|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Yellow Pr-zircon Pigments:The Role of Praseodymium and of the Mineralizer显示文摘 | Giulia D N Giuseppe C Silvia A | 2004 | Journal of European Ceramic Society2004，24，14： | 1 |
| 3 | Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells显示文摘 | ANGELO D M GIUSEPPE F KATIA A | 2006 | Journal of Nutritional Biochemistry2006，17，： | 1 |
| 4 | Eigenvalues and eigenvectors of linearized elastic inversion 显示文摘 | Nicolao A D Giuseppe D Fabio R | 1993 | Geophysics1993，58，5： | 1 |
| 5 | Energy conservation in wireless sensor networks:a survey显示文摘 | Giuseppe A Marco C Mario D F | | 0，，03： | 1 |
| 6 | Branched- chain amino acid supplementation promotes survival and supporls cardiac and skeletal muscle mitochondrial biogenesis in mid- die-aged mice显示文摘 | GIUSEPPE D A MAURIZIO R ANNAI ISA C et el | 2010 | Cell Metall2010，12，10： | 1 |
| 7 | Data collection in wireless sensor networks with mobile elements: a survey显示文摘 | MARIO D F SAJAL K D GIUSEPPE A | 2011 | ACM Trans on Sensor Networks2011，8，1： | 1 |
| 8 | Visual cryptography for general access structures显示文摘 | Giuseppe A Carlo B Alfredo D S | 1996 | Information and Computation1996，129，2： | 1 |
| 9 | A simple and rapid assay based on hot water extraction and liquid chromatography- tandem mass spectrometry for monitoring quinolone residues in bovine milk显示文摘 | GIUSEPPE D A ANTONIO D C ALDO L | 2008 | Food Chemistry2008，108，1： | 1 |
| 10 | A software architecture to ease the development of distributed simulation systems 显示文摘 | Gianni D Andrea D A Giuseppe L | 2011 | Simulation2011，87，9： | 1 |
| 11 | Monitoring natural and synthetic estrogens at activated sludge sewage treatment plant s and in a receiving river water 显示文摘 | CHIARA B ROBERTA C,GIUSEPPE D A | 2000 | Environ2000，34，24： | 1 |
| 12 | Energy Conservation in Wireless Sensor Networks: a Survey显示文摘 | Giuseppe A Marco C Mario D F | 2009 | Ad Hoc Networks2009，7，3： | 1 |
| 13 | Rotating biological contactor-solid contact system for the treatment of wastewater from small communities显示文摘 | Giuseppe d'A Mendia L | 1997 | Wat Sci Tech1997，35，6： | 1 |
| 14 | Fish consumption,dietary long-chain n-3 fatty acids,and risk of type 2 diabetes:systematic review and meta-analysis of prospective studies显示文摘 | Wallin A Di Giuseppe D Orsini N | 2012 | Diabetes Care2012，35，： | 1 |
| 15 | Energy conserva- tion in wireless sensor networks: a survey 显示文摘 | GIUSEPPE A MARCO C MARIO D F | 2009 | Ad hoc Networks2009，7，3： | 1 |
| 16 | The value of location in keyword auctions显示文摘 | MAUTIZIO N GIUSEPPE D A GIUSEPPE F I | 2010 | Electronic Commerce Research and Applications2010，，9： | 1 |
| 17 | A highly com- plex home care service for COPD in LTOT may reduce the exacerbations and the hospitalizations显示文摘 | Luigi D R Antonio O Giuseppe A | 2011 | Eur Respir J2011，38，55： | 1 |
| 18 | Adaptive gating for multitarget tracking with Gaussian mixture filters 显示文摘 | DAVIDE M GIUSEPPE T F D A | 2012 | IEEE Transactions on Signal Processing2012，60，3： | 1 |
| 19 | Synthesis, spectroscopic, and X-ray characterization of rhenium carbonyl complexes with different silsesquioxanes, as models that mimic the chemical behavior and the topol-- ogy of the silica surface 显示文摘 | Claudia D Lucia C Giuseppe D A | 2009 | Organometallics2009，28，： | 1 |
| 20 | WallFlex colonic stent placement for management of malignant colonic obstruction:a prospective study at two centers显示文摘 | Repici A Giuseppe D Luigiano C | | Gastrointestinal Endoscopy0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员