|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 3 | Early Steroid-Free Immunosuppression With FK506 After Liver Transplantation: Long-Term Results of a Prospectively Randomized Double-Blinded Trial显示文摘 | Nina Weiler Ina Thrun Maria Hoppe-Lotichius Tim Zimmermann Irene Kraemer Gerd Otto | 2010 | Transplantation2010，，12： | 2 |
| 4 | Downregulation of organic cation transporter 1 (SLC22A1) is associatedwith tumor progression and reduced patient survival in human cholangiocellularcarcinoma显示文摘 | Anja Lautem Michael Heise Andreas Gr?sel Maria Hoppe?Lotichius Nina Weiler Daniel Foltys Johanna Knapstein J?rn Schattenberg Arno Schad Anca Zimmermann Gerd Otto Hauke Lang Peter Galle Marcus Schuchmann Tim Zimmermann | 2013 | International Journal of Oncology2013，，4： | 1 |
| 5 | Fast SMD resistor based pressure gauge显示文摘 | Gerd Zimmermann Helmut Grumann | 2000 | Propellants Explosives Pyrotechnics2000，25，2： | 1 |
| 6 | Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder: Influence of Age and Body Mass Index显示文摘To the Editor:With great interest we read the original article of Chen et al.[1] published in the Chinese Medical Journal comparing serum concentrations of cytokines in patients of Han and Li ethnicity with posttraumatic stress disorder (PTSD).The authors found significantly higher serum concentrations of the cytokines interleukin (IL)-2,IL-6,IL-8,and tumor necrosis factor (TNF)-α in PTSD patients compared to normal controls,and differences in cytokine concentrations according to ethnicity. | Hubertus Himmerich Jorg-Egbert Wolf Peter Zimmermann Antje H Biihler Lesca M Holdt Daniel Teupser Kenneth C Kirkby Gerd D Willmund Ulrich Wesemann | 2016 | Chinese Medical Journal2016，，6： | 0 |
| 7 | Stigma and its impact on the families of former soldiers of the German Armed Forces: An exploratory study显示文摘Background: Military families who have a family member with a mental illness see themselves confronted with many demands. Stigmatization is one of these challenges. Stigmatization affects not only the individual who suffers from a mental illness but also other family members via stigma by association and vicarious stigma. Stigma by association occurs when mental illness stigma spills over to individuals associated with an individual with a mental illness. Vicarious stigma describes the suffering of family members when they note the impact of stigma on their relative with mental illness. As a societal phenomenon, stigma plays out in social interactions and might therefore influence the social networks of families. It is also associated with healthcare utilization.Methods: Narrative interviews were conducted with 15 family members(partners, spouses, parents and children) of former soldiers of the German Armed Forces with a service-induced mental illness. The transcribed interview data were analyzed using a thematic analysis approach, in which codes were formed and emerging themes were systemized. Relationships between stigma, the families’ reactions to it, its effects on their social relationships and its interference with their healthcare utilization were analyzed.Results: This study provides a detailed description of how relatives of former German soldiers with mental health problems experience stigma by association and vicarious stigma. Their perceptions are shown in a model that describes stigma-related attitudes, reactions to them and their effects on the social relationships of former soldiers’ families. These families felt stigmatized because of the former soldiers’ mental illness(mental illness stigma) and the military context in which it occurred(former soldier stigma). They reacted with nondisclosure, anger, acceptance and self-blame. Stigma was associated with smaller and weaker social networks that were characterized by social exclusion, self-segregation and conflicts with extended family, friends and colleagues. Stigma also affected the families’ healthcare utilization.Conclusions: Urgently needed anti-stigma campaigns, particularly in the civilian context, should address the stigmatization of both mental illness and the military participation of the families affected. They should consider the needs of both former soldiers with a mental illness and their families. | Katrin Schuy Simone Dors Loni Brants Marie Horzetzky Gerd Willmund Andreas Strohle Peter Zimmermann Heinrich Rau Stefan Siegel | 2019 | Military Medical Research2019，6，2： | 0 |
| 8 | 焊接机器人缩短生产制造时间显示文摘长期以来,在重燃气涡轮机上完成的角焊缝和V型焊缝焊接都是采用手工焊接,现在,将焊接机器人安装在C型支架上以后,焊接时间由114h减少到80h,并且后续的清理工作量也减少了10%。,可代替手工焊接完成80%的生产任务。 | Walter Lutz Gerd Zimmermann | 2009 | 现代制造2009，，48： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员