bacterial infection as well as insect attack.These findings reveal that phase separation of the NPC central barrier serves as an important mechanism to mediate nucleocytoplasmic transport of immune regulators and activate plant defense against a broad range of biotic stresses. | Jiaojiao Wang Gaofeng Pei Yupei Wang Dewei Wu Xiaokang Liu Gaoming Li Jianfang He Xiaolin Zhang Xiaoyi Shan Pilong Li Daoxin Xie | 2023 | Molecular Plant2023，16，6： | 1 |
| 9 | Adap: tive noise variance identification for probability hy- pothesis density-based multi-target filter by variation- al Bayesian approximations 显示文摘 | WU Xinhui HUANG Gaoming GAO Jun | 2013 | lET Radar Sonar Navigation2013，7，8： | 1 |
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