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| 1 | Lipid metabolism reprogramming and its potential targets in cancer显示文摘Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.Increased lipid uptake,storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth.Lipids constitute the basic struc-ture of membranes and also function as signaling molecules and energy sources.Sterol regulatory element-binding proteins(SREBPs),a family of membrane-bound transcription factors in the endoplasmic reticulum,play a central role in the regulation of lipid metabolism.Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth.SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor,thus linking glucose metabolism and de novo lipid synthesis.Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy.This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy,and highlights potential molecu-lar targets and their inhibitors for cancer treatment. | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | Cancer Communications2018，38，1： | 34 |
| 2 | 脂质代谢重编程及其在癌症中潜在靶点的研究显示文摘脂质代谢的重编程是恶性肿瘤的一个新特征。在多种癌症中,脂肪摄取、储存和脂肪生成均被上调,这也促进了肿瘤的快速生长。脂质是构成膜的基本结构,并且具有信号分子和能量来源的功能。固醇调节元件结合蛋白(Sterol regulatory element-binding proteins,SREBPs)是内质网中一类膜结合转录因子,在调节脂质代谢中起着核心作用。最近的研究表明,SREBPs在各种癌症中高度上调并促进肿瘤生长。SREBP切割激活蛋白(SREBP cleavage-activating protein,SCAP)是SREBPs转运和激活的关键转运蛋白,也是一种关键的葡萄糖传感器,因此它将葡萄糖代谢与脂类从头合成联系在一起。靶向变异的脂质代谢途径已成为一种很有前景的抗癌策略。本综述总结了近年来我们所知的对恶性肿瘤中脂质代谢调节的最新研究进展,并着重介绍了癌症治疗中潜在的分子靶点及其抑制剂。 | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | 癌症2018，37，11： | 6 |
| 3 | Noncircular Bevel gear Tranamission with Intersectiong Axes显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | Transactions of the ASME2008，130，5： | 1 |
| 4 | Noncircular bevel gear transmission with intersecting axes显示文摘 | Xia Jiqiang Liu Yuanyan Geng Chunming | | 0，，05： | 1 |
| 5 | A Distributed Honeypots for Grid Security显示文摘 | YANG Geng RONG Chunming DAI Yueping | 2004 | Lecture Notes in Computer Science2004，3032，： | 1 |
| 6 | Non-circular bevel gear transmission with intersecting axes显示文摘 | XIA Jiqiang LIU Yuanyuan GENG Chunming | 2008 | Journal of Mechanical Design Transactions of theASME2008，130，5： | 1 |
| 7 | Noncircular Bevel Gear Transmission With Intersecting Axes 显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | Journal of Mechanical Design2008，130，5： | 1 |
| 8 | Noncircular bevel gear transmission with intersectingaxes显示文摘 | XIA Jiqiang LIU Yuanyuan GENG Chunming | 2008 | Journal of Mechanical Design2008，130，5： | 1 |
| 9 | High-efficiency separation and extraction of naphthenic acid from high acid oils using imidazolium carbonate ionic liquids显示文摘N-alkyl imidazolium carbonate ionic liquids were employed to separate and recover naphthenic acid from model oils.The effects of the cationic and anionic structures of ionic liquids and operating conditions on the deacidification performance were investigated.The deacidification performance of traditional organic solvents was also investigated for comparison.The results indicated that the naphthenic acid could be completely removed from the model oil with a small mass ratio of ionic liquid to oil.The extracted naphthenic acid was regenerated with a recovery of up to 92%.In addition,imidazolium carbonate ionic liquids could be successfully regenerated and recycled.The mechanism of interaction between imidazole ionic liquids and the naphthenic acid molecules were explained by Gauss calculation. | Fenghua Geng Rui Zhang Luo Wu Zheng Tang Han Liu Haiyan Liu Zhichang Liu Chunming Xu Xianghai Meng | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 10 | Non-circular bevel gear transmission with intersecting axes显示文摘 | XIA Jiqiang LIU Yuanyuan GENG Chunming | 2008 | Journal of Mechanical Design Transactions of the ASME2008，130，5： | 1 |
| 11 | Preparation, characterization and photocatalytic applications of amine-functionalized mesoporous silica impregnated with transition-metal-monosubstituted polyoxometalates显示文摘 | LI Li LIU Chunming GENG Aifang | 2006 | Materials Research Bulletin2006，41，2： | 1 |
| 12 | Noncircular bevel gear transmission with intersecting axes 显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | ASME Journal of Mechanical Design2008，130，05： | 1 |
| 13 | Noncircular bevel gear transmission with intersecting axes显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | Transactions of the American Society of Mechanical Engineers Journal of Mechanical Design2008，130，5： | 1 |
| 14 | Identity-based Key Agreement and Encryption for Wireless Sensor Networks显示文摘 | Geng Yang Chunming Rong Christian Veigner | 2006 | Journal of China Universities of Posts and Telecommunications2006，13，4： | 1 |
| 15 | Noncircular bevel gear transmission with intersecting axes显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | Journal of Mechanical Design Transactions of the ASME2008，130，5： | 1 |
| 16 | A Novel Approach for Role-Based Access Control显示文摘 | YANG Geng RONG Chunming SHEN Jiangang WANG Jiangtao | 2007 | Chinese Journal of Electronics2007，16，1： | 1 |
| 17 | Non-circular bevel gear transmission with intersecting axes 显示文摘 | XIA Jiqiang LIU Yuanyuan GENG Chunming | 2008 | Journal of Mechanical Design2008，130，5： | 1 |
| 18 | Non-cir- cular bevel gear transmission with intersecting axes 显示文摘 | Xia Jiqiang Liu Yuanyuan Geng Chunming | 2008 | Journal of Mechanical Design Transactions of the ASME2008，130，5： | 1 |
| 19 | Simultaneous Optimization of Efficiency,Stretchability,and Stability in All-Polymer Solar Cells via Aggregation Control显示文摘With the emergence of Y-series small molecule acceptors,polymerizing the small molecule acceptors with aromatic linker units has attracted significant research attention,which has greatly advanced the photovoltaic performance of all-polymer solar cells.Despite the rapid increase in efficiency,the unique characteristics(e.g.,mechanical stretchability and flexibility)of all-polymer systems were still not thoroughly explored.In this work,we demonstrate an effective approach to simultaneously improve device performance,stability,and mechanical robustness of all-polymer solar cells by properly suppressing the aggregation and crystallization behaviors of polymerized Y-series acceptors.Strikingly,when introducing 50 wt%PYF-IT(a fluorinated version of PY-IT)into the well-known PM6:PY-IT system,the all-polymer devices delivered an impressive photovoltaic efficiency of 16.6%,significantly higher than that of the control binary cell(15.0%).Compared with the two binary systems,the optimal ternary blend exhibits more efficient charge separation and balanced charge transport accompanying with less recombination.Moreover,a high-performance 1.0 cm^(2)large-area device of 15%efficiency was demonstrated for the optimized ternary all-polymer blend,which offered a desirable PCE of 14.5%on flexible substrates and improved mechanical flexibility after bending 1000 cycles.Notably,these are among the best results for 1.0 cm^(2)all-polymer OPVs thus far.This work also heralds a bright future of all-polymer systems for flexible wearable energy-harvesting applications. | Kaihu Xian Kangkang Zhou Mingfei Li Junwei Liu Yaowen Zhang Tao Zhang Yong Cui Wenchao Zhao Chunming Yang Jianhui Hou Yanhou Geng Long Ye | 2023 | Chinese Journal of Chemistry2023，41，2： | 1 |
| 20 | Noncircular bevel gear transmission with intersecting axes显示文摘 | XIA Jiqiang LIU Yuanyuan GENG Chunming | 2008 | Journal of Mechanical Design Transactions of the ASME2008，130，5： | 1 |
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