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| 1 | Restoration Prospects for Heitutan Degraded Grassland in the Sanjiangyuan显示文摘In many ecosystems ungulates have coexisted with grasslands over long periods of time. However, high densities of grazing animals may change the floristic and structural characteristics of vegetation, reduce biodiversity, and increase soil erosion, potentially triggering abrupt and rapid changes in ecosystem condition. Alternate stable state theory provides a framework for understanding this type of dynamic. In the Sanjiangyuan atop the Qinghai-Tibetan plateau (QTP), grassland degradation has been accompanied by irruptions of native burrowing animals, which has accentuated the loss of ground cover. Severely degraded areas of alpine meadows are referred to as 'Heitutan'. Here, using the framework of alternate stable state theory, we describe the proximate and ultimate drivers of the formation of Heitutan on the QTP, and we assess prospects for recovery, in relation to the degree of biophysical alteration, of these alpine meadows. Effective rehabilitation measures must address the underlying causes of degradation rather than their symptoms. Heitutan degradation is not uni-causal. Rather it reflects different mechanisms operating at different spatio-temporal scales across this vast region. Underlying causes include overly aggressive exploitation of the grasslands (e.g. overgrazing), amplification of grazing and erosion damage by small mammals when outbreaks occur, and/or climate change. Given marked variability in environmental conditions and stressors, restorative efforts must vary across the region. Restoration efforts are likely toyield greatest success if moderately and severely degraded areas are targeted as the first priority in management programmes, before these areas are transformed into extreme Heitutan. | LI Xi-lai PERRY LW George BRIERLEY Gary GAO Jay ZHANG Jing YANG Yuan-wu | 2013 | Journal of Mountain Science2013，10，4： | 23 |
| 2 | First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial显示文摘 | QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin | 2012 | Chinese Medical Journal2012，，6： | 14 |
| 3 | Geomorphic-centered Classification of Wetlands on the Qinghai-Tibet Plateau, Western China显示文摘In this paper a geomorphic-centered system was proposed for classifying the wetlands on the Qinghai-Tibet Plateau in western China, where the flora comprises primarily grasses. Although the geomorphic properties (e.g., elevation and morphology) of wetlands form the primary criteria of classification, this system also takes hydrological processes into implicit consideration. It represents an improvement over the hydrogeomorphic perspective as the relative importance of the two components (wetness and landform) of wetlands is clearly differentiated. This geomorphic-centered perspective yields insights into the hydrogeomorphic dynamics of plateau wetlands while indicates their vulnerability to change and degradation indirectly. According to this geomorphic-centered perspective, all plateau wetlands fall into one of the seven types of alpine, piedmont, valley, terrace, floodplain, lacustrine, and riverine in three elevational categories of upland, midland, and lowland. Upland (alpine and piedmont) wetlands with the steepest topography are the most sensitive to change whereas midland (floodplain, terrace and valley) wetlands are less vulnerable to degradation owing to a high water reserve except terrace wetlands. They have a dry surface caused by infrequent hydrological replenishment owing to their higher elevation than the channel. Low lying (lacustrine and riverine) wetlands are the most resilient. The geomorphic-centered perspective developed in this paper provides a framework for improving recognition and management of wetlands on the Plateau. Resilient wetlands can be grazed more intensively without the risk of degradation. Fragile and vulnerable wetlands require careful managementto avoid degradation. | GAO Jay LI Xi-lai Gary BRIERLEY Alan CHEUNG YANG Yuan-wu | 2013 | Journal of Mountain Science2013，10，4： | 12 |
| 4 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 5 | Nanostructured fibers as a versatile photonic platform: radiative cooling and waveguiding through transverse Anderson localization显示文摘Broadband high reflectance in nature is often the result of randomly,three-dimensionally structured materials.This study explores unique optical properties associated with one-dimensional nanostructures discovered in silk cocoon fibers of the comet moth,Argema mittrei.The fibers are populated with a high density of air voids randomly distributed across the fiber cross-section but are invariant along the fiber.These filamentary air voids strongly scatter light in the solar spectrum.A single silk fiber measuring~50μm thick can reflect 66%of incoming solar radiation,and this,together with the fibers’high emissivity of 0.88 in the mid-infrared range,allows the cocoon to act as an efficient radiative-cooling device.Drawing inspiration from these natural radiative-cooling fibers,biomimetic nanostructured fibers based on both regenerated silk fibroin and polyvinylidene difluoride are fabricated through wet spinning.Optical characterization shows that these fibers exhibit exceptional optical properties for radiative-cooling applications:nanostructured regenerated silk fibers provide a solar reflectivity of 0.73 and a thermal emissivity of 0.90,and nanostructured polyvinylidene difluoride fibers provide a solar reflectivity of 0.93 and a thermal emissivity of 0.91.The filamentary air voids lead to highly directional scattering,giving the fibers a highly reflective sheen,but more interestingly,they enable guided optical modes to propagate along the fibers through transverse Anderson localization.This discovery opens up the possibility of using wild silkmoth fibers as a biocompatible and bioresorbable material for optical signal and image transport. | Norman Nan Shi Cheng-Chia Tsai Michael J.Carter Jyotirmoy Mandal Adam C.Overvig Matthew Y.Sfeir Ming Lu Catherine L.Craig Gary D.Bernard Yuan Yang Nanfang Yu | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 6 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 7 | Functional analysis of tomato calmodulin gene family during fruit development and ripening显示文摘Calmodulin is a ubiquitous calcium sensor to recognize the different developmental and/or stimulus-triggered calcium changes and regulate plant growth and development.However,the function of calmodulin remains elusive for fleshy fruit development.We performed expression studies of a family of six calmodulin genes(SlCaMs)in tomato fruit.All calmodulins showed a double peak expression pattern.The first flat peak appeared at 10–30 days after anthesis,but their expression rapidly declined at mature green and breaker.Then a sharp and even higher peak came at turning/pink stages.Among six calmodulins,SlCaM1 had the highest expression during fruit enlargement,whereas SlCaM2 was the major calmodulin during fruit ripening.However,SlCaMs showed different patterns in three ripening mutants rin,Nor and Nr.In particular,at the stages corresponding to mature green and breaker,the expression levels of SlCaMs in those mutants were significantly higher than wild-type.Furthermore,SlCaMs,especially SlCaM2 were upregulated by ethylene.Transiently overexpressing SlCaM2 in mature green fruit delayed ripening,while reducing SlCaM2 expression accelerated ripening.Our results suggest that SlCaMs play double roles to regulate fruit ripening.Prior to the ethylene burst,the ethylene-independent repression of SlCaMs might be critical for fruit to initiate the ripening process.After the ethylene burst,SlCaMs could participate in the ethylene coordinated rapid ripening. | Tianbao Yang Hui Peng Gary R Bauchan | 2014 | Horticulture Research2014，1，1： | 3 |
| 8 | Laser-induced microjet-assisted ablation for high-quality microfabrication显示文摘Liquid-assisted laser ablation has the advantage of relieving thermal effects of common laser ablation processes, whereas the light scattering and shielding effects by laser-induced cavitation bubbles, suspended debris, and turbulent liquid flow generally deteriorate laser beam transmission stability, leading to low energy efficiency and poor surface quality. Here, we report that a continuous and directional high-speed microjet will form in the laser ablation zone if laser-induced primary cavitation bubbles asymmetrically collapse sequentially near the air-liquid interface under a critical thin liquid layer. The laser-induced microjet can instantaneously and directionally remove secondary bubbles and ablation debris around the laser ablation region, and thus a very stable material removal process can be obtained. The shadowgraphs of high-speed camera reveal that the average speed of laser-induced continuous microjet can be as high as 1.1 m sin its initial 500 μm displacement. The coupling effect of laser ablation, mechanical impact along with the collapse of cavitation bubbles and flushing of high-speed microjet helps achieve a high material removal rate and significantly improved surface quality. We name this uncovered liquid-assisted laser ablation process as laser-induced microjet-assisted ablation(LIMJAA) based on its unique characteristics. High-quality microgrooves with a large depth-to-width ratio of 5.2 are obtained by LIMJAA with a single-pass laser scanning process in our experiments. LIMJAA is capable of machining various types of difficult-to-process materials with high-quality arrays of micro-channels, square and circle microscale through-holes. The results and disclosed mechanisms in our work provide a deep understanding of the role of laser-induced microjet in improving the processing quality of liquid-assisted laser micromachining. | Yang Guo Pei Qiu Shaolin Xu Gary J Cheng | 2022 | International Journal of Extreme Manufacturing2022，4，3： | 3 |
| 9 | Development of a reverse transcription quantitative polymerase chain reaction-based assay for broad coverage detection of African and Asian Zika virus lineages显示文摘The Zika virus(ZIKV) is an arbovirus that has spread rapidly worldwide within recent times. There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome(GBS) and microcephaly in humans. The ZIKV is genetically diverse and can be separated into Asian and African lineages. A rapid, sensitive, and specific assay is needed for the detection of ZIKV across various pandemic regions. So far, the available primers and probes do not cover the genetic diversity and geographic distribution of all ZIKV strains. To this end, we have developed a one-step quantitative reverse transcription polymerase chain reaction(qRT-PCR) assay based on conserved sequences in the ZIKV envelope(E) gene. The detection limit of the assay was determined to be five RNA transcript copies and 2.94 × 10^(–3) 50% tissue culture infectious doses(TCID50) of live ZIKV per reaction. The assay was highly specific and able to detect five different ZIKV strains covering the Asian and African lineages without nonspecific amplification, when tested against other flaviviruses. The assay was also successful in testing for ZIKV in clinical samples. Our assay represents an improvement over the current methods available for the detection ZIKV and would be valuable as a diagnostic tool in various pandemic regions. | Yang Yang Gary Wong Baoguo Ye Shihua Li Shanqin Li Haixia Zheng Qiang Wang Mifang Liang George F Gao Lei Liu Yingxia Liu Yuhai Bi | 2017 | Virologica Sinica2017，32，3： | 3 |
| 10 | Formation of the highest sand dunes on Earth显示文摘 | Xiaoping Yang Louis Scuderi Tao Liu Philippe Paillou Hongwei Li Jufeng Dong Bingqi Zhu Weiwei Jiang Andrew Jochems Gary Weissmann | 2011 | Geomorphology2011，，1： | 2 |
| 11 | Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China显示文摘Dear Editor,Chikungunya virus(CHIKV)is a mosquito-borne virus belonging to the family Togaviridae,genus Alphavirus,and was first isolated in Tanzania in the 1950s(Silva and Dermody 2017;Weaver and Lecuit 2015).Human infections with CHIKV typically result in a rapid-onset febrile disease,with symptoms that include fever,headache,rash,severe joint and muscle pain,as well as prolonged periods of disability in some patients(Weaver and Lecuit 2015;Silva and Dermody 2017). | Yang Yang Zhixiang Xu Haixia Zheng Jingdong Song Ying Wu Zhou Tong Jing Yuan Gary Wong William J.Liu Yuhai Bi Yingxia Liu George F.Gao | 2020 | Virologica Sinica2020，35，1： | 2 |
| 12 | Low power 3.1–10.6 GHz IR-UWB transmitter for Gbps wireless communications显示文摘This paper reviews and discusses the design of a low-power single-full-band (3.1-10.6 GHz) non- carrier impulse-radio ultra wideband (UWB) transmitter featuring 5th-order Gaussian derivative pulse shaping, integrated BPSK modulation, and 2.5 kV whole-chip ESD (electrostatic discharge) protection. The UWB transmitter design has been implemented in a commercial 0.18 μm CMOS technology with a very small die size of 0.25 mm2. The fabricated chips have demonstrated full functionality, extremely low power consumption of 0.14 pJ/p-mV, and an ultra short pulse width of 394 ps. This ESD-protected UWB transmitter has the potential to support wireless streaming to gigabit per second (Gbps). | WANG Xin LIN Lin TANG He ZHAO Hui FANG Qiang LIU Jian FAN SiQiang WANG Albert ZHAO Bin YANG LiWu ZHANG Gary | 2011 | Science China(Information Sciences)2011，54，5： | 2 |
| 13 | H5N6禽流感病毒的基因起源、进化和流行显示文摘2014~2016年间对我国16个省份活禽市场的监测,共鉴定了3174份流感阳性样品,分离并测序了1135份禽流感病毒,分属于31种亚型。 | yuhai bi quanjiao chen qianli wang jianjun chen tao jin gary wong chuansong quan jun liu jun wu renfu yin lihua zhao mingxin li zhuang ding rongrong zou wen xu hong li huijun wang kegong tian guanghua fu yu huang alexander shestopalov shoujun li bing xu hongjie yu tingrong luo lin lu xun xu yang luo 刘映霞 史卫峰 刘翟 高福 | 2017 | 科学新闻2017，0，4： | 2 |
| 14 | Associa-tions of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the HongKong diabetes registry显示文摘 | Xilin Yang Gary TCKO Wing Yee So | 2010 | Diabetes2010，59，5： | 1 |
| 15 | Linking organizational culture, structure, strategy, and organizational effectiveness: Mediating role of knowledge management显示文摘 | Wei Zheng Baiyin Yang Gary N. McLean | 2009 | Journal of Business Research2009，，7： | 1 |
| 16 | Computer simu- lation of asisotropic grain growth显示文摘 | Yang Wei Chen Longqing Gary L Messing | 1995 | Mater Sci Eng A1995，195，： | 1 |
| 17 | Needle localization for excision- al biopsy of breast lesions : comparison of effect of use of full-field digital versus screen-film mammographic guidance on proocedure time显示文摘 | Wei Tse Yang MD Gary J | 2004 | Radiology2004，231，1： | 1 |
| 18 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 19 | The role of team problem solving competency ininformation system development projects显示文摘 | Yuzhu Li Ming-Hsien Yang Gary Klein Houn-GeeChen | 2011 | InternationalJournal of Project Management2011，，29： | 1 |
| 20 | TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas显示文摘 | Brandon-Luke L. Seagle Chia-Ping Huang Yang Kevin H. Eng Monica Dandapani Oluwatosin Odunsi-Akanji Gary L. Goldberg Kunle Odunsi Susan Band Horwitz Shohreh Shahabi | 2015 | Gynecologic Oncology2015，，： | 1 |
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