|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | General review of magnetic resonance elastography显示文摘Magnetic resonance elastography(MRE) is an innovative imaging technique for the non-invasive quantification of the biomechanical properties of soft tissues via the direct visualization of propagating shear waves in vivo using a modified phase-contrast magnetic resonance imaging(MRI) sequence. Fundamentally,MRE employs the same physical property that physicians utilize when performing manual palpation- that healthy and diseased tissues can be differentiated on the basis of widely differing mechanical stiffness. By performing 'virtual palpation ',MRE is able to provide information that is beyond the capabilities of conventional morphologic imaging modalities. In an era of increasing adoption of multi-parametric imaging approaches for solving complex problems,MRE can be seamlessly incorporated into a standard MRI examination to provide a rapid,reliable and comprehensive imaging evaluation at a single patient appointment. Originally described by the Mayo Clinic in 1995,the technique represents the most accurate non-invasive method for the detection and staging of liver fibrosis and is currently performed in more than 100 centers worldwide. In this general review,the mechanical properties of soft tissues,principles of MRE,clinical applications of MRE in the liver and beyond,and limitations and future directions of this discipline-are discussed. Selected diagrams and images are provided for illustration. | Gavin Low Scott A Kruse David J Lomas | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | 动态88小时:美国地质调查局国家地震信息中心对2011年3月11日M_W9.0日本地震的响应显示文摘引言
2011年3月11日日本本州岛东海岸附近海域发生的M9.0地震(Tohoku earthquake,以下称“东日本大地震”——译者注)及其引发的海啸造成数以万计的人员死亡,造成的财产损失可能超过1万亿美元,这是有历史记录以来最严重的自然灾害之一。 | Gavin P Hayes Paul S Earle Harley M Benz David J Wald Richard W Briggs 左玉玲(译) 郑需要(校) | 2011 | 国际地震动态2011，，8： | 4 |
| 4 | Changing local geographies of private residential care for older people 1983–1999: lessons for social policy in England and Wales显示文摘 | Gavin J Andrews David R Phillips | 2002 | Social Science & Medicine2002，，1： | 3 |
| 5 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 6 | 三维炭纤维预型体上烷烃气的催化炭沉积(英文)显示文摘研究了承载镍催化剂的三维(3D)炭纤维预型体,在含氢或无氢条件下,乙烷和合成天然气在其上面化学气相沉积形成的炭沉积率和碳纳米构结物。观察了炭沉积所获石墨纳米纤维、碳纳米管和石墨碳壳,得知沉积碳的纳米结构取决于沉积温度和碳源气组成。在650℃~800℃温间,总沉积时程直至12h,研究了烃类碳源气在氢气平衡下,从体积分数100%到20%变化情况。经Ni(NO3)2-6H2O甲醇溶液浸渍的3D炭纤维预型体在炭沉积前因溶液分解可还原出Ni。采用质量变化测定法、热谱-质谱分析仪、SEM、TEM和XRD对样品进行表征。结果表明:纤维状炭与囊包炭的比率随氢气含量的增加而增加,随反应温度的增高而减少。出乎意料的是,氢气的添加并不延长催化剂的寿命。该工艺过程对炭/炭复合材料的制备展示出良好的潜力。 | Matthew J Thornton Gavin S Walker | 2009 | 新型炭材料2009，24，3： | 2 |
| 7 | The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat:a model for periventricular Ieukomalacia显示文摘 | Claire L Gibson I Gavin J | 2003 | Int J Devl Neurosci2003，21，： | 1 |
| 8 | TGF-betal maintains suppressor function and Foxp3 expression in CD4^+ CD25^+ regulatory T cells显示文摘 | Marie J C Letterio J J Gavin M Rudensky A Y | 2005 | J Exp Med2005，201，： | 1 |
| 9 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nature Immunology2003，4，4： | 1 |
| 10 | FoxP3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 11 | Foxp3 pro- grams the development and function of CD4 + CD25 + reg- ulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 12 | Novel clinical markers of vascular wall inflammation显示文摘 | Gavin J Blake Paul M Rider | 2001 | Circ Res2001，89，： | 1 |
| 13 | An antigen produced by splicing of noncontiguous peptides in the reverse order 显示文摘 | Warren E H Vigneron N J Gavin M A | 2006 | Science2006，313，5792： | 1 |
| 14 | Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells 显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，： | 1 |
| 15 | Safety and efficacy of perioperative cell salvage and autotransfusion after coronary artery bypass grafting: a randomized trial 显示文摘 | Gavin J Murphy MD Simon M | 2004 | Ann thorac surg2004，77，： | 1 |
| 16 | Understanding the reproduction of health care: towards geographies in health care work显示文摘 | Andrews Gavin J Evans Josh | 2008 | Progress in Human Geography2008，，6： | 1 |
| 17 | Alternatives to cyanidein the gold mining industry:what prospects for the fu-ture显示文摘 | Gavin Hilson Monhemius A J | 2006 | Journal of Cleaner Production2006，14，： | 1 |
| 18 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 19 | Pigmented contact dermatitis due to kojic acid: A paradoxical side effect of a skin lightener 显示文摘 | GARCIA - GAVIN J GONZALEZ - VILAS D FERNANDEZ - REDONDO V | 2010 | Contact Dermatitis2010，62，1： | 1 |
| 20 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员