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| 1 | Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica显示文摘Recent studies indicated that type II Toxoplasma gondii(Tg)GRA15II favored the generation of classically activated macrophages(M1),whereas type I/III TgROP16I/III promoted the polarization of alternatively activated macrophages(M2).A number of studies have demonstrated that M2 cells are involved in the pathogenesis of the liver fibrogenesis caused by Schistosoma japonicum.The purpose of the present study was to explore the inhibitory effect of Toxoplasma-derived TgGRA15II on mouse hepatic fibrosis with schistosomiasis.The gra15II and rop16I/III genes were amplified from strains T.gondii PRU and Chinese 1 Wh3,respectively.Lentiviral vectors containing the gra15II or rop16I/III plasmid were constructed and used to infect the RAW264.7 cell line.The polarization of the transfected cells was evaluated,followed by co-culture of the biased macrophages with mouse hepatic stellate JS1 cells.Then,mice were injected with GRA15II-driven macrophages via the tail vein and infected with S.japonicum cercariae.TgGRA15II induced a M1-biased response,whereas TgROP16I/III drove the macrophages to a M2-like phenotype.The in vitro experiments indicated that JS1 cell proliferation and collagen synthesis were decreased following co-culture with TgGRA15II-activated macrophages.Furthermore,mice inoculated with TgGRA15II-biased macrophages displayed a notable alleviation of collagen deposition and granuloma formation in their liver tissues.Our results suggest that TgGRA15II-induced M1 cells may dampen the M2 dominant pathogenesis of hepatic fibrosis and granulomatosis.These results provide insights into the use of parasite-derived immunomodulators as potential anti-fibrosis agents and to re-balance the schistosomiasis-induced immune response. | Yuanyuan Xie Huiqin Wen Ke Yan Shushu Wang Xuesong Wang Jian Chen Yuanling Li Yuanhong Xu Zhengrong Zhong Jilong Shen Deyong Chu | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 2 | Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts显示文摘 | Sheng Zhao Hengfang Wu Wenlong Xia Xiangjian Chen Shushu Zhu Shijiang Zhang Yongfeng Shao Wenzhu Ma Di Yang Jinan Zhang | 2013 | Journal of Cardiology2013，，： | 1 |
| 3 | C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes显示文摘 | Jin Yang Junhong Wang Shushu Zhu Xiangjian Chen Hengfang Wu Di Yang Jinan Zhang | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 4 | Fullerene/cobalt porphyrin charge-transfer cocrystals: Excellent thermal stability and high mobility显示文摘尽管有高活动性和热稳定性的器官的半导体为实际应用程序是特别地合乎需要的,为他们的开发的灵巧的方法仍然是大挑战。在这个工作,费用转移 cocrystal 基于 fullerene (C 70)/cobalt 卟啉超分子的建筑学被 solution-processable 合作集会策略准备。这超分子的体系结构象 4.21 cm2 一样高显示出洞活动性 ????? ????????? ?????????????? 壍 ?? ? 吗?? | Shushu Zheng Junwen Zhong Wakana Matsuda Peng Jin Muqing Chen Takeshi Akasaka Kazuhito Tsukagoshi Shu Seki Jun Zhou Xing Lu | 2018 | Nano Research2018，11，4： | 1 |
| 5 | Enhanced recovery of high-purity Fe powder from iron-rich electrolytic manganese residue by slurry electrolysis显示文摘Iron-rich electrolytic manganese residue(IREMR)is an industrial waste produced during the processing of electrolytic metal manganese,and it contains certain amounts of Fe and Mn resources and other heavy metals.In this study,the slurry electrolysis technique was used to recover high-purity Fe powder from IREMR.The effects of IREMR and H2SO4 mass ratio,current density,reaction temper-ature,and electrolytic time on the leaching and current efficiencies of Fe were studied.According to the results,high-purity Fe powder can be recovered from the cathode plate,and the slurry electrolyte can be recycled.The leaching efficiency,current efficiency,and purity of Fe reached 92.58%,80.65%,and 98.72wt%,respectively,at a 1:2.5 mass ratio of H2SO4 and IREMR,reaction temperature of 60℃,electric current density of 30 mA/cm^(2),and reaction time of 8 h.In addition,vibrating sample magnetometer(VSM)analysis showed that the coercivity of electrolytic iron powder was 54.5 A/m,which reached the advanced magnetic grade of electrical pure-iron powder(DT4A coercivity standard).The slurry electrolytic method provides fundamental support for the industrial application of Fe resource recovery in IRMER. | Wenxing Cao Jiancheng Shu Jiaming Chen Zihan Li Songshan Zhou Shushu Liao Mengjun Chen Yong Yang | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，3： | 0 |
| 6 | The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications显示文摘Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma. | Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu | 2023 | Genes & Diseases2023，10，4： | 0 |
| 7 | Identification of Pulmonary Hypertension Animal Models Using a New Evolutionary Machine Learning Framework Based on Blood Routine Indicators显示文摘Pulmonary Hypertension(PH)is a global health problem that affects about 1%of the global population.Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease.The present study proposes a Kernel Extreme Learning Machine(KELM)model based on an improved Whale Optimization Algorithm(WOA)for predicting PH mouse models.The experimental results showed that the selected blood indicators,including Haemoglobin(HGB),Hematocrit(HCT),Mean,Platelet Volume(MPV),Platelet distribution width(PDW),and Platelet–Large Cell Ratio(P-LCR),were essential for identifying PH mouse models using the feature selection method proposed in this paper.Remarkably,the method achieved 100.0%accuracy and 100.0%specificity in classification,demonstrating that our method has great potential to be used for evaluating and identifying mouse PH models. | Jiao Hu Shushu Lv Tao Zhou Huiling Chen Lei Xiao Xiaoying Huang Liangxing Wang Peiliang Wu | 2023 | Journal of Bionic Engineering2023，20，2： | 0 |
| 8 | Special library services for regional economic development(SRED)—Practice of the NSLC显示文摘Purpose: By case studies of the service for regional economic development(SRED) carried out by the National Science Library of the Chinese Academy of Sciences(NSLC), this article tries to describe basic directions of special libraries in the SRED.Design/methodology/approach: By comparing the aims and service forms of the SRED provided by domestic and foreign libraries and information service institutions, the authors examined the basic services provided by special libraries. Through a summary of the SRED exploration carried out by the NSLC, the authors introduce its main content, service methods, products, and service mechanisms. By analyzing the information needs of SRED users and summarizing users' practical experiences of services, the authors propose a design for the SRED framework of the NSLC. In addition, the authors mention key points to be noticed during the process of service implementation, illustrating them with a number of selected SRED cases. The authors suggest that the SRED network and joint service mechanism are effective ways to implement SRED services. Findings: Based on information resource and expert networks, special libraries like the NSLC can carry out SRED to meet user requirements. The NSLC has not only constructed its own SRED framework, but has also expanded the patron service to the industrial intelligence service area. By setting up a nationwide S&T(science and technology) novelty search network and a literature and information service alliance, the NSLC provides a variety of information training services. This enriches the content of the knowledge service of special libraries and enlarges the library service of the NSLC.Research limitations: The SRED of Chinese libraries is still in the exploratory stage. Questions as how to scientifically design service content and service modes, and how to establish a sustainable regional service system based on user needs are still being researchedand discussed. Furthermore, we need to pay more attention to the construction of the service network and respond more quickly to feedback while creating the SRED.Practical implications: The SRED experience of the NSLC has shown that special libraries can implement a knowledge service for economic development, and the SRED is an important direction of knowledge services for special libraries.Originality/value: Through describing a practical SRED, this paper provides a valuable reference for libraries in the transformation process from library service to knowledge service. The experimental SRED of the NSLC has verified the rationality of our service framework in support of regional economic development. | Xiwen LIU Yuling SUN Ping JIA Fang CHEN Hao PENG Yafei YAN Lu DONG Xiaoli CHEN Shushu CHEN Wenjiao GUO Zhuang LI | 2015 | Chinese Journal of Library and Information Science2015，，3： | 0 |
| 9 | A new approach to assessing the science and technology competitiveness of China's provincial academies of sciences显示文摘Purpose: This study aims to establish a new framework for evaluating science and technology(S&T) competitiveness that is appropriate to meet the needs of provincial academies of sciences(PASs) in China.Design/methodology/approaches: An evaluation index, including such assessing indicators as research strength, research impact, research development and trends, and regional contributions, is developed for China's PASs. Taking the Jiangxi Academy of Sciences(JXAS) as an example, we first explain how to apply this framework to analyze the strengths and weaknesses of PASs in China. Then, we compare the results of all 17 PASs in order to get a comprehensive understanding of their competitiveness.Findings: Our results show the development path, current status, innovation advantages, and weaknesses of JXAS very clearly. Based on our comparative analysis, we ranked the 17 PASs from the perspective of different dimensions, by which their competitiveness strengths and weaknesses can be highlighted for improvement.Research limitations: In this analysis, we did not take S&T policies, S&T systems, or historical factors into consideration. Thus, we may have ignored the influence of the soft individual differences of different PASs in China.Practical implications: The evaluation index developed in this paper provides a useful insight into an analytical method that can be used by PASs or other provincial research institutions(PRIs) to assess their competitiveness.Originality/value: Compared with existing evaluation frameworks, our method has two main characteristics: First, we added three new dimensions, including the PASs' applicable research outputs, regional contributions, and comparative advantages; second, we conducted a comparative analysis of local research institutes in their different advantaged industrial areas, which makes our analytical method more comprehensive for local research institutions. | Huifang XU Shushu CHEN Yajing LIU Ling LENG Wenjiao GUO | 2015 | Chinese Journal of Library and Information Science2015，，4： | 0 |
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