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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 3 |
| 3 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 4 | Primary repair of colon wounds显示文摘 | George SM Fabian TC Voeller GR | 1989 | Ann Surg1989，209，： | 1 |
| 5 | Therapeutic interventions following mammalian spinal cord injury 显示文摘 | Alexander GR George MS | 2001 | Arch Neurol2001，58，5： | 1 |
| 6 | Regulation of RYR1 activity by Ca2+ and calmodulin显示文摘 | George GR Barbara YW Gale M S | 2000 | Biochemistry2000，39，26： | 1 |
| 7 | The experience and evolution of trust: Implications for cooperation and teamwork显示文摘 | Jones GR George JM | 1998 | Academy of Management Review1998，23，3： | 1 |
| 8 | Is it time for a cardiovascular primary preve-tion trial in the elderly?显示文摘 | Jennifer GR George B | 2007 | Stroke2007，38，3： | 1 |
| 9 | AIN-93G purified diets for laboratory rodents :final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the AIN-76A rodent diet显示文摘 | Philip GR Forrrest HN George CF | 1993 | Nutr1993，123，11： | 1 |
| 10 | Antiepileptic Drugs and Quality of Life in Patients with Epilepsy:A Tertiary Care Hospital-Based Study显示文摘 | George J Kulkarni C Sarma GR | 2015 | Value Health Regional Issues2015，4，6： | 1 |
| 11 | P1007 SOLUBLE CD163, A MACROPHAGE ACTIVATION MARKER, IS INDEPENDENTLY ASSOCIATED WITH FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C显示文摘 | K. Kazankov F. Barrera H.J. M?ller B.M. Bibby H. Vilstrup J. George H. Gr?nb?k | 2014 | Journal of Hepatology2014，，1： | 1 |
| 12 | Metal-on-metal hip implants: do they impair renal function in the long-term? A 10-year follow-up study显示文摘 | Martina Marker Alexander Grübl Otto Riedl Georg Heinze Erich Pohanka Rainer Kotz | 2008 | Archives of Orthopaedic and Trauma Surgery2008，，9： | 1 |
| 13 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 1 |
| 14 | Phase II Study of Preoperative Helical Tomotherapy for Rectal Cancer显示文摘 | Mark De Ridder Koen Tournel Yves Van Nieuwenhove Benedikt Engels Anne Hoorens Hendrik Everaert Bart Op de Beeck Vincent Vinh-Hung Jacques De Grève Georges Delvaux Dirk Verellen Guy A. Storme | 2008 | International Journal of Radiation Oncology Biology Physics2008，，3： | 1 |
| 15 | Primary repair of colon wounds:A prospective trial in nonselected patients显示文摘 | George SM Fabian TC Voeller GR | 1989 | Ann surg1989，209，： | 1 |
| 16 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulatin of the AIN-76 Arodent diet 显示文摘 | Philip GR Forrest HN George CF | 1993 | J Nutr1993，123，： | 1 |
| 17 | Gap filling strategies for defensible annual sums of net ecosystem exchange显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 1 |
| 18 | Dose escalation study with rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases显示文摘 | Holger Palmedo Stefan Guhlke Hans Bender Johannes Sartor Georg Schoeneich J?rn Risse Frank Grünwald F.F. Knapp Jr. Hans-Jürgen Biersack | 2000 | European Journal of Nuclear Medicine2000，，2： | 1 |
| 19 | The global distribution and burden of dengue 显示文摘 | Bhatt S Gething PW Brady OJ Messina JP Farlow AW Moyes CL Drake JM Brownstein JS Hoen AG Sankoh O Myers MF George DB Jaenisch T Wint GR Simmons CP Scott TW Farrar JJ Hay SI | 2013 | Nature2013，496，7446： | 1 |
| 20 | AIN-93 purified diets for laboratory rodents:final report of the American institute of nutrition Ad hoc writing committee on the reformulation of the AIN-76A rodent diet显示文摘 | Philip GR Forrest HN George CF | | 0，，11： | 1 |
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