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| 1 | Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review显示文摘Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches. | Sabine Gerum Alexandra D Jensen Falk Roeder | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 2 |
| 2 | Dysplasia of the submucous nerve plexus in slow2transit constipation of adults显示文摘 | VODERHOLZER WA WIEBECKE B GERUM M | | 0，，： | 1 |
| 3 | SpaceQualified Low-High-Power Radar TWTs显示文摘 | Werner Gerum Manfred Bruck Gerd Fisher | 2005 | IEEE Transac-tions on Electrin Device2005，52，5： | 1 |
| 4 | 94 GHz TWT for Military Radar Applicatrion显示文摘 | Gerum W Lippert G Malzahn P | 2001 | IEEE Trans on Electron Devices2001，48，1： | 1 |
| 5 | Dysplasia of the submucous nerve plexus in slow-transit constipation of adults显示文摘 | Voderholzer W A Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 6 | Roll-over prevention systems for commecial vehicles-additional sensorless function of the electronic brake system显示文摘 | Palkovics L Semsey A Gerum E | 1999 | Vehicle System Dynamics1999，32，4： | 1 |
| 7 | Observational study mortality in treated primary aldosteronism: the German Conn's registry显示文摘 | Reincke M Fischer E Gerum S | 2012 | Hypertension2012，60，3： | 1 |
| 8 | Dysplasia of the submucous nerve plexus in slow-transit constipation of abults 显示文摘 | VODERHOLZER WA WIEBECKE B GERUM M | 2000 | Eur J Gastroenterol Hepatrol2000，12，7： | 1 |
| 9 | 60-GHz Space TWT to Address Future Market显示文摘 | Kornfeld Guenter K Bosch Ernst Werner Gerum | 2001 | IEEE Transctionsion Eletron Devices2001，48，1： | 1 |
| 10 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 11 | Dysplasia of the submucous nerve plexus in slow-transit constipation of abuhs显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatrol2000，12，： | 1 |
| 12 | Dysplasia of the submucous nerve plexus in slow-transit constipation of adults显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 13 | Dysplasia of the submucous nerve plexus in slow-transit constipation of adults 显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 14 | Space Qualified Low-High-Power Radar TWTs显示文摘 | Werner Gerum Manfred Bruck Gerd Fisher | 2005 | IEEE Transactions on Electrin Device2005，52，5： | 1 |
| 15 | Roll-over prevention system for commercial vehicles-addition sensorless function of the electronic brake system显示文摘 | Palkovics L Semsey A Gerum E | 1999 | Vehicle System Dynamics1999，32，4： | 1 |
| 16 | Dysplasia of the submucous nerve plexus in slow-transit constipation of adults显示文摘 | Winfried A. Voderholzer Baldur Wiebecke Markus Gerum Stefan A. Müller-Lissner | 2000 | European Journal of Gastroenterology & Hepatology2000，，： | 1 |
| 17 | Dysplasia of the submucous nerve plexus in slow-transit constipation of adults显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 18 | Dysplasia of the submucous nerver plexus in slow-transit constipation of adults显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gadtroenterol Hepatol2000，12，7： | 1 |
| 19 | Dysplasiaof the submucous nerve plexus in slow-transit constipationof adults显示文摘 | Voderholzer WA Wiebecke B Gerum M | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 20 | 60 GHz Space TWT to Address Future Market显示文摘 | Kornfeld Guenter K Bosch Ernst Werner Gerum | | 0，，01： | 1 |
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