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| 1 | A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1显示文摘 | Giuseppe Militello Mohammed Rabiul Hosen Yuliya Ponomareva Pascal Gellerts Tyler Weirick David John Sajedah Mahmoud Hindi Kamel Mamchaoui Vincent Mouly Claudia Doring Lidan Zhang Miki Nakamura Ashok Kumar So-ichiro Fukada Stefanie Dimmeler Shizuka Uchida | 2018 | Journal of Molecular Cell Biology2018，10，2： | 7 |
| 2 | Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease显示文摘AIM: With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the fact whether reflux episodes causing complaints for a long time i.e., at least for one year are associated with metabolic changes in the lower esophageal sphincter, and if so,whether these may influence functional results achieved after anti-reflux surgery.METHODS: Between 1 January 2001 and 31 December 2002 we performed anti-reflux surgery on 79 patients.Muscle samples were taken from the lower esophageal sphincter (LES) in 33 patients during anti-reflux surgery.Inclusion criteria were: LES resting pressure below 10 mmHg and a marked, pH proven acid exposure to the esophagus of at least one year's duration, causing subjective complaints and requiring continuous proton pump inhibitor treatment. Control samples were obtained from muscle tissue in the gastroesophageal junction that had been removed from 17 patients undergoing gastric or esophageal resection. Metabolic and lysosomal enzyme activities and special protein concentrations 16 parameters in total were evaluated in tissue taken from control specimens and tissue taken from patients with GERD. The biochemical parameters of these intra-operative biopsies were used to correlate the results of anti-reflux operations (Visick I and II-III).RESULTS: In the reflux-type muscle, we found a significant increase of the energy-enzyme activities e.g., creatine kinase, lactate dehydrogenase, β-hydroxybutyrate dehydrogenase, and aspartate aminotransaminase-. The concentration of the structural protein S-100 and the myofibrillar protein troponin I were also significantly increased. Among lysosomal enzymes, we found that the activities of cathepsin B, tripeptidyl-peptidase I, dipeptidylpeptidase II, β-hexosaminidase B, β-mannosidase and β-galactosidase were significantly decreased as compared to the control LES muscles. By analyzing the activity values of the 9 patients in Visick groups Ⅱ and Ⅲ at two months post-surgery, we found a significant increase in the activity of the so-called energy-enzyme values and in the concentration of structural and myofibrillar proteins as compared to the rest of the reflux patients.CONCLUSION: Our results call attention to the metabolic changes that occurred in the LES muscles of reflux patients. The developing hypertrophy-like changes of LES muscles may be a reason for complaints after anti-reflux surgery, which consisted mainly of reports of persisting dysphagia. | Aron Altorjay Arpad Juhasz Viola Kellner Gellert Sohar Matyas Fekete Istvan Sonar | 2005 | World Journal of Gastroenterology2005，11，11： | 2 |
| 3 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 4 | A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding显示文摘 | Dirk Hartmann Harald Schmidt Georg Bolz Dieter Schilling Frank Kinzel Axel Eickhoff Winfried Huschner Kathleen M?ller Ralf Jakobs Peter Reitzig Uwe Weickert Klaus Gellert Harald Schultz Klaus Guenther Hartmut Hollerbuhl Klaus Schoenleben Hans-Joachim Schu | 2005 | Gastrointestinal Endoscopy2005，，7： | 2 |
| 5 | Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50complex显示文摘 | Paull TT Gellert M | 1999 | Genes Dev1999，13，10： | 1 |
| 6 | Lipid modification of GRN163, an N3'- > P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition显示文摘 | HERBERT BS GELLERT GC HOCHREITER A | 2005 | Oncogene2005，24，33： | 1 |
| 7 | Kappa -opioid system in uremic pruritus, multicenter, random- ized, double - blind, placebo - controlled clinical studies 显示文摘 | WlKSTROM B GELLERT R LADEFOGED SD | 2005 | Am Soc Nephrol2005，16，12： | 1 |
| 8 | Nalidixic acid resistance:a second genetic character involved in DNA gyrase activity显示文摘 | Gellert M Mizuuchi K O'Dea MH | 1977 | Proceedings National Academy Sciences USA1977，74，： | 1 |
| 9 | Review of advanced composite structure for naval ships and submarines 显示文摘 | Mouritz A P Gellert E Burchill P | 2001 | Composite Structures2001，53，11： | 1 |
| 10 | Cancer in patients on dialysis for endstage renal disease:an international collaborative study显示文摘 | MAISONNEUVE P AGODOA L GELLERT R | 1999 | Lancet1999，354，9173： | 1 |
| 11 | Generation of excimer emission in dielectric barrier discharge 显示文摘 | Gellert B Kogelschatz U | 1991 | Appl Phys B1991，52，： | 1 |
| 12 | Selective cancer cell killing by alpha-tocopheryl succinate显示文摘 | Neuzil J Weber T Gellert N | 2001 | Br J Cancer2001，84，1： | 1 |
| 13 | Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer 显示文摘 | GELLERT GC DIKMEN ZG WRIGHT WE | 2006 | Breast CancerRes Treat2006，96，1： | 1 |
| 14 | A study of effect of t arget t hickness on the perforation of glass-fibre-reinforced plastic composites显示文摘 | Gellert E P Cimpoeru S J Woodward R L | 2000 | I nt J Impact Engng2000，24，： | 1 |
| 15 | Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent man- ner显示文摘 | Rutz M Metzger J Gellert T | 2004 | Eur J Immunol2004，34，9： | 1 |
| 16 | The Rosetta Alpha Particle X-Ray Spectrometer (APXS)显示文摘 | G. Klingelh?fer J. Brückner C. D’uston R. Gellert R. Rieder | 2007 | Space Science Reviews2007，，1： | 1 |
| 17 | Epidemiology and demography of treated end-stage renal failure in the elderly: From the European Renal Association(ERAEDTA) Registry显示文摘 | BERTHOUX F GELLERT R JONES E | 1998 | Nephrol Dial Transplant1998，13，： | 1 |
| 18 | Selective cancer cell killing by alpha-tocopheryl succinate显示文摘 | Neuzil J Weber T Gellert N | 2001 | Br J Cancer2001，84，1： | 1 |
| 19 | Diagnose and Therapie des postoperativen chyloperitoneums 显示文摘 | BAUWENS K JACOBI CA GELLERT K | 1996 | Chirurg1996，67，6： | 1 |
| 20 | Investigation of resonance and excimer radiation from a dielectric barrier discharge in mixtures of mercury and the rare-gases 显示文摘 | Eliasson B Gellert B | 1990 | J Appl Phys1990，68，5： | 1 |
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