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| 1 | Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature显示文摘BACKGROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing enteropathy.The disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and lymphopenia.Since the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among others.Although usually developing in early childhood,we present the case of a 34-yearold woman with PIL.Moreover,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in adults.CASE SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower limbs.Interestingly,a striking collinearity of clinical symptoms with female hormone status was evident.Additionally,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were evident.Due to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and hypoalbuminemia.The diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via enteroscopy.Consecutively,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of follow-up.CONCLUSION PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in adulthood.Due to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and welltolerated.This leads to a significant disease burden in affected patients.PIL is increasingly been recognized in adults since the majority of case reports were published within the last 10 years,pointing towards an underestimation of the true prevalence.The association with female hormone status warrants further investigation. | Rudolf Huber Georg Semmler Alexander Mayr Felix Offner Christian Datz | 2020 | World Journal of Gastroenterology2020，26，48： | 6 |
| 2 | Self-referential processing in our brain—A meta-analysis of imaging studies on the self显示文摘 | Georg Northoff Alexander Heinzel Moritz de Greck Felix Bermpohl Henrik Dobrowolny Jaak Panksepp | 2005 | Neuroimage2005，，1： | 3 |
| 3 | Endothelial Microparticle–Mediated Transfer of MicroRNA-126 Promotes Vascular Endothelial Cell Repair via SPRED1 and Is Abrogated in Glucose-Damaged Endothelial Microparticles显示文摘 | Felix Jansen Xiaoyan Yang Marion Hoelscher Arianna Cattelan Theresa Schmitz Sebastian Proebsting Daniela Wenzel Sarah Vosen Bernardo S. Franklin Bernd K. Fleischmann Georg Nickenig Nikos Werner | 2013 | Circulation2013，，18： | 2 |
| 4 | Open Reduction and Internal Fixation of Proximal Humerus Fractures Using a Proximal Humeral Locked Plate: A Prospective Multicenter Analysis显示文摘 | Felix Brunner Christoph Sommer Christian Bahrs Rainer Heuwinkel Christian Hafner Paavo Rillmann Georges Kohut Anders Ekelund Mathias Muller Laurent Audigé Reto Babst | 2009 | Journal of Orthopaedic Trauma2009，，3： | 2 |
| 5 | Hydroxide absorption heat pumps with spray absorber显示文摘 | Franz Summerer Peter Riesch Felix Ziegler Georg Alefeld | 1996 | ASHRAE Transactions1996，，102： | 1 |
| 6 | Level crossing analysis of leakage current envelope of polluted insulators显示文摘 | Felix Amarh George G Karady Raji Sundararajan | 2001 | IEEE Power Engineering Review2001，21，8： | 1 |
| 7 | How do we modulate our emotions? Parametric fMRI reveals cortical midline structures as regions specifically involved in the processing of emotional valences显示文摘 | Alexander Heinzel Felix Bermpohl Robert Niese Andrea Pfennig Alvaro Pascual-Leone Gottfried Schlaug Georg Northoff | | Cognitive Brain Research0，，： | 1 |
| 8 | Cortical midline structures and the self显示文摘 | Georg Northoff Felix Bermpohl | | Trends in Cognitive Sciences0，，： | 1 |
| 9 | The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis显示文摘 | Anthony Lanahan Xi Zhang Alessandro Fantin Zhen Zhuang Felix Rivera-Molina Katherine Speichinger Claudia Prahst Jiasheng Zhang Yingdi Wang George Davis Derek Toomre Christiana Ruhrberg Michael Simons | 2013 | Developmental Cell2013，，： | 1 |
| 10 | MRI Study: Objective Olfactory Function and CNS Pathologies in Patients with Multiple Sclerosis显示文摘 | Holinski Franca Schmidt Felix Dahlslett Sarah B Harms Lutz Bohner Georg Olze Heidi | 2014 | European Neurology . 2014 (3-4)2014，，3： | 1 |
| 11 | Linear stochastic analysis of polluted insulator leakage current显示文摘 | FELIX A GEORGE G KARADY | 2002 | IEEE Transactions on Power Delivery2002，17，4： | 1 |
| 12 | Perception of fungal sterols in plants:Subnanoloar concentration of ergosterol elicits extracellular alkalinization in tomato cells显示文摘 | Jose Granado Georg Felix Thomas Boller | 1995 | Plant Physiol1995，，107： | 1 |
| 13 | T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice显示文摘 | Karin Krebs Nina B?ttinger Li–Rung Huang Markus Chmielewski Silke Arzberger Georg Gasteiger Clemens J?ger Edgar Schmitt Felix Bohne Michaela Aichler Wolfgang Uckert Hinrich Abken Mathias Heikenwalder Percy Knolle Ulrike Protzer | 2013 | Gastroenterology2013，，2： | 1 |
| 14 | Physics and astrophysics of strong magnetic field systems with eXTP显示文摘In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s. | Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef Jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li Lin Lin Roberto Mignani Nanda Rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit Paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 15 | Morphogenesis of Oil Palm Fruit (Elaeis guineensis Jacq.) in Mesocarp and Endocarp Development显示文摘 | Hermine Bille Ngalle Joseph Martin Bell Georges Franck Ngando Ebongue Lambert Nyobe Felix Chancelin Ngangnou Godswill Ntsefong Ntsomboh | 2013 | Journal of Life Sciences2013，7，2： | 1 |
| 16 | Miniaturized Cardiopulmonary Bypass in Coronary Artery Bypass Surgery: Marginal Impact on Inflammation and Coagulation but Loss of Safety Margins显示文摘 | Georg Nollert Ina Schwabenland Deniz Maktav Felix Kur Frank Christ Peter Fraunberger Bruno Reichart Calin Vicol | 2005 | The Annals of Thoracic Surgery2005，，6： | 1 |
| 17 | Microsatellite Analysis of Pleural Supernatants Could Increase Sensitivity of Pleural Fluid Cytology显示文摘 | Matthias Woenckhaus Ulrike Grepmeier Bernhard Werner Christian Schulz Felix Rockmann Peter J. Wild Georg R?ckelein Hagen Blaszyk Marion Schuierer Ferdinand Hofstaedter Arndt Hartmann Wolfgang Dietmaier | 2005 | The Journal of Molecular Diagnostics2005，，4： | 1 |
| 18 | Imbalance between Left and Right Dorsolateral Prefrontal Cortex in Major Depression Is Linked to Negative Emotional Judgment: An fMRI Study in Severe Major Depressive Disorder显示文摘 | Simone Grimm Johannes Beck Daniel Schuepbach Daniel Hell Peter Boesiger Felix Bermpohl Ludwig Niehaus Heinz Boeker Georg Northoff | 2008 | Biological Psychiatry2008，，4： | 1 |
| 19 | Full-field interferometric imaging of propagating action potentials显示文摘Currently,cellular action potentials are detected using either electrical recordings or exogenous fluorescent probes that sense the calcium concentration or transmembrane voltage.Ca imaging has a low temporal resolution,while voltage indicators are vulnerable to phototoxicity,photobleaching,and heating.Here,we report full-field interferometric imaging of individual action potentials by detecting movement across the entire cell membrane.Using spike-triggered averaging of movies synchronized with electrical recordings,we demonstrate deformations up to 3 nm(0.9 mrad)during the action potential in spiking HEK-293 cells,with a rise time of 4ms.The time course of the optically recorded spikes matches the electrical waveforms.Since the shot noise limit of the camera(~2 mrad/pix)precludes detection of the action potential in a single frame,for all-optical spike detection,images are acquired at 50 kHz,and 50 frames are binned into 1 ms steps to achieve a sensitivity of 0.3 mrad in a single pixel.Using a selfreinforcing sensitivity enhancement algorithm based on iteratively expanding the region of interest for spatial averaging,individual spikes can be detected by matching the previously extracted template of the action potential with the optical recording.This allows all-optical full-field imaging of the propagating action potentials without exogeneous labels or electrodes. | Tong Ling Kevin C.Boyle Georges Goetz Peng Zhou Yi Quan Felix S.Alfonso Tiffany W.Huang Daniel Palanker | 2018 | Light(Science & Applications)2018，7，1： | 0 |
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