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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 3 | Mechanism of the Fe^3+ reduction at low temperature for LiFePO4 synthesis from a polymeric additive 显示文摘 | Ravet N Gauthier M Zaghib K Goodenough J B | 2007 | Chem Mater2007，19，： | 1 |
| 4 | ACE inhibi-tion enhances bradykinin relaxations through nitric oxideand B1 receptor activation in bovinecoronary arteries 显示文摘 | Gauthier K M Cepura C J Campbell W B | 2013 | Biol Chem2013，394，9： | 1 |
| 5 | Correlation between chain microstructura/changes and embrittle- ment of LLDPE-based fdms during photo-and thermo-oxidative degradation 显示文摘 | GAUTHIER E LAYCOCK B CUOQ F J J M | 2013 | Polym Degrad Stab2013，98，1： | 1 |
| 6 | Mild cognitive impairment显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
| 7 | A soft chemistry approach to coating of LiFePO4 with a conducting polymer 显示文摘 | LEPAGE D MICHOT C LIANG G X GAUTHIER M SCHOUGAARD S B | 2011 | Angew Chem Int Ed2011，50，： | 1 |
| 8 | Integrated fractural res ervoir eharaeterization~A ease study in a North Africa field显示文摘 | Gauthier B D M Garcia M Daniel J M | 2002 | SPE Reservoir Evaluation ~ Engineering2002，5，28： | 1 |
| 9 | Mild cognitive impairment 显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
| 10 | Mild cognitive impairment显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
| 11 | Vascular phar- macology of epoxyeicosatienoic acids 显示文摘 | Pfiste S E Gauthier K M Campbell W B | 2010 | Adv Pharmacol2010，60，： | 1 |
| 12 | Mild cognitive impairment显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
| 13 | Mild cognitive impairm- ent显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
| 14 | Pathological complete re- sponse and survival according to the level of HER-2 amplification after trastuzumab-based neoadjuvant therapy for breast caucer显示文摘 | Guiu S Gauthier M Coudert B | 2010 | BrJ Cancer2010，103，9： | 1 |
| 15 | Partitio- ning of fish and insect antifreeze proteins into ice suggests they bind with comparableaffinity 显示文摘 | Marshall C B Tomczak M M Gauthier S Y | 2004 | Biochem2004，43，1： | 1 |
| 16 | Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor显示文摘 | Goodwin B Gauthier KC Umetani M | 2003 | Proc Natl Acad Sci USA2003，100，1： | 1 |
| 17 | Probabilistic mod-eling of faults below the limit of seismic resolution in Pelican field,North sea,Offshore United Kingdom显示文摘 | GAUTHIER B D M LAKE S D | 1993 | APPG1993，77，： | 1 |
| 18 | Shock Tube Ignition Measurements of Iso-Octane/Air and Toluene/Air at High Pressures显示文摘 | Davidson D F Gauthier B M Hanson R K | 2005 | Proceedings of the Combustion Institute2005，30，1： | 1 |
| 19 | Vitamin E treatment of focal segmental glomerulosclerosis : results of an open-label study显示文摘 | Tahzib M Frank R Gauthier B | 1999 | Pediatr Nephrol1999，13，8： | 1 |
| 20 | Mild cognitive impairment显示文摘 | Gauthier S Reisberg B Zaudig M | 2006 | Lancet2006，367，9518： | 1 |
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