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| 1 | Semigroup Method for a Mathematical Model in Reliability Analysis显示文摘The system which consists of a reliable machine, an unreliable machine and a storage buffer with infinite many workpieces has been studied. The existence of a unique positive time-dependent solution of the model corresponding to the system has been obtained by using C 0-semigroup theory of linear operators in functional analysis. | Geni Gupur 1,3 , LI Xue-zhi 2,3 1.Department of Mathematics, Xinjiang University, Urumqi 830046,China2. Department of Mathematics, Xinyang Teachers College, Henan 464000, China3. Academy of Mathematics and System Sciences, Chinese Academy of Sci | 2001 | Journal of Systems Science and Systems Engineering2001，13，2： | 12 |
| 2 | FED:a web tool for foreign element detection of genome-edited organism显示文摘Dear Editor,Genome editing,especially the newly developed CRISPR technology,is now widely implemented for diverse medical and agricultural applications(Puchta,2018).However,for genome editing,the DNA cassettes encoding the editing components are usually assembled and delivered into the cells of organisms(Cong et al.,2013). | Qing Liu Xiaozhen Jiao Xiangbing Meng Chun Wang Cao Xu Zhixi Tian Chuanxiao Xie Genying Li Jiayang Li Hong Yu Kejian Wang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
| 3 | Dissecting conserved cis-regulatory modules of Glu-1 promoters which confer the highly active endosperm-specific expression via stable wheat transformation显示文摘Wheat high-molecular-weight glutenin subunits(HMW-GS) determine dough elasticity and play an essential role in processing quality. HMW-GS are encoded by Glu-1 genes and controlled primarily at transcriptional level, implemented through the interactions between cis-acting elements and trans-acting factors. However, transcriptional mechanism of Glu-1 genes remains elusive. Here we made a comprehensive analysis of cis-regulatory elements within 1-kb upstream of the Glu-1 start codon(-1000 to-1) and identified 30 conserved motifs. Based on motif distribution pattern, three conserved cis-regulatory modules(CCRMs), CCRM1(-300 to-101), CCRM2(-650 to-400), and CCRM3(-950 to-750), were defined, and their functions were characterized in wheat stable transgenic lines transformed with progressive 5′ deletion promoter::GUS fusion constructs. GUS staining, qP CR and enzyme activity assays indicated that CCRM2 and CCRM3 could enhance the expression level of Glu-1, whereas the 300-bp promoter(-300 to-1), spanning CCRM1 and core region(-100 to-1), was enough to ensure accurate Glu-1 initiation at 7 days after flowering(DAF) and shape its spatiotemporal expression pattern during seed development. Further transgenic assays demonstrated that CCRM1-2(-300 to-209) containing Complete HMW Enhancer(-246 to-209) was important for expression level but had no effect on expression specificity in the endosperm. In contrast, CCRM1-1(-208 to-101) was critical for both expression specificity and level of Glu-1. Our findings not only provide new insights to uncover Glu-1 transcription regulatory machinery but also lay foundations for modifying Glu-1 expression. | Jihu Li Ke Wang Genying Li Yulian Li Yong Zhang Zhiyong Liu Xingguo Ye Xianchun Xia Zhonghu He Shuanghe Cao | 2019 | The Crop Journal2019，7，1： | 2 |
| 4 | Mathematical theory of age-structured epidemic dynamics显示文摘 | GENI G ZHU G | 2002 | Research Information Ltd UK2002，，： | 1 |
| 5 | Molecular characterization of allelic variations at Pina and Pinb loci in Shandong wheat landraces, historical and current cultivars显示文摘 | Genying Li Zhonghu He Morten Lillemo Qixin Sun Xianchun Xia | 2007 | Journal of Cereal Science2007，，3： | 1 |
| 6 | The threshold and stability results for an age-structured SEIR epidemic model显示文摘 | Li X Geni G Zhu G | 2001 | Comput Math Appl2001，42，： | 1 |
| 7 | Functional analysis method in queueing theory显示文摘 | Geni Gupur Li Xue-zhi Zhu Guang-tian | 2001 | Rearch Information Ltd Hertfordshire2001，3566，： | 1 |
| 8 | Existence and uniqueness of epidemic states for the age-structured MSEIR epidemic model显示文摘 | Xue-zhi Li Geni Gupur Guang-tian Zhu | 2002 | Acta Mathematical Applicatae Sinica English Series2002，18，3： | 1 |
| 9 | Existence and uniqueness of epidemic states for the agestructured MSEIR epidemic model显示文摘 | Xue-zhi Li Geni Gupur Guang-tian Zhu | 2002 | Acta Mathematicae Appilcatae Sinica English Series2002，18，3： | 1 |
| 10 | Analysis of an age-structured SEIR epidemic model with vaccination显示文摘 | Li X Geni G and Zhu G | 2003 | Intern J Diff Equ Appl2003，7，1： | 1 |
| 11 | Existence and uniqueness of nonnegative solution of M/GB/1 queueing mode显示文摘 | Li Xue-zhi Zhu Guang-tian | | Computers and Mathematics with Applications0，39，： | 1 |
| 12 | The application of C0-semigroup theory to dynamic queueing systems显示文摘 | Xue-zhi Li Guang-tian Zhu | 2001 | Semigroup Forum2001，62，： | 1 |
| 13 | The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway显示文摘Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary metastases.It has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for osteosarcoma.In the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma cells.Importantly,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in vivo.Mechanistically,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma cells.These findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases. | Geni Ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Wen Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin Wencai Ye Dongmei Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 14 | Existence and uniqueness of nonnegative solution of M/GB/1 queueingmodel显示文摘 | Geni Gupur Li Xue-zhi Zhu Guang-tian | 2000 | Computers & Mathematics with Applications2000，39，： | 1 |
| 15 | The application of C0-semigroup theory to dynamic queueingsystems显示文摘 | Geni Gupur Li Xue-zhi Zhu Guang-tian | 2001 | Semigroup Forum2001，60，： | 1 |
| 16 | Comparative proteomic analysis of cold responsive proteins in two wheat cultivars with different tolerance to spring radiation frost显示文摘Spring radiation frost(SRF)is a severe environmental stress which impairs wheat yield and productivity worldwide.To better understand the mechanism of wheat(Triticum aestivum)responding to SRF,a comparative proteomic analysis was performed to analyze the changes of the key proteins in two wheat cultivars Jimai22 and Luyuan301 with high and low tolerance to SRF respectively.A total of 43 differentially expressed proteins(DEPs)which mainly involved in carbohydrate metabolism,amino acid metabolism,resistance proteins and antioxidant enzymes,photosynthesis and cellular respiration proteins,cell-wall related proteins,protein translation/processing/degradation and signal transduction were isolated and identified by two-dimensional electrophoresis and MALDI-TOF-TOF MS.The results revealed that of the 21 DEPs in Jimai22 responding to the SRF,13 DEPs were upregulated and 8 DEPs were downregulated,and that of the 22 DEPs in Luyuan301,9 DEPs were upregulated and 13 DEPs were downregulated.These DEPs might be responsible for the stronger cold resistance of Jimai22 compared to Luyuan301.The expression pattern and function analysis of these DEPs were very significant to understanding the mechanism of the SRF responses in wheat. | Shujuan ZHANG Guoqi SONG Yulian LI Jie GAO Jiao WANG Guiju CHEN Haosheng LI Genying LI Zhendong ZHAO | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 1 |
| 17 | Threshold and stability Results for an age-structured SEIR epidemic model显示文摘 | Xuezhi Li Geni Guper Guangtian Zhu | 2001 | Computers and Mathematics with Applications2001，42，： | 1 |
| 18 | Analysis of an age-structured SEIRS epidemic model with varing totalpopulation size and vaccination显示文摘 | LI XUE-ZHI GUPUR GENI ZHU GUANG-RIAN | 2003 | Acta Math Appl Sinica2003，19，4： | 1 |
| 19 | Threshold and stability results for an age-structured SEIR epidemic model显示文摘 | Li X Z Geni G Zhu G T | 2001 | Comp Math Appl2001，42，： | 1 |
| 20 | Existence and uniqueness of epidemic states for the age-structured MSEIR epidemic model显示文摘 | Li X Z Geni G Zhu G T | | Acta Math Appl Sinica0，，： | 1 |
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