|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting显示文摘Fecal calprotectin(FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases(IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome(IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn's disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients. | Maria Gloria Mumolo Lorenzo Bertani Linda Ceccarelli Gabriella Laino Giorgia Di Fluri Eleonora Albano Gherardo Tapete Francesco Costa | 2018 | World Journal of Gastroenterology2018，24，33： | 8 |
| 2 | Osteosarcopenia in autoimmune cholestatic liver diseases:Causes,management,and challenges显示文摘Primary biliary cholangitis and primary sclerosing cholangitis(PSC)are the most common cholestatic liver diseases(CLD)in adults and are both characterized by an immune pathogenesis.While primary biliary cholangitis is a model autoimmune disease,with over 90%of patients presenting very specific autoantibodies against mitochondrial antigens,PSC is considered an immune mediated disease.Osteoporosis is the most common bone disease in CLD,resulting in frequent fractures and leading to significant morbidity.Further,sarcopenia is emerging as a frequent complication of chronic liver diseases with a significant prognostic impact and severe implications on the quality of life of patients.The mechanisms underlying osteoporosis and sarcopenia in CLD are still largely unknown and the association between these clinical conditions remains to be dissected.Although timely diagnosis,prevention,and management of osteosarcopenia are crucial to limit the consequences,there are no specific guidelines for management of osteoporosis and sarcopenia in patients with CLD.International guidelines recommend screening for bone disease at the time of diagnosis of CLD.However,the optimal monitoring strategies and treatments have not been defined yet and vary among centers.We herein aim to comprehensively outline the pathogenic mechanisms and clinical implications of osteosarcopenia in CLD,and to summarize expert recommendations for appropriate diagnostic and therapeutic approaches. | Nicola Pugliese Ivan Arcari Alessio Aghemo Andrea G Lania Ana Lleo Gherardo Mazziotti | 2022 | World Journal of Gastroenterology2022，28，14： | 2 |
| 3 | Resource allocation in cognitive radio networks:a comparison between game theory based and heuristic approaches显示文摘 | ENRICO D R GHERARDO G LUCA S R ROSALBA S | 2009 | Wireless Personal Communications2009，49，3： | 1 |
| 4 | Type-1 response in peripheral CD4 and CD8 T cells form patients with Hashimoto's thyroiditis显示文摘 | Gherardo Mazziotti Francesca Sorvillo Caterina Naclerio | 2003 | European Journal of Endocrinology2003，148，4： | 1 |
| 5 | Design‐based strategies for sampling spatial units from regular grids with applications to forest surveys, land use, and land cover estimation显示文摘 | Lorenzo Fattorini Piermaria Corona Gherardo Chirici Maria Chiara Pagliarella | 2015 | Environmetrics2015，，3： | 1 |
| 6 | Contribution of large-scale forest inventories to biodiversity assessment and monitoring显示文摘 | Piermaria Corona Gherardo Chirici Ronald E. McRoberts Susanne Winter Anna Barbati | 2011 | Forest Ecology and Management2011，，11： | 1 |
| 7 | Parathyroid hormone pulsatility: physiological and clinical aspects显示文摘Parathyroid hormone(PTH) secretion is characterized by an ultradian rhythm with tonic and pulsatile components. In healthy subjects, the majority of PTH is secreted in tonic fashion, whereas approximately 30%is secreted in low-amplitude and high-frequency bursts occurring every 10–20 min, superimposed on tonic secretion. Changes in the ultradian PTH secretion were shown to occur in patients with primary and secondary osteoporosis, with skeletal effects depending on the reciprocal modifications of pulsatile and tonic components. Indeed, pathophysiology of spontaneous PTH secretion remains an area potentially suitable to be explored, particularly in those conditions such as secondary forms of osteoporosis, in which conventional biochemical and densitometric parameters may not always give reliable diagnostic and therapeutic indications.This review will highlight the literature data supporting the hypothesis that changes of ultradian PTH secretion may be correlated with skeletal fragility in primary and secondary osteoporosis. | Silvia Chiavistelli Andrea Giustina Gherardo Mazziotti | 2015 | Bone Research2015，3，1： | 1 |
| 8 | Recombinant Human Thyrotropin Reduces Serum Vascular Endothelial Growth Factor Levels in Patients Monitored for Thyroid Carcinoma Even in the Absence of Thyroid Tissue显示文摘 | Francesca Sorvillo Gherardo Mazziotti Antonella Carbone Marco Piscopo Mario Rotondi Michele Cioffi Pasquale Musto Bernadette Biondi Sergio Iorio Giovanni Amato Carlo Carella | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，，： | 1 |
| 9 | Growth hor- mone, insulin-like growth factors, and the skeleton 显示文摘 | Giustina Andrea Mazziotti Gherardo Canalis Emesto | 2008 | Endocrine Reviews2008，29，5： | 1 |
| 10 | Glucocorticoid-induced osteoporosis: an update显示文摘 | Gherardo Mazziotti Alberto Angeli John P. Bilezikian Ernesto Canalis Andrea Giustina | 2006 | Trends in Endocrinology & Metabolism2006，，4： | 1 |
| 11 | Growth hormone,insulin-like growth factors,and the skeleton显示文摘 | Andrea G Gherardo M Ernesto G | 2008 | Endocr Rev2008，29，5： | 1 |
| 12 | Treatment of glucocorticoid-induced Osteoporosis显示文摘 | Gherardo Mazziotti Andrea Giustina Ernesto Canalis etal | 2009 | Ther Adv Musculoskel Dis2009，1，1： | 1 |
| 13 | Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population显示文摘 | Giuseppe Danilo Norata Katia Garlaschelli Liliana Grigore Gianpaolo Tibolla Sara Raselli Laura Redaelli Gherardo Buccianti Alberico Luigi Catapano | 2008 | Nutrition Metabolism and Cardiovascular Diseases2008，，2： | 1 |
| 14 | Monitoring the abundance of saproxylic red-listed species in a managed beech forest by landsat temporal metrics显示文摘Background:Rapid climate changes lead to an increase in forest disturbance,which in turn lead to growing concerns for biodiversity.While saproxylic beetles are relevant indicators for studying different aspects of biodiversity,most are smaller than 2 mm and difficult to sample.This,together with a high number of species and trophic roles,make their study remarkably challenging,time-consuming,and expensive.The Landsat mission provides data since 1984 and represents a powerful tool in this scenario.While we believe that remote sensing data cannot replace on-site sampling and analysis,in this study we aim to prove that the Landsat Time Series(TS)may support the identification of insects’hotspots and consequently guide the selection of areas where to concentrate field analysis.Methods:With this aim,we constructed a Landsat-derived NDVI TS(1984–2020)and we summarised the NDVI trend over time by calculating eight Temporal Metrics(TMs)among which four resulted particularly successful in predicting the amount of saproxylic insects:(i)the slope of the regression line obtained by linear interpolating the NDVI values over time;(ii)the Root Mean Square Error(RMSE)between the regression line and the NDVI TS;(iii)the median,and the(iv)minimum values of the NDVI TS.The study area consists of four monitoring sectors in a Mediterranean-managed beech forest located in the Apennines(Molise,Italy),where 60 window flight traps for flying beetles were installed.First,the saproxylic beetle's biodiversities of monitoring sectors were quantified in terms of species richness and alpha-diversity.Second,the capability of TMs in predicting the richness of saproxylic beetles family and trophic categories was assessed in terms of Pearson's product-moment correlation.Results:The alpha diversity and species richness analysis indicate dissimilarities across the four monitored sectors(Shannon and Simpson's index ranging between 0.67 to 2.31 and 0.69 to 0.88,respectively),with Landsat TS resulting in effective predictors for estimating saproxylic beetle richness.The strongest correlation was reached between the Monotomidae family and the RMSE temporal metric(R=0.66).The mean absolute correlation(r)between the NDVI TMs and the saproxylic community was 0.46 for Monotomidae,0.31 for Cerambycidae,and 0.25 for Curculionidae.Conclusions:Our results suggest that Landsat TS has important implications for studying saproxylic beetle distribution and,by helping the selection of monitoring areas,increasing the amount of information acquired while decreasing the effort required for field analysis. | Francesco Parisi Elia Vangi Saverio Francini Gherardo Chirici Davide Travaglini Marco Marchetti Roberto Tognetti | 2022 | Forest Ecosystems2022，9，4： | 0 |
| 15 | Diversity of beetle species and functional traits along gradients of deadwood suggests weak environmental filtering显示文摘Background: Gradients in local environmental characteristics may favour the abundance of species with particular traits, while other species decline, or favour species with different traits at the same time, without an increase in average species abundances. Therefore, we asked: do variations in species and traits differ along gradients of deadwood variables? Do species abundance and trait occurrence change with species richness within or between functional groups? Thus, we analysed the beetle assemblages of five forest sites located in Italy, along the Apennines mountains.Methods: From 2012 to 2018 we sampled beetles and five deadwood types in 193 plots to characterise the deadwood gradient: standing dead trees, snags, dead downed trees, coarse woody debris, and stumps. We modelled beetle species relative abundances and trophic traits occurrences against the deadwood variables using joint species distribution models.Results: Out of 462 species, only 77 showed significant responses to at least one deadwood type, with a weak mean response across species. Trophic groups showed mostly negative responses to deadwood variables. Species abundance increased with species richness among sites only for phytophagous and saproxylophagous. Trait occurrence did not increase with species richness among sites, except for phytophagous and saproxylophagous.However, trait occurrence changed significantly with species richness of several trophic groups within some sites.We found that increases in species richness do not result in decreases in species abundance of a given trophic group, but rather null or positive relationships were found suggesting low interspecific competition.Conclusions: Our findings suggest that in Mediterranean mountain forests there is still room for increasing the level of naturalness, at least for what concerns deadwood management. On one side, our findings suggest that competition for deadwood substrates is still low, on the other side they indicate that increasing deadwood volume and types to improve overall beetle richness may increase also beetle abundances. | Marco Basile Francesco Parisi Roberto Tognetti Saverio Francini Fabio Lombardi Marco Marchetti Davide Travaglini Elena De Santis Gherardo Chirici | 2023 | Forest Ecosystems2023，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员