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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Impact of a 12-month exercise program on the physical and psychological health of osteopenic women显示文摘 | Bravo G Gauthier P Roy P M | 1996 | J Am Geriatr Soc1996，44，： | 1 |
| 3 | Arborescent polystyrene-graft-poly(2-vinylpyridine) copolymers as unimolecular micelles: solubilization studies显示文摘 | Njikang G Gauthier M Li J | 2008 | Polymer2008，49，5： | 1 |
| 4 | Long-term monitoring at multiple trophic levels suggests heterogeneity in responses to climate change in the Canadian Arctic tundra显示文摘 | GAUTHIER G BETY J CADIEUX M C | 2013 | Philosophical Transactions of the Royal Society B:Biological Sciences2013，368，20： | 1 |
| 5 | A soft chemistry approach to coating of LiFePO4 with a conducting polymer 显示文摘 | LEPAGE D MICHOT C LIANG G X GAUTHIER M SCHOUGAARD S B | 2011 | Angew Chem Int Ed2011，50，： | 1 |
| 6 | Phosphonate based bipyridine dyes for stable photovohaic devices 显示文摘 | Gauthier I G Odobel F Alebbi M | 2001 | Inorganic Chemistry2001，40，23： | 1 |
| 7 | Protective effect of glycine betaine on survival of Escherichia Coli cells in marine environment显示文摘 | GAUTHIER M J FLATAU G N BREITTMAYER U A | 1991 | Wat Sci Tech1991，24，2： | 1 |
| 8 | Protective effect of glycine betaine on survival of escherichia coli cells in marine environment显示文摘 | Gauthier M J Flatau G N Breittmayer U A | 1991 | Wat Sci Tech1991，24，2： | 1 |
| 9 | Protective effect of glycine betaine on survival of escherlchia coil cells in marine environment显示文摘 | Gauthier M J Flatau G N Breittmayer U A | 1991 | Wat Sci Tech1991，24，2： | 1 |
| 10 | W-band finite ground coplanar waveguide ( FGCPW ) to microstrip linetransition 显示文摘 | Gauthier G P Katehi L P Rebeiz G M | 1998 | IEEE MTT-S International Microwave Symposium Digest1998，1，： | 1 |
| 11 | Contagion effect on bond portfolio risk measures in a hybrid credit risk model 显示文摘 | Boudreault M Gauthier G | 2014 | FinanceResearch Letters2014，11，2： | 1 |
| 12 | 查看详情显示文摘 | Gauthier M G Slater G W | | 0，，： | 1 |
| 13 | Antibiotic prophylaxis for childhood urinary tract infection: a national survey 显示文摘 | Chevalier I Beno t G Gauthier M | 2008 | J Paediatr Child Health2008，44，10： | 1 |
| 14 | High velocity atomic oxygen/surface accommodation coefficient显示文摘 | GAUTHIER M J CALEDONIA G E | 1993 | Journal of Spacecraft and Rockets1993，30，4： | 1 |
| 15 | Caminoside A,an Antimicrobial Glycolipid Isolated from the Marine Sponge Caminus sphaeroconia显示文摘 | Linington R G Robertson M Gauthier A | 2002 | Org Lett2002，4，23： | 1 |
| 16 | Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning 显示文摘 | Gauthier K M Yang W Gross G J | 2007 | J Cardiovasc Pharmacol2007，50，6： | 1 |
| 17 | Early choline levelsfrom 3-tesla MR spectroscopy after exclusive radiation therapy inpatients with clinically localized prostate cancer are predictive ofplasmatic levels of PSA at I year显示文摘 | Crehange G Maingon P Gauthier M | 2011 | Int J Radiat Oncol BiolPhys2011，81，4： | 1 |
| 18 | Stability of inorganic arsenic (Ⅲ) and arsenic ( Ⅴ ) in water samples 显示文摘 | Hall G E M Pelchat J C Gauthier G | 1999 | Journal of Analytical Atomic Spectrometry1999，，14： | 1 |
| 19 | Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog显示文摘 | Gross G J Gauthier K M Moore J | 2009 | Am J Physiol Heart Circ Physiol2009，297，1： | 1 |
| 20 | Vertical and horizontal eye movement recording in the unrestrained cat显示文摘 | GAUTHIER G M | 1975 | IEEE Transactions on Biomedical Engineering1975，22，3： | 1 |
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