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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Streptococcus pneumoniae type 3 encodes a protein highly similar to the human glutamate decarboxylase (GAD65) 显示文摘 | GARCIA E LOPEZ R | 1995 | FEMS Microbiol Lett1995，133，12： | 1 |
| 3 | Phage Lytic Enzymes as Therapy for Antibiotic - resistant Streptococcus Pneumoniae Infection in a Murine,Sepsis,Model显示文摘 | Jado I R Lopez E Garcia | 2003 | J Antimic - rob Chemother2003，52，： | 1 |
| 4 | Biological roles of two new murein hydrolases of Streptococcus pneumoni- ae representing examples of module shuffling显示文摘 | Lopez R Gonzalez MP Garcia E | 2000 | Research in Microbiology2000，151，6： | 1 |
| 5 | Combining stereo vision and inertial navigation system for a quad-rotor uav显示文摘 | Garcia Carrillo L R Dzul Lopez A E Lozano R | 2012 | Journal of Intelligent & Robotic Systems2012，65，14： | 1 |
| 6 | Protection against Porcine Reproductive and Respiratory Syn-drome Virus(PRRSV)Infection through Passive Transfer of PRRSV-Neutralizing Antibodies Is Dose Dependent显示文摘 | Lopez O J Oliveira M F Garcia E A | 2007 | Clin Vaccine Immunol2007，14，3： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | Predictive value of nuclear factor-κB activity and plasma cytokine levels in patients with sepsis显示文摘 | ARNALICH F GARCIA PALOMERO E LOPEZ J | 2000 | Infect Immun2000，68，4： | 1 |
| 9 | Predictive value of nuclear factor B activity and plasma cytokine levels in patients with sepsis 显示文摘 | Arnalich F Garcia -Palomero E Lopez J | 2000 | Infect Immun2000，68，4： | 1 |
| 10 | Influ ence of carbon source on nitrate removal of contaminated groundwater in a denitrifying submerged filter显示文摘 | Gomez M A Gonzcilez Lopez J Hontoria Garcia E | 2000 | Journal of Hazardous Materials2000，80，： | 1 |
| 11 | The pneumococcal cell wall degrading enzymes: a modular design to create new lysins显示文摘 | Lopez R Garcia E Garcia P | 1997 | Microbial Drug Resistance1997，3，2： | 1 |
| 12 | Motivation to change unhealthy life styles and cardiovascular risk显示文摘 | Perez - Manchon D Alvarez - Garcia GM Gonzalez - Lopez E | 2014 | Enferm Clin2014，24，6： | 1 |
| 13 | Characteristic signatures of the lytA gene provide a basis for rapid and reliable diagnosis of Streptococcus pneumoniae infections显示文摘 | Llull D Lopez R Garcia E | 2006 | J Clin Mierobiol2006，44，4： | 1 |
| 14 | Longitu- dinal relationships between fluid status, inflammation, urine volume and plasma metabolites of icodextrin in pa tients randomized to glucose or icodextrin for the long exchange显示文摘 | Davies S J Garcia Lopez E Woodrow G | 2008 | Nephrol Dial Transplant2008，23，9： | 1 |
| 15 | Inflix- imab rescue therapy after cyclosporin failure in steroid - refractory ulcerative colitis 显示文摘 | Manosa M Lopez SRA Garcia - Planella E | 2009 | Digestion2009，80，1： | 1 |
| 16 | Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gcdlus domesticus)显示文摘 | Koutsos E A Garcia Lopez J C Klasing K C | 2006 | Journal of Nutrition2006，136，： | 1 |
| 17 | Primary angioplasty reduces the risk of left ventricular free wall rupture compared with thrombolysis in patients with acute myocardial infarction 显示文摘 | Moreno R Lopez - Sendon J Garcia E | 2002 | J Am Coil Cardio12002，39，4： | 1 |
| 18 | Excess properties of some methanol+amid systems proposed as working fluid for absorption machines显示文摘 | Lopez E R Garcia J Fernandez J | 1999 | J Chem Eng Data1999，44，2： | 1 |
| 19 | Chimeric phage-bacterial enzymes: a clue to the modular evolution of genes显示文摘 | Diaz E Lopez R Garcia JL | 1990 | Proceedings of National Academy of Science of the United States of America1990，87，20： | 1 |
| 20 | Adult height in children with idiopathic short stature treated with growth hormone显示文摘 | Lopez S J P Garcia G E Carralero I | 2000 | J Pediatr Endocrinol Metab2000，13，9： | 1 |
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