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| 1 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 2 | Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKca channels and reducing intracellular Ca2+ levels显示文摘 | Xiang-yun GAI Yu-hai WEI Wei ZHANG Ta-na WUREN Ya-ping WANG Zhan-qiang LI Shou LIU Lan MA Dian-xiang LU Yi ZHOU Ri-li GE | 2015 | Acta Pharmacologica Sinica2015，36，5： | 11 |
| 3 | Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats显示文摘A correlation between metabolic alterations of neuroactive steroids and Alzheimer's disease remains unknown. In the present study, amyloid beta(Aβ) 25–35(Aβ25–35) injected into the bilateral hippocampus CA1 region significantly reduced learning and memory. At the biochemical level, hippocampal levels of pregnenolone were significantly reduced with Aβ25–35treatment. Furthermore, progesterone was considerably decreased in the prefrontal cortex and hippocampus, and 17β-estradiol was significantly elevated. To our knowledge, this is the first report showing that Aβ25–35, a main etiological factor of Alzheimer's disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory.Aβ25–35exposure also increased the expression of inflammatory mediators, tumor necrosis factor-αand interleukin-1β. However, subcutaneous injection of progesterone reversed the upregulation of tumor necrosis factor-α and interleukin-1β in a dose-dependent manner. Concomitant with improved cognitive abilities, progesterone blocked Aβ-mediated inflammation and increased the survival rate of hippocampal pyramidal cells. We thus hypothesize that Aβ-mediated cognitive deficits may occur via changes in neuroactive steroids. Moreover, our findings provide a possible therapeutic strategy for Alzheimer's disease via neuroactive steroids, particularly progesterone. | Sha Liu Honghai Wu Gai Xue Xin Ma Jie Wu Yabin Qin Yanning Hou | 2013 | Neural Regeneration Research2013，8，30： | 7 |
| 4 | Effect of moxibustion combined with five‑element music therapy on postoperative pain relief after mixed hemorrhoid operation显示文摘Objective:To investigate the effect of moxibustion combined with five‑element music therapy on the postoperative pain relief of patients undergoing surgical operation for mixed hemorrhoid with damp‑heat syndrome.Methods:Totally,159 patients meeting the inclusion criteria were assigned to the control group,study group 1,and study group 2,with 53 cases in each group.All patients received routine care after surgical treatment,including acupoint application and Chinese herbal fumigation.In addition,patients in the study group 1 received moxibustion,and those in the study group 2 were given moxibustion combined with five‑element music therapy.The degree of postoperative pain was evaluated using visual analog scale(VAS).Results:There was no significant difference in VAS score on pain during dressing changes among three groups(P>0.05).After 3,5,and 7 days of intervention,there was a significant difference in VAS score on pain at rest among three groups(P<0.001),and VAS score in the study group 2 was lower than that in the study group 1 and the control group after 3 and 5 days of intervention,respectively(P<0.05).Conclusion:Moxibustion combined with five‑element music therapy is effective to relieve the postoperative pain of patients undergoing a surgical operation for mixed hemorrhoids with damp‑heat syndrome. | Li‑Yuan WANG Hai‑Yun GAI Yu WEN Ming‑Hui MA | 2020 | Journal of Integrative Nursing2020，2，1： | 6 |
| 5 | Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP^(+)显示文摘Objective:Buyinqianzheng Formula(BYQZF)is clinically employed in traditional Chinese medicine to treat Parkinson's disease(PD)by improving mitochondrial dysfunction.However,the underlying mechanisms by which BYQZF affects mitochondrial morphology remain unknown.Therefore,we observed the effects of BYQZF on mitochondria from the perspective of the PINK1/Parkin pathway.Methods:Cell survival rates were assessed by Cell Counting Kit-8 assay.Expression levels of PINK1 and Parkin mRNA were examined by qRT-PCR.Protein expression levels of PINK1,PINK1-Ser228,Parkin,Parkin-Ser65,Drp1,and Drp1-Ser637 were examined by western blotting.PINK1,Parkin,and MitoTracker?Red CMXRos(MTR)were stained by triple-labeled immunofluorescence,and observed under laser confocal microscopy.Results:Cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and protein expression levels of PINK1,Parkin,and Drp1-Ser637 were reduced after 1-methyl-4-phenylpyridinium(MPP^(+))intervention.In contrast,Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 increased significantly after MPP^(+) intervention.Treatment with BYQZF increased cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and expression of PINK1,Parkin,and Drp1-Ser637 proteins.Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 decreased after BYQZF treatment.Conclusion:These results demonstrate that BYQZF has a protective effect on mitochondrial molecular mechanisms in the PD cell model,and the mechanism is related to the PINK1/Parkin pathway. | Haojie Ma Zhenyu Guo Cong Gai Cuicui Cheng Jinkun Zhang Yuxin Zhang Luping Yang Wandi Feng Yushan Gao Hongmei Sun | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 3 |
| 6 | Simultaneous quantitative determination of five alkaloids in Catharanthus roseus by HPLC-ESI-MS/MS显示文摘AIM: To establish a method to simultaneously determine the main five alkaloids of Catharanthus roseus for trace samples, a high-performance liquid chromatography–electrospray ionization-tandem mass spectrometry(HPLC-ESI-MS/MS) analysis method was developed. METHOD: The five Catharanthus alkaloids, vinblastine, vincristine, vinleurosine, vindoline, and catharanthine were chromatographically separated on a C18 HPLC column. The mobile phase was methanol-15 nmol?L–1 ammonium acetate containing 0.02% formic acid(65 : 35, V/V). The quantification of these alkaloids was based on the Multiple Reaction Monitoring(MRM) mode. RESULTS: This method was validated, and the results achieved the aims of the study. The intra- and inter-day precision and accuracy of the five alkaloids were within 1.2%-11.5%(RSD%) and-10.9%-10.5%(RE%). The recovery rates of the five alkaloids of samples were from 79.9% to 91.5%. The five analytes were stable at room temperature for 2 h, at 4 °C for 12 h, and at-20 °C for two weeks. The developed method was applied successfully to determine the content of the five alkaloids in three plant parts of three batches of C. roseus with a minute amount collected from three regions of China. CONCLUSION: The HPLC-ESI-MS/MS method can be used for the simultaneous determination of five important alkaloids in trace C. roseus samples. | ZHANG Lin GAI Qing-Hui ZU Yuan-Gang YANG Lei MA Yu-Liang LIU Yang | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 3 |
| 7 | Geochemistry, Sr-Nd-Pb Isotopic Compositions and Zircon U-Pb Geochronology of Neoproterozoic Mafic Dyke in the Douling Complex, South Qinling Belt, China显示文摘Mafic dyke swarm is widely developed in Proterozoic continental lithosphere.The Gangou diabase dyke from the Xixia area,intruded into the Douling complex of the South Qinling belt,yields zircon UPb age of 731 Ma.It has low SiO2 content(49.02 wt.%-49.37 wt.%)and Mg^#(34.0–37.7)and shows characteristics of subalkaline tholeiite series.They show highΣREE(155.5×10^-6–184.7×10^-6),weak negative Eu anomaly(δEu=0.88-0.93),slight depletion of Nb and Ta,and enrichment of LILE.Their major and trace element,Sr-Nd-Pb isotope and clinopyroxene compositions indicate that it originated from the partial melting of the asthenospheric mantle within-plate extension setting and was slightly contaminated by crust compositions.The similarities of formation age,petrogenesis,source characteristic and tectonic setting for Gangou diabase with mafic dykes in Wudang Block and mafic volcanic rocks in Yaolinghe Group indicate that the South Qinling belt underwent strong continental extension in Neoproterozoic during 796–685 Ma most likely correspondence to the breaking-up of the Rodinia supercontinent. | Tong Li Liang Liu Xiao-Ying Liao Yong-Sheng Gai Tuo Ma Chao Wang | 2020 | Journal of Earth Science2020，31，2： | 2 |
| 8 | Pre-sodiation strategy for superior sodium storage batteries显示文摘The irreversible consumption of sodium in the initial several cycles greatly led to the attenuation of capacity,which caused the low initial coulombic efficiency(ICE)and obvious poor cycle stability.Presodiation can effectively improve the electrochemical performance by compensating the capacity loss in the initial cycle.Here,carbon-coated sodium-pretreated iron disulfide(NaFeS_(2)@C)has been synthesized through conventional chemical method and used in sodium metal battery as a cathode material.The calculated density of states(DOS)of NaFeS2@C is higher,which implies enhanced electron mobility and improved cycle reversibility.Because of the highly reversible conversion reaction and the compensation of irreversible capacity loss during the initial cycle,the Na/NaFeS_(2)@C battery achieves ultrahigh initial coulombic efficiency(96.7%)and remarkable capacity(751 mA·h·g^(-1) at 0.1 A·g^(-1)).In addition,highly reversible electrochemical reactions and ultra-thin NaF-rich solid electrolyte interphase(SEI)also benefit for the electrochemical performance,even at high current density of 100 A·g^(-1),it still exhibits a reversible capacity of 136 mA·h·g^(-1),and 343 mA·h·g^(-1) after 2500 cycles at 5.0 A·g^(-1).This work aims to bring up new insights to improve the ICE and stability of sodium metal batteries. | Yongkai Xu Haozheng Sun Cunshuang Ma Jingjing Gai Yanhua Wan Weihua Chen | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 2 |
| 9 | Warm dense matter research at HIAF显示文摘The research activities on warm dense matter driven by intense heavy ion beams at the new project High Intensity heavy-ion AcceleratorFacility (HIAF) are presented. The ion beam parameters and the simulated accessible state of matter at HIAF are introduced, respectively. Theprogresses of the developed diagnostics for warm dense matter research including high energy electron radiography, multiple-channel pyrometer,in-situ energy loss and charge state of ion detector are briefly introduced. | Rui Cheng Yu Lei Xianming Zhou Yuyu Wang Yanhong Chen Yongtao Zhao Jieru Ren Lina Sheng Jiancheng Yang Zimin Zhang Yingchao Du Wei Gai Xinwen Ma Guoqing Xiao | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 10 | Bone marrow mesenchymal stem cells can differentiate into type Ⅱ alveolar epithelial cells in vitro显示文摘 | Ma N Gai H Mei J | | 0，，12： | 1 |
| 11 | An analytical method for wind measurement using miniature aircraft 显示文摘 | Ma Shuqing Wang Gai Pan Yi | 1999 | Chinese Journal of Atmospheric Science1999，23，2： | 1 |
| 12 | Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response显示文摘In response to DNA double strand breaks(DSBs),DNA damage repair factors are recruited to DNA lesions and form nuclear foci.However,the underlying molecular mechanism remains largely elusive.Here,by analyzing the localization of DSB repair factors in the XY body and DSB foci,we demonstrate that pre-ribosomal RNA(pre-rRNA)mediates the recruitment of DSB repair factors around DNA lesions.Pre-rRNA exists in the XY body,a DSB repair hub,during meiotic prophase,and colocalizes with DSB repair factors,such as MDC1,BRCA1 and TopBP1.Moreover,pre-rRNA-associated proteins and RNAs,such as ribosomal protein subunits,RNase MRP and snoRNAs,also localize in the XY body.Similar to those in the XY body,pre-rRNA and ribosomal proteins also localize at DSB foci and associate with DSB repair factors.RNA polymerase I inhibitor treatment that transiently suppresses transcription of rDNA but does not affect global protein translation abolishes foci formation of DSB repair factors as well as DSB repair.The FHA domain and PST repeats of MDC1 recognize pre-rRNA and mediate phase separation of DSB repair factors,which may be the molecular basis for the foci formation of DSB repair factors during DSB response. | Xiaochen Gai Di Xin Duo Wu Xin Wang Linlin Chen Yiqing Wang Kai Ma Qilin Li Peng Li Xiaochun Yu | 2022 | Cell Research2022，32，3： | 1 |
| 13 | Formation of emergency medicine in Italy 显示文摘 | Cottino A Grazia-de MA Gai V | 1998 | Eur-J-Emerg-Med1998，5，4： | 1 |
| 14 | Elevated Serum YKL-40 Level Predicts Poor Prognosis in Hepatocellular Carcinoma After Surgery显示文摘 | Cheng-Bao Zhu MSc Li-Li Chen MSc Jian-Jun Tian BSc Liang Su MSc Can Wang MSc Zhong-Tao Gai MSc Wen-Jun Du MSc Guo-Liang Ma BSc | 2012 | Annals of Surgical Oncology2012，，： | 1 |
| 15 | Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo显示文摘 | Lin Zheng Yingying Fu Linhan Zhuang Renhua Gai Jian Ma Jianshu Lou Hong Zhu Qiaojun He Bo Yang | 2014 | Int. J. Cancer2014，，： | 1 |
| 16 | 显示文摘 | Gai L G Ma L Jiang H H | 2012 | Cryst Eng Comm2012，14，21： | 1 |
| 17 | A study of slow pyrolysis of one low rank coal via pyrolysis-GC/MS显示文摘 | LIEVENS C CI D BAI Y MA L ZHANG R CHEN J Y GAI Q LONG Y GUO X | 2013 | Fuel Process Technol2013，116，： | 1 |
| 18 | Formation of emergency medicine in Italy显示文摘 | Cottino A Grazia-de MA Gai V | 1998 | Eur J Emerg Med1998，5，： | 1 |
| 19 | From the Himalayan region or the Malay Archipelago:Molecular dating to trace the origin of a fern genus Phymatopteris(Polypodiaceae)显示文摘Phymatopteris Pic.Serm.,a derived polypodiaceous fern,is one of the many fern genera that still suffer from nomenclatural confusion.Its generic circumscription and phylogenetic relationships with other selligueoid ferns have been controversial,and its geographic origin,whether in the Himalayan region of continental Asia or in Malay Archipelago,is still unknown.A phylogeny of all selligueoid ferns based on 4 cpDNA(rbcL,trnL-F,rps4 and rps4-trnS) regions indicates that Phymatopteris is not monophyletic.Phymatopteris species are distributed in 5 well-supported clades that can be distinguished with frond-shape and frond-margin characters.All early-divergent species are from the Malaysian Archipelago,while the remaining species are all from the Himalayan region and form a recently diverged group that is largely unresolved,most likely having resulted from an explosive radiation.Divergence-time estimation suggests that the first diversification of selligueoid ferns occurred at ca.27 Ma in the Malaysian Archipelago,followed by migration into the Himalayan region around 20 Ma.The radiation of the Himalayan species occurred mostly within the last 20 million years,within the period of recent major uplifts of the Qinghai-Tibetan Plateau(between the early Miocene and the Pleistocene) and late-Cenozoic global cooling.Our evidence leads us to propose that the Malaysian Archipelago is the ancestral area for Phymatopteris. | LI ChunXiang LU ShuGang MA JunYe SUN XiaoYan GAI YongHua BARRINGTON David S YANG Qun | 2012 | Chinese Science Bulletin2012，57，35： | 1 |
| 20 | In situ Carbon Modification of g-C3N4 from Urea co-Crystal with Enhanced Photocatalytic Activity Towards Degradation of Organic Dyes Under Visible Light显示文摘An in sitt strategy was introduced for synthesizing carbon modified graphitic carbon nitride(g-C3N4)by using urea/4-aminobenzoic acid(PABA)co-crystal(PABA@Urea)as precursor materials.Via co-calcination of the PABA co-former and the urea in PABA@a Urea co-crystals,C guest species were generated and compounded into g-C3Na matrix in situ by replacing the lattice N of the carbon nitride and forming carbon dots onto its layer surface.The carbon modification dramatically enhanced visible-light harvesting and charge carrier separation.Therefore.visible light photo-catalytic oxidation of methylene blue(MB)pollution in water over the carbon modified g-C3Na(C/g-C3Na)was notably improved.Up to 99%of methylene blue(MB)was eliminated within 60 min by the optima sample prepared from the PABA@Urea co-crystal with a PABA content of 0.1%(mass ratio),faster than the degrada-tion rate over bare g-C3N4.The present study demonstrates a new way to boost up the photocatalysis performance of g-C3Na,which holds great potential concerning the degradation of organic dyes from water. | ZHAO Weifeng HAO Ning ZHANG Gai MA Aijie CHEN Weixing ZHOU Hongwei YANG Dong XU Ben Bin KONG Jie | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
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