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| 1 | Development and Validation of a Nomogram for Prediction of the Risk of MAFLD in an Overweight and Obese Population显示文摘Background and Aims:Metabolic associated fatty liver disease(MAFLD)is a serious condition,and a simple meth-od is needed for practitioners to identify patients with the disease and have a high risk of disease progression.Meth-ods:We developed and validated a nomogram for fatty liver disease and reclassified the risk factors for MAFLD.The development cohort had 335 patients who received bioel-ectrical impedance analysis and liver ultrasound attenua-tion measurements at Shenzhen People’s Hospital between September 2020 and June 2021.The validation cohort had 200 patients from other hospitals who received the same evaluation.A random forest procedure and binary logistic analysis were used to screen for risk factors,establish a fatty liver disease predictive model,and forecast the risk of MAFLD.The performance of the nomogram was evaluated by measurement of discrimination,calibration,and clinical usefulness.Results:The nomogram provided good predic-tions in a model that included body mass index(BMI)and waist circumference.The areas under the curve of the nom-ogram were 0.793 in the development cohort and 0.774 in the validation cohort.The nomogram performed well for calibration,category-free net reclassification improvement,and integrated discrimination improvement.Decision curve analysis indicated the nomogram performed better than BMI for predicting net outcome.Conclusions:The nomo-gram was an effective screening tool for fatty liver disease,and for those overweight individuals,may help physicians make appropriate decisions regarding treatment of MAFLD. | Di Song Qian Ge Ming Chen Song Bai Xiaoshu Lai Gege Huang Mengmeng Liu Miaofang Lin Jinfeng Xu Fajin Dong | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 1 |
| 2 | Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults显示文摘This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method. | Li-Ying Hao Gege Dong Tieshan Li Zhouhua Peng | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，4： | 0 |
| 3 | The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications显示文摘Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma. | Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu | 2023 | Genes & Diseases2023，10，4： | 0 |
| 4 | Rh/CeO_(2) composites prepared by combining dealloying with calcination as an efficient catalyst for CO oxidation and CH4 combustion显示文摘In this paper,a series of Rh/CeO_(2) catalysts with three-dimensional porous nanorod frameworks and large specific surface area were prepared by chemical dealloying Al–Ce–Rh precursor alloys and then calcining in pure O_(2).The effects of the Rh content and calcination temperature on CO oxidation and CH_(4) combustion were studied,and the results reveal that the Rh/CeO_(2) catalysts produced by dealloying melt-spun Al_(91.3)Ce_(8)Rh_(0.7) alloy ribbons and then calcining at 500℃ exhibit the best catalytic activity,the reaction temperatures for the complete conversion of CO and CH_(4) are as low as 90 and 400℃,respectively.Furthermore,after 150 h of continuous testing at high concentrations of H2O and CO_(2),the nature of the catalyst is not irreversibly destroyed and can still return to its initial level of activity.This excellent catalytic activity is attributed to a portion of Rh being uniformly distributed on the CeO_(2) nanorod surface in the form of nanoparticles,forming strong Rh–CeO_(2) interfacial synergy.Another portion of Rh permeated into the CeO_(2) lattice,which results in a significant increase in the number of oxygen vacancies in CeO_(2),thus allowing more surface active oxygen to be adsorbed and converted from the gas phase.Moreover,the catalytic reaction can proceed even in an oxygen-free environment due to the excellent oxygen storage performance of the Rh/CeO_(2) catalyst. | Dong Duan Chunxi Hao Gege He Yang Wen Zhanbo Sun | 2022 | Journal of Rare Earths2022，40，4： | 0 |
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