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| 1 | Paleozoic and Mesozoic Basement Magmatisms of Eastern Qaidam Basin,Northern Qinghai-Tibet Plateau:LA-ICP-MS Zircon U-Pb Geochronology and its Geological Significance显示文摘The eastern margin of the Qaidam Basin lies in the key tectonic location connecting the Qinling,Qilian and East Kunlun orogens.The paper presents an investigation and analysis of the geologic structures of the area and LA-ICP MS zircon U-Pb dating of Paleozoic and Mesozoic magmatisms of granitoids in the basement of the eastern Qaidam Basin on the basis of 16 granitoid samples collected from the South Qilian Mountains,the Qaidam Basin basement and the East Kunlun Mountains.According to the results in this paper,the basement of the basin,from the northern margin of the Qaidam Basin to the East Kunlun Mountains,has experienced at least three periods of intrusive activities of granitoids since the Early Paleozoic,i.e.the magmatisms occurring in the Late Cambrian(493.1±4.9 Ma),the Silurian(422.9±8.0 Ma-420.4±4.6 Ma) and the Late Permian-Middle Triassic(257.8±4.0 Ma-228.8±1.5 Ma),respectively.Among them,the Late Permian-Middle Triassic granitoids form the main components of the basement of the basin.The statistics of dated zircons in this paper shows the intrusive magmatic activities in the basement of the basin have three peak ages of 244 Ma(main),418 Ma,and 493 Ma respectively.The dating results reveal that the Early Paleozoic magmatism of granitoids mainly occurred on the northern margin of the Qaidam Basin and the southern margin of the Qilian Mountains,with only weak indications in the East Kunlun Mountains.However,the distribution of Permo-Triassic(P-T) granitoids occupied across the whole basement of the eastern Qaidam Basin from the southern margin of the Qilian Mountains to the East Kunlun Mountains.An integrated analysis of the age distribution of P-T granitoids in the Qaidam Basin and its surrounding mountains shows that the earliest P-T magmatism(293.6-270 Ma) occurred in the northwestern part of the basin and expanded eastwards and southwards,resulting in the P-T intrusive magmatism that ran through the whole basin basement.As the Cenozoic basement thrust system developed in the eastern Qaidam Basin,the nearly N-S-trending shortening and deformation in the basement of the basin tended to intensify from west to east,which went contrary to the distribution trend of N-S-trending shortening and deformation in the Cenozoic cover of the basin,reflecting that there was a transformation of shortening and thickening of Cenozoic crust between the eastern and western parts of the Qaidam Basin,i.e.,the crustal shortening of eastern Qaidam was dominated by the basement deformation(triggered at the middle and lower crust),whereas that of western Qaidam was mainly by folding and thrusting of the sedimentary cover(the upper crust). | CHEN Xuanhua George GEHRELS YIN An LI Li JIANG Rongbao | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 32 |
| 2 | Community analysis of ammonia-oxidizing bacteria in activated sludge of eight wastewater treatment systems显示文摘We investigated the communities of ammonia-oxidizing bacteria(AOB) in activated sludge collected from eight wastewater treatment systems using polymerase chain reaction(PCR) followed by terminal restriction fragment length polymorphism(T-RFLP),cloning,and sequencing of the α-subunit of the ammonia monooxygenase gene(amoA).The T-RFLP fingerprint analyses showed that different wastewater treatment systems harbored distinct AOB communities.However,there was no remarkable difference among the AOB TRFLP profiles from different parts of the same system.The T-RFLP fingerprints showed that a full-scale wastewater treatment plant(WWTP) contained a larger number of dominant AOB species than a pilot-scale reactor.The source of influent affected the AOB community,and the WWTPs treating domestic wastewater contained a higher AOB diversity than those receiving mixed domestic and industrial wastewater.However,the AOB community structure was little affected by the treatment process in this study.Phylogenetic analysis of the cloned amoA genes clearly indicated that all the dominant AOB in the systems was closely related to Nitrosomonas spp.not to Nitrosospira spp.Members of the Nitrosomonas oligotropha and Nitrosomonas communis clusters were found in all samples,while members of Nitrosomonas europaea cluster occurred in some systems. | Xiaohui Wang Xianghua Wen Craig Criddle George Wells Jie Zhang Yin Zhao | 2010 | Journal of Environmental Sciences2010，22，4： | 17 |
| 3 | Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo显示文摘OBJECTIVE: Little effort has been made to study the protein-encoding genes isolated from traditional Chinese medicine(TCM) drugs, and the delivery of these genes into malignant cells through recombinant adeno-associated virus(r AAV) vectors has not been attempted. METHODS: We synthesized the c DNAs of five known cytotoxic proteins isolated from TCM drugs and the FLAG epitope-tagged c DNAs were subcloned into a r AAV plasmid vector. The protein expression was confi rmed by Western blot assay. Various cancer cell lines were transfected with the above plasmids and cell growth was monitored both in vitro and in vivo. The best cytotoxic gene was further packaged into r AAV vectors, under the control of a liver cancer-specifi c promoter. The liver tumor growth was then monitored following intratumor administration of the r AAV vectors.RESULTS: The expression plasmids, encoding individual potential cytotoxic genes tagged with FLAG epitope, were successfully generated and sequenced. Among these genes, trichosanthin(TCS) gene yielded the most promising results for the inhibition of cancer cell growth in vitro. The over-expressed TCS functioned as a type I ribosome-inactivating protein, followed by inducing apoptosis that is associated with the Bcl-PARP signaling pathway. Furthermore, intratumor injection of r AAV vectors containing the TCS gene signifi cantly inhibited the growth of human hepatocellular carcinoma tumors in a murine xenograft model.CONCLUSION: Our studies suggest that the use of TCM cytotoxic genes is a useful therapeutic strategy for treating human cancers in general, and liver tumors in particular. | Yuan-hui Zhang Yuan Wang Ali Hussein Yusufali Frederick Ashby Daniel Zhang Zi-fei Yin George V.Aslanidi Arun Srivastava Chang-quan Ling Chen Ling | 2014 | Journal of Integrative Medicine2014，12，6： | 14 |
| 4 | Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo显示文摘OBJECTIVE:In the present study,we systemically evaluated the ability of two bioactive compounds from traditional Chinese medicine,celastrol and pristimerin,to enhance recombinant adeno-associated virus(rAAV) serotype vector-mediated transgene expression both in human cell lines in vitro,and in murine hepatocytes in vivo.METHODS:Human cell lines were infected with rAAV vectors with either mock treatment or treatment with celastrol or pristimerin.The transgene expression,percentage of nuclear translocated viral genomes and the ubiquitination of intracellular proteins were investigated post-treatment.In addition,nonobese diabetic/severe combined immunodeficient gamma(NSG) mice were tail vain-injected with rAAV vectors and co-administered with either dimethyl sulfoxide,celastrol,pristimerin or a positive control,bortezomib.The transgene expression in liver was detected and compared over time.RESULTS:We observed that treatment with pristimerin,at as low as 1 umol/L concentration,significantly enhanced rAAV2 vector-mediated transgene expression in vitro,and intraperitoneal coadministration with pristimerin at 4 mg/(kgd) for 3 d dramatically facilitated viral transduction in murine hepatocytes in vivo.The transduction efficiency of the tyrosine-mutant rAAV2 vectors as well as that of rAAV8 vectors carrying oversized transgene cassette was also augmented significantly by pristimerin.The underlying molecular mechanisms by which pristimerin mediated the observed increase in the transduction efficiency of rAAV vectors include both inhibition of proteasomal degradation of the intracellular proteins and enhanced nuclear translocation of the vector genomes.CONCLUSION:These studies suggest the potential beneficial use of pristimerin and pristimerincontaining herb extract in future liver-targeted gene therapy with rAAV vectors. | Li-na Wang Yuan Wang Yuan Lu Zi-fei Yin Yuan-hui Zhang George V.Aslanidi Arun Srivastava Chang-quan Ling Chen Ling | 2014 | Journal of Integrative Medicine2014，12，1： | 8 |
| 5 | Physics-informed neural networks(PINNs)for fluidmechanics:a review显示文摘Despite the significant progress over the last 50 years in simulating flow problems using numerical discretization of the Navier–Stokes equations(NSE),we still cannot incorporate seamlessly noisy data into existing algorithms,mesh-generation is complex,and we cannot tackle high-dimensional problems governed by parametrized NSE.Moreover,solving inverse flow problems is often prohibitively expensive and requires complex and expensive formulations and new computer codes.Here,we review flow physics-informed learning,integrating seamlessly data and mathematical models,and implement them using physics-informed neural networks(PINNs).We demonstrate the effectiveness of PINNs for inverse problems related to three-dimensional wake flows,supersonic flows,and biomedical flows. | Shengze Cai Zhiping Mao Zhicheng Wang Minglang Yin George Em Karniadakis | 2021 | Acta Mechanica Sinica2021，37，12： | 7 |
| 6 | CONTROL OF VEHICLE PLATOONS FOR HIGHWAY SAFETY AND EFFICIENT UTILITY:CONSENSUS WITH COMMUNICATIONS AND VEHICLE DYNAMICS显示文摘Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intelligent transportation systems.Platoon control encounters great challenges from vehicle control,communications,team coordination,and uncertainties.This paper introduces a new method for coordinated control of platoons by using integrated network consensus decisions and vehicle control.To achieve suitable coordination of the team vehicles based on terrain and environmental conditions,the emerging technology of network consensus control is modified to a weighted and constrained consensus-seeking framework.Algorithms are introduced and their convergence properties are established.The methodology employs neighborhood information through on-board sensors and V2 V or V2 I communications,but achieves global coordination of the entire platoon.The ability of the methods in terms of robustness,disturbance rejection,noise attenuation,and cyber-physical interaction is analyzed and demonstrated with simulated case studies. | WANG Le Yi SYED Ali YIN Gang George PANDYA Abhilash ZHANG Hongwei | 2014 | Journal of Systems Science & Complexity2014，27，4： | 5 |
| 7 | Guangdong’s Study of the Effectiveness of China’s Inactivated Vaccines Against the SARS-CoV-2 B.1.617.2(Delta)Variant显示文摘Guangdong CDC published in preprint a critically important study of the effectiveness of China’s inactivated vaccines against the B.1.617.2(Delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)—a strain of the virus that causes coronavirus disease 2019(COVID-19)and is circulating globally(1–2).The Delta variant managed to get through China’s strong international border quarantine protection and spark an outbreak in Guangdong Province in May–June 2021.While the outbreak was being stopped using guidance of the Protocol for Prevention and Control of COVID-19(3),the investigators took advantage of provisions in the Protocol that identified close contacts of anyone infected with SARS-CoV-2。 | Fuzhen Wang Zhijie An Lance Rodewald Dan Wu Lin Tang Hui Zheng Qianqian Liu George F.Gao Zundong Yin | 2021 | China CDC weekly2021，3，34： | 3 |
| 8 | 国际医学物理组织(International Organization for Medical Physics,IOMP)第1号政策声明(2010年6月17日)医学物理师:作用和职责显示文摘前言 本政策声明为IOMP成员组织在确立医学物理师的作用和职责时提供总体指导方针。它可以作为医学物理专业组织和卫生主管部门在筹划和发展临床医学物理服务,以及学术机构在教育和培训医学物理师时的参考。本文件应当与IOMP第2号政策声明(教育和培训医学物理师的基本要求)一起结合阅读。 | Kin Yin Cheung Cari Boris Stelios Christofides Anchali Krishanachinda Tomas Kron George Starkschall 胡志辉 | 2012 | 中国医学物理学杂志2012，29，4： | 3 |
| 9 | 高铝相变诱发塑性钢用硅钙和铝钙结晶器保护渣的开发评估显示文摘连铸生产高强钢时,如高铝相变诱发塑性钢(简称TRIP钢),传统的硅钙保护渣由于SiO2的急剧减少而表现出了固有的不稳定性。保护渣中二氧化硅的减少导致氧化铝增加约30%,这种变化的程度和不稳定性会影响到保护渣的物理性能,从而影响结晶器散热、保护渣的消耗量及保护渣在结晶器内的行为。以上因素综合作用,导致铸坯表面产生横向和纵向凹陷及裂纹。由于这种铝钙保护渣在连铸生产高铝TRIP钢时,不易发生反应而备受人们的关注。在安赛乐米塔尔美国公司(AM-USA)的两家研发中心—东芝加哥中心和施托尔贝格进行了这两种保护渣的生产试验,研究相对于传统的硅钙保护渣,新保护渣对生产高铝TRIP钢的影响。利用光学显微镜、阴极发光显微镜和扫描电子显微镜来检查结晶器中的渣膜层,以此来确定渣层中沉淀物的性质和分布。铝钙保护渣的使用使钢/渣间的化学反应有了明显的变化,改善了铸坯的表面质量。 | Kenneth Blazek Hongbin Yin George Skoczylas Marc McClymonds Mike Frazee 毛天成(译) 刘金学(译) 杜锋(校) | 2013 | 世界钢铁2013，，3： | 2 |
| 10 | Genomic Surveillance for SARS-CoV-2 Variants of Concern from Imported COVID-19 Cases-the Mainland of China,2021显示文摘Introduction:After the epidemic in Wuhan City was brought under control in 2020,local outbreaks of coronavirus disease 2019(COVID-19)in the mainland of China were mainly due to imported COVID-19 cases.The ongoing evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has continued to generate new variants.Some have been designated as variants of concern(VOCs)by the World Health Organization(WHO).To better assess the role of imported SARS-CoV-2 surveillance and the prevalence of VOCs in 2021,the genomic surveillance data of SARS-CoV-2 from imported COVID-19 cases of 2021 in the mainland of China were analyzed.Methods:The analyses included the number of sequence submissions,time of sequence deposition,and time of detection of the VOCs in order to determine the timeliness and sensitivity of the surveillance.The proportions of VOCs were analyzed and compared with data from the Global Initiative of Sharing All Influenza Data(GISAID).Results:A total of 3,355 sequences of imported cases were submitted from 29 provincial-level administrative divisions,with differences in the number of sequence submissions and median time of sequence deposition.A total of 2,388 sequences with more than 90%genomic coverage were used for lineage analysis.The epidemic trend from Alpha to Delta to Omicron in imported cases was consistent with that in the GISAID.In addition,VOCs from imported cases were usually identified after WHO designation and before causing local outbreaks.Conclusions:The global distribution of SARSCoV-2 VOCs changed rapidly in 2021.Robust genomic surveillance of the imported SARS-CoV-2 in the mainland of China is of great significance.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of coronavirus disease 2019(COVID-19),is constantly mutating under the different circumstances of global transmission(1).The emerging SARS-CoV-2 variants may have potential adverse impacts on epidemic traits and severity.To some extent,it is also capable of escaping natural and vaccine-induced immunity(2–3).Some of them were designated as variants of concern(VOCs)by the World Health Organization(WHO)(4).Therefore,robust surveillance is essential to assess the evolution of viruses in real time.After the epidemic in Wuhan City was brought under control in 2020,several COVID-19 outbreaks in the mainland of China have been proven to relate to SARS-CoV-2 contaminated cold-chain products(5–7),while most were caused by transmission through imported cases on flights,at isolation facilities,or in designated hospitals(8–9).Therefore,genomic surveillance for SARS-CoV-2 from imported cases is of great significance for monitoring the risk of different variants that were imported into the mainland of China,assessing the risk of importation-associated domestic spread,and helping guide public health interventions.On March 17,2020,the China CDC released a notice and launched genomic surveillance for SARS-CoV-2 from imported COVID-19 cases nationwide.The laboratories of provincial CDCs were required to conduct SARS-CoV-2 whole-genome sequencing for samples from imported cases and submit the genomic sequences to the China CDC in time.This study includes the analysis of genomic surveillance data of imported SARS-CoV-2 cases of 2021 from the mainland of China. | Yenan Feng Xiang Zhao Zhixiao Chen Kai Nie Zeyuan Yin Ying Xia Ji Wang Peihua Niu Ruhan A Lili Li Dayan Wang Wenjie Tan Xuejun Ma Shiwen Wang Huanyu Wang George F.Gao Cao Chen Wenbo Xu | 2022 | China CDC weekly2022，4，31： | 1 |
| 11 | Prognostics for drilling process with wavelet packet decomposition 显示文摘 | YIN H GEORGE Q | 2010 | The International Journal of Advanced Manufacturing Technology2010，50，1： | 1 |
| 12 | <ce:link locator='fx1'/> Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells显示文摘 | Stuart A.C. McDonald Laura C. Greaves Lydia Gutierrez–Gonzalez Manuel Rodriguez–Justo Maesha Deheragoda Simon J. Leedham Robert W. Taylor Chung Yin Lee Sean L. Preston Matthew Lovell Toby Hunt George Elia Dahmane Oukrif Rebecca Harrison Marco R. Novelli I | 2008 | Gastroenterology2008，，2： | 1 |
| 13 | A biomarker study of depositional paleoenvironments and source inputs for the massive formation of Upper Cretaceous lacustrine source rocks in the Songliao Basin, China 显示文摘 | Song Z G Yin Q George S C Wang L Guo J T Feng Z H | 2013 | Pa- laeogeogr Palaeoclimatol Palaeoecol2013，385，： | 1 |
| 14 | Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely noving rats after MCA occlusion 显示文摘 | Ahmed E Wei Yin George M | 2001 | Brain Reaearch2001，916，： | 1 |
| 15 | Hybrid competitive Lotka–Volterra ecosystems with a hidden Markov chain显示文摘This work concerns Lotka–Volterra models that are formulated using stochastic differential equations with regime-switching.Distinct from the existing formulations,the Markov chain that models random environments is unobservable.For such partially observed systems,we use Wonham’s filter to estimate the Markov chain from the observable evolution of the population,and convert the original system to a completely observable one.We then show that the positive solution of our model does not explode in finite time with probability 1.Several properties including stochastic boundedness,finite moments,sample path continuity and large-time asymptotic behaviour are also obtained.Moreover,stochastic permanence,extinction and feedback controls are also investigated. | Ky Tran George Yin | 2014 | Journal of Control and Decision2014，1，1： | 1 |
| 16 | Vikrmn krlshnamurthy and cristina ion, iterate-averaging sign algorithms for adaptive filtering with applications to blind multiuser detection显示文摘 | Yin George G | 2003 | IEEE Trans Inform Theory2003，49，3： | 1 |
| 17 | An acupoint-originated human interstitial fluid circulatory network显示文摘To the Editor:Since 1027,when the Tian Sheng Bronze Statue showing acupoints and meridians was first introduced for medical practitioners,it has evolved to the currently used acupoints and meridians atlas in traditional Chinese medicine(TCM).[1]To date,the acupoints represent defined areas on the body surface relative to certain landmarks.The acupoints in the extremity endings would connect anatomically with diverse associated visceral organs or tissues,forming a Meridian and Collateral network.Illustrated on the atlas,each main meridian is usually a virtual line connecting a group of adjacent acupoints that correlate with certain visceral organ.In modern medical science,the anatomical structures of main meridians remain largely unclarified. | Hong-Yi Li Fang Wang Min Chen Zhi-Jian Zheng Ya-Jun Yin Jun Hu Hua Li Andreas Sammer Georg Feigl Norbert Maurer Chao Ma Fu-Sui Ji | 2021 | Chinese Medical Journal2021，，19： | 1 |
| 18 | Parameter estimation and reliable fault detection of electric motors显示文摘Accurate model identification and fault detection are necessary for reliable motor control. Motor-characterizing parameters experience substantial changes due to aging, motor operating conditions, and faults. Consequently, motor parameters must be estimated accurately and reliably during operation. Based on enhanced model structures of electric motors that accommodate both normal and faulty modes, this paper introduces bias-corrected least-squares(LS) estimation algorithms that incorporate functions for correcting estimation bias, forgetting factors for capturing sudden faults, and recursive structures for efficient real-time implementation. Permanent magnet motors are used as a benchmark type for concrete algorithm development and evaluation.Algorithms are presented, their properties are established, and their accuracy and robustness are evaluated by simulation case studies under both normal operations and inter-turn winding faults. Implementation issues from different motor control schemes are also discussed. | Dusan PROGOVAC Le Yi WANG George YIN | 2014 | Control Theory and Technology2014，12，2： | 1 |
| 19 | Markowitz's mean-variance asset-liability management with regime switching:A continuous-time model显示文摘 | Chen P Yang H George Yin | | 0，，： | 1 |
| 20 | Effect of hyperbaric oxygen on striatal metabolites:a microdialysis study in awake freely mov2 ing rats after MCA occlusion显示文摘 | Ahmed E Wei Yin George M | 2001 | B rain Reaearch2001，916，： | 1 |
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