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| 1 | FOXP3 expression and clinical characteristics of hepatocellular carcinoma显示文摘AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC). METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessedto identify the clinical characteristics of FOXP3 in HCC. RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC. CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC. | Wei-Hua Wang, Jun-Zhi Wang, National Center for Safety Evaluation of Drugs, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, Biotechnology Center, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Wei-Hua Wang, Chang-Li Jiang, Cun Zhang, Bo Yan, Wei Zhang, Wei Han, Ying-Qi Zhang, State Key Laboratory of Cancer Biology, Xi’an 710032, Shaanxi Province, China Wei Yan, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Yu-Hai Zhang, Department of Health Statistics, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China Jiang-Tao Yang, Department of Pathology, Xi’an Gaoxin Hospital, Xi’an 710032, Shaanxi Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 10 |
| 2 | A review of oxygen reduction mechanisms for metal-free carbon-based electrocatalysts显示文摘The sluggish kinetics of Oxygen Reduction Reaction(ORR)at the cathode in proton exchange membrane fuel cells or metal-air batteries requires highly effective and stable electrocatalysts to boost the reaction.The low abundance and high price of Pt-based electrocatalysts hamper the widespread application of proton exchange membrane fuel cells and metal-air batteries.As promising alternatives,metal-free carbon materials,especially upon doping heteroatoms or creating defects demonstrated excellent ORR activity,which is as efficient as or even superior to commercial platinum on carbon.Significant progress on the development of advanced carbon materials as highly stable and durable catalysts has been achieved,but the catalytic mechanisms of these materials still remain undistinguished.In present review,we summarized the up-to-date progress in the studies of carbon materials,and emphasized on the combination of experiment and theory to clarify the underlying mechanisms of these materials.At last,we proposed the perspectives on the proper strategies of elucidating the mechanisms of carbon materials as electrocatalysts towards ORR. | Ruguang Ma Gaoxin Lin Yao Zhou Qian Liu Tao Zhang Guangcun Shan Minghui Yang Jiacheng Wang | 2019 | npj Computational Materials2019，，1： | 9 |
| 3 | Anatomy of the lateral ligaments of the rectum: A controversial point of view显示文摘The existence and composition of the lateral ligaments of the rectum (LLR) are still the subjects of anatomical confusion and surgical misconception up to now. Since Miles proposed abdominoperineal excision as radical surgery for rectal cancer, the identification by 'hooking them on the finger' has been accepted by many surgeons with no doubt; clamping, dividing and ligating are considered to be essential procedures in mobilization of the rectum in many surgical textbooks. But in cadaveric studies, many anatomists could not find LLR described by the textbooks, and more and more surgeons also failed to find LLR during the proctectomy according to the principle of total mesorectal excision. The anatomy of LLR has diverse descriptions in literatures. According to our clinical observations, the traditional anatomical structures of LLR do exist; LLR are constant dense connective bundles which are located in either lateral side of the lower part of the rectum, run between rectal visceral fascia and pelvic parietal fascia above the levator ani, and covered by superior fascia of pelvic diaphragm. They are pathways of blood vessels and nerve fibers toward the rectum and lymphatic vessels from the lower rectum toward the iliac lymph nodes. | Guo-Jun Wang, Chun-Fang Gao, Dong Wei, Cun Wang, Wen-Jian Meng, Institute of Digestive Surgery and Department of General Surgery, 150 Hospital of PLA, Gaoxin District, Luoyang 471031, Henan Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 8 |
| 4 | Rheological Properties and Structural Changes in Different Sections of Boiled Abalone Meat显示文摘Changes in tissue structures, rheological properties of cross- and vertical section boiled abalone meat were studied in relation to boiling time. The adductor muscle of abalone Haliotis discus which was removed from the shell, was boiled for 1, 2, and 3 h, respectively. Then it was cut up and separated into cross- and vertical section meat. When observed by a light microscope and a scanning electron microscope, structural changes in the myofibrils were greatest in the cross section meat compared with the vertical section meat. When boiling time was increased from 1 h to 3 h, the instantaneous modulus E 0 and rupture strength of both section meat decreased gradually with increased boiling time, and no significant differences were observed between these two section meat for the same boiling time. When boiled for 1 h, the relaxation time of cross section meat was much longer than that of vertical section meat. There were no significant changes in the relaxation time of vertical section for different boiling time, but the relaxation time of cross section meat was reduced gradually with increasing boiling time. These results confirmed that the difference in rheological properties between the cross- and vertical section meat was mainly due to the denaturation level of myofibrils when heated for 1 h, as well as due to the changes in the amount of denatured proteins, and the manner in which the inner denatured protein components weve exchanged after boiling time was increased from 1 h to 3 h. | GAOXin TANGZhixu ZHANGZhaohui OgawaHiroo | 2003 | Journal of Ocean University of Qingdao2003，2，1： | 7 |
| 5 | Off-design Characteristics of IGCC System Based on Two-stage Coal-slurry Gasification Technology显示文摘整体煤气化联合循环(integrated gasification combinedcycle,IGCC)机组在一定情况下处于非设计工况运行。为了研究IGCC系统变工况特性,采用ThermoFlex软件建立基于两段式水煤浆气化技术的200 MW级整体煤气化联合循环系统模型,主要考查燃气轮机负荷、整体空分系数Xas、大气温度、大气压力对系统性能的影响。研究结果表明,降低燃气轮机负荷或者提高大气温度系统效率均呈先升高而后降低的趋势。整体空分系数Xas增加,机组发电效率降低。大气压力对系统效率影响较小。上述条件下采用两段水煤浆气化技术,系统性能可以得到有效改善。研究结果可为采用两段式水煤浆气化技术的IGCC系统的设计、运行提供参考。 | LIU gaoxin WU Shaohua LI Zhenzhong WANG Yang | 2012 | 中国电机工程学报2012，32，14： | 2 |
| 6 | Design,Modeling and Experimentation of a Biomimetic Wall-climbing Robot for Multiple Surfaces显示文摘Wall-climbing robots can work on steep terrain and obtain environment information in three dimensions for human in real time,which can improve operation efficiency.However,traditional single-mode robots cannot ensure the stable attachment on complex wall surfaces.Inspired by the structure characteristics of flies and clingfishes,three bionic structures including the flexible spine wheel,the adhesive material and the adsorption system are proposed.Aiming at task requirements on multiple walls and based on the above three bionic structures,a wall-climbing robot with the composed mode of“grabbing+adhesion+adsorption”is presented v/a the law of mechanism configuration synthesis.Using static analysis,the safe attachment conditions for the robot on smooth and rough walls are that the adsorption force is 30 N or more.Based on Newton's Euler and Lagrange formulas,the dynamic equations of the robot on vertical walls are established to deduce that the maximum theoretical torque of the driving motor is 1.43 N·m at a uniform speed.Finally,the prototype of the wall-climbing robot is manufactured and tested on the vertical lime wall,coarse sandpaper wall and acrylic ceiling wall.Meanwhile,experiment results imply that the average maximum moving speed and the corresponding load are 7.19 cm·s-1 and 0.8 kg on the vertical lime wall,7.78 cm·s-1 and 0.6 kg on the coarse sandpaper wall,and 5.93 cm·s-1 and 0.2 kg on the acrylic ceiling wall respectively.These findings could provide practical reference for the robot’s application on walls. | Jinfu Liu Linsen Xu Jiajun Xu Tao Li Shouqi Chen Hong Xu Gaoxin Cheng Marco Ceccarelli | 2020 | Journal of Bionic Engineering2020，17，3： | 2 |
| 7 | 显示文摘 | XUFeng-xiang GAOXin LIZhao-yong etal(徐凤香 高昕 李昭勇 等) | 2007 | 食品工业科技2007，28，1： | 1 |
| 8 | Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system显示文摘Adenovirus 5 type E1A as a tumor suppressor gene can inhibit tumor growth and enhance the sensitivity of chemotherapy and radiotherapy. E1A have the ability to integrate into the host genome, resulting in long-time expres-sion that induces Rb gene inactivation and animal cells im-mortalization. This prompted us to select the E1A protein for treatment of cancer in order to overcome the limitations of E1A gene therapy. Thus, we firstly constructed E1A eu-caryotic expression vector (pPIC9/E1A), transformated the pichia pastoris yeast cells (GS115) and screened the high-expressing recombinant strains. The positive yeast strains were cultured in the shake flask, and induced for 3 d. The crude E1A protein was purified using two steps of col-umn chromatography on HiTrap Q and HiTrap SP. The pu-rified E1A protein was identified by SDS-PAGE and Western blot. E1A protein was mostly located at cellular nuclear when Chariot delivered E1A protein into cells. The analysis in vitro indicated that the E1A protein arrested LN686 cell cycle at G2/M phase, and significantly inhibited the growth of LN686 tumor cells. The current studies firstly provided an experimental basis to further develop E1A protein for tumor treatment. | MAYewei ZHOUXiaoshan QIANXinlai ZHAOQingzheng YANGJun GAOXin LIYanchun LIUYuying WANGZheng | 2003 | Chinese Science Bulletin2003，48，7： | 1 |
| 9 | Thermal field characteristic analysis of steel box girder based on long-term measurement data显示文摘 | Youliang Ding Guangdong Zhou Aiqun Li Gaoxin Wang | 2012 | International Journal of Steel Structures2012，，2： | 1 |
| 10 | Researches on the Stability of Porphyra-334 Solution and Its Influence Factors显示文摘The stability of porphyra-334 in solutions of different pH values at different temperatures was studied. In high acidic conditions, below pH 3, the absorption maximum, λ max, of porphyra-334 shows hypsochromic shift towards lower wavelength and the absorbance also has a light decrease. In high alkaline conditions of over pH 12, the absorbance of porphyra-334 decreases and an unknown compound with a peak maximum at 225 nm appears. The peak height of the unknown compound increases with the decrease of absorbance of porphyra-334. This might be related to the decomposition of porphyra-334. At room temperature, porphyra-334 solutions, except high alkaline solutions, are stable. Increasing the temperature, especially higher than 60℃, promotes the decomposition of porphyra-334 and causes the absorbance decrease both in basic and acidic solutions. | ZHANGZhaohui GAOXin YuriTashiro ShingoMatsukawa HirooOgawa | 2004 | Journal of Ocean University of China2004，3，2： | 1 |
| 11 | Thermal field characteristic analysis of steel box girder based on long-term measurement data显示文摘 | Youliang Ding Guangdong Zhou Aiqun Li Gaoxin Wang | 2012 | International Journal of Steel Structures2012，，2： | 1 |
| 12 | Establishment of Novel Monoclonal Fabs Specific for Epstein-Barr Virus Encoded Latent Membrane Protein 1显示文摘Dear Editor,Epstein-Barr virus(EBV,also termed human herpesvirus-4)was the first identified human tumor virus.Since its discovery in 1964,studies have shown that EBV infects over 90%of all people by the time they are adults(Williams and Crawford 2006).EBV infection can result in mucocutaneous and systemic diseases,ranging from selflimited illnesses to aggressive malignancies,including B cell Hodgkin lymphoma and nasopharyngeal carcinoma.In vitro,EBV transforms resting B cells into proliferating blast cells(Pope et al.1968). | Gaoxin Li Ling Ding Xiaojing Ma Qiliang Cai Tianlei Ying Fang Wei | 2019 | Virologica Sinica2019，34，4： | 1 |
| 13 | Modified Blair ankle fusion for ankle arthritis显示文摘ObjectiveTo 为脚关节 arthritis.MethodsBetween 2009 年 11 月和 2012 年 6 月调查修改布莱尔脚关节熔化的临床的结果,有脚关节关节炎的 28 个病人被对待,在谁之中 11 有明显的脚内翻足畸形,并且 17 在外观是几乎正常的。与 49.4 年的平均年龄有 13 男性和 15 女性(范围, 23-67 年) 。主要症状包括了胀大,疼痛,和脚关节的运动的一个有限范围。脚关节关节功能被美国矫形的脚和脚关节社会(AOFAS ) 脚关节和 hindfoot 分数和视觉模拟规模(管) 外科手术前地并且在 follow-up.ResultsTwenty-eight 病人被列在后面在上面的 1 年估计为 19.8 个月平均(范围, 1-2 年) 。表面的创伤感染在 3 种情况中发生了,并且在清创术以后被治好;没有复杂并发症,另外的切口由第一个意愿愈合了。所有脚关节在操作以后在 1 年后续被熔化。症状最后在所有病人完全被减轻没有复杂并发症的后续植入失败,或不属于工会。手术后的 AOFAS 脚关节和 hindfoot 分数是 83.13 ±3.76,看重要差别什么时候与外科手术前的分数相比(45.38 ±3.21, P < 0.01 ) 。管显著地在 1 年后续从 8.01 ±0.63 被减少到 2.31 ±1.05 (P < 0.05 ).ConclusionModified 布莱尔脚关节熔化有高 feasiblity,更少的费用和僵硬固定的优点。它显示出高可靠性在伤害地势并且可以获得好临床的有效性。 | Wang Shuangli Huang Zhang Xiong Gaoxin Chen Guang Yin Zhongxiang Jiang Hua | 2014 | Chinese Journal of Traumatology2014，17，3： | 1 |
| 14 | Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples显示文摘Flame retardants(FRs)are ubiquitous in environment and biota and may pose harm to human health.In recent years,concern regarding legacy and alternative FRs has been intensified due to their widespread production and increasing contamination in environmental and human matrices.In this study,we developed and validated a novel analytical method for simultaneous determination of legacy and alternative FRs,including polychlorinated naphthalenes(PCNs),short-and middle-chain chlorinated paraffins(SCCPs and MCCPs),novel brominated flame retardants(NBFRs),and organophosphate esters(OPEs)in human serum.Serum samples were prepared by liquid-liquid extraction using ethyl acetate,and purified with Oasis®HLB cartridge and Florisil–silica gel columns.Instrumental analyses were carried out using gas chromatography-triple quadrupole mass spectrometry,highresolution gas chromatography coupled with high-resolution mass spectrometry,and gas chromatography coupled with quadrupole time-of-flight mass spectrometry,respectively.The proposed method was validated for linearity,sensitivity,precision,accuracy,and matrix effects.Method detection limits for NBFRs,OPEs,PCNs,SCCPs,and MCCPs were 4.6×10^(–4)–8.6×10^(–2),4.3×10^(–3)–1.3,1.1×10^(–5)–1.0×10^(–4),1.5,and 9.0×10–1 ng/mL,respectively.Matrix spike recoveries ranged from 73%–122%,71%–124%,75%–129%,92%–126%,and 94%–126%for NBFRs,OPEs,PCNs,SCCPs,and MCCPs,respectively.The analytical method was applied for detection of real human serum.CPs were the dominant FRs in serum,indicating CPs were widely presented in human serum and should be pay more attention for their health risk. | Xiaolin Guan Gaoxin Zhang Lingling Meng Mei Liu Liyuan Zhang Chuxuan Zhao Yingming Li Qinghua Zhang Guibin Jiang | 2023 | Journal of Environmental Sciences2023，，9： | 0 |
| 15 | Complex systems and network science:a survey显示文摘Complex systems widely exist in nature and human society.There are complex interactions between system elements in a complex system,and systems show complex features at the macro level,such as emergence,self-organization,uncertainty,and dynamics.These complex features make it difficult to understand the internal operation mechanism of complex systems.Networked modeling of complex systems is a favorable means of understanding complex systems.It not only represents complex interactions but also reflects essential attributes of complex systems.This paper summarizes the research progress of complex systems modeling and analysis from the perspective of network science,including networked modeling,vital node analysis,network invulnerability analysis,network disintegration analysis,resilience analysis,complex network link prediction,and the attacker-defender game in complex networks.In addition,this paper presents some points of view on the trend and focus of future research on network analysis of complex systems. | YANG Kewei LI Jichao LIU Maidi LEI Tianyang XU Xueming WU Hongqian CAO Jiaping QI Gaoxin | 2023 | Journal of Systems Engineering and Electronics2023，34，3： | 0 |
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